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Materials 2016, 9(6), 411; doi:10.3390/ma9060411

In Vitro Assessment of the Antibacterial Potential of Silver Nano-Coatings on Cotton Gauzes for Prevention of Wound Infections

1
Department of Engineering for Innovation, University of Salento, Via per Monteroni, Lecce 73100, Italy
2
CNR-IFN U.O.S. Bari, Via Amendola 173, Bari 70126, Italy
3
Dipartimento Interateneo di Fisica, University of Bari Aldo Moro, Via Amendola 173, Bari 70126, Italy
*
Author to whom correspondence should be addressed.
Academic Editor: Jaroslaw W. Drelich
Received: 22 February 2016 / Revised: 12 May 2016 / Accepted: 16 May 2016 / Published: 25 May 2016
(This article belongs to the Special Issue Advances and Applications of Nano-antimicrobial Treatments)
View Full-Text   |   Download PDF [4949 KB, uploaded 25 May 2016]   |  

Abstract

Multidrug-resistant organisms are increasingly implicated in acute and chronic wound infections, thus compromising the chance of therapeutic options. The resistance to conventional antibiotics demonstrated by some bacterial strains has encouraged new approaches for the prevention of infections in wounds and burns, among them the use of silver compounds and nanocrystalline silver. Recently, silver wound dressings have become widely accepted in wound healing centers and are commercially available. In this work, novel antibacterial wound dressings have been developed through a silver deposition technology based on the photochemical synthesis of silver nanoparticles. The devices obtained are completely natural and the silver coatings are characterized by an excellent adhesion without the use of any binder. The silver-treated cotton gauzes were characterized through scanning electron microscopy (SEM) and thermo-gravimetric analysis (TGA) in order to verify the distribution and the dimension of the silver particles on the cotton fibers. The effectiveness of the silver-treated gauzes in reducing the bacterial growth and biofilm proliferation has been demonstrated through agar diffusion tests, bacterial enumeration test, biofilm quantification tests, fluorescence and SEM microscopy. Moreover, potential cytotoxicity of the silver coating was evaluated through 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide colorimetric assay (MTT) and the extract method on fibroblasts and keratinocytes. Inductively coupled plasma mass spectrometry (ICP-MS) was performed in order to determine the silver release in different media and to relate the results to the biological characterization. All the results obtained were compared with plain gauzes as a negative control, as well as gauzes treated with a higher silver percentage as a positive control. View Full-Text
Keywords: silver dressing; biofilm; antibacterial; wound infection silver dressing; biofilm; antibacterial; wound infection
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MDPI and ACS Style

Paladini, F.; Di Franco, C.; Panico, A.; Scamarcio, G.; Sannino, A.; Pollini, M. In Vitro Assessment of the Antibacterial Potential of Silver Nano-Coatings on Cotton Gauzes for Prevention of Wound Infections. Materials 2016, 9, 411.

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