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Materials 2015, 8(3), 1150-1161; doi:10.3390/ma8031150

Combined Effect of a Microporous Layer and Type I Collagen Coating on a Biphasic Calcium Phosphate Scaffold for Bone Tissue Engineering

1
Department of Medical & Biological Engineering, Graduate School, Kyungpook National University, 2-188-1 Samduk-dong, Jung-gu, Daegu 700-412, Korea
2
Department of Dental Biomaterials, School of Dentistry, Kyungpook National University, 2-188-1 Samduk-dong, Jung-gu, Daegu 700-412, Korea
*
Author to whom correspondence should be addressed.
Academic Editor: Ihtesham ur Rehman
Received: 30 January 2015 / Revised: 10 March 2015 / Accepted: 10 March 2015 / Published: 16 March 2015
(This article belongs to the Special Issue Dental Materials)
View Full-Text   |   Download PDF [1582 KB, uploaded 16 March 2015]   |  

Abstract

In this study, type I collagen was coated onto unmodified and modified microporous biphasic calcium phosphate (BCP) scaffolds. Surface characterization using a scanning electron microscope (SEM) and a surface goniometer confirmed the modification of the BCP coating. The quantity of the collagen coating was investigated using Sirius Red staining, and quantitative assessment of the collagen coating showed no significant differences between the two groups. MG63 cells were used to evaluate cell proliferation and ALP activity on the modified BCP scaffolds. The modified microporous surfaces showed low contact angles and large surface areas, which enhanced cell spreading and proliferation. Coating of the BCP scaffolds with type I collagen led to enhanced cell-material interactions and improved MG63 functions, such as spreading, proliferation, and differentiation. The micropore/collagen-coated scaffold showed the highest rate of cell response. These results indicate that a combination of micropores and collagen enhances cellular function on bioengineered bone allograft tissue. View Full-Text
Keywords: biphasic calcium phosphate; microporous layer; type I collagen; combined effect; bone tissue engineering biphasic calcium phosphate; microporous layer; type I collagen; combined effect; bone tissue engineering
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Lee, M.-H.; You, C.; Kim, K.-H. Combined Effect of a Microporous Layer and Type I Collagen Coating on a Biphasic Calcium Phosphate Scaffold for Bone Tissue Engineering. Materials 2015, 8, 1150-1161.

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