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Materials 2018, 11(1), 6; https://doi.org/10.3390/ma11010006

Osteointegration of Porous Poly-ε-Caprolactone-Coated and Previtalised Magnesium Implants in Critically Sized Calvarial Bone Defects in the Mouse Model

1
Small Animal Clinic, University of Veterinary Medicine Hannover, Foundation, D-30559 Hannover, Germany
2
Division of Medicine Clinic III, Hematology, Oncology and Palliative Medicine, University of Rostock, D-18057 Rostock, Germany
3
Institute for General Radiology and Medical Physics, University of Veterinary Medicine Hannover, Foundation, D-30173 Hannover, Germany
4
Institute for Biomedical Engineering, Rostock University Medical Center, D-18119 Rostock, Germany
5
Clinic for Cranio-Maxillo-Facial Surgery, Hannover Medical School, D-30625 Hannover, Germany
6
Institut fuer Werkstoffkunde, Leibniz Universitaet Hannover, D-30823 Garbsen, Germany
These authors contributed equally to this study.
*
Author to whom correspondence should be addressed.
Received: 9 September 2017 / Revised: 15 December 2017 / Accepted: 18 December 2017 / Published: 21 December 2017
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Abstract

Metallic biomaterials are widely used in maxillofacial surgery. While titanium is presumed to be the gold standard, magnesium-based implants are a current topic of interest and investigation due to their biocompatible, osteoconductive and degradable properties. This study investigates the effects of poly-ε-caprolactone-coated and previtalised magnesium implants on osteointegration within murine calvarial bone defects: After setting a 3 mm × 3 mm defect into the calvaria of 40 BALB/c mice the animals were treated with poly-ε-caprolactone-coated porous magnesium implants (without previtalisation or previtalised with either osteoblasts or adipose derived mesenchymal stem cells), porous Ti6Al4V implants or without any implant. To evaluate bone formation and implant degradation, micro-computertomographic scans were performed at day 0, 28, 56 and 84 after surgery. Additionally, histological thin sections were prepared and evaluated histomorphometrically. The outcomes revealed no significant differences within the differently treated groups regarding bone formation and the amount of osteoid. While the implant degradation resulted in implant shifting, both implant geometry and previtalisation appeared to have positive effects on vascularisation. Although adjustments in degradation behaviour and implant fixation are indicated, this study still considers magnesium as a promising alternative to titanium-based implants in maxillofacial surgery in future. View Full-Text
Keywords: magnesium; poly-caprolactone; implant; calvarial defect; mouse; in vivo small animal imaging; micro-computed tomography; previtalisation; osteoblast; ADMSC magnesium; poly-caprolactone; implant; calvarial defect; mouse; in vivo small animal imaging; micro-computed tomography; previtalisation; osteoblast; ADMSC
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Grau, M.; Seiler, C.; Roland, L.; Matena, J.; Windhövel, C.; Teske, M.; Murua Escobar, H.; Lüpke, M.; Seifert, H.; Gellrich, N.-C.; Haferkamp, H.; Nolte, I. Osteointegration of Porous Poly-ε-Caprolactone-Coated and Previtalised Magnesium Implants in Critically Sized Calvarial Bone Defects in the Mouse Model. Materials 2018, 11, 6.

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