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Materials 2018, 11(2), 281; https://doi.org/10.3390/ma11020281

Carrier-Free Microspheres of an Anti-Cancer Drug Synthesized via a Sodium Catalyst for Controlled-Release Drug Delivery

1
Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, China
2
State Key Laboratory of New Ceramics and Fine Processing, School of Materials Science and Engineering, Tsinghua University, Beijing 100084, China
3
Southern China Branch, Sinopec Commercial Holding Company Limited, Guangzhou 510630, China
*
Authors to whom correspondence should be addressed.
Received: 30 December 2017 / Revised: 31 January 2018 / Accepted: 6 February 2018 / Published: 11 February 2018
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Abstract

There are several challenges involved in the development of effective anti-cancer drugs, including accurate drug delivery without toxic side effects. Possible systemic toxicity and the rapid biodegradation of drug carriers are potential risks in the use of carriers for drug-delivery formulations. Therefore, the carrier-free drug delivery of an anti-cancer drug is desirable. Herein, 4-amino-2-benzyl-6-methylpyrimidine (ABMP) was synthesized via a new method using a sodium catalyst, and proved to be effective in inducing breast cancer cell (MDA-MB-231) apoptosis. Moreover, the transparent amorphous state solid of ABMP was demonstrated to have a slow-release property in phosphate buffer solution (PBS). Microspheres of ABMP were prepared with diameters in the range of 5–15 μm. The slow-release property of the ABMP microspheres indicated their potential use for controlled-release drug delivery. We believe that microspheres of ABMP have potential as a new kind of carrier-free anti-cancer drug delivery system. View Full-Text
Keywords: carrier-free; 4-amino-2-benzyl-6-methylpyrimidine; biomaterial; drug delivery carrier-free; 4-amino-2-benzyl-6-methylpyrimidine; biomaterial; drug delivery
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Xie, Y.; Ma, X.; Liu, X.; Long, Q.; Wang, Y.; Yao, Y.; Cai, Q. Carrier-Free Microspheres of an Anti-Cancer Drug Synthesized via a Sodium Catalyst for Controlled-Release Drug Delivery. Materials 2018, 11, 281.

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