Next Article in Journal
Research on the Mechanism of In-Plane Vibration on Friction Reduction
Previous Article in Journal
Force Transmission Modes of Non-Cohesive and Cohesive Materials at the Critical State
Article Menu
Issue 9 (September) cover image

Export Article

Open AccessReview
Materials 2017, 10(9), 1013; doi:10.3390/ma10091013

A Review of Recent Advances towards the Development of (Quantitative) Structure-Activity Relationships for Metallic Nanomaterials

1
Institute of Environmental Sciences, Leiden University, 2300 RA Leiden, The Netherlands
2
Centre for Safety of Substances and Products, National Institute of Public Health and the Environment (RIVM), 3720 BA Bilthoven, The Netherlands
*
Author to whom correspondence should be addressed.
Received: 1 July 2017 / Revised: 8 August 2017 / Accepted: 28 August 2017 / Published: 31 August 2017
(This article belongs to the Special Issue Environmental Impact of Nanomaterials)
View Full-Text   |   Download PDF [882 KB, uploaded 1 September 2017]   |  

Abstract

Gathering required information in a fast and inexpensive way is essential for assessing the risks of engineered nanomaterials (ENMs). The extension of conventional (quantitative) structure-activity relationships ((Q)SARs) approach to nanotoxicology, i.e., nano-(Q)SARs, is a possible solution. The preliminary attempts of correlating ENMs’ characteristics to the biological effects elicited by ENMs highlighted the potential applicability of (Q)SARs in the nanotoxicity field. This review discusses the current knowledge on the development of nano-(Q)SARs for metallic ENMs, on the aspects of data sources, reported nano-(Q)SARs, and mechanistic interpretation. An outlook is given on the further development of this frontier. As concluded, the used experimental data mainly concern the uptake of ENMs by different cell lines and the toxicity of ENMs to cells lines and Escherichia coli. The widely applied techniques of deriving models are linear and non-linear regressions, support vector machine, artificial neural network, k-nearest neighbors, etc. Concluded from the descriptors, surface properties of ENMs are seen as vital for the cellular uptake of ENMs; the capability of releasing ions and surface redox properties of ENMs are of importance for evaluating nanotoxicity. This review aims to present key advances in relevant nano-modeling studies and stimulate future research efforts in this quickly developing field of research. View Full-Text
Keywords: nano-(Q)SARs; metallic nanomaterials; risk assessment; cellular uptake; toxicity nano-(Q)SARs; metallic nanomaterials; risk assessment; cellular uptake; toxicity
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Chen, G.; Vijver, M.G.; Xiao, Y.; Peijnenburg, W.J. A Review of Recent Advances towards the Development of (Quantitative) Structure-Activity Relationships for Metallic Nanomaterials. Materials 2017, 10, 1013.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Materials EISSN 1996-1944 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top