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Materials 2013, 6(8), 3213-3225; doi:10.3390/ma6083213

Fluorescent Magnetic Bioprobes by Surface Modification of Magnetite Nanoparticles

1 Department of Chemistry-CICECO (Centre for Research in Ceramics and Composite Materials), Aveiro Institute of Nanotechnology, University of Aveiro, 3810-193 Aveiro, Portugal 2 Institute of Nanoscience of Aragón (INA), University of Zaragoza, 50018 Zaragoza, Spain
* Author to whom correspondence should be addressed.
Received: 3 June 2013 / Revised: 28 June 2013 / Accepted: 23 July 2013 / Published: 31 July 2013
(This article belongs to the Special Issue Luminescent Materials 2013)
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Bimodal nanoprobes comprising both magnetic and optical functionalities have been prepared via a sequential two-step process. Firstly, magnetite nanoparticles (MNPs) with well-defined cubic shape and an average dimension of 80 nm were produced by hydrolysis of iron sulfate and were then surface modified with silica shells by using the sol-gel method. The Fe3O4@SiO2 particles were then functionalized with the fluorophore, fluorescein isothiocyanate (FITC), mediated by assembled shells of the cationic polyelectrolyte, polyethyleneimine (PEI). The Fe3O4 functionalized particles were then preliminary evaluated as fluorescent and magnetic probes by performing studies in which neuroblast cells have been contacted with these nanomaterials.
Keywords: magnetic nanoparticles; fluorescence; polyelectrolyte; surface functionalization magnetic nanoparticles; fluorescence; polyelectrolyte; surface functionalization
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Pinheiro, P.C.; Daniel-da-Silva, A.L.; Tavares, D.S.; Calatayud, M.P.; Goya, G.F.; Trindade, T. Fluorescent Magnetic Bioprobes by Surface Modification of Magnetite Nanoparticles. Materials 2013, 6, 3213-3225.

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