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Materials 2017, 10(10), 1151; doi:10.3390/ma10101151

Magnetic Force-Driven Graphene Patterns to Direct Synaptogenesis of Human Neuronal Cells

1
Department of Biomedical Engineering, Sogang University, 35 Baekbeom-ro (Sinsu-dong), Mapo-gu, Seoul 121-742, Korea
2
School of Integrative Engineering, Chung-Ang University, Heukseok-dong, Dongjak-gu, Seoul 156-756, Korea
3
Department of Chemical and Biomolecular Engineering, Sogang University, 35 Baekbeom-ro (Sinsu-dong), Mapo-gu, Seoul 121-742, Korea
*
Author to whom correspondence should be addressed.
Received: 5 September 2017 / Revised: 27 September 2017 / Accepted: 30 September 2017 / Published: 2 October 2017
(This article belongs to the Special Issue Constitutive Modelling of Biological Tissues and Biomaterials)
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Abstract

Precise control of axonal growth and synaptic junction formation are incredibly important to repair and/or to mimic human neuronal network. Here, we report a graphene oxide (GO)-based hybrid patterns that were proven to be excellent for guiding axonal growth and its consequent synapse formation of human neural cells. Unlike the previous method that utilized micro-contacting printing technique to generate GO patterns, here, GO-encapsulated magnetic nanoparticles were first synthesized and utilized as core materials wherein the external magnetic force facilitated the transfer of GO film to the desired substrate. Owing to the intrinsic property of GO that provides stable cell attachment and growth for long-term culture, human neuronal cells could be effectively patterned on the biocompatible polymer substrates with different pattern sizes. By using magnetic force-driven GO hybrid patterns, we demonstrated that accumulation and expression level of Synaptophysin of neurons could be effectively controlled with varying sizes of each pattern. The synaptic network between each neuron could be precisely controlled and matched by guiding axonal direction. This work provides treatment and modeling of brain diseases and spinal cord injuries. View Full-Text
Keywords: GO-encapsulated magnetic nanoparticles; GO hybrid pattern; human neuronal cell; synapse; axonal growth guidance GO-encapsulated magnetic nanoparticles; GO hybrid pattern; human neuronal cell; synapse; axonal growth guidance
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Min, K.-J.; Kim, T.-H.; Choi, J.-W. Magnetic Force-Driven Graphene Patterns to Direct Synaptogenesis of Human Neuronal Cells. Materials 2017, 10, 1151.

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