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Materials 2014, 7(4), 2395-2410; doi:10.3390/ma7042395

Bioeutectic® Ceramics for Biomedical Application Obtained by Laser Floating Zone Method. In vivo Evaluation

Instituto de Bioingenieria, Universidad Miguel Hernandez, Avda. Ferrocarril s/n, Elche 03202, Alicante, Spain
Department of Science and Technology of Materials and Fluids, Material Science Institute of Aragon, University of Zaragoza-CSIC, c/ Maria de Luna 3, Zaragoza 50018, Spain
Materials Science Department, School of Engineering and Materials Science, Queen Mary University of London, Mile End Road London E1 4NS, UK
Unidad de Bioingeniería ósea, Servicio de Cirugía Ortopédica, Hospital Clínico Universitario Virgen de la Arrixaca, Universidad de Murcia, Murcia 30120, Spain
Author to whom correspondence should be addressed.
Received: 4 December 2013 / Revised: 20 February 2014 / Accepted: 10 March 2014 / Published: 25 March 2014
(This article belongs to the Section Biomaterials)
View Full-Text   |   Download PDF [4354 KB, uploaded 25 March 2014]   |  


In this study, the Bioeutectic® blocks were inserted into the critical size defects of eight rabbits, using both tibiae, and the physical and chemical nature of the remodeled interface between the Bioeutectic® implants and the surrounding bone were performed at four and 15 months. The results showed a new fully mineralized bone growing in direct contact with the implants. The ionic exchange, taking place at the implant interface with the body fluids was essential in the process of the implant integration through a dissolution-precipitation-transformation mechanism. The study found the interface biologically and chemically active over the 15 months implantation period. The osteoblastic cells migrated towards the interface and colonized the surface at the contact areas with the bone. The new developed apatite structure of porous morphology mimics natural bone. View Full-Text
Keywords: calcium phosphate silicate; osseointegration; implantation; in vivo evaluation calcium phosphate silicate; osseointegration; implantation; in vivo evaluation

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

De Aza, P.N.; Peña, J.I.; Luklinska, Z.B.; Meseguer-Olmo, L. Bioeutectic® Ceramics for Biomedical Application Obtained by Laser Floating Zone Method. In vivo Evaluation. Materials 2014, 7, 2395-2410.

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