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Materials 2016, 9(7), 520; doi:10.3390/ma9070520

Curcumin and Osteosarcoma: Can Invertible Polymeric Micelles Help?

1
Department of Orthopedics, Mayo Clinic, 200 1st St SW, Rochester, MN 55905, USA
2
Department of Organic Chemistry, Lviv Polytechnic National University, vul. S. Bandery, 12, Lviv 79013, Ukraine
3
Department of Coatings and Polymeric Materials, North Dakota State University, NDSU Dept. 2760, P.O. Box 6050, Fargo, ND 58108-6050, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Carlos Lodeiro
Received: 17 May 2016 / Revised: 21 June 2016 / Accepted: 23 June 2016 / Published: 27 June 2016
(This article belongs to the Special Issue Selected papers from ISN2A2016)
View Full-Text   |   Download PDF [1813 KB, uploaded 27 June 2016]   |  

Abstract

Systematic review of experimental and clinical data on the use of curcumin in the treatment of osteosarcoma is presented. The current status of curcumin’s therapeutic potential against bone cancer is analyzed in regard to using polymeric micelles (including recently developed invertible, responsive, micelles) as a platform for curcumin delivery to treat osteosarcoma. The potential of micellar assemblies from responsive macromolecules in a controlled delivery of curcumin to osteosarcoma cells, and the release using a new inversion mechanism is revealed. View Full-Text
Keywords: invertible polymer micelles; micellar nanoassemblies; curcumin delivery; bone tumor treatment invertible polymer micelles; micellar nanoassemblies; curcumin delivery; bone tumor treatment
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Maran, A.; Yaszemski, M.J.; Kohut, A.; Voronov, A. Curcumin and Osteosarcoma: Can Invertible Polymeric Micelles Help? Materials 2016, 9, 520.

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