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Materials 2016, 9(11), 871; doi:10.3390/ma9110871

Bacterial Infection and Implant Loosening in Hip and Knee Arthroplasty: Evaluation of 209 Cases

1
Center for Orthopaedics, Trauma Surgery and Spinal Cord Injury, Heidelberg University Hospital, Schlierbacher Landstrasse 200a, Heidelberg 69118, Germany
2
Institute for Immunology, Heidelberg University, Im Neuenheimer Feld 305, Heidelberg 69120, Germany
*
Author to whom correspondence should be addressed.
Academic Editor: Carla Renata Arciola
Received: 13 June 2016 / Revised: 2 October 2016 / Accepted: 11 October 2016 / Published: 26 October 2016
(This article belongs to the Special Issue Anti-Infective Materials in Medicine and Technology)
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Abstract

The aim of this study was to evaluate bacteria species detected in a large number of patients treated for prosthetic joint infection of the hip and knee at a single specialized center. Furthermore, the rate of implant loosening was investigated in a time-dependent manner for the most frequently detected bacteria species. A retrospective analysis of patients (n = 209) treated for prosthetic joint infection of the hip and knee was performed. The following parameters were evaluated: C-Reactive Protein (CRP) concentration, microbiological evaluation of tissue samples, loosening of the implant, the time that had elapsed since the primary prosthetic joint replacement, and the duration since the last surgical intervention. Coagulase-negative Staphylococcus spp. were most frequently detected, followed by Staphylococcus aureus. Differences in CRP concentration were detected among various bacteria species. Osteolysis was not associated with one causative agent in particular. Patients who had undergone previous revision surgery had a higher probability of implant loosening. Coagulase-negative Staphylococcus spp. are the most common causative agents of prosthetic joint infection and show no significant differences with regard to implant loosening or the time-course when compared to S. aureus. Infections with Enterococcus spp. seem to develop faster than with other bacteria species. The risk of implant loosening increases with revision surgery, in particular in the hip joint. View Full-Text
Keywords: coagulase-negative Staphylococcus spp.; hip arthroplasty; implant loosening; knee arthroplasty; prosthetic joint infection coagulase-negative Staphylococcus spp.; hip arthroplasty; implant loosening; knee arthroplasty; prosthetic joint infection
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Dapunt, U.; Radzuweit-Mihaljevic, S.; Lehner, B.; Haensch, G.M.; Ewerbeck, V. Bacterial Infection and Implant Loosening in Hip and Knee Arthroplasty: Evaluation of 209 Cases. Materials 2016, 9, 871.

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