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Materials 2017, 10(4), 358; doi:10.3390/ma10040358

RGDC Peptide-Induced Biomimetic Calcium Phosphate Coating Formed on AZ31 Magnesium Alloy

1
School of Stomatology, Lanzhou University, Lanzhou 730000, China
2
State Key Laboratory of Solid Lubrication, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, China
*
Author to whom correspondence should be addressed.
Academic Editor: Franz E. Weber
Received: 22 December 2016 / Revised: 19 March 2017 / Accepted: 24 March 2017 / Published: 28 March 2017
(This article belongs to the Section Biomaterials)
View Full-Text   |   Download PDF [6401 KB, uploaded 29 March 2017]   |  

Abstract

Magnesium alloys as biodegradable metal implants have received a lot of interest in biomedical applications. However, magnesium alloys have extremely high corrosion rates a in physiological environment, which have limited their application in the orthopedic field. In this study, calcium phosphate compounds (Ca–P) coating was prepared by arginine–glycine–aspartic acid–cysteine (RGDC) peptide-induced mineralization in 1.5 simulated body fluid (SBF) to improve the corrosion resistance and biocompatibility of the AZ31 magnesium alloys. The adhesion of Ca–P coating to the AZ31 substrates was evaluated by a scratch test. Corrosion resistance and cytocompatibility of the Ca–P coating were investigated. The results showed that the RGDC could effectively promote the nucleation and crystallization of the Ca–P coating and the Ca–P coating had poor adhesion to the AZ31 substrates. The corrosion resistance and biocompatibility of the biomimetic Ca–P coating Mg alloys were greatly improved compared with that of the uncoated sample. View Full-Text
Keywords: biomimetic; calcium phosphate coating; RGDC; magnesium alloy; corrosion resistance; biocompatibility biomimetic; calcium phosphate coating; RGDC; magnesium alloy; corrosion resistance; biocompatibility
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Cao, L.; Wang, L.; Fan, L.; Xiao, W.; Lin, B.; Xu, Y.; Liang, J.; Cao, B. RGDC Peptide-Induced Biomimetic Calcium Phosphate Coating Formed on AZ31 Magnesium Alloy. Materials 2017, 10, 358.

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