Next Article in Journal
Nanotextured Shrink Wrap Superhydrophobic Surfaces by Argon Plasma Etching
Next Article in Special Issue
Synthesis of Dendronized Poly(l-Glutamate) via Azide-Alkyne Click Chemistry
Previous Article in Journal
Repopulating Decellularized Kidney Scaffolds: An Avenue for Ex Vivo Organ Generation
Previous Article in Special Issue
Newly Developed Techniques on Polycondensation, Ring-Opening Polymerization and Polymer Modification: Focus on Poly(Lactic Acid)
Article Menu
Issue 3 (March) cover image

Export Article

Open AccessArticle
Materials 2016, 9(3), 191; doi:10.3390/ma9030191

A Novel HA/β-TCP-Collagen Composite Enhanced New Bone Formation for Dental Extraction Socket Preservation in Beagle Dogs

1
School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei 110, Taiwan
2
Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, Taipei 106, Taiwan
3
Graduate Institute of Biomedical Materials & Tissue Engineering, College of Oral Medicine, Taipei Medical University, Taipei 110, Taiwan
4
Dental Department, Taipei Medical University Hospital, Taipei 110, Taiwan
5
Dental Department, Taipei Medical University, Shuang-Ho Hospital, New Taipei 235, Taiwan
The authors are equal contributors to this study.
*
Author to whom correspondence should be addressed.
Academic Editor: Marek M. Kowalczuk
Received: 9 November 2015 / Revised: 7 March 2016 / Accepted: 9 March 2016 / Published: 11 March 2016
(This article belongs to the Special Issue Biodegradable and Bio-Based Polymers)
View Full-Text   |   Download PDF [5030 KB, uploaded 14 March 2016]   |  

Abstract

Past studies in humans have demonstrated horizontal and vertical bone loss after six months following tooth extraction. Many biomaterials have been developed to preserve bone volume after tooth extraction. Type I collagen serves as an excellent delivery system for growth factors and promotes angiogenesis. Calcium phosphate ceramics have also been investigated because their mineral chemistry resembles human bone. The aim of this study was to compare the performance of a novel bioresorbable purified fibrillar collagen and hydroxyapatite/β-tricalcium phosphate (HA/β-TCP) ceramic composite versus collagen alone and a bovine xenograft-collagen composite in beagles. Collagen plugs, bovine graft-collagen composite and HA/β-TCP-collagen composite were implanted into the left and right first, second and third mandibular premolars, and the fourth molar was left empty for natural healing. In total, 20 male beagle dogs were used, and quantitative and histological analyses of the extraction ridge was done. The smallest width reduction was 19.09% ± 8.81% with the HA/β-TCP-collagen composite at Week 8, accompanied by new bone formation at Weeks 4 and 8. The HA/β-TCP-collagen composite performed well, as a new osteoconductive and biomimetic composite biomaterial, for socket bone preservation after tooth extraction. View Full-Text
Keywords: hydroxyapatite; β-tricalcium phosphate; composite; collagen; allograft; socket preservation; animal study hydroxyapatite; β-tricalcium phosphate; composite; collagen; allograft; socket preservation; animal study
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Ho, K.-N.; Salamanca, E.; Chang, K.-C.; Shih, T.-C.; Chang, Y.-C.; Huang, H.-M.; Teng, N.-C.; Lin, C.-T.; Feng, S.-W.; Chang, W.-J. A Novel HA/β-TCP-Collagen Composite Enhanced New Bone Formation for Dental Extraction Socket Preservation in Beagle Dogs. Materials 2016, 9, 191.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Materials EISSN 1996-1944 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top