Next Article in Journal
Linear Graphene Nanocomposite Synthesis and an Analytical Application for the Amino Acid Detection of Camellia nitidissima Chi Seeds
Previous Article in Journal
Cesium and Strontium Retentions Governed by Aluminosilicate Gel in Alkali-Activated Cements
Article Menu
Issue 4 (April) cover image

Export Article

Open AccessArticle
Materials 2017, 10(4), 445; doi:10.3390/ma10040445

Osteoblast Cell Response on the Ti6Al4V Alloy Heat-Treated

1
Departamento de Ingeniería en Metalurgia y Materiales, Instituto Politécnico Nacional (ESIQIE-IPN), UPALM Zacatenco, Ciudad de México 07738, Mexico
2
Departamento de Ingeniería de Superficies, Corrosión y Durabilidad, Centro Nacional de Investigaciones Metalúrgicas (CENIM-CSIC), Madrid 28040, Spain
3
Departamento de Ingeniería Química Industrial, Instituto Politécnico Nacional (ESIQIE-IPN), UPALM Zacatenco, Ciudad de México 07738, Mexico
*
Author to whom correspondence should be addressed.
Academic Editor: Daolun Chen
Received: 13 March 2017 / Revised: 12 April 2017 / Accepted: 17 April 2017 / Published: 23 April 2017
(This article belongs to the Section Biomaterials)
View Full-Text   |   Download PDF [4851 KB, uploaded 23 April 2017]   |  

Abstract

In an effort to examine the effect of the microstructural changes of the Ti6Al4V alloy, two heat treatments were carried out below (Ti6Al4V800) and above (Ti6Al4V1050) its β-phase transformation temperature. After each treatment, globular and lamellar microstructures were obtained. Saos-2 pre-osteoblast human osteosarcoma cells were seeded onto Ti6Al4V alloy disks and immersed in cell culture for 7 days. Electrochemical assays in situ were performed using OCP and EIS measurements. Impedance data show a passive behavior for the three Ti6Al4V alloys; additionally, enhanced impedance values were recorded for Ti6Al4V800 and Ti6Al4V1050 alloys. This passive behavior in culture medium is mostly due to the formation of TiO2 during their sterilization. Biocompatibility and cell adhesion were characterized using the SEM technique; Ti6Al4V as received and Ti6Al4V800 alloys exhibited polygonal and elongated morphology, whereas Ti6Al4V1050 alloy displayed a spherical morphology. Ti and O elements were identified by EDX analysis due to the TiO2 and signals of C, N and O, related to the formation of organic compounds from extracellular matrix. These results suggest that cell adhesion is more likely to occur on TiO2 formed in discrete α-phase regions (hcp) depending on its microstructure (grains). View Full-Text
Keywords: Ti6Al4V; biomaterials; microstructure; osteoblasts; heat treatment; titanium oxide Ti6Al4V; biomaterials; microstructure; osteoblasts; heat treatment; titanium oxide
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Chávez-Díaz, M.P.; Escudero-Rincón, M.L.; Arce-Estrada, E.M.; Cabrera-Sierra, R. Osteoblast Cell Response on the Ti6Al4V Alloy Heat-Treated. Materials 2017, 10, 445.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Materials EISSN 1996-1944 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top