Abstract: Cylindrical elastomers were prepared through the UV-initiated crosslinking of terminally acrylated, 8,000 Da star-poly(trimethylene carbonate-co-ε-caprolactone) and star-poly(trimethylene carbonate-co-D,L-lactide). These elastomers were implanted intramuscularly into the hind legs of male Wistar rats to determine the influence of the comonomer on the weight loss, tissue response, and change in mechanical properties of the elastomer. The elastomers exhibited only a mild inflammatory response that subsided after the first week; the response was greater for the stiffer D,L-lactide-containing elastomers. The elastomers exhibited weight loss and sol content changes consistent with a bulk degradation mechanism. The D,L-lactide-containing elastomers displayed a nearly zeroorder change in Young’s modulus and stress at break over the 30 week degradation time, while the ε-caprolactone-containing elastomers exhibited little change in modulus or stress at break.
Keywords: in vivo; trimethylene carbonate; elastomer; lactide; caprolactone; tissue response; mechanical properties
This is an open access article distributed under the
Creative Commons Attribution License which permits unrestricted use, distribution,
and reproduction in any medium, provided the original work is properly cited.
Export to BibTeX
MDPI and ACS Style
Timbart, L.; Tse, M.Y.; Pang, S.C.; Amsden, B.G. Tissue Response to, and Degradation Rate of, Photocrosslinked Trimethylene Carbonate-Based Elastomers Following Intramuscular Implantation. Materials 2010, 3, 1156-1171.
Timbart L, Tse MY, Pang SC, Amsden BG. Tissue Response to, and Degradation Rate of, Photocrosslinked Trimethylene Carbonate-Based Elastomers Following Intramuscular Implantation. Materials. 2010; 3(2):1156-1171.
Timbart, Laurianne; Tse, Man Yat; Pang, Stephen C.; Amsden, Brian G. 2010. "Tissue Response to, and Degradation Rate of, Photocrosslinked Trimethylene Carbonate-Based Elastomers Following Intramuscular Implantation." Materials 3, no. 2: 1156-1171.