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Materials 2017, 10(4), 335; doi:10.3390/ma10040335

Effect of Immobilized Antithrombin III on the Thromboresistance of Polycarbonate Urethane

1
IMHR, Institute for Medical Microbiology and Hygiene, University of Regensburg, Franz-Josef-Strauss-Allee 11, 93042 Regensburg, Germany
2
Dualis Medtech GmbH, Am Technologiepark 8+10, 82229 Seefeld, Germany
3
Department of Thoracic, Cardiac, and Vascular Surgery, University Hospital Tübingen, Hoppe-Seyler-Str. 3, 72076 Tübingen, Germany
4
Department of Cardiothoracic Surgery, University Medical Center Regensburg, Josef-Strauss-Allee 11, 93042 Regensburg, Germany
*
Author to whom correspondence should be addressed.
Academic Editor: Aldo R. Boccaccini
Received: 17 January 2017 / Revised: 28 February 2017 / Accepted: 21 March 2017 / Published: 24 March 2017
(This article belongs to the Section Biomaterials)
View Full-Text   |   Download PDF [3643 KB, uploaded 29 March 2017]   |  

Abstract

The surface of foils and vascular grafts made from a thermoplastic polycarbonate urethanes (PCU) (Chronoflex AR) were chemically modified using gas plasma treatment, binding of hydrogels—(1) polyethylene glycol bisdiamine and carboxymethyl dextran (PEG-DEX) and (2) polyethyleneimine (PEI)—and immobilization of human antithrombin III (AT). Their biological impact was tested in vitro under static and dynamic conditions. Static test methods showed a significantly reduced adhesion of endothelial cells, platelets, and bacteria, compared to untreated PCU. Modified PCU grafts were circulated in a Chandler-Loop model for 90 min at 37 °C with human blood. Before and after circulation, parameters of the hemostatic system (coagulation, platelets, complement, and leukocyte activation) were analyzed. PEI-AT significantly inhibited the activation of both coagulation and platelets and prevented the activation of leukocytes and complement. In conclusion, both modifications significantly reduce coagulation activation, but only PEI-AT creates anti-bacterial and anti-thrombogenic functionality. View Full-Text
Keywords: polycarbonate urethane; thromboresistance; antithrombin III; anti-bacterial; hemocomaptibility polycarbonate urethane; thromboresistance; antithrombin III; anti-bacterial; hemocomaptibility
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MDPI and ACS Style

Lukas, K.; Stadtherr, K.; Gessner, A.; Wehner, D.; Schmid, T.; Wendel, H.P.; Schmid, C.; Lehle, K. Effect of Immobilized Antithrombin III on the Thromboresistance of Polycarbonate Urethane. Materials 2017, 10, 335.

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