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Bone Substitute Fabrication Based on Dissolution-Precipitation Reactions
Department of Biomaterials, Faculty of Dental Science, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582 Japan
Received: 7 December 2009; in revised form: 29 January 2010 / Accepted: 9 February 2010 / Published: 10 February 2010
Abstract: Although block- or granular-type sintered hydroxyapatite are known to show excellent tissue responses and good osteoconductivity, apatite powder elicits inflammatory response. For the fabrication of hydroxyapatite block or granules, sintering is commonly employed. However, the inorganic component of bone and tooth is not high crystalline hydroxyapatite but low crystalline B-type carbonate apatite. Unfortunately, carbonate apatite powder cannot be sintered due to its instability at high temperature. Another method to fabricate apatite block and/or granule is through phase transformation based on dissolution-precipitation reactions using a precursor phase. This reaction basically is the same as a setting and hardening reaction of calcium sulfate or plaster. In this paper, apatite block fabrication methods by phase transformation based on dissolution-precipitation reactions will be discussed, with a focus on the similarity of the setting and hardening reaction of calcium sulfate.
Keywords: apatite; phase transformation; dissolution-precipitation; carbonate apatite; low-crystallinity; precursor
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MDPI and ACS Style
Ishikawa, K. Bone Substitute Fabrication Based on Dissolution-Precipitation Reactions. Materials 2010, 3, 1138-1155.
Ishikawa K. Bone Substitute Fabrication Based on Dissolution-Precipitation Reactions. Materials. 2010; 3(2):1138-1155.
Ishikawa, Kunio. 2010. "Bone Substitute Fabrication Based on Dissolution-Precipitation Reactions." Materials 3, no. 2: 1138-1155.