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Materials 2016, 9(3), 190; doi:10.3390/ma9030190

Repopulating Decellularized Kidney Scaffolds: An Avenue for Ex Vivo Organ Generation

Department of Biological Sciences, Center for Stem Cells and Regenerative Medicine, Center for Zebrafish Research, University of Notre Dame, Notre Dame, IN 46556, USA
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Academic Editor: Michael Nerlich
Received: 15 December 2015 / Revised: 1 March 2016 / Accepted: 4 March 2016 / Published: 11 March 2016
(This article belongs to the Special Issue Regenerative Materials)
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Abstract

Recent research has shown that fully developed organs can be decellularized, resulting in a complex scaffold and extracellular matrix (ECM) network capable of being populated with other cells. This work has resulted in a growing field in bioengineering focused on the isolation, characterization, and modification of organ derived acellular scaffolds and their potential to sustain and interact with new cell populations, a process termed reseeding. In this review, we cover contemporary advancements in the bioengineering of kidney scaffolds including novel work showing that reseeded donor scaffolds can be transplanted and can function in recipients using animal models. Several major areas of the field are taken into consideration, including the decellularization process, characterization of acellular and reseeded scaffolds, culture conditions, and cell sources. Finally, we discuss future avenues based on the advent of 3D bioprinting and recent developments in kidney organoid cultures as well as animal models of renal genesis. The ongoing mergers and collaborations between these fields hold the potential to produce functional kidneys that can be generated ex vivo and utilized for kidney transplantations in patients suffering with renal disease. View Full-Text
Keywords: bioartificial kidney; renal scaffold; extracellular matrix; matrix-cell signaling; reseeding; renal assist device; stem cell; cell therapy; regenerative medicine bioartificial kidney; renal scaffold; extracellular matrix; matrix-cell signaling; reseeding; renal assist device; stem cell; cell therapy; regenerative medicine
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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McKee, R.A.; Wingert, R.A. Repopulating Decellularized Kidney Scaffolds: An Avenue for Ex Vivo Organ Generation. Materials 2016, 9, 190.

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