Mineralized Collagen: Rationale, Current Status, and Clinical Applications
Abstract
:1. Introduction
2. Rationale for Mineralized Collagen
3. Studies on Biomimetic Mineralized Collagen
4. Commercially Available Mineralized Collagen Products
Product | Company | Composition | Porosity | Pore Size | Form | Claimed mechanisms of action |
---|---|---|---|---|---|---|
Bio-Oss Collagen® | Geistlich, Switzerland | 10% type I collagen and 90% bovine mineral | 70%–75% | 300–1500 μm | Block |
|
Bongold® | Allgens, China | Self-assembled type I bovine collagen and hydroxyapatite (HA) similar to the natural mineralized collagen | 70%–88% | 50–550 μm | Strip, granule, block, putty, sponge |
|
CopiOs® | Zimmer, USA | Type I bovine collagen and 67% mineral | 93.39% | - | Sponge, paste |
|
HEALOS® | Johnson & Johnson, USA | 70% type I bovine collagen and HA | > 95% | 4–200 μm | Strip |
|
MOZAIK™ | Integra, USA | 20% type I collagen and 80% β-TCP | - | 12–350 μm | Strip, putty |
|
MASTERGRAFT® Strip/Putty | Medtronic, USA | Bovine type I collagen and biphasic ceramics (15% HA and 85% β-TCP) | 89% | - | Strip |
|
OSTEON™ | Dentium, Korea | 8% type I collagen and 92% mineral (30% HA and 70% β-TCP) | 70% | 500–1000 μm | Cylinder |
|
OssiMend™ | Collagen Matrix, USA | 45% bovine type I collagen and 55% synthetic calcium phosphate | - | - | Strip, block, putty |
|
Refit | HOYA, Japan | 20% type I bovine collagen and 80% HA | 95% | 100–500 μm | Block |
|
SynOss™ Putty | Collagen Matrix, USA | Type I collagen and carbonate HA | - | - | Putty |
|
Vitoss® FOAM | Stryker, USA | Type I bovine collagen and calcium phosphate | 90% | 1–1000 μm | Putty, strip, flow, morsels and shapes |
|
5. Clinical Applications of Mineralized Collagen Products
5.1. Restoration of Bone Defects in Orthopedic Applications
5.2. Bone Volume Augmentation in Dental Surgeries
5.3. Reconstruction of Skull Defects in Neurosurgical Applications
6. Conclusions
Acknowledgments
Author Contributions
Conflicts of Interest
References
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Qiu, Z.-Y.; Cui, Y.; Tao, C.-S.; Zhang, Z.-Q.; Tang, P.-F.; Mao, K.-Y.; Wang, X.-M.; Cui, F.-Z. Mineralized Collagen: Rationale, Current Status, and Clinical Applications. Materials 2015, 8, 4733-4750. https://doi.org/10.3390/ma8084733
Qiu Z-Y, Cui Y, Tao C-S, Zhang Z-Q, Tang P-F, Mao K-Y, Wang X-M, Cui F-Z. Mineralized Collagen: Rationale, Current Status, and Clinical Applications. Materials. 2015; 8(8):4733-4750. https://doi.org/10.3390/ma8084733
Chicago/Turabian StyleQiu, Zhi-Ye, Yun Cui, Chun-Sheng Tao, Zi-Qiang Zhang, Pei-Fu Tang, Ke-Ya Mao, Xiu-Mei Wang, and Fu-Zhai Cui. 2015. "Mineralized Collagen: Rationale, Current Status, and Clinical Applications" Materials 8, no. 8: 4733-4750. https://doi.org/10.3390/ma8084733