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Materials 2016, 9(11), 867; doi:10.3390/ma9110867

Investigation on the Regional Loss Factor and Its Anisotropy for Aortic Aneurysms

1
Department of Mechanical Engineering, McGill University, Montreal, QC H3A 0C3, Canada
2
Research Center, Montreal Heart Institute, Montreal, QC H1T 1C8, Canada
3
Division of Cardiac Surgery, Royal Victoria Hospital, Montreal, Montreal, QC H4A 3J1, Canada
4
Department of Chemical Engineering, McGill University, Montreal, QC H3A 2B2, Canada
5
Division of Cardiac Surgery, Montreal Heart Institute, Université de Montréal, Montreal, QC H1T 1C8, Canada
*
Author to whom correspondence should be addressed.
Academic Editor: Amir A. Zadpoor
Received: 27 July 2016 / Revised: 25 September 2016 / Accepted: 12 October 2016 / Published: 26 October 2016
(This article belongs to the Special Issue Biomaterials and Tissue Biomechanics)
View Full-Text   |   Download PDF [4622 KB, uploaded 26 October 2016]   |  

Abstract

An aortic aneurysm is a lethal arterial disease that mainly occurs in the thoracic and abdominal regions of the aorta. Thoracic aortic aneurysms are prevalent in the root/ascending parts of the aorta and can lead to aortic rupture resulting in the sudden death of patients. Understanding the biomechanical and histopathological changes associated with ascending thoracic aortic aneurysms (ATAAs), this study investigates the mechanical properties of the aorta during strip-biaxial tensile cycles. The loss factor—defined as the ratio of dissipated energy to the energy absorbed during a tensile cycle—the incremental modulus, and their anisotropy indexes were compared with the media fiber compositions for aneurysmal (n = 26) and control (n = 4) human ascending aortas. The aneurysmal aortas were categorized into the aortas with bicuspid aortic valves (BAV) and tricuspid aortic valves (TAV). The strip-biaxial loss factor correlates well with the diameter of the aortas with BAV and TAV (for the axial direction, respectively, R2 = 0.71, p = 0.0022 and R2 = 0.54, p = 0.0096). The loss factor increases significantly with patients’ age in the BAV group (for the axial direction: R2 = 0.45, p = 0.0164). The loss factor is isotropic for all TAV quadrants, whereas it is on average only isotropic in the anterior and outer curvature regions of the BAV group. The results suggest that loss factor may be a useful surrogate measure to describe the histopathology of aneurysmal tissue and to demonstrate the differences between ATAAs with the BAV and TAV. View Full-Text
Keywords: aortic aneurysm; loss factor; strip-biaxial tensile test; age; aortic diameter; collagen and elastin aortic aneurysm; loss factor; strip-biaxial tensile test; age; aortic diameter; collagen and elastin
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Shahmansouri, N.; Alreshidan, M.; Emmott, A.; Lachapelle, K.; El-Hamamsy, I.; Cartier, R.; Leask, R.L.; Mongrain, R. Investigation on the Regional Loss Factor and Its Anisotropy for Aortic Aneurysms. Materials 2016, 9, 867.

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