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Materials 2008, 1(1), 25-43; doi:10.3390/ma1010025
Article

Modulating the Release Kinetics of Paclitaxel from Membrane-Covered Stents Using Different Loading Strategies

1,2
,
1,2,3
,
4
 and
1,2,3,*
1 Department of Biomedical Engineering, Faculty of Medicine, McGill University, 3775 Rue University, Lyman Duff Medical Sciences Building, 3rd floor, Montréal (Québec), H3A 2B4, Canada 2 Center for Biorecognition and Biosensors, McGill University, 3775 Rue University, Lyman Duff Medical Sciences Building, Room 313, Montréal (Québec) H3A 2B4, Canada 3 Faculty of Dentistry, McGill University, Strathcona Anatomy & Dentistry Building, 3640 Rue University, Montréal (Québec) H3A 2B2 Canada 4 Institut de Cardiologie de Montréal, 5000 Rue Belanger Est, Montréal (Québec) H1T 1C8 Canada
* Author to whom correspondence should be addressed.
Received: 7 October 2008 / Revised: 5 November 2008 / Accepted: 6 November 2008 / Published: 7 November 2008
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Abstract

Membrane-covered Express2TM Monorail® stents composed of chitosan (CH) blended with polyethylene oxide (PEO) in 70:30% wt (CH-PEO) were coated with a monolayer of hyaluronic acid (HA). This significantly improved the resistance to platelet adhesion and demonstrated excellent mechanical properties, resisting the harsh conditions during stent crimping and subsequent inflation. CH-PEO/HA membrane was then combined with a paclitaxel (Pac) delivery system via three different approaches for comparison of release profiles of Pac. The activity of Pac in these systems was confirmed since its presence in the membrane significantly decreased cell viability of U937 macrophages. Presented results are promising for applications requiring different release patterns of hydrophobic drugs.
Keywords: Chitosan; controlled drug release; hyaluronic acid; polyethylene oxide; Paclitaxel; restenosis; stent; thrombogenecity Chitosan; controlled drug release; hyaluronic acid; polyethylene oxide; Paclitaxel; restenosis; stent; thrombogenecity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Sydow-Plum, G.; Haidar, Z.S.; Merhi, Y.; Tabrizian, M. Modulating the Release Kinetics of Paclitaxel from Membrane-Covered Stents Using Different Loading Strategies. Materials 2008, 1, 25-43.

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