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Materials 2011, 4(10), 1793-1804; doi:10.3390/ma4101793

Mesenchymal Stem Cells in Combination with Scaffolds for Bone Tissue Engineering

Received: 27 July 2011 / Accepted: 16 August 2011 / Published: 11 October 2011
(This article belongs to the Special Issue Orthopaedic Biomaterials)
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This article reviews past and current strategies of the use of bone graft substitutes along with the future biologic alternatives that can enhance the functional capabilities of those grafts. Many of these bone graft substitute alternatives include ceramic-based, allograft-based, factor-based and polymer-based whereas others are cell-based. The ways of achieving the goal of tissue engineering using stem cells and their lineage to regenerate tissue have been detailed with regard to both the generation of sufficient vascular invasion of the tissue to improve oxygen and nutrient supply, and the development of innovative physical/chemical stimuli to induce bone formation with the proper biomaterial to carry the cells. It is imperative to integrate basic polymer science with molecular biology and stem cell biology, in the design of new materials that perform very sophisticated signaling needed for integration and function.
Keywords: stem cells; bone grafts; biomaterial; tissue engineering stem cells; bone grafts; biomaterial; tissue engineering
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Nassif, L.; El Sabban, M. Mesenchymal Stem Cells in Combination with Scaffolds for Bone Tissue Engineering. Materials 2011, 4, 1793-1804.

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