Int. J. Environ. Res. Public Health 2012, 9(8), 2936-2948; doi:10.3390/ijerph9082936
Article

Radioactive Iodide (131I) Excretion Profiles in Response to Potassium Iodide (KI) and Ammonium Perchlorate (NH4ClO4) Prophylaxis

Received: 21 June 2012; in revised form: 12 July 2012 / Accepted: 9 August 2012 / Published: 16 August 2012
(This article belongs to the Special Issue Radiation and Cancer Risk)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Radioactive iodide (131I) protection studies have focused primarily on the thyroid gland and disturbances in the hypothalamic-pituitary-thyroid axis. The objective of the current study was to establish 131I urinary excretion profiles for saline, and the thyroid protectants, potassium iodide (KI) and ammonium perchlorate over a 75 hour time-course. Rats were administered 131I and 3 hours later dosed with either saline, 30 mg/kg of NH4ClO4 or 30 mg/kg of KI. Urinalysis of the first 36 hours of the time-course revealed that NH4ClO4 treated animals excreted significantly more 131I compared with KI and saline treatments. A second study followed the same protocol, but thyroxine (T4) was administered daily over a 3 day period. During the first 6–12 hour after 131I dosing, rats administered NH4ClO4 excreted significantly more 131I than the other treatment groups. T4 treatment resulted in increased retention of radioiodide in the thyroid gland 75 hour after 131I administration. We speculate that the T4 treatment related reduction in serum TSH caused a decrease synthesis and secretion of thyroid hormones resulting in greater residual radioiodide in the thyroid gland. Our findings suggest that ammonium perchlorate treatment accelerates the elimination rate of radioiodide within the first 24 to 36 hours and thus may be more effective at reducing harmful exposure to 131I compared to KI treatment for repeated dosing situations. Repeated dosing studies are needed to compare the effectiveness of these treatments to reduce the radioactive iodide burden of the thyroid gland.
Keywords: perchlorate; iodide; radioiodide; thyroid
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MDPI and ACS Style

Harris, C.; Dallas, C.; Rollor III, E.; White, C.; Blount, B.; Valentin-Blasini, L.; Fisher, J. Radioactive Iodide (131I) Excretion Profiles in Response to Potassium Iodide (KI) and Ammonium Perchlorate (NH4ClO4) Prophylaxis. Int. J. Environ. Res. Public Health 2012, 9, 2936-2948.

AMA Style

Harris C, Dallas C, Rollor III E, White C, Blount B, Valentin-Blasini L, Fisher J. Radioactive Iodide (131I) Excretion Profiles in Response to Potassium Iodide (KI) and Ammonium Perchlorate (NH4ClO4) Prophylaxis. International Journal of Environmental Research and Public Health. 2012; 9(8):2936-2948.

Chicago/Turabian Style

Harris, Curtis; Dallas, Cham; Rollor III, Edward; White, Catherine; Blount, Benjamin; Valentin-Blasini, Liza; Fisher, Jeffrey. 2012. "Radioactive Iodide (131I) Excretion Profiles in Response to Potassium Iodide (KI) and Ammonium Perchlorate (NH4ClO4) Prophylaxis." Int. J. Environ. Res. Public Health 9, no. 8: 2936-2948.

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