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Self-Assembled Hydrogel Nanoparticles for Drug Delivery Applications
IBB-Institute for Biotechnology and Bioengineering, Centre for Biological Engineering, Minho University, Campus de Gualtar 4710-057, Braga, Portugal
* Author to whom correspondence should be addressed.
Received: 13 January 2010; in revised form: 4 February 2010 / Accepted: 21 February 2010 / Published: 24 February 2010
Abstract: Hydrogel nanoparticles—also referred to as polymeric nanogels or macromolecular micelles—are emerging as promising drug carriers for therapeutic applications. These nanostructures hold versatility and properties suitable for the delivery of bioactive molecules, namely of biopharmaceuticals. This article reviews the latest developments in the use of self-assembled polymeric nanogels for drug delivery applications, including small molecular weight drugs, proteins, peptides, oligosaccharides, vaccines and nucleic acids. The materials and techniques used in the development of self-assembling nanogels are also described.
Keywords: polymer; delivery; targeting; self-assembly; drugs
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Cite This Article
MDPI and ACS Style
Gonçalves, C.; Pereira, P.; Gama, M. Self-Assembled Hydrogel Nanoparticles for Drug Delivery Applications. Materials 2010, 3, 1420-1460.
Gonçalves C, Pereira P, Gama M. Self-Assembled Hydrogel Nanoparticles for Drug Delivery Applications. Materials. 2010; 3(2):1420-1460.
Gonçalves, Catarina; Pereira, Paula; Gama, Miguel. 2010. "Self-Assembled Hydrogel Nanoparticles for Drug Delivery Applications." Materials 3, no. 2: 1420-1460.