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Mesenchymal Stem Cells in Combination with Scaffolds for Bone Tissue Engineering
Division of Orthodontics, American University of Beirut, P.O.Box 11-0236, Riad El-Solh, Beirut 1107-2020, Lebanon
Department of Anatomy, Cell Biology and Physiological Sciences, Faculty of Medecine, American University of Beirut, P.O.Box 11-0236, Riad El-Solh, Beirut 1107-2020, Lebanon
* Author to whom correspondence should be addressed.
Received: 27 July 2011; Accepted: 16 August 2011 / Published: 11 October 2011
Abstract: This article reviews past and current strategies of the use of bone graft substitutes along with the future biologic alternatives that can enhance the functional capabilities of those grafts. Many of these bone graft substitute alternatives include ceramic-based, allograft-based, factor-based and polymer-based whereas others are cell-based. The ways of achieving the goal of tissue engineering using stem cells and their lineage to regenerate tissue have been detailed with regard to both the generation of sufficient vascular invasion of the tissue to improve oxygen and nutrient supply, and the development of innovative physical/chemical stimuli to induce bone formation with the proper biomaterial to carry the cells. It is imperative to integrate basic polymer science with molecular biology and stem cell biology, in the design of new materials that perform very sophisticated signaling needed for integration and function.
Keywords: stem cells; bone grafts; biomaterial; tissue engineering
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Cite This Article
MDPI and ACS Style
Nassif, L.; El Sabban, M. Mesenchymal Stem Cells in Combination with Scaffolds for Bone Tissue Engineering. Materials 2011, 4, 1793-1804.
Nassif L, El Sabban M. Mesenchymal Stem Cells in Combination with Scaffolds for Bone Tissue Engineering. Materials. 2011; 4(10):1793-1804.
Nassif, Laeticia; El Sabban, Marwan. 2011. "Mesenchymal Stem Cells in Combination with Scaffolds for Bone Tissue Engineering." Materials 4, no. 10: 1793-1804.