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Materials 2015, 8(11), 7634-7649; doi:10.3390/ma8115411

Reduction of Adipose Tissue Formation by the Controlled Release of BMP-2 Using a Hydroxyapatite-Coated Collagen Carrier System for Sinus-Augmentation/Extraction-Socket Grafting

1
Department of Periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University, Seoul 03722, Korea
2
Department of Applied Life Science, BK21 PLUS Project, College of Dentistry, Yonsei University, Seoul 03722, Korea
3
School of Chemical and Biological Engineering, Seoul National University, Seoul 08826, Korea
4
Department of Orthopaedic Surgery, Ilsan Hospital, Dongguk University, Goyang 10326, Korea
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Wen-Hsiang Hsieh
Received: 11 August 2015 / Revised: 29 October 2015 / Accepted: 4 November 2015 / Published: 11 November 2015
(This article belongs to the Special Issue Selected Papers from ICBEI2015)
View Full-Text   |   Download PDF [6233 KB, uploaded 11 November 2015]   |  

Abstract

The effects of hydroxyapatite (HA)-coating onto collagen carriers for application of recombinant human bone morphogenetic protein 2 (rhBMP-2) on cell differentiation in vitro, and on in vivo healing patterns after sinus-augmentation and alveolar socket-grafting were evaluated. In vitro induction of osteogenic/adipogenic differentiation was compared between the culture media with rhBMP-2 solution and with the released rhBMP-2 from the control collagen and from the HA-coated collagen. Demineralized bovine bone and collagen/HA-coated collagen were grafted with/without rhBMP-2 in sinus-augmentation and tooth-extraction-socket models. Adipogenic induction by rhBMP-2 released from HA-coated collagen was significantly reduced compared to collagen. In the sinus-augmentation model, sites that received rhBMP-2 exhibited large amounts of vascular tissue formation at two weeks and increased adipose tissue formation at eight weeks; this could be significantly reduced by using HA-coated collagen as a carrier for rhBMP-2. In extraction-socket grafting, dimensional reduction of alveolar ridge was significantly decreased at sites received rhBMP-2 compared to control sites, but adipose tissue was increased within the regenerated socket area. In conclusion, HA-coated collagen carrier for Escherichia coli-derived rhBMP-2 (ErhBMP-2) may reduce in vitro induction of adipogenic differentiation and in vivo adipose bone marrow tissue formation in bone tissue engineering by ErhBMP-2. View Full-Text
Keywords: bone morphogenetic protein; collagen; hydroxyapatite; drug delivery system; bone regeneration bone morphogenetic protein; collagen; hydroxyapatite; drug delivery system; bone regeneration
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Lee, J.-S.; Kim, T.-W.; Park, S.; Kim, B.-S.; Im, G.-I.; Cho, K.-S.; Kim, C.-S. Reduction of Adipose Tissue Formation by the Controlled Release of BMP-2 Using a Hydroxyapatite-Coated Collagen Carrier System for Sinus-Augmentation/Extraction-Socket Grafting. Materials 2015, 8, 7634-7649.

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