Investigation on the Regional Loss Factor and Its Anisotropy for Aortic Aneurysms
AbstractAn aortic aneurysm is a lethal arterial disease that mainly occurs in the thoracic and abdominal regions of the aorta. Thoracic aortic aneurysms are prevalent in the root/ascending parts of the aorta and can lead to aortic rupture resulting in the sudden death of patients. Understanding the biomechanical and histopathological changes associated with ascending thoracic aortic aneurysms (ATAAs), this study investigates the mechanical properties of the aorta during strip-biaxial tensile cycles. The loss factor—defined as the ratio of dissipated energy to the energy absorbed during a tensile cycle—the incremental modulus, and their anisotropy indexes were compared with the media fiber compositions for aneurysmal (n = 26) and control (n = 4) human ascending aortas. The aneurysmal aortas were categorized into the aortas with bicuspid aortic valves (BAV) and tricuspid aortic valves (TAV). The strip-biaxial loss factor correlates well with the diameter of the aortas with BAV and TAV (for the axial direction, respectively, R2 = 0.71, p = 0.0022 and R2 = 0.54, p = 0.0096). The loss factor increases significantly with patients’ age in the BAV group (for the axial direction: R2 = 0.45, p = 0.0164). The loss factor is isotropic for all TAV quadrants, whereas it is on average only isotropic in the anterior and outer curvature regions of the BAV group. The results suggest that loss factor may be a useful surrogate measure to describe the histopathology of aneurysmal tissue and to demonstrate the differences between ATAAs with the BAV and TAV. View Full-Text
Scifeed alert for new publicationsNever miss any articles matching your research from any publisher
- Get alerts for new papers matching your research
- Find out the new papers from selected authors
- Updated daily for 49'000+ journals and 6000+ publishers
- Define your Scifeed now
Shahmansouri, N.; Alreshidan, M.; Emmott, A.; Lachapelle, K.; El-Hamamsy, I.; Cartier, R.; Leask, R.L.; Mongrain, R. Investigation on the Regional Loss Factor and Its Anisotropy for Aortic Aneurysms. Materials 2016, 9, 867.
Shahmansouri N, Alreshidan M, Emmott A, Lachapelle K, El-Hamamsy I, Cartier R, Leask RL, Mongrain R. Investigation on the Regional Loss Factor and Its Anisotropy for Aortic Aneurysms. Materials. 2016; 9(11):867.Chicago/Turabian Style
Shahmansouri, Nastaran; Alreshidan, Mohammed; Emmott, Alexander; Lachapelle, Kevin; El-Hamamsy, Ismaïl; Cartier, Raymond; Leask, Richard L.; Mongrain, Rosaire. 2016. "Investigation on the Regional Loss Factor and Its Anisotropy for Aortic Aneurysms." Materials 9, no. 11: 867.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.