Next Article in Journal
Stability and Hydrocarbon/Fluorocarbon Sorption of a Metal-Organic Framework with Fluorinated Channels
Next Article in Special Issue
Graphene–Gold Nanoparticles Hybrid—Synthesis, Functionalization, and Application in a Electrochemical and Surface-Enhanced Raman Scattering Biosensor
Previous Article in Journal
Revising the Subsystem Nurse’s A-Phase-Silicocarnotite within the System Ca3(PO4)2–Ca2SiO4
Previous Article in Special Issue
Removal of 4-Chlorophenol from Contaminated Water Using Activated Carbon from Dried Date Pits: Equilibrium, Kinetics, and Thermodynamics Analyses
Article Menu
Issue 5 (May) cover image

Export Article

Open AccessFeature PaperArticle
Materials 2016, 9(5), 325; doi:10.3390/ma9050325

Rapid Biosynthesis of Silver Nanoparticles Using Pepino (Solanum muricatum) Leaf Extract and Their Cytotoxicity on HeLa Cells

1
Instituto Interuniversitario de Investigación de Reconocimiento Molecular y Desarrollo Tecnológico (IDM), Unidad Mixta Universitat Politècnica de València-Universitat de València, Camino de Vera s/n, Valencia 46022, Spain
2
CIBER de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Valencia 46022, Spain
3
Materials Chemistry Laboratory, Department of Chemistry, Gulbarga University, Gulbarga, Karnataka 585106, India
4
Biological Research Innovation Centre and Solutions LLP, Bengaluru, Karnataka 56004, India
5
Departamento de Química, Universitat Politècnica de València, Camino de Vera s/n, Valencia 46022, Spain
6
Instituto de Conservación y Mejora de la Agrodiversidad Valenciana, Universitat Politècnica de València, Camino de Vera 14, Valencia 46022, Spain
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Carlos Lodeiro
Received: 30 March 2016 / Revised: 21 April 2016 / Accepted: 25 April 2016 / Published: 28 April 2016
View Full-Text   |   Download PDF [2757 KB, uploaded 28 April 2016]   |  

Abstract

Within nanotechnology, gold and silver nanostructures have unique physical, chemical, and electronic properties [1,2], which make them suitable for a number of applications. Moreover, biosynthetic methods are considered to be a safer alternative to conventional physicochemical procedures for both the environmental and biomedical applications, due to their eco-friendly nature and the avoidance of toxic chemicals in the synthesis. For this reason, employing bio routes in the synthesis of functionalized silver nanoparticles (FAgNP) have gained importance recently in this field. In the present study, we report the rapid synthesis of FAgNP through the extract of pepino (Solanum muricatum) leaves and employing microwave oven irradiation. The core-shell globular morphology and characterization of the different shaped and sized FAgNP, with a core of 20–50 nm of diameter is established using the UV-Visible spectroscopy (UV-vis), field emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM) and Zeta potential and dynamic light scanning (DLS) studies. Moreover, cytotoxic studies employing HeLa (human cervix carcinoma) cells were undertaken to understand FAgNP interactions with cells. HeLa cells showed significant dose dependent antiproliferative activity in the presence of FAgNP at relatively low concentrations. The calculated IC50 value was 37.5 µg/mL, similar to others obtained for FAgNPs against HeLa cells. View Full-Text
Keywords: biosynthesis; silver nanoparticles; Solanum muricatum; microwave irradiation; cytotoxic studies biosynthesis; silver nanoparticles; Solanum muricatum; microwave irradiation; cytotoxic studies
Figures

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Gorbe, M.; Bhat, R.; Aznar, E.; Sancenón, F.; Marcos, M.D.; Herraiz, F.J.; Prohens, J.; Venkataraman, A.; Martínez-Máñez, R. Rapid Biosynthesis of Silver Nanoparticles Using Pepino (Solanum muricatum) Leaf Extract and Their Cytotoxicity on HeLa Cells. Materials 2016, 9, 325.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Materials EISSN 1996-1944 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top