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Materials 2013, 6(10), 4787-4800; doi:10.3390/ma6104787

Controlled Aloin Release from Crosslinked Polyacrylamide Hydrogels: Effects of Mesh Size, Electric Field Strength and a Conductive Polymer

1
Department of Materials and Metallurgical Engineering, Faculty of Engineering, Rajamangala University of Technology Thanyaburi, Klong 6, Thanyaburi, Pathumthani 12110, Thailand
2
Conductive and Electroactive Polymers Research Unit, The Petroleum and Petrochemical College, Chulalongkorn University, Bangkok 10330, Thailand
*
Author to whom correspondence should be addressed.
Received: 21 September 2013 / Revised: 6 October 2013 / Accepted: 11 October 2013 / Published: 22 October 2013
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Abstract

The aim of this paper is to investigate the effects of hydrogel mesh size, a conductive polymer, and electric field strength on controlled drug delivery phenomena using drug-loaded polyacrylamide hydrogels prepared at various crosslinking ratios both with and without a conductive polymer system. Poly(p-phenylene vinylene), PPV, as the model conductive polymer, was used to study its ability to control aloin released from aloin-doped poly(p-phenylene vinylene)/polyacrylamide hydrogel (aloin-doped PPV/PAAM). In the passive release, the diffusion of aloin from five aloin-doped PPV/PAAM hydrogel systems each was delayed ranging from during the first three hours to during the first 14 h due to the ionic interaction between the anionic drug and PPV. After the delayed periods, aloin could diffuse continuously into the buffer solution through the PAAM matrix. The amount of aloin released from the aloin-doped PPV/PAAM rose with increasing electric field strength as a result of the three mechanisms: the expansion of PPV chains inside the hydrogel, iontophoresis, and the electroporation of the matrix pore size, combined. Furthermore, the conductive polymer and the electric field could be used in combination to regulate the amount of release drug to a desired level, to control the release rate, and to switch the drug delivery on/off.
Keywords: aloin; iontophoresis; transdermal drug delivery; conductive polymer aloin; iontophoresis; transdermal drug delivery; conductive polymer
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Niamlang, S.; Buranut, T.; Niansiri, A.; Sirivat, A. Controlled Aloin Release from Crosslinked Polyacrylamide Hydrogels: Effects of Mesh Size, Electric Field Strength and a Conductive Polymer. Materials 2013, 6, 4787-4800.

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