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Materials 2017, 10(6), 590; doi:10.3390/ma10060590

Cytotoxicity Evaluation of High-Temperature Annealed Nanohydroxyapatite in Contact with Fibroblast Cells

1
Department of Experimental Surgery and Biomaterial Research, Wroclaw Medical University, Poniatowskiego 2, 50-326 Wroclaw, Poland
2
Department of Environment Hygiene and Animal Welfare, Wroclaw University of Environmental and Life Sciences, Chelmonskiego 38c, 51-630 Wroclaw, Poland
3
Department of Conservative Dentistry and Pedodontics, Wroclaw Medical University, Krakowska 26, 50-425 Wroclaw, Poland
4
Institute of Low Temperature and Structure Research, Polish Academy of Sciences, Okolna 2, 50-422 Wroclaw, Poland
5
Department of Dentofacial Orthopeadics and Orthodontics, Division of Facial Abnormalities, Wroclaw Medical University, Krakowska 26, 50-425 Wroclaw, Poland
6
Department of Epizootiology and Clinic of Bird and Exotic Animals, Wrocław University of Environmental and Life Sciences, Pl. Grunwaldzki 45, 50-366 Wrocław, Poland
*
Author to whom correspondence should be addressed.
Academic Editors: Subbu Venkatraman and Carla Renata Arciola
Received: 17 March 2017 / Revised: 21 April 2017 / Accepted: 23 May 2017 / Published: 27 May 2017
(This article belongs to the Section Biomaterials)
View Full-Text   |   Download PDF [5948 KB, uploaded 30 May 2017]   |  

Abstract

Biomaterials are substances manufactured for medical purposes in direct contact with the tissues of organisms. Prior to their use, they are tested to determine their usefulness and safety of application. Hydroxyapatites are used in medicine as a bony complement because of their similarity to the natural apatite therein. Thanks to their bioactivity, biocompatibility, stability and non-toxicity hydroxyapatite are the most commonly used materials in osteoimplantology. The use of materials at the nanoscale in medicine or biology may carry the risk of undesirable effects. The aim of the study was to evaluate the cytotoxic effect of high-temperature annealed nanohydroxyapatites on the L929 murine fibroblasts. Nanohydroxyapatites in powder form were obtained by the wet chemistry method: in the temperature range of 800–1000 °C and used for the study. Based on performed studies evaluating the morphology and fibroblast viability, it was found that nanohydroxyapatites show no cytotoxic effects on the L929 cell line. View Full-Text
Keywords: nanohydroxyapatite; biodegradable; fibroblasts cells; cytotoxicity test nanohydroxyapatite; biodegradable; fibroblasts cells; cytotoxicity test
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Szymonowicz, M.; Korczynski, M.; Dobrzynski, M.; Zawisza, K.; Mikulewicz, M.; Karuga-Kuzniewska, E.; Zywickab, B.; Rybak, Z.; Wiglusz, R.J. Cytotoxicity Evaluation of High-Temperature Annealed Nanohydroxyapatite in Contact with Fibroblast Cells. Materials 2017, 10, 590.

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