Next Article in Journal
Chitin-Methacrylate: Preparation, Characterization and Hydrogel Formation
Next Article in Special Issue
Crystallization Study and Comparative in Vitroin Vivo Hydrolysis of PLA Reinforcement Ligament
Previous Article in Journal
Manganese-based Materials Inspired by Photosynthesis for Water-Splitting
Previous Article in Special Issue
The Effect of Synovial Fluid Enzymes on the Biodegradability of Collagen and Fibrin Clots
Article Menu

Export Article

Open AccessArticle
Materials 2011, 4(10), 1705-1727; doi:10.3390/ma4101705

Polyacylurethanes as Novel Degradable Cell Carrier Materials for Tissue Engineering

Department of Polymer Science, Faculty of Mathematics and Natural Sciences, Zernike Institute for Advanced Materials, University of Groningen, Nijenborgh 4, 9747 AG Groningen, The Netherlands
Institute for Bioengineering, Martin-Luther University, Halle 06108, Germany
Department of Biomedical Engineering, University Medical Centre Groningen, University of Groningen, A. Deusinglaan 1, building 3215, FB40, 9713AV Groningen, The Netherlands
Department of Pathology and Medical Biology, University Medical Centre Groningen, University of Groningen, Hanzeplein 1, 9713 GZ, Groningen, The Netherlands
Author to whom correspondence should be addressed.
Received: 10 September 2011 / Accepted: 21 September 2011 / Published: 6 October 2011
(This article belongs to the Special Issue Biodegradability of Materials in Biomedical Applications 2011)
View Full-Text   |   Download PDF [566 KB, uploaded 11 October 2011]   |  


Polycaprolactone (PCL) polyester and segmented aliphatic polyester urethanes based on PCL soft segment have been thoroughly investigated as biodegradable scaffolds for tissue engineering. Although proven beneficial as long term implants, these materials degrade very slowly and are therefore not suitable in applications in which scaffold support is needed for a shorter time. A recently developed class of polyacylurethanes (PAUs) is expected to fulfill such requirements. Our aim was to assess in vitro the degradation of PAUs and evaluate their suitability as temporary scaffold materials to support soft tissue repair. With both a mass loss of 2.5–3.0% and a decrease in molar mass of approx. 35% over a period of 80 days, PAUs were shown to degrade via both bulk and surface erosion mechanisms. Fourier Transform Infra Red (FTIR) spectroscopy was successfully applied to study the extent of PAUs microphase separation during in vitro degradation. The microphase separated morphology of PAU1000 (molar mass of the oligocaprolactone soft segment = 1000 g/mol) provided this polymer with mechano-physical characteristics that would render it a suitable material for constructs and devices. PAU1000 exhibited excellent haemocompatibility in vitro. In addition, PAU1000 supported both adhesion and proliferation of vascular endothelial cells and this could be further enhanced by pre-coating of PAU1000 with fibronectin (Fn). The contact angle of PAU1000 decreased both with in vitro degradation and by incubation in biological fluids. In endothelial cell culture medium the contact angle reached 60°, which is optimal for cell adhesion. Taken together, these results support the application of PAU1000 in the field of soft tissue repair as a temporary degradable scaffold. View Full-Text
Keywords: biodegradable polymers; tissue engineering; biomedical polyurethanes; hydrolytic degradation; acylurethanes; blood compatibility; endothelial cells biodegradable polymers; tissue engineering; biomedical polyurethanes; hydrolytic degradation; acylurethanes; blood compatibility; endothelial cells

Figure 1

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Jovanovic, D.; Roukes, F.V.; Löber, A.; Engels, G.E.; Oeveren, W.; Seijen, X.J.G.; Luyn, M.J.; Harmsen, M.C.; Schouten, A.J. Polyacylurethanes as Novel Degradable Cell Carrier Materials for Tissue Engineering. Materials 2011, 4, 1705-1727.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Materials EISSN 1996-1944 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top