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Materials 2016, 9(4), 215; doi:10.3390/ma9040215

Antimicrobial Silver Chloride Nanoparticles Stabilized with Chitosan Oligomer for the Healing of Burns

1
Department of Nano Manufacturing Technology, Nano Convergence Mechanical Systems Research Division, Korea Institute of Machinery and Materials, Daejeon 34103, Korea
2
Department of Veterinary Medicine, Chungnam National University, Daejeon 305-764, Korea
3
Department of Polymer Science and Engineering, Kumoh National Institute of Technology, Gumi 39177, Korea
4
Department of Advanced Organic Materials and Textile System Engineering, Chungnam National University, Daejeon 305-764, Korea
*
Author to whom correspondence should be addressed.
Academic Editor: Mauro Pollini
Received: 11 February 2016 / Revised: 7 March 2016 / Accepted: 11 March 2016 / Published: 23 March 2016
(This article belongs to the Special Issue Advances and Applications of Nano-antimicrobial Treatments)
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Abstract

Recently, numerous compounds have been studied in order to develop antibacterial agents, which can prevent colonized wounds from infection, and assist the wound healing. For this purpose, novel silver chloride nanoparticles stabilized with chitosan oligomer (CHI-AgCl NPs) were synthesized to investigate the influence of antibacterial chitosan oligomer (CHI) exerted by the silver chloride nanoparticles (AgCl NPs) on burn wound healing in a rat model. The CHI-AgCl NPs had a spherical morphology with a mean diameter of 42 ± 15 nm. The burn wound healing of CHI-AgCl NPs ointment was compared with untreated group, Vaseline ointment, and chitosan ointment group. The burn wound treated with CHI-AgCl NPs ointment was completely healed by 14 treatment days, and was similar to normal skin. Particularly, the regenerated collagen density became the highest in the CHI-AgCl NPs ointment group. The CHI-AgCl NPs ointment is considered a suitable healing agent for burn wounds, due to dual antibacterial activity of the AgCl NPs and CHI. View Full-Text
Keywords: Silver chloride nanoparticles; Chitosan oligomer; Burn wound healing; Antibacterial activity Silver chloride nanoparticles; Chitosan oligomer; Burn wound healing; Antibacterial activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Kang, Y.O.; Jung, J.-Y.; Cho, D.; Kwon, O.H.; Cheon, J.Y.; Park, W.H. Antimicrobial Silver Chloride Nanoparticles Stabilized with Chitosan Oligomer for the Healing of Burns. Materials 2016, 9, 215.

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