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Materials 2017, 10(5), 501; doi:10.3390/ma10050501

Calcium Silicate/Chitosan-Coated Electrospun Poly (Lactic Acid) Fibers for Bone Tissue Engineering

Antai Medical Care Cooperation, Antai Tian-Sheng Memorial Hospital, Pingtung City 928, Taiwan
School of Dentistry, China Medical University, Taichung City 404, Taiwan
3D Printing Medical Research Center, China Medical University Hospital, China Medical University, Taichung City 404, Taiwan
School of Dentistry, Chung Shan Medical University, Taichung City 404, Taiwan
Department of Stomatology, Chung Shan Medical University Hospital, Taichung City 404, Taiwan
Institute of Oral Science, Chung Shan Medical University, Taichung City 404, Taiwan
Both authors contributed equally to this work.
Author to whom correspondence should be addressed.
Academic Editor: Nicole Zander
Received: 27 February 2017 / Revised: 2 May 2017 / Accepted: 2 May 2017 / Published: 5 May 2017
(This article belongs to the Section Biomaterials)
View Full-Text   |   Download PDF [6421 KB, uploaded 5 May 2017]   |  


Electrospinning technology allows fabrication of nano- or microfibrous fibers with inorganic and organic matrix and it is widely applied in bone tissue engineering as it allows precise control over the shapes and structures of the fibers. Natural bone has an ordered composition of organic fibers with dispersion of inorganic apatite among them. In this study, poly (lactic acid) (PLA) mats were fabricated with electrospinning and coated with chitosan (CH)/calcium silicate (CS) mixer. The microstructure, chemical component, and contact angle of CS/CH-PLA composites were analyzed by scanning electron microscopy, X-ray diffraction, and Fourier transform infrared spectroscopy. In vitro, various CS/CH-coated PLA mats increased the formation of hydroxyapatite on the specimens’ surface when soaked in cell cultured medium. During culture, several biological characteristics of the human mesenchymal stem cells (hMSCs) cultured on CS/CH-PLA groups were promoted as compared to those on pure PLA mat. Increased secretion levels of Collagen I and fibronectin were observed in calcium silicate-powder content. Furthermore, with comparison to PLA mats without CS/CH, CS10 and CS15 mats markedly enhanced the proliferation of hMSCs and their osteogenesis properties, which was characterized by osteogenic-related gene expression. These results clearly demonstrated that the biodegradable and electroactive CS/CH-PLA composite mats are an ideal and suitable candidate for bone tissue engineering. View Full-Text
Keywords: poly (lactic acid); chitosan; calcium silicate; tissue engineering; osteogenesis poly (lactic acid); chitosan; calcium silicate; tissue engineering; osteogenesis

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Su, C.-J.; Tu, M.-G.; Wei, L.-J.; Hsu, T.-T.; Kao, C.-T.; Chen, T.-H.; Huang, T.-H. Calcium Silicate/Chitosan-Coated Electrospun Poly (Lactic Acid) Fibers for Bone Tissue Engineering. Materials 2017, 10, 501.

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