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Effects of Cold Air on Cardiovascular Disease Risk Factors in Rat
School of Applied Meteorology, Nanjing University of Information Science and Technology, 219 Ningliu Road, Nanjing 210044, China
Key Laboratories of Arid Climatic Change and Reducing Disaster of Gansu Province, Lanzhou Institute of Arid Meteorology, China Meteorological Administration, 2070 Donggang East Road, Chengguan District, Lanzhou 730020, China
Lanzhou Central Meteorological Observatory, 2070 Donggang East Road, Chengguan District, Lanzhou 730020, China
* Author to whom correspondence should be addressed.
Received: 16 May 2012; in revised form: 14 June 2012 / Accepted: 21 June 2012 / Published: 29 June 2012
Abstract: The purpose of this study is to explore possible potential implications of cold air in cardiovascular disease (CVD) risk in rats. Healthy Wistar rats were exposed to artificial cold air under laboratory conditions, and their systolic blood pressure, heart rate, vasoconstriction, CVD risk factors, and myocardial damage indicators after cold air exposure were determined and evaluated. Systolic blood pressure, whole blood viscosity, and plasma level of norepinephrine, angiotensinⅡ, low density lipoprotein, total cholesterol, and fibrinogen in treatment groups increased significantly compared with control groups. No significant variations were found in plasma Mb and cTnT and myocardial tissue between the treatment and control groups. Results indicate that: (1) higher levels of SBP, WBV and LDL/HDL, total cholesterol (TC), and FG in blood may indicate higher CVD risks during cold air exposure; (2) cold air may exert continuous impacts on SBP and other CVD risk factors.
Keywords: cold air exposure; CVD risk factors; myocardial injury indicators
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Cite This Article
MDPI and ACS Style
Luo, B.; Zhang, S.; Ma, S.; Zhou, J.; Wang, B. Effects of Cold Air on Cardiovascular Disease Risk Factors in Rat. Int. J. Environ. Res. Public Health 2012, 9, 2312-2325.
Luo B, Zhang S, Ma S, Zhou J, Wang B. Effects of Cold Air on Cardiovascular Disease Risk Factors in Rat. International Journal of Environmental Research and Public Health. 2012; 9(7):2312-2325.
Luo, Bin; Zhang, Shuyu; Ma, Shoucun; Zhou, Ji; Wang, Baojian. 2012. "Effects of Cold Air on Cardiovascular Disease Risk Factors in Rat." Int. J. Environ. Res. Public Health 9, no. 7: 2312-2325.