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Materials 2013, 6(8), 3213-3225; doi:10.3390/ma6083213
Article

Fluorescent Magnetic Bioprobes by Surface Modification of Magnetite Nanoparticles

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Received: 3 June 2013; in revised form: 28 June 2013 / Accepted: 23 July 2013 / Published: 31 July 2013
(This article belongs to the Special Issue Luminescent Materials 2013)
Download PDF [648 KB, uploaded 31 July 2013]
Abstract: Bimodal nanoprobes comprising both magnetic and optical functionalities have been prepared via a sequential two-step process. Firstly, magnetite nanoparticles (MNPs) with well-defined cubic shape and an average dimension of 80 nm were produced by hydrolysis of iron sulfate and were then surface modified with silica shells by using the sol-gel method. The Fe3O4@SiO2 particles were then functionalized with the fluorophore, fluorescein isothiocyanate (FITC), mediated by assembled shells of the cationic polyelectrolyte, polyethyleneimine (PEI). The Fe3O4 functionalized particles were then preliminary evaluated as fluorescent and magnetic probes by performing studies in which neuroblast cells have been contacted with these nanomaterials.
Keywords: magnetic nanoparticles; fluorescence; polyelectrolyte; surface functionalization magnetic nanoparticles; fluorescence; polyelectrolyte; surface functionalization
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Pinheiro, P.C.; Daniel-da-Silva, A.L.; Tavares, D.S.; Calatayud, M.P.; Goya, G.F.; Trindade, T. Fluorescent Magnetic Bioprobes by Surface Modification of Magnetite Nanoparticles. Materials 2013, 6, 3213-3225.

AMA Style

Pinheiro PC, Daniel-da-Silva AL, Tavares DS, Calatayud MP, Goya GF, Trindade T. Fluorescent Magnetic Bioprobes by Surface Modification of Magnetite Nanoparticles. Materials. 2013; 6(8):3213-3225.

Chicago/Turabian Style

Pinheiro, Paula C.; Daniel-da-Silva, Ana L.; Tavares, Daniela S.; Calatayud, M. P.; Goya, Gerardo F.; Trindade, Tito. 2013. "Fluorescent Magnetic Bioprobes by Surface Modification of Magnetite Nanoparticles." Materials 6, no. 8: 3213-3225.


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