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Materials 2010, 3(2), 1420-1460; doi:10.3390/ma3021420

Self-Assembled Hydrogel Nanoparticles for Drug Delivery Applications

IBB-Institute for Biotechnology and Bioengineering, Centre for Biological Engineering, Minho University, Campus de Gualtar 4710-057, Braga, Portugal
* Author to whom correspondence should be addressed.
Received: 13 January 2010 / Revised: 4 February 2010 / Accepted: 21 February 2010 / Published: 24 February 2010
(This article belongs to the Special Issue Advances in Biomaterials)
Download PDF [797 KB, uploaded 24 February 2010]


Hydrogel nanoparticles—also referred to as polymeric nanogels or macromolecular micelles—are emerging as promising drug carriers for therapeutic applications. These nanostructures hold versatility and properties suitable for the delivery of bioactive molecules, namely of biopharmaceuticals. This article reviews the latest developments in the use of self-assembled polymeric nanogels for drug delivery applications, including small molecular weight drugs, proteins, peptides, oligosaccharides, vaccines and nucleic acids. The materials and techniques used in the development of self-assembling nanogels are also described.
Keywords: polymer; delivery; targeting; self-assembly; drugs polymer; delivery; targeting; self-assembly; drugs
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Gonçalves, C.; Pereira, P.; Gama, M. Self-Assembled Hydrogel Nanoparticles for Drug Delivery Applications. Materials 2010, 3, 1420-1460.

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