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Materials 2017, 10(9), 983; doi:10.3390/ma10090983

In Vitro Effectiveness of Microspheres Based on Silk Sericin and Chlorella vulgaris or Arthrospira platensis for Wound Healing Applications

1
Department of Drug Sciences, University of Pavia, Viale Taramelli 12, 27100 Pavia, Italy
2
Research Unit on Implant Infections, Rizzoli Orthopaedic Institute of Bologna, Via di Barbiano 1/10, 40136 Bologna, Italy
3
Department of Experimental, University of Bologna, Diagnostic and Specialty Medicine (DIMES), Via San Giacomo 14, 40126 Bologna, Italy
4
Department of Chemistry, University of Pavia, Viale Taramelli 16, 27100 Pavia, Italy
5
Osteoarticular Regeneration Laboratory, Rizzoli Orthopaedic Institute of Bologna, Via Giulio Cesare Pupilli 1, 40136 Bologna, Italy
*
Author to whom correspondence should be addressed.
Received: 5 July 2017 / Revised: 10 August 2017 / Accepted: 21 August 2017 / Published: 23 August 2017
(This article belongs to the Special Issue State-of-the-Art Materials Science in Italy 2017)
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Abstract

Some natural compounds have recently been widely employed in wound healing applications due to their biological properties. One such compound is sericin, which is produced by Bombix mori, while active polyphenols, polysaccharides and proteins are synthetized by Chlorella vulgaris and Arthrospira platensis microalgae. Our hypothesis was that sericin, as an optimal bioactive polymeric carrier for microencapsulation process, could also improve the regenerative effect of the microalgae. A solvent-free extraction method and spray drying technique were combined to obtain five formulations, based on algal extracts (C. vulgaris and A. platensis, Chl and Art, respectively) or silk sericin (Ser) or their mixtures (Chl-Ser and Art-Ser). The spray drying was a suitable method to produce microspheres with similar dimensions, characterized by collapsed morphology with a rough surface. Art and Art-Ser showed higher antioxidant properties than other formulations. All microspheres resulted in cytocompatibility on fibroblasts until 1.25 mg/mL and promoted cell migration and the complete wound closure; this positive effect was further highlighted after treatment with Art and Art-Ser. To our surprize the combination of sericin to Art did not improve the microalgae extract efficacy, at least in our experimental conditions. View Full-Text
Keywords: silk sericin; Chlorella vulgaris; Arthrospira platensis; spray drying; microspheres; wound healing silk sericin; Chlorella vulgaris; Arthrospira platensis; spray drying; microspheres; wound healing
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MDPI and ACS Style

Bari, E.; Arciola, C.R.; Vigani, B.; Crivelli, B.; Moro, P.; Marrubini, G.; Sorrenti, M.; Catenacci, L.; Bruni, G.; Chlapanidas, T.; Lucarelli, E.; Perteghella, S.; Torre, M.L. In Vitro Effectiveness of Microspheres Based on Silk Sericin and Chlorella vulgaris or Arthrospira platensis for Wound Healing Applications. Materials 2017, 10, 983.

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