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Materials 2016, 9(6), 474; doi:10.3390/ma9060474

Morphological and Structural Study of a Novel Porous Nurse’s A Ceramic with Osteoconductive Properties for Tissue Engineering

1
Grupo de Investigación en Regeneración y Reparación de Tejidos, UCAM—Universidad Católica San Antonio de Murcia, Guadalupe, Murcia 30107, Spain
2
Instituto de Bioingeniería, Universidad Miguel Hernández Avda, Universidad s/n, Elche, Alicante 03202, Spain
3
Service of Orthopaedic at Arrixaca University Hospital, UCAM—Catholic University of Murcia, Murcia 30120, Spain
*
Author to whom correspondence should be addressed.
Academic Editor: Alina Maria Holban
Received: 25 May 2016 / Revised: 6 June 2016 / Accepted: 7 June 2016 / Published: 15 June 2016
(This article belongs to the Special Issue Materials for Hard and Soft Tissue Engineering: Novel Approaches)
View Full-Text   |   Download PDF [17887 KB, uploaded 15 June 2016]   |  

Abstract

The characterization process of a new porous Nurse’s A ceramic and the physico chemical nature of the remodeled interface between the implant and the surrounding bone were studied after in vivo implantation. Scaffolds were prepared by a solid-state reaction and implanted in New Zealand rabbits. Animals were sacrificed on days 15, 30, and 60. The porous biomaterial displayed biocompatible, bioresorbable, and osteoconductive capacity. The degradation processes of implants also encouraged osseous tissue ingrowths into the material’s pores, and drastically changed the macro- and microstructure of the implants. After 60 healing days, the resorption rates were 52.62% ± 1.12% for the ceramic and 47.38% ± 1.24% for the residual biomaterial. The elemental analysis showed a gradual diffusion of the Ca and Si ions from the materials into the newly forming bone during the biomaterial’s resorption process. The energy dispersive spectroscopy (EDS) analysis of the residual ceramic revealed some particle categories with different mean Ca/P ratios according to size, and indicated various resorption process stages. Since osteoconductive capacity was indicated for this material and bone ingrowth was possible, it could be applied to progressively substitute an implant. View Full-Text
Keywords: bioceramics; calcium silicophosphate; scanning electron microscopy; µ-Raman spectroscopy; bone response; biocompatibility bioceramics; calcium silicophosphate; scanning electron microscopy; µ-Raman spectroscopy; bone response; biocompatibility
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Rabadan-Ros, R.; Velásquez, P.A.; Meseguer-Olmo, L.; De Aza, P.N. Morphological and Structural Study of a Novel Porous Nurse’s A Ceramic with Osteoconductive Properties for Tissue Engineering. Materials 2016, 9, 474.

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