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Materials 2017, 10(2), 136; doi:10.3390/ma10020136

3D Printing of Cytocompatible Water-Based Light-Cured Polyurethane with Hyaluronic Acid for Cartilage Tissue Engineering Applications

1
3D Printing Medical Research Center, China Medical University Hospital, China Medical University, Taichung 40447, Taiwan
2
School of Dentistry, China Medical University, Taichung 40447, Taiwan
3
School of Medicine, College of Medicine, China Medical University, Taichung 40447, Taiwan
4
Graduate Institute of Biomedical Sciences, China Medical University, Taichung 40447, Taiwan
5
Department of Bioinformatics and Medical Engineering, Asia University, Taichung 40447, Taiwan
*
Authors to whom correspondence should be addressed.
Academic Editors: Chee Kai Chua, Wai Yee Yeong and Jia An
Received: 29 November 2016 / Revised: 19 January 2017 / Accepted: 3 February 2017 / Published: 8 February 2017
(This article belongs to the Special Issue 3D Printing for Biomedical Engineering)
View Full-Text   |   Download PDF [4337 KB, uploaded 8 February 2017]   |  

Abstract

Diseases in articular cartilages have affected millions of people globally. Although the biochemical and cellular composition of articular cartilages is relatively simple, there is a limitation in the self-repair ability of the cartilage. Therefore, developing strategies for cartilage repair is very important. Here, we report on a new liquid resin preparation process of water-based polyurethane based photosensitive materials with hyaluronic acid with application of the materials for 3D printed customized cartilage scaffolds. The scaffold has high cytocompatibility and is one that closely mimics the mechanical properties of articular cartilages. It is suitable for culturing human Wharton’s jelly mesenchymal stem cells (hWJMSCs) and the cells in this case showed an excellent chondrogenic differentiation capacity. We consider that the 3D printing hybrid scaffolds may have potential in customized tissue engineering and also facilitate the development of cartilage tissue engineering. View Full-Text
Keywords: water-based polyurethane; hyaluronic acid; cartilage tissue engineering; scaffold water-based polyurethane; hyaluronic acid; cartilage tissue engineering; scaffold
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Shie, M.-Y.; Chang, W.-C.; Wei, L.-J.; Huang, Y.-H.; Chen, C.-H.; Shih, C.-T.; Chen, Y.-W.; Shen, Y.-F. 3D Printing of Cytocompatible Water-Based Light-Cured Polyurethane with Hyaluronic Acid for Cartilage Tissue Engineering Applications. Materials 2017, 10, 136.

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