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Materials 2016, 9(11), 934; doi:10.3390/ma9110934

Characterization and Bioactivity Evaluation of (Polyetheretherketone/Polyglycolicacid)-Hydroyapatite Scaffolds for Tissue Regeneration

1
State Key Laboratory of High Performance Complex Manufacturing, the State Key Laboratory for Powder Metallurgy, Central South University, Changsha 410083, China
2
State Key Laboratory of Solidification Processing, Northwestern Polytechnical University, Xi’an 710072, China
3
College of Chemistry, Xiangtan University, Xiangtan 411105, China
4
Hunan Farsoon High-Technology Co. Ltd., Changsha 410205, China
5
Health Management Center, Xiangya Hospital, Central South University, Changsha 410008, China
6
The Key Laboratory of Carcinogenesis of the Chinese Ministry of Health, Xiangya Hospital, Central South University, Changsha 410008, China
7
The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha 410078, China
8
Hunan Key Laboratory of Nonresolving Inflammation and Cancer, Disease Genome Research Center, The Third Xiangya Hospital, Central South University, Changsha 410078, China
*
Authors to whom correspondence should be addressed.
Academic Editor: Biqiong Chen
Received: 22 September 2016 / Revised: 3 November 2016 / Accepted: 14 November 2016 / Published: 18 November 2016
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Abstract

Bioactivity and biocompatibility are crucial for tissue engineering scaffolds. In this study, hydroxyapatite (HAP) was incorporated into polyetheretherketone/polyglycolicacid (PEEK/PGA) hybrid to improve its biological properties, and the composite scaffolds were developed via selective laser sintering (SLS). The effects of HAP on physical and chemical properties of the composite scaffolds were investigated. The results demonstrated that HAP particles were distributed evenly in PEEK/PGA matrix when its content was no more than 10 wt %. Furthermore, the apatite-forming ability became better with increasing HAP content after immersing in simulated body fluid (SBF). Meanwhile, the composite scaffolds presented a greater degree of cell attachment and proliferation than PEEK/PGA scaffolds. These results highlighted the potential of (PEEK/PGA)-HAP scaffolds for tissue regeneration. View Full-Text
Keywords: bioactivity; biocompatibility; Hydroxyapatite; composite scaffolds; selective laser sintering bioactivity; biocompatibility; Hydroxyapatite; composite scaffolds; selective laser sintering
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Shuai, C.; Shuai, C.; Wu, P.; Yuan, F.; Feng, P.; Yang, Y.; Guo, W.; Fan, X.; Su, T.; Peng, S.; Gao, C. Characterization and Bioactivity Evaluation of (Polyetheretherketone/Polyglycolicacid)-Hydroyapatite Scaffolds for Tissue Regeneration. Materials 2016, 9, 934.

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