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Materials 2017, 10(3), 219; doi:10.3390/ma10030219

A Novel Preparation Method of Two Polymer Dyes with Low Cytotoxicity

Department of Chemistry, School of Science, Tianjin University, Tianjin 300354, China
National Foodstuff Inspection Center, Tianjin Product Quality Inspection Technology Research Institute, Tianjin 300384, China
Shandong Yu Hong New Pigment Co., Ltd., Dezhou 253000, China
Author to whom correspondence should be addressed.
Academic Editor: Gerald Anthony Murphy
Received: 5 January 2017 / Revised: 15 February 2017 / Accepted: 17 February 2017 / Published: 23 February 2017
View Full-Text   |   Download PDF [23086 KB, uploaded 23 February 2017]   |  


A new preparation method of polymer dyes was developed to improve both the grafting degree of the azo dyes onto O-carboxymethyl chitosan (OMCS) and the water solubility of prepared polymer dyes. Firstly, the coupling compound of two azo edible colorants, sunset yellow (SY) and allura red (AR), was grafted onto OMCS, and then coupled with their diazonium salt. The chemical structure of prepared polymer dyes was determined by Fourier transform-infrared spectroscopy and 1H-NMR, and the results showed that the two azo dyes were successfully grafted onto OMCS. The grafting degree onto OMCS and the water solubility of polymer dyes were tested, and the results showed that they were both improved as expected. The UV-vis spectra analysis results showed that the prepared polymer dyes showed similar color performance with the original azo dyes. Eventually, the cytotoxicity of prepared polymer dyes was tested and compared with the original azo dyes by a cytotoxicity test on human liver cell lines LO2, and the results showed that their grafting onto OMCS significantly reduced the cytotoxicity. View Full-Text
Keywords: polymer dyes; azo edible colorant; O-carboxymethyl chitosan; low cytotoxicity polymer dyes; azo edible colorant; O-carboxymethyl chitosan; low cytotoxicity

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Lv, D.; Zhang, M.; Cui, J.; Li, W.; Zhu, G. A Novel Preparation Method of Two Polymer Dyes with Low Cytotoxicity. Materials 2017, 10, 219.

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