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Materials 2017, 10(10), 1122; doi:10.3390/ma10101122

Effects of Liposomes Contained in Thermosensitive Hydrogels as Biomaterials Useful in Neural Tissue Engineering

1
Center for Integrative Medicine and Innovative Science (CIMIS), Facultad de Medicina, Universidad Andrés Bello, Echaurren 183, Santiago 8320000, Chile
2
Departamento de Química, Facultad de Ciencias, Universidad de Chile, Las Palmeras 3425 Ñuñoa, Santiago 8320000, Chile
3
Escuela de Ingeniería en Biotecnología, Facultad de Ciencias Biológicas, Universidad Andres Bello, República 239, Santiago 8320000, Chile
4
Department of Food Science and Technology, Universidad de Santiago de Chile, Avenida Ecuador 3769, Santiago 8320000, Chile
5
Escuela de Obstetricia y Puericultura, Facultad de Medicina, Campus de la Salud, Universidad de Valparaíso, Angamos 655, Reñaca, Viña del Mar 2520000, Chile
6
Departamento de Química, Facultad de Ciencias Naturales y Exactas, Universidad de Playa Ancha, Avda, Leopoldo Carvallo 270, Playa Ancha, Valparaíso 2340000, Chile
7
Centro de Biotecnología, Universidad Técnica Federico Santa María, Avenida España 1680, Valparaíso 2340000, Chile
8
Departamento de Física, Universidad Técnica Federico Santa María, Avenida España 1680, Valparaíso 2340000, Chile
9
Centro Científico Tecnológico de Valparaíso, Universidad Técnica Federico Santa María, Avenida España 1680, Valparaíso 2340000, Chile
*
Author to whom correspondence should be addressed.
Received: 20 August 2017 / Revised: 16 September 2017 / Accepted: 20 September 2017 / Published: 22 September 2017
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Abstract

Advances in the generation of suitable thermosensitive hydrogels for the delivery of cells in neural tissue engineering demonstrate a delicate relationship between physical properties and capabilities to promote cell proliferation and differentiation. To improve the properties of these materials, it is possible to add liposomes for the controlled release of bioactive elements, which in turn can affect the physical and biological properties of the hydrogels. In the present investigation, different hydrogels based on Pluronic F127 have been formulated with the incorporation of chitosan and two types of liposomes of two different sizes. The rheological and thermal properties and their relation with the neurite proliferation and growth of the PC12 cell line were evaluated. Our results show that the incorporation of liposomes modifies the properties of the hydrogels dependent on the concentration of chitosan and the lipid type in the liposomes, which directly affect the capabilities of the hydrogels to promote the viability and differentiation of PC12 cells. View Full-Text
Keywords: Pluronic F127/Chitosan hydrogels; growth of neurites PC12 cells; effect of Liposomes Pluronic F127/Chitosan hydrogels; growth of neurites PC12 cells; effect of Liposomes
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Olguín, Y.; Campos, C.; Catalán, J.; Velásquez, L.; Osorio, F.; Montenegro, I.; Madrid, A.; Acevedo, C. Effects of Liposomes Contained in Thermosensitive Hydrogels as Biomaterials Useful in Neural Tissue Engineering. Materials 2017, 10, 1122.

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