The Effects of Relative Humidity on the Flowability and Dispersion Performance of Lactose Mixtures
AbstractThe flowability and dispersion behavior are two important physicochemical properties of pharmaceutical formulations for dry powder inhalers (DPIs). They are usually affected by the environmental conditions, such as temperature and relative humidity (RH). However, very few studies have been focused on the relationship between the two properties and their dependence on RH during storage. In this research, model pharmaceutical formulations were prepared using mixtures of coarse and fine lactose. The fractions of fines in the mixtures were 0%, 5%, 10%, and 20%, respectively. These blends were stored at four different RH levels, 0%, 30%, 58%, and 85%, for 48 h. The FT4 Powder Rheometer was used to evaluate the powder flowability, and the Malvern Spraytec® laser diffraction system was employed to assess the powder dispersion performance. The results indicated that both the flow and dispersion properties of lactose blends deteriorate after being stored at 85% RH, but improved after being conditioned at 58% RH. The fine particle fractions (FPFs) of the blends with 5% and 10% fine fractions and the as-received coarse lactose decreased when they were conditioned at 30% RH. For the blend with 20% fine fraction, a high RH during storage (i.e., 85% RH) affected the dispersion property, but had a limited influence on its flowability, while, for the coarse lactose powder, the different RH conditions affected its flowability, but not the dispersion results. A strong correlation between the powder flowability and its dispersion performance was found. View Full-Text
Scifeed alert for new publicationsNever miss any articles matching your research from any publisher
- Get alerts for new papers matching your research
- Find out the new papers from selected authors
- Updated daily for 49'000+ journals and 6000+ publishers
- Define your Scifeed now
Lu, X.-Y.; Chen, L.; Wu, C.-Y.; Chan, H.-K.; Freeman, T. The Effects of Relative Humidity on the Flowability and Dispersion Performance of Lactose Mixtures. Materials 2017, 10, 592.
Lu X-Y, Chen L, Wu C-Y, Chan H-K, Freeman T. The Effects of Relative Humidity on the Flowability and Dispersion Performance of Lactose Mixtures. Materials. 2017; 10(6):592.Chicago/Turabian Style
Lu, Xiang-Yun; Chen, Lan; Wu, Chuan-Yu; Chan, Hak-Kim; Freeman, Tim. 2017. "The Effects of Relative Humidity on the Flowability and Dispersion Performance of Lactose Mixtures." Materials 10, no. 6: 592.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.