Next Article in Journal
The Design and Investigation of Nanocomposites Containing Dimeric Nematogens and Liquid Crystal Gold Nanoparticles with Plasmonic Properties Showing a Nematic-Nematic Phase Transition (Nu-Nx/Ntb)
Previous Article in Journal
Modeling the Formation of Transverse Weld during Billet-on-Billet Extrusion
Materials 2014, 7(5), 3481-3493; doi:10.3390/ma7053481
Article

Encapsulation of Hydrophobic Phthalocyanine with Poly(N-isopropylacrylamide)/Lipid Composite Microspheres for Thermo-Responsive Release and Photodynamic Therapy

1
, 3
, 1
, 1
, 1
, 1,* , 1
 and 1,2,*
Received: 6 March 2014; in revised form: 26 March 2014 / Accepted: 21 April 2014 / Published: 30 April 2014
View Full-Text   |   Download PDF [774 KB, uploaded 30 April 2014]   |   Browse Figures
Abstract: Phthalocyanine (Pc) is a type of promising sensitizer molecules for photodynamic therapy (PDT), but its hydrophobicity substantially prevents its applications. In this study, we efficiently encapsulate Pc into poly(N-isopropylacrylamide) (pNIPAM) microgel particles, without or with lipid decoration (i.e., Pc@pNIPAM or Pc@pNIPAM/lipid), to improve its water solubility and prevent aggregation in aqueous medium. The incorporation of lipid molecules significantly enhances the Pc loading efficiency of pNIPAM. These Pc@pNIPAM and Pc@pNIPAM/lipid composite microspheres show thermo-triggered release of Pc and/or lipid due to the phase transition of pNIPAM. Furthermore, in the in vitro experiments, these composite particles work as drug carriers for the hydrophobic Pc to be internalized into HeLa cells. After internalization, the particles show efficient fluorescent imaging and PDT effect. Our work demonstrates promising candidates in promoting the use of hydrophobic drugs including photosensitizers in tumor therapies.
Keywords: phthalocyanine; phospholipid; composite microsphere; controlled release; photodynamic therapy phthalocyanine; phospholipid; composite microsphere; controlled release; photodynamic therapy
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

Liu, J.; Li, J.; Zhang, Z.; Weng, Y.; Chen, G.; Yuan, B.; Yang, K.; Ma, Y. Encapsulation of Hydrophobic Phthalocyanine with Poly(N-isopropylacrylamide)/Lipid Composite Microspheres for Thermo-Responsive Release and Photodynamic Therapy. Materials 2014, 7, 3481-3493.

AMA Style

Liu J, Li J, Zhang Z, Weng Y, Chen G, Yuan B, Yang K, Ma Y. Encapsulation of Hydrophobic Phthalocyanine with Poly(N-isopropylacrylamide)/Lipid Composite Microspheres for Thermo-Responsive Release and Photodynamic Therapy. Materials. 2014; 7(5):3481-3493.

Chicago/Turabian Style

Liu, Jiaojiao; Li, Jingliang; Zhang, Zexin; Weng, Yuyan; Chen, Gaojian; Yuan, Bing; Yang, Kai; Ma, Yuqiang. 2014. "Encapsulation of Hydrophobic Phthalocyanine with Poly(N-isopropylacrylamide)/Lipid Composite Microspheres for Thermo-Responsive Release and Photodynamic Therapy." Materials 7, no. 5: 3481-3493.


Materials EISSN 1996-1944 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert