Collagen Type I Conduits for the Regeneration of Nerve Defects
AbstractTo date, reliable data to support the general use of biodegradable materials for bridging nerve defects are still scarce. We present the outcome of nerve regeneration following type I collagen conduit nerve repair in patients with large-diameter nerve gaps. Ten patients underwent nerve repair using a type I collagen nerve conduit. Patients were re-examined at a minimal follow-up of 14.0 months and a mean follow-up of 19.9 months. Regeneration of nerve tissue within the conduits was assessed by nerve conduction velocity (NCV), a static two-point discrimination (S2PD) test, and as disability of arm shoulder and hand (DASH) outcome measure scoring. Quality of life measures including patients’ perceived satisfaction and residual pain were evaluated using a visual analog scale (VAS). No implant-related complications were observed. Seven out of 10 patients reported being free of pain, and the mean VAS was 1.1. The mean DASH score was 17.0. The S2PD was below 6 mm in 40%, between 6 and 10 mm in another 40% and above 10 mm in 20% of the patients. Eight out of 10 patients were satisfied with the procedure and would undergo surgery again. Early treatment correlated with lower DASH score levels. The use of type I collagen in large-diameter gaps in young patients and early treatment presented superior functional outcomes. View Full-Text
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Klein, S.; Vykoukal, J.; Felthaus, O.; Dienstknecht, T.; Prantl, L. Collagen Type I Conduits for the Regeneration of Nerve Defects. Materials 2016, 9, 219.
Klein S, Vykoukal J, Felthaus O, Dienstknecht T, Prantl L. Collagen Type I Conduits for the Regeneration of Nerve Defects. Materials. 2016; 9(4):219.Chicago/Turabian Style
Klein, Silvan; Vykoukal, Jody; Felthaus, Oliver; Dienstknecht, Thomas; Prantl, Lukas. 2016. "Collagen Type I Conduits for the Regeneration of Nerve Defects." Materials 9, no. 4: 219.
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