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Materials 2017, 10(7), 758; doi:10.3390/ma10070758

A New Biphasic Dicalcium Silicate Bone Cement Implant

1
Escuela de Arquitectura y Diseño, Universidad Pontificia Bolivariana, Circular 1 N° 70-01, Bloque 10 Of 306, Medellín-Antioquia 050031, Colombia
2
Departamento de Materiales, Óptica y Tecnologia Electrónica, Universidad Miguel Hernández, Avda. Universidad s/n, 03202-Elche, Alicante, Spain
3
Biotecnos Research Center, Rua Dr. Bonazo n° 57, Santa Maria (RS) 97015-001, Brazil
4
Cátedra Internacional de Investigación en Odontología, Universidad Católica San Antonio de Murcia, Avda. Jerónimos, 135, 30107 Guadalupe, Murcia, Spain
5
Instituto de Bioingenieria, Universidad Miguel Hernandez, Avda. Ferrocarril s/n, 03202-Elche, Alicante, Spain
*
Author to whom correspondence should be addressed.
Received: 12 June 2017 / Revised: 1 July 2017 / Accepted: 3 July 2017 / Published: 6 July 2017
(This article belongs to the Special Issue Dental Implant Materials)
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Abstract

This study aimed to investigate the processing parameters and biocompatibility of a novel biphasic dicalcium silicate (C2S) cement. Biphasic α´L + β-C2Sss was synthesized by solid-state processing, and was used as a raw material to prepare the cement. In vitro bioactivity and biocompatibility studies were assessed by soaking the cement samples in simulated body fluid (SBF) and human adipose stem cell cultures. Two critical-sized defects of 6 mm Ø were created in 15 NZ tibias. A porous cement made of the high temperature forms of C2S, with a low phosphorous substitution level, was produced. An apatite-like layer covered the cement’s surface after soaking in SBF. The cell attachment test showed that α´L + β-C2Sss supported cells sticking and spreading after 24 h of culture. The cement paste (55.86 ± 0.23) obtained higher bone-to-implant contact (BIC) percentage values (better quality, closer contact) in the histomorphometric analysis, and defect closure was significant compared to the control group (plastic). The residual material volume of the porous cement was 35.42 ± 2.08% of the initial value. The highest BIC and bone formation percentages were obtained on day 60. These results suggest that the cement paste is advantageous for initial bone regeneration. View Full-Text
Keywords: implant surface; bone cement; bioactivity; biocompatibility; dicalcium silicate implant surface; bone cement; bioactivity; biocompatibility; dicalcium silicate
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MDPI and ACS Style

Zuleta, F.; Murciano, A.; Gehrke, S.A.; Maté-Sánchez de Val, J.E.; Calvo-Guirado, J.L.; De Aza, P.N. A New Biphasic Dicalcium Silicate Bone Cement Implant. Materials 2017, 10, 758.

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