Next Article in Journal
The π-Electron Delocalization in 2-Oxazolines Revisited: Quantification and Comparison with Its Analogue in Esters
Previous Article in Journal
Preparation of LuAG Powders with Single Phase and Good Dispersion for Transparent Ceramics Using Co-Precipitation Method
Article Menu

Export Article

Open AccessArticle
Materials 2015, 8(8), 5376-5384; doi:10.3390/ma8085254

Towards Tuning the Mechanical Properties of Three-Dimensional Collagen Scaffolds Using a Coupled Fiber-Matrix Model

1
Department of Mechanical and Materials Engineering, University of Nebraska-Lincoln, Lincoln, NE 68588-0656, USA
2
Biomedical Engineering, Cornell University, Ithaca, NY 14853, USA
3
Nebraska Center for Materials and Nanoscience, Lincoln, NE 68588-0656, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Juergen Stampfl
Received: 24 June 2015 / Revised: 12 August 2015 / Accepted: 14 August 2015 / Published: 20 August 2015
(This article belongs to the Section Biomaterials)
View Full-Text   |   Download PDF [3293 KB, uploaded 20 August 2015]   |  

Abstract

Scaffold mechanical properties are essential in regulating the microenvironment of three-dimensional cell culture. A coupled fiber-matrix numerical model was developed in this work for predicting the mechanical response of collagen scaffolds subjected to various levels of non-enzymatic glycation and collagen concentrations. The scaffold was simulated by a Voronoi network embedded in a matrix. The computational model was validated using published experimental data. Results indicate that both non-enzymatic glycation-induced matrix stiffening and fiber network density, as regulated by collagen concentration, influence scaffold behavior. The heterogeneous stress patterns of the scaffold were induced by the interfacial mechanics between the collagen fiber network and the matrix. The knowledge obtained in this work could help to fine-tune the mechanical properties of collagen scaffolds for improved tissue regeneration applications. View Full-Text
Keywords: collagen scaffold; fiber-matrix interaction; glycation; collagen concentration; computational biomechanics collagen scaffold; fiber-matrix interaction; glycation; collagen concentration; computational biomechanics
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Lin, S.; Hapach, L.A.; Reinhart-King, C.; Gu, L. Towards Tuning the Mechanical Properties of Three-Dimensional Collagen Scaffolds Using a Coupled Fiber-Matrix Model. Materials 2015, 8, 5376-5384.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Materials EISSN 1996-1944 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top