Next Article in Journal
Optothermal Switching of Cholesteric Liquid Crystals: A Study of Azobenzene Derivatives and Laser Wavelengths
Previous Article in Journal
Spark Plasma Sintering of Commercial Zirconium Carbide Powders: Densification Behavior and Mechanical Properties
Article Menu

Export Article

Open AccessArticle
Materials 2015, 8(9), 6062-6070; doi:10.3390/ma8095291

In Vitro Studies of Polyhedral Oligo Silsesquioxanes: Evidence for Their Low Cytotoxicity

1
Department of General Biophysics, Faculty of Biology and Environmental Protection, University of Lodz, Pomorska 141/143, Lodz 90-236, Poland
2
Centre of Molecular and Macromolecular Sciences, Sienkiewicza 112, Lodz 90-236, Poland
3
Leibniz-Institut für Polymerforschung Dresden e.V., Hohe Strasse 6, Dresden 01069, Germany
*
Author to whom correspondence should be addressed.
Academic Editor: Aldo Boccaccini
Received: 26 June 2015 / Revised: 25 August 2015 / Accepted: 6 September 2015 / Published: 10 September 2015
(This article belongs to the Section Biomaterials)
View Full-Text   |   Download PDF [780 KB, uploaded 10 September 2015]   |  

Abstract

As scientific literature considers polyhedral oligosilsesquioxanes (POSS) as potential drug delivery systems, it is necessary to check their impact on mammalian cells. Toxicity of octaammonium chloride salt of octaaminopropyl polyhedral oligomeric silsesquioxane (oap-POSS) towards two cell lines: mouse neuroblastoma (N2a) and embryonic mouse hippocampal cells (mHippoE-18) was studied. Experiments consisted of analysis of a cell cycle, cell viability, amount of apoptotic and necrotic cells, and generation of reactive oxygen species (ROS). POSS caused a shift in the cell population from the S and M/G2 phases to the G0/G1 phase. However, the changes affected less than 10% of the cell population and were not accompanied by increased cytotoxicity. POSS did not induce either apoptosis or necrosis and did not generate reactive oxygen species. A cytotoxicity profile of POSS makes it a promising starting material as drug carrier. View Full-Text
Keywords: POSS; silsesquioxane; in vitro toxicity; MTT assay; cell cycle; apoptosis; necrosis; reactive oxygen species POSS; silsesquioxane; in vitro toxicity; MTT assay; cell cycle; apoptosis; necrosis; reactive oxygen species
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Supplementary material

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Janaszewska, A.; Gradzinska, K.; Marcinkowska, M.; Klajnert-Maculewicz, B.; Stanczyk, W.A. In Vitro Studies of Polyhedral Oligo Silsesquioxanes: Evidence for Their Low Cytotoxicity. Materials 2015, 8, 6062-6070.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Materials EISSN 1996-1944 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top