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Materials 2017, 10(2), 170; doi:10.3390/ma10020170

Boronic Acid as Glucose-Sensitive Agent Regulates Drug Delivery for Diabetes Treatment

1
Laboratory of Building Energy-Saving Technology Engineering, College of Material Science and Engineering, Jilin Jianzhu University, Changchun 130118, China
2
Department of Endocrinology, China-Japan Union Hospital of Jilin University, Changchun 130033, China
3
Department of Endocrine, the First Affiliated Hospital to Changchun University of Chinese Medicine, Changchun 130117, China
4
Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China
*
Author to whom correspondence should be addressed.
Academic Editor: Jie Zheng
Received: 4 December 2016 / Revised: 18 January 2017 / Accepted: 6 February 2017 / Published: 13 February 2017
(This article belongs to the Special Issue Smart Biomaterials and Biointerfaces)
View Full-Text   |   Download PDF [3578 KB, uploaded 13 February 2017]   |  

Abstract

In recent years, glucose-sensitive drug delivery systems have attracted considerable attention in the treatment of diabetes. These systems can regulate payload release by the changes of blood glucose levels continuously and automatically with potential application in self-regulated drug delivery. Boronic acid (BA), especially phenylboronic acid (PBA), as glucose-sensitive agent has been the focus of research in the design of glucose-sensitive platforms. This article reviews the previous attempts at the developments of PBA-based glucose-sensitive drug delivery systems regarding the PBA-functionalized materials and glucose-triggered drug delivery. The obstacles and potential developments of glucose-sensitive drug delivery systems based on PBA for diabetes treatment in the future are also described. The PBA-functionalized platforms that regulate drug delivery induced by glucose are expected to contribute significantly to the design and development of advanced intelligent self-regulated drug delivery systems for treatment of diabetes. View Full-Text
Keywords: phenylboronic acid; glucose-sensitivity; drug delivery; diabetes therapy phenylboronic acid; glucose-sensitivity; drug delivery; diabetes therapy
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Zhao, L.; Huang, Q.; Liu, Y.; Wang, Q.; Wang, L.; Xiao, S.; Bi, F.; Ding, J. Boronic Acid as Glucose-Sensitive Agent Regulates Drug Delivery for Diabetes Treatment. Materials 2017, 10, 170.

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