Development and Characterization of a Bioinspired Bone Matrix with Aligned Nanocrystalline Hydroxyapatite on Collagen Nanofibers
AbstractVarious kinds of three-dimensional (3D) scaffolds have been designed to mimic the biological spontaneous bone formation characteristics by providing a suitable microenvironment for osteogenesis. In view of this, a natural bone-liked composite scaffold, which was combined with inorganic (hydroxyapatite, Hap) and organic (type I collagen, Col) phases, has been developed through a self-assembly process. This 3D porous scaffold consisting of a c-axis of Hap nanocrystals (nHap) aligning along Col fibrils arrangement is similar to natural bone architecture. A significant increase in mechanical strength and elastic modulus of nHap/Col scaffold is achieved through biomimetic mineralization process when compared with simple mixture of collagen and hydroxyapatite method. It is suggested that the self-organization of Hap and Col produced in vivo could also be achieved in vitro. The oriented nHap/Col composite not only possesses bone-like microstructure and adequate mechanical properties but also enhances the regeneration and reorganization abilities of bone tissue. These results demonstrated that biomimetic nHap/Col can be successfully reconstructed as a bone graft substitute in bone tissue engineering. View Full-Text
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Wu, H.-C.; Wang, T.-W.; Sun, J.-S.; Lee, Y.-H.; Shen, M.-H.; Tsai, Z.-R.; Chen, C.-Y.; Hsu, H.-C. Development and Characterization of a Bioinspired Bone Matrix with Aligned Nanocrystalline Hydroxyapatite on Collagen Nanofibers. Materials 2016, 9, 198.
Wu H-C, Wang T-W, Sun J-S, Lee Y-H, Shen M-H, Tsai Z-R, Chen C-Y, Hsu H-C. Development and Characterization of a Bioinspired Bone Matrix with Aligned Nanocrystalline Hydroxyapatite on Collagen Nanofibers. Materials. 2016; 9(3):198.Chicago/Turabian Style
Wu, Hsi-Chin; Wang, Tzu-Wei; Sun, Jui-Sheng; Lee, Yi-Hsuan; Shen, Meng-Han; Tsai, Zong-Ruei; Chen, Chih-Yu; Hsu, Horng-Chaung. 2016. "Development and Characterization of a Bioinspired Bone Matrix with Aligned Nanocrystalline Hydroxyapatite on Collagen Nanofibers." Materials 9, no. 3: 198.
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