In Vitro Studies of Polyhedral Oligo Silsesquioxanes: Evidence for Their Low Cytotoxicity
AbstractAs scientific literature considers polyhedral oligosilsesquioxanes (POSS) as potential drug delivery systems, it is necessary to check their impact on mammalian cells. Toxicity of octaammonium chloride salt of octaaminopropyl polyhedral oligomeric silsesquioxane (oap-POSS) towards two cell lines: mouse neuroblastoma (N2a) and embryonic mouse hippocampal cells (mHippoE-18) was studied. Experiments consisted of analysis of a cell cycle, cell viability, amount of apoptotic and necrotic cells, and generation of reactive oxygen species (ROS). POSS caused a shift in the cell population from the S and M/G2 phases to the G0/G1 phase. However, the changes affected less than 10% of the cell population and were not accompanied by increased cytotoxicity. POSS did not induce either apoptosis or necrosis and did not generate reactive oxygen species. A cytotoxicity profile of POSS makes it a promising starting material as drug carrier. View Full-Text
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Janaszewska, A.; Gradzinska, K.; Marcinkowska, M.; Klajnert-Maculewicz, B.; Stanczyk, W.A. In Vitro Studies of Polyhedral Oligo Silsesquioxanes: Evidence for Their Low Cytotoxicity. Materials 2015, 8, 6062-6070.
Janaszewska A, Gradzinska K, Marcinkowska M, Klajnert-Maculewicz B, Stanczyk WA. In Vitro Studies of Polyhedral Oligo Silsesquioxanes: Evidence for Their Low Cytotoxicity. Materials. 2015; 8(9):6062-6070.Chicago/Turabian Style
Janaszewska, Anna; Gradzinska, Kinga; Marcinkowska, Monika; Klajnert-Maculewicz, Barbara; Stanczyk, Wlodzimierz A. 2015. "In Vitro Studies of Polyhedral Oligo Silsesquioxanes: Evidence for Their Low Cytotoxicity." Materials 8, no. 9: 6062-6070.