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Materials 2016, 9(3), 212; doi:10.3390/ma9030212

Polystyrene-co-Divinylbenzene PolyHIPE Monoliths in 1.0 mm Column Formats for Liquid Chromatography

1
National Centre for Sensor Research, School of Chemical Sciences, Dublin City University, Dublin 9, Ireland
2
Pharmaceutical and Molecular Biotechnology Research Centre (PMBRC), Department of Science, Waterford Institute of Technology, Waterford, Ireland
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Academic Editor: Dermot Brabazon
Received: 18 January 2016 / Revised: 26 February 2016 / Accepted: 15 March 2016 / Published: 18 March 2016
(This article belongs to the Special Issue Porous Monolithic Materials for Applications in Separation Science)
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Abstract

The reversed phase liquid chromatographic (RP-HPLC) separation of small molecules using a polystyrene-co-divinylbenzene (PS-co-DVB) polyHIPE stationary phases housed within 1.0 mm i.d. silcosteel columns is presented within this study. A 90% PS-co-DVB polyHIPE was covalently attached to the walls of the column housing by prior wall modification with 3-(trimethoxysilyl) propyl methacrylate and could withstand operating backpressures in excess of 200 bar at a flow rate of 1.2 mL/min. Permeability studies revealed that the monolith swelled slightly in 100% acetonitrile relative to 100% water but could nevertheless be used to separate five alkylbenzenes using a flow rate of 40 µL/min (linear velocity: 0.57 mm/s). Remarkable column-to-column reproducibility is shown with retention factor variation between 2.6% and 6.1% for two separately prepared columns. View Full-Text
Keywords: polystyrene; polyHIPE; silcosteel; microbore; reversed phase LC; isocratic separation polystyrene; polyHIPE; silcosteel; microbore; reversed phase LC; isocratic separation
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Choudhury, S.; Fitzhenry, L.; White, B.; Connolly, D. Polystyrene-co-Divinylbenzene PolyHIPE Monoliths in 1.0 mm Column Formats for Liquid Chromatography. Materials 2016, 9, 212.

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