ࡱ>        4bjbjVV Q<<SAAD999,9#~f"7777NUWH} } } } } } }$+ZD}XDN@NXXD}AA77Q}hhhX@A77nhX}hh3h7])9_(h|n}0#~h@bhhXXhXXXXXD}D}hXXX#~XXXXXXXXXXXXX : Supplementary Information Trichloroethylene and Cancer: Systematic and Quantitative Review of Epidemiologic Evidence for Identifying Hazard Cheryl Siegel Scott * and Jennifer Jinot National Center for Environmental Assessment, Office of Research and Development, United States Environmental Protection Agency, 1200 Pennsylvania Avenue, Washington, DC 20460, USA; E-Mail: Jinot.Jennifer@epa.gov * Author to whom correspondence should be addressed: E-Mail: Scott.Cheryl@epa.gov; Tel: +1-703-347-8590; Fax: +1-703-347-8694. Received: 22 September 2011; in revised form: 21 October 2011 / Accepted: 26 October 2011 / Published: ______________________________________________________________________________ Supplemental Table 1. Summary of rationales for study selection for meta-analysis. Decision OutcomeStudiesPrimary reason(s)Studies Recommended for Meta-analysis:Siemiatycki  ADDIN EN.CITE Siemiatycki1991174[1]1741746Siemiatycki, J.Risk factors for cancer in the workplaceNOT IN FILEcancerNRC 2006 documentORISERiskrisk factorRisk FactorsSelectedU.S.EPA,TCE Issue Papers,2005Workplace1991Boca Raton, FLCRC Press[ HYPERLINK \l "_ENREF_1" \o "Siemiatycki, 1991 #174" 1];HYPERLINK \l "_ENREF_1" \o "Siemiatycki, 1991 #174" Axelson et al. ADDIN EN.CITE Axelson1994120[2]12012017Axelson, O.Selden, A.Andersson, K.Hogstedt, C.Department of Occupational and Environmental Medicine, University Hospital, Linkoping, SwedenUpdated and expanded Swedish cohort study on trichloroethylene and cancer riskJ.Occup.Med.J.Occup.Med.556-562365NOT IN FILEAAdultadverse effectsarticlecancerCardiovascular DiseasesCohort StudiesConfidence IntervalsdeathepidemiologyexposureFemaleFollow-Up StudieshumanHumansIncidenceMaleMorbiditymortalityNeoplasmsOccupational DiseasesOccupational ExposurePopulationRiskstudySwedenTrichloroethyleneworker1994PM:8027881[ HYPERLINK \l "_ENREF_2" \o "Axelson, 1994 #120" 2]; Hardell et al.  ADDIN EN.CITE  ADDIN EN.CITE.DATA [ HYPERLINK \l "_ENREF_3" \o "Hardell, 1994 #144" 3]; Greenland et al.  ADDIN EN.CITE  ADDIN EN.CITE.DATA [ HYPERLINK \l "_ENREF_4" \o "Greenland, 1994 #141" 4]; Anttila et al.  ADDIN EN.CITE  ADDIN EN.CITE.DATA [ HYPERLINK \l "_ENREF_5" \o "Anttila, 1995 #119" 5]; Morgan et al.  ADDIN EN.CITE  ADDIN EN.CITE.DATA [ HYPERLINK \l "_ENREF_6" \o "Morgan, 1998 #157" 6]; Nordstrom et al.  ADDIN EN.CITE  ADDIN EN.CITE.DATA [ HYPERLINK \l "_ENREF_7" \o "Nordstrom, 1998 #160" 7]; Boice et al.  ADDIN EN.CITE  ADDIN EN.CITE.DATA [ HYPERLINK \l "_ENREF_8" \o "Boice, 2006 #128" 8, HYPERLINK \l "_ENREF_9" \o "Boice, 1999 #126" 9]; Dosemeci et al.  ADDIN EN.CITE  ADDIN EN.CITE.DATA [ HYPERLINK \l "_ENREF_10" \o "Dosemeci, 1999 #324" 10]; Persson and Fredriksson ADDIN EN.CITE  ADDIN EN.CITE.DATA [ HYPERLINK \l "_ENREF_11" \o "Persson, 1999 #166" 11]; Pesch et al.  ADDIN EN.CITE  ADDIN EN.CITE.DATA [ HYPERLINK \l "_ENREF_12" \o "Pesch, 2000 #167" 12]; Hansen et al.  ADDIN EN.CITE Hansen2001142[13]14214217Hansen, J.Raaschou-Nielsen, O.Christensen, J. M.Johansen, I.McLaughlin, J. K.Lipworth, L.Blot, W. J.Olsen, J. H.Danish Cancer Society, Institute of Cancer Epidemiology, Strandboulevarden 49, DK-2100 Copenhagen O, Denmark. johnni@cancer.dkCancer incidence among Danish workers exposed to trichloroethyleneJ.Occup.Environ.Med.J.Occup.Environ.Med.133-139432NOT IN FILEadverse effectsarticlecancerchemically inducedDenmarkepidemiologyEsophageal NeoplasmsFemalehumanHumansIncidenceLymphomaLymphoma,Non-HodgkinMaleNeoplasmsOccupational ExposureResearchResearch SupportRiskTrichloroethyleneurineUterine Cervical Neoplasmsworker2001PM:11227631[ HYPERLINK \l "_ENREF_13" \o "Hansen, 2001 #142" 13]; Brning et al.  ADDIN EN.CITE  ADDIN EN.CITE.DATA [ HYPERLINK \l "_ENREF_14" \o "Bruning, 2003 #131" 14]; Raaschou-Nielsen et al.  ADDIN EN.CITE  ADDIN EN.CITE.DATA [ HYPERLINK \l "_ENREF_15" \o "Raaschou-Nielsen, 2003 #168" 15]; Zhao et al.  ADDIN EN.CITE  ADDIN EN.CITE.DATA [ HYPERLINK \l "_ENREF_16" \o "Zhao, 2005 #184" 16]; Miligi et al.  ADDIN EN.CITE  ADDIN EN.CITE.DATA [ HYPERLINK \l "_ENREF_17" \o "Miligi, 2006 #155" 17]; Charbotel et al.  ADDIN EN.CITE  ADDIN EN.CITE.DATA [ HYPERLINK \l "_ENREF_18" \o "Charbotel, 2006 #132" 18]; Radican et al.  ADDIN EN.CITE  ADDIN EN.CITE.DATA [ HYPERLINK \l "_ENREF_19" \o "Radican, 2008 #169" 19] (Blair et al.  ADDIN EN.CITE  ADDIN EN.CITE.DATA [ HYPERLINK \l "_ENREF_20" \o "Blair, 1998 #125" 20] incidence); Wang et al.  ADDIN EN.CITE  ADDIN EN.CITE.DATA [ HYPERLINK \l "_ENREF_21" \o "Wang, 2009 #179" 21]; Moore et al.  ADDIN EN.CITE  ADDIN EN.CITE.DATA [ HYPERLINK \l "_ENREF_22" \o "Moore, 2010 #236" 22]; Cocco et al.  ADDIN EN.CITE  ADDIN EN.CITE.DATA [ HYPERLINK \l "_ENREF_23" \o "Cocco, 2010 #232" 23]; Purdue et al.  ADDIN EN.CITE Purdue2011208[24]20820817Purdue, M. P.Bakke, B.Stewart, P.De Roos, A. J.Schenk, M.Lynch, C. F.Bernstein, L.Morton, L. M.Cerhan, J. R.Severson, R. K.Cozen, W.Davis, S.Rothman, N.Hartge, P.Colt, J. S.Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA.A case-control study of occupational exposure to trichloroethylene and non-hodgkin lymphomaEnviron Health PerspectEnviron Health Perspect232-811922011/02/042011Nov 21552-9924 (Electronic) 0091-6765 (Linking)21288806http://www.ncbi.nlm.nih.gov/pubmed/21288806304061110.1289/ehp.1002106eng[ HYPERLINK \l "_ENREF_24" \o "Purdue, 2011 #208" 24]Analytical study designs of cohort or case-control approaches; Evaluation of cancer incidence or cancer mortality; Specifically identified TCE exposure potential to individual study subjects by reference to industrial hygiene records, individual biomarkers, job exposure matrices, water distribution models, or self-reports (case-control studies); Reported results for kidney cancer, liver cancer, or non-Hodgkin lymphoma (NHL) with relative risk estimates and corresponding confidence intervals (or information to allow calculation). Supplementary Table 1. Cont. Decision OutcomeStudiesPrimary reason(s)Studies Not Recommended for Meta-analysis:ATSDR  ADDIN EN.CITE ATSDR2004589[25]58958946ATSDR, Agency for Toxic Substances and Disease RegistryFeasibility investigation of worker exposure to trichloroethylene at the view-master factory in Beaverton, Oregon. 512004Atlanta, GARetrieved from http://www.ntis.gov/search/product.aspx?ABBR=PB2005102173[ HYPERLINK \l "_ENREF_25" \o "ATSDR, 2004 #589" 25]; Clapp and Hoffman  ADDIN EN.CITE Clapp2008502[26]50250217Clapp, R. W.Hoffman, K.Department of Environmental Health, Boston University School of Public Health, 715 Albany Street, Boston, MA 02118, USA. rclapp@bu.eduCancer mortality in IBM Endicott plant workers, 1969-2001: an update on a NY production plantEnviron HealthEnviron Health1372008/04/30AdultAgedAged, 80 and overCarcinogensComputersDeath CertificatesFeasibility StudiesFemaleHumansIndustryMaleMiddle AgedNeoplasms/chemically induced/*mortalityNew York/epidemiologyOccupational Diseases/chemically induced/*mortalityOccupational Exposure20081476-069X (Electronic) 1476-069X (Linking)18442394http://www.ncbi.nlm.nih.gov/pubmed/1844239423838841476-069X-7-13 [pii] 10.1186/1476-069X-7-13eng[ HYPERLINK \l "_ENREF_26" \o "Clapp, 2008 #502" 26]; Cohn et al.  ADDIN EN.CITE Cohn1994508[27]50850817Cohn, P.Klotz, J.Bove, F.Berkowitz, M.Fagliano, J.New Jersey Department of Health, Environmental Health Services, Trenton, NJ 08625 USA.Drinking Water Contamination and the Incidence of Leukemia and Non-Hodgkin's LymphomaEnviron Health PerspectEnviron Health Perspect556-611026-71994/06/011994Jun1552-9924 (Electronic) 0091-6765 (Linking)9679115http://www.ncbi.nlm.nih.gov/pubmed/96791151569761sc271_5_1835 [pii]Eng[ HYPERLINK \l "_ENREF_27" \o "Cohn, 1994 #508" 27]Weakness with respect to analytical study design (i.e., geographic-based, ecological or proportional mortality ratio design). Wilcosky et al.  ADDIN EN.CITE Wilcosky1984513[28]51351317Wilcosky, T. C.Checkoway, H.Marshall, E. G.Tyroler, H. A.Cancer mortality and solvent exposures in the rubber industryAm Ind Hyg Assoc JAm Ind Hyg Assoc J809-1145121984/12/01AdultAgedCarbon Disulfide/adverse effectsCarbon Tetrachloride/adverse effectsHumansLeukemia, Lymphoid/chemically inducedLymphatic Diseases/chemically inducedLymphoma, Non-Hodgkin/chemically inducedMiddle AgedNeoplasms/chemically induced/*mortalityOccupational Diseases/*mortality*RubberSolvents/*adverse effects1984Dec0002-8894 (Print) 0002-8894 (Linking)6549104http://www.ncbi.nlm.nih.gov/pubmed/6549104eng[ HYPERLINK \l "_ENREF_28" \o "Wilcosky, 1984 #513" 28]; Isacson et al.  ADDIN EN.CITE  ADDIN EN.CITE.DATA [ HYPERLINK \l "_ENREF_29" \o "Isacson, 1985 #519" 29]; Shindell and Ulrich  ADDIN EN.CITE Shindell1985524[30]52452417Shindell, S.Ulrich, S.A cohort study of employees of a manufacturing plant using trichlorethyleneJ Occup MedJ Occup Med577-92781985/08/01AdultAgedFemaleFollow-Up StudiesHumansMaleMiddle AgedOccupational Diseases/*chemically induced/mortalityRiskTrichloroethylene/*adverse effectsUnited States1985Aug0096-1736 (Print) 0096-1736 (Linking)4032094http://www.ncbi.nlm.nih.gov/pubmed/4032094eng[ HYPERLINK \l "_ENREF_30" \o "Shindell, 1985 #524" 30]; Garabrant et al.  ADDIN EN.CITE  ADDIN EN.CITE.DATA [ HYPERLINK \l "_ENREF_31" \o "Garabrant, 1988 #139" 31]; Shannon et al.  ADDIN EN.CITE Shannon1988532[32]53253217Shannon, H. S.Haines, T.Bernholz, C.Julian, J. A.Verma, D. K.Jamieson, E.Walsh, C.Occupational Health Program, McMaster University Medical Centre, Hamilton, Ontario, Canada.Cancer morbidity in lamp manufacturing workersAm J Ind MedAm J Ind Med281-901431988/01/01Breast Neoplasms/*epidemiology/etiologyCanadaFemaleHumansIndustryLightingMaleNeoplasms/*epidemiology/etiologyOccupational Diseases/*epidemiology/etiologyProspective StudiesTime Factors19880271-3586 (Print) 0271-3586 (Linking)3189346http://www.ncbi.nlm.nih.gov/pubmed/3189346eng[ HYPERLINK \l "_ENREF_32" \o "Shannon, 1988 #532" 32]; Blair et al.  ADDIN EN.CITE  ADDIN EN.CITE.DATA [ HYPERLINK \l "_ENREF_33" \o "Blair, 1989 #123" 33]; Costa et al.  ADDIN EN.CITE Costa1989534[34]53453417Costa, G.Merletti, F.Segnan, N.Unit of Epidemiology, Local Health Authority of Turin, Italy.A mortality cohort study in a north Italian aircraft factoryBr J Ind MedBr J Ind Med738-4346101989/10/01AdolescentAdult*AircraftCause of DeathCohort StudiesFemaleHumans*IndustryItaly/epidemiologyMaleMiddle Aged*MortalityNeoplasms/mortalityOccupational Diseases/mortalityRetrospective Studies1989Oct0007-1072 (Print) 0007-1072 (Linking)2818961http://www.ncbi.nlm.nih.gov/pubmed/28189611009856eng[ HYPERLINK \l "_ENREF_34" \o "Costa, 1989 #534" 34]; ADHS  ADDIN EN.CITE ADHS1995585[35,36]58558546ADHS, Arizona Department Health ServicesUpdate of the incidence of childhood cancers and testicular cancer in Southwest Tuscon: 1987-1991.1995Phoenizhttp://www.azdhs.gov/phs/oeh/epistudy.htmADHS199058658658646ADHS, Arizona Department Health ServicesIncidence study of childhood cancer in Maricopa County: 1965-1986.1990http://www.azdhs.gov/phs/oeh/epistudy.htm[ HYPERLINK \l "_ENREF_35" \o "ADHS, 1995 #585" 35, HYPERLINK \l "_ENREF_36" \o "ADHS, 1990 #586" 36]; Mallin  ADDIN EN.CITE Mallin1990538[37]53853817Mallin, K.Illinois Cancer Council, Division of Epidemiology, Chicago 60603.Investigation of a bladder cancer cluster in northwestern IllinoisAm J EpidemiolAm J EpidemiolS96-1061321 Suppl1990/07/01AdolescentAdultAgedAged, 80 and overChildChild, PreschoolCluster AnalysisFemaleHumansIllinoisIncidenceInfantInfant, NewbornMaleMiddle AgedResidence CharacteristicsRisk FactorsSurvival RateUrinary Bladder Neoplasms/*epidemiology/etiology/mortalityWater Pollution, Chemical/adverse effects1990Jul0002-9262 (Print) 0002-9262 (Linking)2356842http://www.ncbi.nlm.nih.gov/pubmed/2356842eng[ HYPERLINK \l "_ENREF_37" \o "Mallin, 1990 #538" 37]; Aickin et al.  ADDIN EN.CITE Aickin1992591[38]59159117Aickin, M.Chapin, C. A.Flood, T. J.Englender, S. J.Caldwell, G. G.Department of Family and Community Medicine, University of Arizona, Tucson.Assessment of the spatial occurrence of childhood leukaemia mortality using standardized rate ratios with a simple linear Poisson modelInt J EpidemiolInt J Epidemiol649-552141992/08/01AdolescentArizona/epidemiologyChildChild, PreschoolCluster AnalysisFemaleHumansInfantLeukemia/epidemiology/*mortalityLinear ModelsMaleModels, StatisticalPoisson Distribution*Statistics as Topic1992Aug0300-5771 (Print) 0300-5771 (Linking)1521967http://www.ncbi.nlm.nih.gov/pubmed/1521967eng[ HYPERLINK \l "_ENREF_38" \o "Aickin, 1992 #591" 38]; Sinks et al.  ADDIN EN.CITE Sinks1992539[39]53953917Sinks, T.Lushniak, B.Haussler, B. J.Sniezek, J.Deng, J. F.Roper, P.Dill, P.Coates, R.National Institute for Occupational Safety and Health, Cincinnati, OH.Renal cell cancer among paperboard printing workersEpidemiologyEpidemiology483-9361992/11/01AdolescentAdultCarcinoma, Renal Cell/*epidemiology/etiology/mortalityCase-Control StudiesCause of DeathCohort StudiesCross-Sectional StudiesFemaleFollow-Up StudiesHumansIncidenceKidney Neoplasms/*epidemiology/etiology/mortalityMaleMiddle AgedOccupational Diseases/*epidemiology/etiology/mortalityOccupational Exposure/*adverse effectsOdds Ratio*Paper*PrintingRisk Factors1992Nov1044-3983 (Print) 1044-3983 (Linking)1420513http://www.ncbi.nlm.nih.gov/pubmed/1420513eng[ HYPERLINK \l "_ENREF_39" \o "Sinks, 1992 #539" 39]; Vartiainen et al.  ADDIN EN.CITE  ADDIN EN.CITE.DATA [ HYPERLINK \l "_ENREF_40" \o "Vartiainen, 1993 #560" 40]; Morgan and Cassady  ADDIN EN.CITE Morgan2002564[41]56456417Morgan, J. W.Cassady, R. E.Loma Linda University School of Public Health, USA. jmorgan@dscsp.comCommunity cancer assessment in response to long-time exposure to perchlorate and trichloroethylene in drinking waterJ Occup Environ MedJ Occup Environ Med616-214472002/07/24AdultCalifornia/epidemiologyChildCommunity Health ServicesConfidence IntervalsEducational StatusFemaleHumansIncidenceIncomeMaleNeoplasms/chemically induced/*epidemiologyPerchloric Acid/*analysisRegistriesSodium Compounds/*analysisTrichloroethylene/*analysisWater Pollution, Chemical/adverse effects/*analysis2002Jul1076-2752 (Print) 1076-2752 (Linking)12134524http://www.ncbi.nlm.nih.gov/pubmed/12134524eng[ HYPERLINK \l "_ENREF_41" \o "Morgan, 2002 #564" 41]; Lee et al.  ADDIN EN.CITE Lee2003565[42]56556517Lee, L. J.Chung, C. W.Ma, Y. C.Wang, G. S.Chen, P. C.Hwang, Y. H.Wang, J. D.Institute of Occupational Medicine and Industrial Hygiene, College of Public Health, National Taiwan University, Taipei, Taiwan.Increased mortality odds ratio of male liver cancer in a community contaminated by chlorinated hydrocarbons in groundwaterOccup Environ MedOccup Environ Med364-96052003/04/24AdultAgedCause of DeathDeath CertificatesEnvironmental ExposureFemaleHumansHydrocarbons, Chlorinated/*adverse effectsLiver Neoplasms/epidemiology/*mortalityMaleMiddle AgedOdds Ratio*Public HealthResidence CharacteristicsRisk FactorsWater Pollutants, Chemical/*adverse effectsWater Supply/analysis2003May1351-0711 (Print) 1351-0711 (Linking)12709523http://www.ncbi.nlm.nih.gov/pubmed/127095231740539eng[ HYPERLINK \l "_ENREF_42" \o "Lee, 2003 #565" 42]; Aickin  ADDIN EN.CITE Aickin2004573[43]57357317Aickin, M.Center for Health Research, 3800 North Interstate Avenue, Portland, OR 97227, USA. mikel.aickin@kpchr.orgBayes without priorsJ Clin EpidemiolJ Clin Epidemiol4-135712004/03/17Arizona/epidemiologyBayes TheoremCluster AnalysisEpidemiologic MethodsHumansIllinois/epidemiologyIncidenceMesothelioma/mortalityPrecursor Cell Lymphoblastic Leukemia-Lymphoma/epidemiology*Statistics as TopicSurvival Rate2004Jan0895-4356 (Print) 0895-4356 (Linking)15019005http://www.ncbi.nlm.nih.gov/pubmed/1501900510.1016/S0895-4356(03)00251-8 S0895435603002518 [pii]eng[ HYPERLINK \l "_ENREF_43" \o "Aickin, 2004 #573" 43]; Chang et al.  ADDIN EN.CITE  ADDIN EN.CITE.DATA [ HYPERLINK \l "_ENREF_44" \o "Chang, 2003 #576" 44, HYPERLINK \l "_ENREF_45" \o "Chang, 2005 #575" 45]; Coyle et al.  ADDIN EN.CITE  ADDIN EN.CITE.DATA [ HYPERLINK \l "_ENREF_46" \o "Coyle, 2005 #584" 46]; ATSDR  ADDIN EN.CITE ATSDR2006587[47,48]58758746ATSDR, Agency for Toxic Substances and Disease RegistryU. S. Department of Health and Human Services, Public Health ServiceHealth Consultation, Endicott Area Investigation, Cancer and Birth Outcome Analysis, Endicott Area, Town of Union, Broome County, New York862006Atlanta, GA 30333http://www.atsdr.cdc.gov/HAC/pha/EndicottAreaInvestigation/EndicottHealthStatsReviewHC052606.pdfATSDR200858858858846ATSDR, Agency for Toxic Substances and Disease RegistryU.S. Department of Health and Human Services, Public Health ServiceHealth Consultation, Health Statistics Review Follow-up, Cancer and Birth Outcome Analysis, Endicott Area Investigation, Endicott Area, Town of Union, Broome County, New York602008Atlanta, GAhttp://www.atsdr.cdc.gov/HAC/pha//EndicottAreaInvestigationFollowUp/EndicottAreaHC051508.pdf[ HYPERLINK \l "_ENREF_47" \o "ATSDR, 2006 #587" 47, HYPERLINK \l "_ENREF_48" \o "ATSDR, 2008 #588" 48]; Sung et al.  ADDIN EN.CITE  ADDIN EN.CITE.DATA [ HYPERLINK \l "_ENREF_49" \o "Sung, 2007 #582" 49, HYPERLINK \l "_ENREF_50" \o "Sung, 2008 #581" 50]TCE exposure potential not assigned to individual subjects using job exposure matrix, individual biomarkers, water distribution models, or industrial hygiene data. Lowengart et al.  ADDIN EN.CITE Lowengart1987593[51]59359317Lowengart, R. A.Peters, J. M.Cicioni, C.Buckley, J.Bernstein, L.Preston-Martin, S.Rappaport, E.Childhood leukemia and parents' occupational and home exposuresJ Natl Cancer InstJ Natl Cancer Inst39-467911987/07/01Acute DiseaseCaliforniaChildChild, Preschool*Environmental ExposureEpidemiologic MethodsFemaleHumansLeukemia/*etiologyMale*ParentsPregnancyPrenatal Exposure Delayed EffectsRisk1987Jul0027-8874 (Print) 0027-8874 (Linking)3474448http://www.ncbi.nlm.nih.gov/pubmed/3474448eng[ HYPERLINK \l "_ENREF_51" \o "Lowengart, 1987 #593" 51]; Fredriksson et al.  ADDIN EN.CITE Fredriksson1989599[52]59959917Fredriksson, M.Bengtsson, N. O.Hardell, L.Axelson, O.Department of Occupational Medicine, University Hospital, Linkoping, Sweden.Colon cancer, physical activity, and occupational exposures. A case-control studyCancerCancer1838-426391989/05/01Adenocarcinoma/*epidemiologyAdultAgedColitis, Ulcerative/complicationsColonic Neoplasms/*epidemiologyEpidemiologic MethodsFemaleHumansMaleMiddle AgedOccupational Diseases/*epidemiology*Physical ExertionRiskRisk Factors1989May 10008-543X (Print) 0008-543X (Linking)2702592http://www.ncbi.nlm.nih.gov/pubmed/2702592eng[ HYPERLINK \l "_ENREF_52" \o "Fredriksson, 1989 #599" 52]; McKinney et al.  ADDIN EN.CITE McKinney1991610[53]61061017McKinney, P. A.Alexander, F. E.Cartwright, R. A.Parker, L.Leukaemia Research Fund, University of Leeds.Parental occupations of children with leukaemia in west Cumbria, north Humberside, and GatesheadBMJBMJ681-730267781991/03/23AdolescentBenzene/adverse effectsCase-Control StudiesChildChild, PreschoolEnglandFemaleHumansInfantLeukemia/chemically induced/*etiologyLeukemia, Radiation-Induced/etiologyLymphoma, Non-Hodgkin/*etiologyMaleOccupational Exposure*OccupationsOdds Ratio*ParentsPregnancyPrenatal Exposure Delayed EffectsRisk FactorsTime FactorsWood1991Mar 230959-8138 (Print) 0959-535X (Linking)2021741http://www.ncbi.nlm.nih.gov/pubmed/20217411669138eng[ HYPERLINK \l "_ENREF_53" \o "McKinney, 1991 #610" 53]; Heineman et al.  ADDIN EN.CITE Heineman1994614[54]61461417Heineman, E. F.Cocco, P.Gomez, M. R.Dosemeci, M.Stewart, P. A.Hayes, R. B.Zahm, S. H.Thomas, T. L.Blair, A.Occupational Studies Section, National Cancer Institute, Rockville, MD 20892.Occupational exposure to chlorinated aliphatic hydrocarbons and risk of astrocytic brain cancerAm J Ind MedAm J Ind Med155-692621994/08/01Astrocytoma/chemically induced/epidemiologyBrain Neoplasms/*chemically inducedCarbon Tetrachloride Poisoning/epidemiologyGlioblastoma/*chemically induced/epidemiologyHumansHydrocarbons, Chlorinated/*poisoningLouisiana/epidemiologyMaleMethylene Chloride/poisoningNew Jersey/epidemiology*Occupational ExposurePhiladelphia/epidemiologyRisk FactorsTetrachloroethylene/poisoningTrichloroethylene/poisoning1994Aug0271-3586 (Print) 0271-3586 (Linking)7977393http://www.ncbi.nlm.nih.gov/pubmed/7977393eng[ HYPERLINK \l "_ENREF_54" \o "Heineman, 1994 #614" 54] Siemiatycki et al.  ADDIN EN.CITE Siemiatycki1994615[55]61561517Siemiatycki, J.Dewar, R.Nadon, L.Gerin, M.Epidemiology and Biostatistics Unit, Institut Armand-Frappier, Laval, Quebec, Canada.Occupational risk factors for bladder cancer: results from a case-control study in Montreal, Quebec, CanadaAm J EpidemiolAm J Epidemiol1061-80140121994/12/15AdultCarcinoma/*chemically induced/*epidemiologyCase-Control StudiesDose-Response Relationship, DrugFemaleHumansLogistic ModelsMaleMiddle AgedMultivariate Analysis*Occupational ExposureOdds RatioQuebec/epidemiologyRisk FactorsTime FactorsUrinary Bladder Neoplasms/*chemically induced/*epidemiology1994Dec 150002-9262 (Print) 0002-9262 (Linking)7998589http://www.ncbi.nlm.nih.gov/pubmed/7998589eng[ HYPERLINK \l "_ENREF_55" \o "Siemiatycki, 1994 #615" 55]; Aronson et al.  ADDIN EN.CITE Aronson1996623[56]62362317Aronson, K. J.Siemiatycki, J.Dewar, R.Gerin, M.University of Toronto, Toronto, Ontario, Canada.Occupational risk factors for prostate cancer: results from a case-control study in Montreal, Quebec, CanadaAm J EpidemiolAm J Epidemiol363-7314341996/02/15AdultAgedCase-Control StudiesHumansLogistic ModelsMaleMiddle AgedOccupational Diseases/epidemiology/*etiology*OccupationsOdds RatioPopulation SurveillanceProstatic Neoplasms/epidemiology/*etiologyQuebec/epidemiologyQuestionnairesRisk FactorsUrban Health1996Feb 150002-9262 (Print) 0002-9262 (Linking)8633620http://www.ncbi.nlm.nih.gov/pubmed/8633620eng[ HYPERLINK \l "_ENREF_56" \o "Aronson, 1996 #623" 56]; Fritchi and Siemiatycki  ADDIN EN.CITE Fritschi1996622[57]62262217Fritschi, L.Siemiatycki, J.Epidemiology and Biostatistics Unit, Institut Armand-Frappier, Laval, Quebec, Canada.Melanoma and occupation: results of a case-control studyOccup Environ MedOccup Environ Med168-735331996/03/01Adhesives/adverse effectsAdultAgedAir Pollutants, Occupational/adverse effectsCase-Control StudiesHumansIndustryMaleMelanoma/*epidemiology/etiologyMiddle AgedMultivariate AnalysisOccupational Exposure/*adverse effects*OccupationsOdds RatioPaint/adverse effectsQuebec/epidemiologySkin Neoplasms/*epidemiology/etiologyTrichloroethylene/adverse effects1996Mar1351-0711 (Print) 1351-0711 (Linking)8704857http://www.ncbi.nlm.nih.gov/pubmed/87048571128439eng[ HYPERLINK \l "_ENREF_57" \o "Fritschi, 1996 #622" 57]; Dumas et al.  ADDIN EN.CITE Dumas2000626[58]62662617Dumas, S.Parent, M. E.Siemiatycki, J.Brisson, J.INRS-Institut Armand-Frappier, Laval, Quebec, Canada.Rectal cancer and occupational risk factors: a hypothesis-generating, exposure-based case-control studyInt J CancerInt J Cancer874-98762000/08/24AdultAgedCase-Control StudiesDust/adverse effectsHumansMaleMiddle AgedOccupational Diseases/*etiologyOccupational Exposure/*adverse effectsOccupationsOdds RatioQuebecRectal Neoplasms/*etiologyRegression Analysis2000Sep 150020-7136 (Print) 0020-7136 (Linking)10956400http://www.ncbi.nlm.nih.gov/pubmed/1095640010.1002/1097-0215(20000915)87:6<874::AID-IJC18>3.0.CO;2-L [pii]eng[ HYPERLINK \l "_ENREF_58" \o "Dumas, 2000 #626" 58]; Kernan et al.  ADDIN EN.CITE  ADDIN EN.CITE.DATA [ HYPERLINK \l "_ENREF_59" \o "Kernan, 1999 #636" 59]; Shu et al.  ADDIN EN.CITE  ADDIN EN.CITE.DATA [ HYPERLINK \l "_ENREF_60" \o "Shu, 2004 #641" 60, HYPERLINK \l "_ENREF_61" \o "Shu, 2002 #644" 61]; Parent et al.  ADDIN EN.CITE Parent2000629[62]62962917Parent, M. E.Siemiatycki, J.Fritschi, L.INRS, Institut Armand-Frappier 531, Boulevard des Prairies Laval, Quebec, Canada H7V 1B7. marie-elise.parent@inrs-iaf.uquebec.caWorkplace exposures and oesophageal cancerOccup Environ MedOccup Environ Med325-345752000/04/19AdultAgedCarbon/adverse effectsCarcinoma, Squamous Cell/*chemically induced/*epidemiologyCase-Control StudiesEsophageal Neoplasms/*chemically induced/epidemiologyHumansIndustryMaleMiddle AgedOccupational Diseases/*chemically induced/epidemiologyOccupational Exposure/*adverse effectsOccupationsOdds RatioQuebec/epidemiologyRisk FactorsSulfuric Acids/adverse effects2000May1351-0711 (Print) 1351-0711 (Linking)10769298http://www.ncbi.nlm.nih.gov/pubmed/107692981739952eng[ HYPERLINK \l "_ENREF_62" \o "Parent, 2000 #629" 62]; Pesch et al.  ADDIN EN.CITE  ADDIN EN.CITE.DATA [ HYPERLINK \l "_ENREF_63" \o "Pesch, 2000 #631" 63]; DeRoos et al.  ADDIN EN.CITE De Roos2001679[64]67967917De Roos, A. J.Teschke, K.Savitz, D. A.Poole, C.Grufferman, S.Pollock, B. H.Olshan, A. F.Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, NC, USA. deroosa@mail.nih.govParental occupational exposures to electromagnetic fields and radiation and the incidence of neuroblastoma in offspringEpidemiologyEpidemiology508-171252001/08/16Case-Control StudiesElectromagnetic Fields/*adverse effectsFemaleHumansIncidenceInfant, NewbornMaleMaternal ExposureNeuroblastoma/epidemiology/*etiology*Occupational Exposure*Paternal ExposurePregnancy*RadiationUnited States/epidemiology2001Sep1044-3983 (Print) 1044-3983 (Linking)11505168http://www.ncbi.nlm.nih.gov/pubmed/11505168eng[ HYPERLINK \l "_ENREF_64" \o "De Roos, 2001 #679" 64]; Goldberg et al.  ADDIN EN.CITE Goldberg2001653[65]65365317Goldberg, M. S.Parent, M. E.Siemiatycki, J.Desy, M.Nadon, L.Richardson, L.Lakhani, R.Latreille, B.Valois, M. F.Department of Medicine, McGill University, Montreal, Quebec, Canada. mark.goldberg@mcgill.caA case-control study of the relationship between the risk of colon cancer in men and exposures to occupational agentsAm J Ind MedAm J Ind Med531-463962001/06/01AdultAgedCanadaCase-Control StudiesColonic Neoplasms/*etiologyHealth SurveysHumansLogistic ModelsMaleMiddle AgedMultivariate AnalysisOccupational Exposure/*adverse effects/classificationOccupationsOdds RatioQuestionnairesRisk Factors2001Jun0271-3586 (Print) 0271-3586 (Linking)11385637http://www.ncbi.nlm.nih.gov/pubmed/1138563710.1002/ajim.1052 [pii]eng[ HYPERLINK \l "_ENREF_65" \o "Goldberg, 2001 #653" 65]; Costas et al.  ADDIN EN.CITE  ADDIN EN.CITE.DATA [ HYPERLINK \l "_ENREF_66" \o "Costas, 2002 #655" 66]; Krishnadasan et al.  ADDIN EN.CITE  ADDIN EN.CITE.DATA [ HYPERLINK \l "_ENREF_67" \o "Krishnadasan, 2007 #657" 67]Cancer incidence or mortality reported for cancers other than kidney, liver, or NHL. Ritz  ADDIN EN.CITE Ritz1999660[68]66066017Ritz, B.Department of Epidemiology, School of Public Health, University of California, Los Angeles 90095-1772, USA.Cancer mortality among workers exposed to chemicals during uranium processingJ Occup Environ MedJ Occup Environ Med556-664171999/07/21AdultCohort StudiesConfidence IntervalsHumansIncidenceIndustrial Oils/*adverse effectsKerosene/*adverse effectsLogistic ModelsMaleNeoplasms/chemically induced/*mortalityOccupational Diseases/chemically induced/*mortalityOccupational Exposure/*adverse effectsOhio/epidemiologyProportional Hazards ModelsRadiation DosageSmoking/epidemiologyTrichloroethylene/*adverse effects*Uranium1999Jul1076-2752 (Print) 1076-2752 (Linking)10412097http://www.ncbi.nlm.nih.gov/pubmed/10412097eng[ HYPERLINK \l "_ENREF_68" \o "Ritz, 1999 #660" 68]Subjects monitored for radiation exposure with likelihood for potential confounding; Cancer mortality and TCE exposure not reported for kidney cancer and all hemato- and lymphopoietic cancer reported as broad category. Henschler et al.  ADDIN EN.CITE Henschler1995337[69]33733717Henschler, D.Vamvakas, S.Lammert, M.Dekant, W.Kraus, B.Thomas, B.Ulm, K.Institut fur Toxikologie, Universitat Wurzburg, Germany.Increased incidence of renal cell tumors in a cohort of cardboard workers exposed to trichloroetheneArch ToxicolArch Toxicol291-96951995/01/01AdolescentAdultAgedAged, 80 and overCarcinogens/toxicityCarcinoma, Renal Cell/*chemically induced/*epidemiology/mortalityCohort StudiesHumansKidney Neoplasms/*chemically induced/*epidemiology/mortalityMaleMiddle AgedOccupational Exposure/*adverse effectsPaper/standardsTrichloroethylene/*adverse effects/metabolism19950340-5761 (Print) 0340-5761 (Linking)7654132http://www.ncbi.nlm.nih.gov/pubmed/7654132eng[ HYPERLINK \l "_ENREF_69" \o "Henschler, 1995 #337" 69]Incomplete identification of cohort and index kidney cancer cases included in case seriesVamvakas et al.  ADDIN EN.CITE Vamvakas1998342[70]34234217Vamvakas, S.Bruning, T.Thomasson, B.Lammert, M.Baumuller, A.Bolt, H. M.Dekant, W.Birner, G.Henschler, D.Ulm, K.Institute of Toxicology, University of Wurzburg, Germany.Renal cell cancer correlated with occupational exposure to trichloroetheneJ Cancer Res Clin OncolJ Cancer Res Clin Oncol374-8212471998/08/27AgedCarcinoma, Renal Cell/epidemiology/*etiologyCohort StudiesFemaleHumansMaleMiddle AgedOccupational Diseases/epidemiology/*etiology*Occupational ExposureSolvents/*adverse effectsTrichloroethylene/*adverse effects19980171-5216 (Print) 0171-5216 (Linking)9719500http://www.ncbi.nlm.nih.gov/pubmed/9719500eng[ HYPERLINK \l "_ENREF_70" \o "Vamvakas, 1998 #342" 70]Control selection may not represent case series, with potential for selection bias. Supplemental Table 2. Summary of some meta-analysis results for TCE (overall) and kidney cancer. Analysis# of studiesModelRRm 95% LCL95% UCLHeterogeneityCommentsAll studies15Random1.271.131.43None obs (fixed = random)Statistical significance not dependent on single study. No apparent publication bias.Fixed1.271.131.43Cohort9Random1.160.961.40None obsNot significant difference between CC and cohort studies (p = 0.12).Fixed1.160.961.40Not significant difference between CC and cohort studies (p = 0.19).Case-control6Random1.481.151.91Not significant (p = 0.14)Fixed1.361.171.39Alternate RR selections a15Random1.271.281.131.141.42"1.43None obsWith 3 different alternates from Zhao et al.  ADDIN EN.CITE  ADDIN EN.CITE.DATA [ HYPERLINK \l "_ENREF_16" \o "Zhao, 2005 #184" 16]. 15Random1.291.151.45None obsWith Boice et al.  ADDIN EN.CITE  ADDIN EN.CITE.DATA [ HYPERLINK \l "_ENREF_8" \o "Boice, 2006 #128" 8] rather than Zhao et al.  ADDIN EN.CITE  ADDIN EN.CITE.DATA [ HYPERLINK \l "_ENREF_16" \o "Zhao, 2005 #184" 16].15Random1.271.131.43None obsWith estimated female contribution to Axelson et al.  ADDIN EN.CITE Axelson1994120[2]12012017Axelson, O.Selden, A.Andersson, K.Hogstedt, C.Department of Occupational and Environmental Medicine, University Hospital, Linkoping, SwedenUpdated and expanded Swedish cohort study on trichloroethylene and cancer riskJ.Occup.Med.J.Occup.Med.556-562365NOT IN FILEAAdultadverse effectsarticlecancerCardiovascular DiseasesCohort StudiesConfidence IntervalsdeathepidemiologyexposureFemaleFollow-Up StudieshumanHumansIncidenceMaleMorbiditymortalityNeoplasmsOccupational DiseasesOccupational ExposurePopulationRiskstudySwedenTrichloroethyleneworker1994PM:8027881[ HYPERLINK \l "_ENREF_2" \o "Axelson, 1994 #120" 2]. 15Random1.281.141.43None obsWith Morgan et al.  ADDIN EN.CITE  ADDIN EN.CITE.DATA [ HYPERLINK \l "_ENREF_6" \o "Morgan, 1998 #157" 6] published SMR.15Random1.271.131.42None obsWith Raaschou-Nielsen et al.  ADDIN EN.CITE  ADDIN EN.CITE.DATA [ HYPERLINK \l "_ENREF_15" \o "Raaschou-Nielsen, 2003 #168" 15] all kidney cancer.15Random1.321.171.49None obsWith Raaschou-Nielsen et al.  ADDIN EN.CITE  ADDIN EN.CITE.DATA [ HYPERLINK \l "_ENREF_15" \o "Raaschou-Nielsen, 2003 #168" 15] high-exposure subcohort. Supplemental Table 2. Cont. Analysis# of studiesModelRRm 95% LCL95% UCLHeterogeneityComments15Random1.261.121.41None obsWith Brning et al.  ADDIN EN.CITE  ADDIN EN.CITE.DATA [14] longest job held in industry with TCE. 15Random1.281.141.43None obsWith Charbotel et al.  ADDIN EN.CITE  ADDIN EN.CITE.DATA [18] full study, with and without 10-year lag.15Random1.271.131.43None obsWith Moore et al.  ADDIN EN.CITE  ADDIN EN.CITE.DATA [22] full study.15Random1.211.091.34None obsWith Pesch et al.  ADDIN EN.CITE  ADDIN EN.CITE.DATA [12] JEM.Highest exposure groups10Random1.641.312.04None obs13Random1.581.281.96None obsUsing RR=1 for Anttila et al.  ADDIN EN.CITE  ADDIN EN.CITE.DATA [5], Axelson et al.  ADDIN EN.CITE Axelson1994120[2]12012017Axelson, O.Selden, A.Andersson, K.Hogstedt, C.Department of Occupational and Environmental Medicine, University Hospital, Linkoping, SwedenUpdated and expanded Swedish cohort study on trichloroethylene and cancer riskJ.Occup.Med.J.Occup.Med.556-562365NOT IN FILEAAdultadverse effectsarticlecancerCardiovascular DiseasesCohort StudiesConfidence IntervalsdeathepidemiologyexposureFemaleFollow-Up StudieshumanHumansIncidenceMaleMorbiditymortalityNeoplasmsOccupational DiseasesOccupational ExposurePopulationRiskstudySwedenTrichloroethyleneworker1994PM:8027881[2], and Hansen et al.  ADDIN EN.CITE Hansen2001142[13]14214217Hansen, J.Raaschou-Nielsen, O.Christensen, J. M.Johansen, I.McLaughlin, J. K.Lipworth, L.Blot, W. J.Olsen, J. H.Danish Cancer Society, Institute of Cancer Epidemiology, Strandboulevarden 49, DK-2100 Copenhagen O, Denmark. johnni@cancer.dkCancer incidence among Danish workers exposed to trichloroethyleneJ.Occup.Environ.Med.J.Occup.Environ.Med.133-139432NOT IN FILEadverse effectsarticlecancerchemically inducedDenmarkepidemiologyEsophageal NeoplasmsFemalehumanHumansIncidenceLymphomaLymphoma,Non-HodgkinMaleNeoplasmsOccupational ExposureResearchResearch SupportRiskTrichloroethyleneurineUterine Cervical Neoplasmsworker2001PM:11227631[13].13Random1.471.601.201.291.791.98See Supplemental Table 3Using RR=1 for Anttila et al.  ADDIN EN.CITE  ADDIN EN.CITE.DATA [5], Axelson et al.  ADDIN EN.CITE Axelson1994120[2]12012017Axelson, O.Selden, A.Andersson, K.Hogstedt, C.Department of Occupational and Environmental Medicine, University Hospital, Linkoping, SwedenUpdated and expanded Swedish cohort study on trichloroethylene and cancer riskJ.Occup.Med.J.Occup.Med.556-562365NOT IN FILEAAdultadverse effectsarticlecancerCardiovascular DiseasesCohort StudiesConfidence IntervalsdeathepidemiologyexposureFemaleFollow-Up StudieshumanHumansIncidenceMaleMorbiditymortalityNeoplasmsOccupational DiseasesOccupational ExposurePopulationRiskstudySwedenTrichloroethyleneworker1994PM:8027881[2], and Hansen et al.  ADDIN EN.CITE Hansen2001142[13]14214217Hansen, J.Raaschou-Nielsen, O.Christensen, J. M.Johansen, I.McLaughlin, J. K.Lipworth, L.Blot, W. J.Olsen, J. H.Danish Cancer Society, Institute of Cancer Epidemiology, Strandboulevarden 49, DK-2100 Copenhagen O, Denmark. johnni@cancer.dkCancer incidence among Danish workers exposed to trichloroethyleneJ.Occup.Environ.Med.J.Occup.Environ.Med.133-139432NOT IN FILEadverse effectsarticlecancerchemically inducedDenmarkepidemiologyEsophageal NeoplasmsFemalehumanHumansIncidenceLymphomaLymphoma,Non-HodgkinMaleNeoplasmsOccupational ExposureResearchResearch SupportRiskTrichloroethyleneurineUterine Cervical Neoplasmsworker2001PM:11227631[13] and various alternate RR selection results.a a Changing the primary analysis by one alternate RR each time. CC = case-control; JEM = job-exposure-matrix; LCL = lower confidence limit; obs = observable; RR = relative risk estimate; RRm = summary relative risk estimate; UCL = upper confidence limit. Supplemental Table 3. Summary of some meta-analysis results for TCE (highest exposure groups) and kidney cancer. AnalysisModelRRm 95% LCL95% UCLHeterogeneityCommentsAnalysis based on reported resultsRandom1.641.312.04None obs (fixed = random)Primary analysisRandom1.581.281.96None obs Includes assumed values for Anttila et al.  ADDIN EN.CITE  ADDIN EN.CITE.DATA [ HYPERLINK \l "_ENREF_5" \o "Anttila, 1995 #119" 5], Axelson et al.  ADDIN EN.CITE Axelson1994120[2]12012017Axelson, O.Selden, A.Andersson, K.Hogstedt, C.Department of Occupational and Environmental Medicine, University Hospital, Linkoping, SwedenUpdated and expanded Swedish cohort study on trichloroethylene and cancer riskJ.Occup.Med.J.Occup.Med.556-562365NOT IN FILEAAdultadverse effectsarticlecancerCardiovascular DiseasesCohort StudiesConfidence IntervalsdeathepidemiologyexposureFemaleFollow-Up StudieshumanHumansIncidenceMaleMorbiditymortalityNeoplasmsOccupational DiseasesOccupational ExposurePopulationRiskstudySwedenTrichloroethyleneworker1994PM:8027881[ HYPERLINK \l "_ENREF_2" \o "Axelson, 1994 #120" 2], and Hansen et al.  ADDIN EN.CITE Hansen2001142[13]14214217Hansen, J.Raaschou-Nielsen, O.Christensen, J. M.Johansen, I.McLaughlin, J. K.Lipworth, L.Blot, W. J.Olsen, J. H.Danish Cancer Society, Institute of Cancer Epidemiology, Strandboulevarden 49, DK-2100 Copenhagen O, Denmark. johnni@cancer.dkCancer incidence among Danish workers exposed to trichloroethyleneJ.Occup.Environ.Med.J.Occup.Environ.Med.133-139432NOT IN FILEadverse effectsarticlecancerchemically inducedDenmarkepidemiologyEsophageal NeoplasmsFemalehumanHumansIncidenceLymphomaLymphoma,Non-HodgkinMaleNeoplasmsOccupational ExposureResearchResearch SupportRiskTrichloroethyleneurineUterine Cervical Neoplasmsworker2001PM:11227631[ HYPERLINK \l "_ENREF_13" \o "Hansen, 2001 #142" 13]. Statistical significance not dependent on single study.Alternate RR selections aRandom1.571.271.95None obsWith Blair et al.  ADDIN EN.CITE  ADDIN EN.CITE.DATA [ HYPERLINK \l "_ENREF_20" \o "Blair, 1998 #125" 20] incidence RR instead of Radican et al.  ADDIN EN.CITE  ADDIN EN.CITE.DATA [ HYPERLINK \l "_ENREF_19" \o "Radican, 2008 #169" 19] mortality HR.Random1.601.291.98None obsWith Morgan et al.  ADDIN EN.CITE  ADDIN EN.CITE.DATA [ HYPERLINK \l "_ENREF_6" \o "Morgan, 1998 #157" 6] peak metric.Random1.47, 1.551.20, 1.251.80, 1.91None obsWith Raaschou-Nielsen et al.  ADDIN EN.CITE  ADDIN EN.CITE.DATA [ HYPERLINK \l "_ENREF_15" \o "Raaschou-Nielsen, 2003 #168" 15] >5years in total cohort for all kidney cancer and for RCC, respectively. Random1.56"1.581.26"1.281.93"1.96None obsWith Zhao et al.  ADDIN EN.CITE  ADDIN EN.CITE.DATA [ HYPERLINK \l "_ENREF_16" \o "Zhao, 2005 #184" 16] incidence unlagged and mortality with and without lag.Random1.58"1.591.28"1.291.95"1.96None obsWith Boice et al.  ADDIN EN.CITE  ADDIN EN.CITE.DATA [ HYPERLINK \l "_ENREF_8" \o "Boice, 2006 #128" 8] alternate for Zhao et al.  ADDIN EN.CITE  ADDIN EN.CITE.DATA [ HYPERLINK \l "_ENREF_16" \o "Zhao, 2005 #184" 16].Random1.591.291.95None obsWith Moore et al.  ADDIN EN.CITE  ADDIN EN.CITE.DATA [ HYPERLINK \l "_ENREF_22" \o "Moore, 2010 #236" 22] full study.Random1.54"1.581.24"1.271.90"1.95None obsWith Charbotel et al.  ADDIN EN.CITE  ADDIN EN.CITE.DATA [ HYPERLINK \l "_ENREF_18" \o "Charbotel, 2006 #132" 18] high cumulative dose + peaks in subgroup; and high cumulative dose and high cumulative dose + peaks in full study with and without 10-year lag and with and without additional adjustment for exposure to cutting fluids and other petroleum oils. Random1.471.201.79Not significant (p = 0.44)With Pesch et al.  ADDIN EN.CITE  ADDIN EN.CITE.DATA [ HYPERLINK \l "_ENREF_12" \o "Pesch, 2000 #167" 12] JEM. a Changing the primary analysis by one alternate RR each time. HR = hazard ratio; JEM = job-exposure-matrix; LCL = lower confidence limit; obs = observable; RCC = renal cell carcinoma; RR = relative risk estimate; RRm = summary relative risk estimate; UCL = upper confidence limit. Supplemental Table 4. Summary of some meta-analysis results for TCE and liver cancer. Analysis# of studiesModelRRm95% LCL95% UCLHeterogeneityCommentsAll studies (all cohort studies)9Random1.291.071.56None obs (fixed = random)Statistical significance not dependent on single study, except for Raaschou-Nielsen et al.  ADDIN EN.CITE  ADDIN EN.CITE.DATA [ HYPERLINK \l "_ENREF_15" \o "Raaschou-Nielsen, 2003 #168" 15], without which p=0.15. No apparent publication bias.Fixed1.291.071.56All studies; liver cancer only, when available9Random1.250.991.57None obsUsed RR estimates for liver cancer alone for the 3studies that presented these; remaining RR estimates are for liver and gall bladder/biliary passage cancers.Alternate RR selections a9Random1.281.061.55None obsWith RR = 1 assumed for Zhao et al.  ADDIN EN.CITE  ADDIN EN.CITE.DATA [ HYPERLINK \l "_ENREF_16" \o "Zhao, 2005 #184" 16] in lieu of Boice et al.  ADDIN EN.CITE  ADDIN EN.CITE.DATA [ HYPERLINK \l "_ENREF_8" \o "Boice, 2006 #128" 8].9Random1.341.091.63None obsWith Boice et al.  ADDIN EN.CITE  ADDIN EN.CITE.DATA [ HYPERLINK \l "_ENREF_9" \o "Boice, 1999 #126" 9] potential routine exposure rather than any potential exposure.9Random1.291.071.55None obsWith estimated female contribution to Axelson et al.  ADDIN EN.CITE Axelson1994120[2]12012017Axelson, O.Selden, A.Andersson, K.Hogstedt, C.Department of Occupational and Environmental Medicine, University Hospital, Linkoping, SwedenUpdated and expanded Swedish cohort study on trichloroethylene and cancer riskJ.Occup.Med.J.Occup.Med.556-562365NOT IN FILEAAdultadverse effectsarticlecancerCardiovascular DiseasesCohort StudiesConfidence IntervalsdeathepidemiologyexposureFemaleFollow-Up StudieshumanHumansIncidenceMaleMorbiditymortalityNeoplasmsOccupational DiseasesOccupational ExposurePopulationRiskstudySwedenTrichloroethyleneworker1994PM:8027881[ HYPERLINK \l "_ENREF_2" \o "Axelson, 1994 #120" 2].9Random1.261.051.52None obsWith Morgan et al.  ADDIN EN.CITE  ADDIN EN.CITE.DATA [ HYPERLINK \l "_ENREF_6" \o "Morgan, 1998 #157" 6] published SMR.Highest exposure groups6Random1.320.931.86None obs8Random1.280.931.77None obsPrimary analysis. Using RR=1 for Hansen et al.  ADDIN EN.CITE Hansen2001142[13]14214217Hansen, J.Raaschou-Nielsen, O.Christensen, J. M.Johansen, I.McLaughlin, J. K.Lipworth, L.Blot, W. J.Olsen, J. H.Danish Cancer Society, Institute of Cancer Epidemiology, Strandboulevarden 49, DK-2100 Copenhagen O, Denmark. johnni@cancer.dkCancer incidence among Danish workers exposed to trichloroethyleneJ.Occup.Environ.Med.J.Occup.Environ.Med.133-139432NOT IN FILEadverse effectsarticlecancerchemically inducedDenmarkepidemiologyEsophageal NeoplasmsFemalehumanHumansIncidenceLymphomaLymphoma,Non-HodgkinMaleNeoplasmsOccupational ExposureResearchResearch SupportRiskTrichloroethyleneurineUterine Cervical Neoplasmsworker2001PM:11227631[ HYPERLINK \l "_ENREF_13" \o "Hansen, 2001 #142" 13] and Zhao et al.  ADDIN EN.CITE  ADDIN EN.CITE.DATA [ HYPERLINK \l "_ENREF_16" \o "Zhao, 2005 #184" 16].7"8Random1.24"1.260.88"0.91 1.73"1.82None obsUsing alternate selectionsa for Morgan et al.  ADDIN EN.CITE  ADDIN EN.CITE.DATA [ HYPERLINK \l "_ENREF_6" \o "Morgan, 1998 #157" 6] and Raaschou-Nielsen et al.  ADDIN EN.CITE  ADDIN EN.CITE.DATA [ HYPERLINK \l "_ENREF_15" \o "Raaschou-Nielsen, 2003 #168" 15] and excluding Axelson et al.  ADDIN EN.CITE Axelson1994120[2]12012017Axelson, O.Selden, A.Andersson, K.Hogstedt, C.Department of Occupational and Environmental Medicine, University Hospital, Linkoping, SwedenUpdated and expanded Swedish cohort study on trichloroethylene and cancer riskJ.Occup.Med.J.Occup.Med.556-562365NOT IN FILEAAdultadverse effectsarticlecancerCardiovascular DiseasesCohort StudiesConfidence IntervalsdeathepidemiologyexposureFemaleFollow-Up StudieshumanHumansIncidenceMaleMorbiditymortalityNeoplasmsOccupational DiseasesOccupational ExposurePopulationRiskstudySwedenTrichloroethyleneworker1994PM:8027881[ HYPERLINK \l "_ENREF_2" \o "Axelson, 1994 #120" 2].HYPERLINK \l "_ENREF_70" \o "Axelson, 1994 #6981"a Changing the primary analysis by one alternate RR each time. LCL = lower confidence limit; obs = observable; RR = relative risk estimate; RRm = summary relative risk estimate; SMR = standardized mortality ratio; UCL = upper confidence limit. Supplemental Table 5. Summary of some meta-analysis results for TCE (overall) and NHL. Analysis# of studiesModel RRm95% LCL95% UCLHeterogeneityCommentsAll studies17Random1.231.071.42Not significant (p = 0.16) I2 = 26% Statistical significance of RRm not dependent on individual studies.Fixed1.211.081.35Cohort9Random1.331.131.58Not significant (p = 0.34) I2 = 12% Not significant difference between CC and cohort studies (p = 0.19).Fixed1.311.141.51Not significant difference between CC and cohort studies (p = 0.08).Case-control8Random1.110.891.38Not significant (p = 0.22) I2 = 27%Fixed1.070.901.28Alternate RR selections a 17Random1.201.031.39Not significant (p = 0.11) I2 = 31%With estimated Zhao et al.  ADDIN EN.CITE  ADDIN EN.CITE.DATA [ HYPERLINK \l "_ENREF_16" \o "Zhao, 2005 #184" 16] overall RR for incidence rather than mortality.17Random1.221.031.43Not significant (p = 0.09) I2 = 34%With Boice et al.  ADDIN EN.CITE  ADDIN EN.CITE.DATA [ HYPERLINK \l "_ENREF_8" \o "Boice, 2006 #128" 8] rather than Zhao et al.  ADDIN EN.CITE  ADDIN EN.CITE.DATA [ HYPERLINK \l "_ENREF_16" \o "Zhao, 2005 #184" 16].17Random1.231.071.42Not significant (p = 0.16) I2 = 25%With estimated female contribution to Axelson et al.  ADDIN EN.CITE Axelson1994120[2]12012017Axelson, O.Selden, A.Andersson, K.Hogstedt, C.Department of Occupational and Environmental Medicine, University Hospital, Linkoping, SwedenUpdated and expanded Swedish cohort study on trichloroethylene and cancer riskJ.Occup.Med.J.Occup.Med.556-562365NOT IN FILEAAdultadverse effectsarticlecancerCardiovascular DiseasesCohort StudiesConfidence IntervalsdeathepidemiologyexposureFemaleFollow-Up StudieshumanHumansIncidenceMaleMorbiditymortalityNeoplasmsOccupational DiseasesOccupational ExposurePopulationRiskstudySwedenTrichloroethyleneworker1994PM:8027881[ HYPERLINK \l "_ENREF_2" \o "Axelson, 1994 #120" 2].17Random1.241.071.44Not significant (p = 0.16) I2 = 26%With Boice et al.  ADDIN EN.CITE  ADDIN EN.CITE.DATA [ HYPERLINK \l "_ENREF_9" \o "Boice, 1999 #126" 9] potential routine exposure SMR. Supplemental Table 5. Summary of some meta-analysis results for TCE (overall) and NHL. Analysis# of studiesModel RRm95% LCL95% UCLHeterogeneityComments17Random1.251.081.44Not significant (p = 0.17) I2 = 25%With Morgan et al.  ADDIN EN.CITE Morgan1997499[71]49949926Morgan, R. W.Kelsh, M. A.Zhao, K.Heringer, S.Final Report "Cohort Mortality Study of Aerospace Workers with Exposure to Trichloroethylene." Letter from Paul A. Cammer, Ph. D., Trichloroethylene Issues Group, to Cheryl Siegel Scott, U. S. Environmental Protection Agency. Available from U. S. EPA, Health and Environmental Reserach Online (HERO), HERO ID 645806.1997December 22, 1997.Menlo Park, CAEnvironmental Health Strategies, Inc.http://hero.epa.gov/index.cfm?action=search.view&reference_id=645806[71] unpublished RR.17Random1.281.091.49Not significant (p = 0.09) I2 = 34%With Raaschou-Nielsen et al.  ADDIN EN.CITE  ADDIN EN.CITE.DATA [15] subgroup expected to have higher exposures. Alternate analysis; traditional definition of NHL only13Random1.271.051.55Not significant (p = 0.054) I2 = 42%Omitting Miligi et al.  ADDIN EN.CITE  ADDIN EN.CITE.DATA [17], Nordstrom et al.  ADDIN EN.CITE  ADDIN EN.CITE.DATA [7], Persson and Frederikson  ADDIN EN.CITE  ADDIN EN.CITE.DATA [11], and Greenland et al.  ADDIN EN.CITE  ADDIN EN.CITE.DATA [4], and including Boice et al.  ADDIN EN.CITE  ADDIN EN.CITE.DATA [8] instead of Zhao et al.  ADDIN EN.CITE  ADDIN EN.CITE.DATA [16].Highest exposure groups13Random1.431.131.82Not significant (p = 0.30) I2 = 14%Statistical significance not dependent on single study. Fixed1.431.161.75Random1.40"1.491.05"1.151.75"1.93See Supplemental Table 6. Using alternative RR selection results a a Changing the primary analysis by one alternate RR each time; more details on alternate RR estimates in text. CC = case-control; LCL = lower confidence limit; NHL = non-Hodgkin lymphoma; RR = relative risk estimate; RRm = summary relative risk estimate; SMR = standardized mortality ratio; UCL = upper confidence limit. Supplemental Table 6. Summary of some meta-analysis results for TCE (highest exposure groups) and NHL. Analysis # of studiesModelCombined RR estimate95% LCL95% UCLHeterogeneityCommentsAll studies 13Random1.431.131.82Not significant (p = 0.30) I2 = 14%Statistical significance not dependent on single study.13Fixed1.431.161.75Cohort Studies 8Random1.601.242.08None observable (random = fixed)Not significant difference between CC and cohort studies (p = 0.47).8Fixed1.601.242.08Not significant difference between CC and cohort studies (p = 0.15).Case-Control Studies 5Random1.290.762.20NS (p = 0.08) I2 = 53%5Fixed1.180.841.64Alternate RR selections a13Random1.401.111.75NS (p = 0.33) I2 = 11%With Raaschou-Nielsen et al.  ADDIN EN.CITE  ADDIN EN.CITE.DATA [ HYPERLINK \l "_ENREF_15" \o "Raaschou-Nielsen, 2003 #168" 15]HYPERLINK \l "_ENREF_14" \o "Raaschou-Nielsen, 2003 #168" full cohort instead of subgroup expected to have higher exposures.13Random1.401.091.80NS (p = 0.25) I2 = 19%With Blair et al.  ADDIN EN.CITE  ADDIN EN.CITE.DATA [ HYPERLINK \l "_ENREF_20" \o "Blair, 1998 #125" 20] incidence RR instead of Radican et al.  ADDIN EN.CITE  ADDIN EN.CITE.DATA [ HYPERLINK \l "_ENREF_19" \o "Radican, 2008 #169" 19] mortality HR.13Random1.411.051.88NS (p = 0.12) I2 = 33%With Zhao et al.  ADDIN EN.CITE  ADDIN EN.CITE.DATA [ HYPERLINK \l "_ENREF_16" \o "Zhao, 2005 #184" 16]HYPERLINK \l "_ENREF_15" \o "Zhao, 2005 #184" incidence.13Random1.431.131.80NS (p = 0.32) I2 = 13%With estimated female contribution for Axelson et al.  ADDIN EN.CITE Axelson1994120[2]12012017Axelson, O.Selden, A.Andersson, K.Hogstedt, C.Department of Occupational and Environmental Medicine, University Hospital, Linkoping, SwedenUpdated and expanded Swedish cohort study on trichloroethylene and cancer riskJ.Occup.Med.J.Occup.Med.556-562365NOT IN FILEAAdultadverse effectsarticlecancerCardiovascular DiseasesCohort StudiesConfidence IntervalsdeathepidemiologyexposureFemaleFollow-Up StudieshumanHumansIncidenceMaleMorbiditymortalityNeoplasmsOccupational DiseasesOccupational ExposurePopulationRiskstudySwedenTrichloroethyleneworker1994PM:8027881[ HYPERLINK \l "_ENREF_2" \o "Axelson, 1994 #120" 2].13Random1.431.151.78NS (p = 0.37) I2 = 9%With Purdue et al.  ADDIN EN.CITE Purdue2011208[24]20820817Purdue, M. P.Bakke, B.Stewart, P.De Roos, A. J.Schenk, M.Lynch, C. F.Bernstein, L.Morton, L. M.Cerhan, J. R.Severson, R. K.Cozen, W.Davis, S.Rothman, N.Hartge, P.Colt, J. S.Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA.A case-control study of occupational exposure to trichloroethylene and non-hodgkin lymphomaEnviron Health PerspectEnviron Health Perspect232-811922011/02/042011Nov 21552-9924 (Electronic) 0091-6765 (Linking)21288806http://www.ncbi.nlm.nih.gov/pubmed/21288806304061110.1289/ehp.1002106eng[ HYPERLINK \l "_ENREF_24" \o "Purdue, 2011 #208" 24] highest cumulative exposure tertile.13Random1.441.121.85NS (p = 0.29) I2 = 16%With Miligi et al.  ADDIN EN.CITE  ADDIN EN.CITE.DATA [ HYPERLINK \l "_ENREF_17" \o "Miligi, 2006 #155" 17] with >15 years.  Supplemental Table 6. Summary of some meta-analysis results for TCE (highest exposure groups) and NHL. Analysis # of studiesModelCombined RR estimate95% LCL95% UCLHeterogeneityComments13Random1.441.141.83NS (p = 0.32) I2 = 13%With Morgan et al.  ADDIN EN.CITE  ADDIN EN.CITE.DATA [6] peak.13Random1.451.141.86NS (p = 0.25) I2 = 19%With Hansen et al.  ADDIN EN.CITE Hansen2001142[13]14214217Hansen, J.Raaschou-Nielsen, O.Christensen, J. M.Johansen, I.McLaughlin, J. K.Lipworth, L.Blot, W. J.Olsen, J. H.Danish Cancer Society, Institute of Cancer Epidemiology, Strandboulevarden 49, DK-2100 Copenhagen O, Denmark. johnni@cancer.dkCancer incidence among Danish workers exposed to trichloroethyleneJ.Occup.Environ.Med.J.Occup.Environ.Med.133-139432NOT IN FILEadverse effectsarticlecancerchemically inducedDenmarkepidemiologyEsophageal NeoplasmsFemalehumanHumansIncidenceLymphomaLymphoma,Non-HodgkinMaleNeoplasmsOccupational ExposureResearchResearch SupportRiskTrichloroethyleneurineUterine Cervical Neoplasmsworker2001PM:11227631[13] mean exposure.13Random1.491.141.93NS (p = 0.17) I2 = 27%With Hansen et al.  ADDIN EN.CITE Hansen2001142[13]14214217Hansen, J.Raaschou-Nielsen, O.Christensen, J. M.Johansen, I.McLaughlin, J. K.Lipworth, L.Blot, W. J.Olsen, J. H.Danish Cancer Society, Institute of Cancer Epidemiology, Strandboulevarden 49, DK-2100 Copenhagen O, Denmark. johnni@cancer.dkCancer incidence among Danish workers exposed to trichloroethyleneJ.Occup.Environ.Med.J.Occup.Environ.Med.133-139432NOT IN FILEadverse effectsarticlecancerchemically inducedDenmarkepidemiologyEsophageal NeoplasmsFemalehumanHumansIncidenceLymphomaLymphoma,Non-HodgkinMaleNeoplasmsOccupational ExposureResearchResearch SupportRiskTrichloroethyleneurineUterine Cervical Neoplasmsworker2001PM:11227631[13] duration.a Changing the primary analysis by one alternate RR estimate each time. CC = case-control; HR = hazard ratio; LCL = lower confidence limit; NHL = non-Hodgkin lymphoma; NS = not statistically significant; RR = relative risk estimate; RRm = summary relative risk estimate; UCL = upper confidence limit. Supplemental Figure 1. Funnel plots of SE by log RR estimate for TCE and (a) kidney cancer, (b) liver cancer, and (c) NHL. Funnel plots were created using the software package Comprehensive Meta-Analysis, Version 2 ( 2006, Biostat, Inc.). a. b.  Supplemental Figure 1. Cont. c. References  ADDIN EN.REFLIST 1. Siemiatycki, J. Risk Factors for Cancer in the Workplace; CRC Press: Boca Raton, FL, USA, 1991. 2. Axelson, O.; Selden, A.; Andersson, K.; Hogstedt, C. Updated and expanded Swedish cohort study on trichloroethylene and cancer risk. J. Occup. Med. 1994, 36, 556-562. 3. Hardell, L.; Eriksson, M.; Degerman, A. Exposure to phenoxyacetic acids, chlorophenols, or organic solvents in relation to histopathology, stage, and anatomical localization of non-Hodgkins lymphoma. Cancer Res. 1994, 54, 2386-2389. 4. Greenland, S.; Salvan, A.; Wegman, D.H.; Hallock, M.F.; Smith, T.J. A case-control study of cancer mortality at a transformer-assembly facility. Int. Arch. Occup. Environ. Health 1994, 66, 49-54. 5. Anttila, A.; Pukkala, E.; Sallmen, M.; Hernberg, S.; Hemminki, K. Cancer incidence among Finnish workers exposed to halogenated hydrocarbons. J. Occup. Environ. Med. 1995, 37, 797-806. 6. Morgan, R.W.; Kelsh, M.A.; Zhao, K.; Heringer, S. Mortality of aerospace workers exposed to trichloroethylene. Epidemiology 1998, 9, 424-431. 7. Nordstrom, M.; Hardell, L.; Magnuson, A.; Hagberg, H.; Rask-Andersen, A. Occupational exposures, animal exposure and smoking as risk factors for hairy cell leukaemia evaluated in a case-control study. Br. J. Cancer 1998, 77, 2048-2052. 8. Boice, J.D., Jr.; Marano, D.E.; Cohen, S.S.; Mumma, M.T.; Blot, W.J.; Brill, A.B.; Fryzek, J.P.; Henderson, B.E.; McLaughlin, J.K. Mortality among rocketdyne workers who tested rocket engines, 19481999. J. Occup. Environ. Med. 2006, 48, 1070-1092. 9. Boice, J.D., Jr.; Marano, D.E.; Fryzek, J.P.; Sadler, C.J.; McLaughlin, J.K. Mortality among aircraft manufacturing workers. Occup. Environ. Med. 1999, 56, 581-597. 10. Dosemeci, M.; Cocco, P.; Chow, W.H. Gender differences in risk of renal cell carcinoma and occupational exposures to chlorinated aliphatic hydrocarbons. Am. J. Ind. Med. 1999, 36, 54-59. 11. Persson, B.; Fredrikson, M. Some risk factors for non-Hodgkins lymphoma. Int. J. Occup. Med. Environ. Health 1999, 12, 135-142. 12. Pesch, B.; Haerting, J.; Ranft, U.; Klimpel, A.; Oelschlagel, B.; Schill, W. Occupational risk factors for renal cell carcinoma: Agent-specific results from a case-control study in Germany. MURC study group. Multicenter urothelial and renal cancer study. Int. J. Epidemiol. 2000, 29, 1014-1024. 13. Hansen, J.; Raaschou-Nielsen, O.; Christensen, J.M.; Johansen, I.; McLaughlin, J.K.; Lipworth, L.; Blot, W.J.; Olsen, J.H. Cancer incidence among Danish workers exposed to trichloroethylene. J. Occup. Environ. Med. 2001, 43, 133-139. 14. Bruning, T.; Pesch, B.; Wiesenhutter, B.; Rabstein, S.; Lammert, M.; Baumuller, A.; Bolt, H.M. Renal cell cancer risk and occupational exposure to trichloroethylene: Results of a consecutive case-control study in Arnsberg, Germany. Am. J. Ind. Med. 2003, 43, 274-285. 15. Raaschou-Nielsen, O.; Hansen, J.; McLaughlin, J.K.; Kolstad, H.; Christensen, J.M.; Tarone, R.E.; Olsen, J.H. Cancer risk among workers at Danish companies using trichloroethylene: A cohort study. Am. J. Epidemiol. 2003, 158, 1182-1192. 16. Zhao, Y.; Krishnadasan, A.; Kennedy, N.; Morgenstern, H.; Ritz, B. Estimated effects of solvents and mineral oils on cancer incidence and mortality in a cohort of aerospace workers. Am. J. Ind. Med. 2005, 48, 249-258. 17. Miligi, L.; Costantini, A.S.; Benvenuti, A.; Kriebel, D.; Bolejack, V.; Tumino, R.; Ramazzotti, V.; Rodella, S.; Stagnaro, E.; Crosignani, P.; et al. Occupational exposure to solvents and the risk of lymphomas. Epidemiology 2006, 17, 552-561. 18. Charbotel, B.; Fevotte, J.; Hours, M.; Martin, J.L.; Bergeret, A. Case-control study on renal cell cancer and occupational exposure to trichloroethylene. Part II: Epidemiological aspects. Ann. Occup. Hyg. 2006, 50, 777-787. 19. Radican, L.; Blair, A.; Stewart, P.; Wartenberg, D. Mortality of aircraft maintenance workers exposed to trichloroethylene and other hydrocarbons and chemicals: Extended follow-up. J. Occup. Environ. Med. 2008, 50, 1306-1319. 20. Blair, A.; Hartge, P.; Stewart, P.A.; McAdams, M.; Lubin, J. Mortality and cancer incidence of aircraft maintenance workers exposed to trichloroethylene and other organic solvents and chemicals: Extended follow up. Occup. Environ. Med. 1998, 55, 161-171. 21. Wang, R.; Zhang, Y.; Lan, Q.; Holford, T.R.; Leaderer, B.; Zahm, S.H.; Boyle, P.; Dosemeci, M.; Rothman, N.; Zhu, Y.; et al. Occupational exposure to solvents and risk of non-Hodgkin lymphoma in Connecticut women. Am. J. Epidemiol. 2009, 169, 176-185. 22. Moore, L.E.; Boffetta, P.; Karami, S.; Brennan, P.; Stewart, P.S.; Hung, R.; Zaridze, D.; Matveev, V.; Janout, V.; Kollarova, H.; et al. Occupational trichloroethylene exposure and renal carcinoma risk: Evidence of genetic susceptibility by reductive metabolism gene variants. Cancer Res. 2010, 70, 6527-6536. 23. Cocco, P.; tMannetje, A.; Fadda, D.; Melis, M.; Becker, N.; de Sanjose, S.; Foretova, L.; Mareckova, J.; Staines, A.; Kleefeld, S.; et al. Occupational exposure to solvents and risk of lymphoma subtypes: Results from the Epilymph case-control study. Occup. Environ. Med. 2010, 67, 341-347. 24. Purdue, M.P.; Bakke, B.; Stewart, P.; De Roos, A.J.; Schenk, M.; Lynch, C.F.; Bernstein, L.; Morton, L.M.; Cerhan, J.R.; Severson, R.K.; et al. A case-control study of occupational exposure to trichloroethylene and non-Hodgkin lymphoma. Environ. Health Perspect. 2011, 119, 232-238. 25. Agency for Toxic Substances and Disease Registry (ATSDR). Feasibility Investigation of Worker Exposure to Trichloroethylene at the View-Master Factory in Beaverton, Oregon; ATSDR: Atlanta, GA, USA, 2004. 26. Clapp, R.W.; Hoffman, K. Cancer mortality in IBM Endicott plant workers, 19692001: An update on a NY production plant. Environ. Health 2008, 7, 13:1-13:4. 27. Cohn, P.; Klotz, J.; Bove, F.; Berkowitz, M.; Fagliano, J. Drinking water contamination and the incidence of leukemia and non-Hodgkins lymphoma. Environ. Health Perspect. 1994, 102, 556-561. 28. Wilcosky, T.C.; Checkoway, H.; Marshall, E.G.; Tyroler, H.A. Cancer mortality and solvent exposures in the rubber industry. Am. Ind. Hyg. Assoc. J. 1984, 45, 809-811. 29. Isacson, P.; Bean, J.A.; Splinter, R.; Olson, D.B.; Kohler, J. Drinking water and cancer incidence in Iowa. III. Association of cancer with indices of contamination. Am. J. Epidemiol. 1985, 121, 856-869. 30. Shindell, S.; Ulrich, S. A cohort study of employees of a manufacturing plant using trichlorethylene. J. Occup. Med. 1985, 27, 577-579. 31. Garabrant, D.H.; Held, J.; Langholz, B.; Bernstein, L. Mortality of aircraft manufacturing workers in southern California. Am. J. Ind. Med. 1988, 13, 683-694. 32. Shannon, H.S.; Haines, T.; Bernholz, C.; Julian, J.A.; Verma, D.K.; Jamieson, E.; Walsh, C. Cancer morbidity in lamp manufacturing workers. Am. J. Ind. Med. 1988, 14, 281-290. 33. Blair, A.; Haas, T.; Prosser, R.; Morrissette, M.; Blackman, K.; Grauman, D.; van, D.P.; Moran, F. Mortality among United States Coast Guard marine inspectors. Arch. Environ. Health 1989, 44, 150-156. 34. Costa, G.; Merletti, F.; Segnan, N. A mortality cohort study in a north Italian aircraft factory. Br. J. Ind. Med. 1989, 46, 738-743. 35. Arizona Department of Health Services (ADHS). Update of the Incidence of Childhood Cancers and Testicular Cancer in Southwest Tuscon: 19871991; ADHS: Phoenix, AZ, USA. 1995. 36. Arizona Department of Health Services (ADHS). Incidence Study of Childhood Cancer in Maricopa County: 19651986; ADHS: Phoenix, AZ, USA. 1990. 37. Mallin, K. Investigation of a bladder cancer cluster in northwestern Illinois. Am. J. Epidemiol. 1990, 132, S96-S106. 38. Aickin, M.; Chapin, C.A.; Flood, T.J.; Englender, S.J.; Caldwell, G.G. Assessment of the spatial occurrence of childhood leukaemia mortality using standardized rate ratios with a simple linear poisson model. Int. J. Epidemiol. 1992, 21, 649-655. 39. Sinks, T.; Lushniak, B.; Haussler, B.J.; Sniezek, J.; Deng, J.F.; Roper, P.; Dill, P.; Coates, R. Renal cell cancer among paperboard printing workers. Epidemiology 1992, 3, 483-489. 40. Vartiainen, T.; Pukkala, E.; Rienoja, T.; Strandman, T.; Kaksonen, K. Population exposure to trichloroethene and tetrachloroethene and cancer riskTwo cases of drinking-water pollution. Chemosphere 1993, 27, 1171-1181. 41. Morgan, J.W.; Cassady, R.E. Community cancer assessment in response to long-time exposure to perchlorate and trichloroethylene in drinking water. J. Occup. Environ. Med. 2002, 44, 616-621. 42. Lee, L.J.; Chung, C.W.; Ma, Y.C.; Wang, G.S.; Chen, P.C.; Hwang, Y.H.; Wang, J.D. Increased mortality odds ratio of male liver cancer in a community contaminated by chlorinated hydrocarbons in groundwater. Occup. Environ. Med. 2003, 60, 364-369. 43. Aickin, M. Bayes without priors. J. Clin. Epidemiol. 2004, 57, 4-13. 44. Chang, Y.M.; Tai, C.F.; Yang, S.C.; Chen, C.J.; Shih, T.S.; Lin, R.S.; Liou, S.H. A cohort mortality study of workers exposed to chlorinated organic solvents in Taiwan. Ann. Epidemiol. 2003, 13, 652-660. 45. Chang, Y.M.; Tai, C.F.; Yang, S.C.; Lin, R.S.; Sung, F.C.; Shih, T.S.; Liou, S.H. Cancer incidence among workers potentially exposed to chlorinated solvents in an electronics factory. J. Occup. Health 2005, 47, 171-180. 46. Coyle, Y.M.; Hynan, L.S.; Euhus, D.M.; Minhajuddin, A.T. An ecological study of the association of environmental chemicals on breast cancer incidence in Texas. Breast Cancer Res. Treat. 2005, 92, 107-114. 47. Agency for Toxic Substances and Disease Registry (ATSDR). Health Consultation, Endicott Area Investigation, Cancer and Birth Outcome Analysis, Endicott area, Town of Union, Broome County, New York; ATSDR: Atlanta, GA, USA. 2006. 48. Agency for Toxic Substances and Disease Registry (ATSDR). Health Consultation, Health Statistics Review Follow-Up, Cancer and Birth Outcome Analysis, Endicott Area Investigation, Endicott Area, Town of Union, Broome County, New York; ATSDR: Atlanta, GA, USA. 2008. 49. Sung, T.I.; Chen, P.C.; Jyuhn-Hsiarn Lee, L.; Lin, Y.P.; Hsieh, G.Y.; Wang, J.D. Increased standardized incidence ratio of breast cancer in female electronics workers. BMC Public Health 2007, 7, 102:1-102:9. 50. Sung, T.I.; Wang, J.D.; Chen, P.C. Increased risk of cancer in the offspring of female electronics workers. Reprod. Toxicol. 2008, 25, 115-119. 51. Lowengart, R.A.; Peters, J.M.; Cicioni, C.; Buckley, J.; Bernstein, L.; Preston-Martin, S.; Rappaport, E. Childhood leukemia and parents occupational and home exposures. J. Natl. Cancer Inst. 1987, 79, 39-46. 52. Fredriksson, M.; Bengtsson, N.O.; Hardell, L.; Axelson, O. Colon cancer, physical activity, and occupational exposures. A case-control study. Cancer 1989, 63, 1838-1842. 53. McKinney, P.A.; Alexander, F.E.; Cartwright, R.A.; Parker, L. Parental occupations of children with leukaemia in West Cumbria, North Humberside, and Gateshead. BMJ 1991, 302, 681-687. 54. Heineman, E.F.; Cocco, P.; Gomez, M.R.; Dosemeci, M.; Stewart, P.A.; Hayes, R.B.; Zahm, S.H.; Thomas, T.L.; Blair, A. Occupational exposure to chlorinated aliphatic hydrocarbons and risk of astrocytic brain cancer. Am. J. Ind. Med. 1994, 26, 155-169. 55. Siemiatycki, J.; Dewar, R.; Nadon, L.; Gerin, M. Occupational risk factors for bladder cancer: Results from a case-control study in Montreal, Quebec, Canada. Am. J. Epidemiol. 1994, 140, 1061-1080. 56. Aronson, K.J.; Siemiatycki, J.; Dewar, R.; Gerin, M. Occupational risk factors for prostate cancer: Results from a case-control study in Montreal, Quebec, Canada. Am. J. Epidemiol. 1996, 143, 363-373. 57. Fritschi, L.; Siemiatycki, J. Melanoma and occupation: Results of a case-control study. Occup. Environ. Med. 1996, 53, 168-173. 58. Dumas, S.; Parent, M.E.; Siemiatycki, J.; Brisson, J. Rectal cancer and occupational risk factors: A hypothesis-generating, exposure-based case-control study. Int. J. Cancer 2000, 87, 874-879. 59. Kernan, G.J.; Ji, B.T.; Dosemeci, M.; Silverman, D.T.; Balbus, J.; Zahm, S.H. Occupational risk factors for pancreatic cancer: A case-control study based on death certificates from 24 U.S. states. Am. J. Ind. Med. 1999, 36, 260-270. 60. Shu, X.O.; Perentesis, J.P.; Wen, W.; Buckley, J.D.; Boyle, E.; Ross, J.A.; Robison, L.L. Parental exposure to medications and hydrocarbons and ras mutations in children with acute lymphoblastic leukemia: A report from the Childrens Oncology Group. Cancer Epidemiol. Biomarkers Prev. 2004, 13, 1230-1235. 61. Shu, X.O.; Potter, J.D.; Linet, M.S.; Severson, R.K.; Han, D.; Kersey, J.H.; Neglia, J.P.; Trigg, M.E.; Robison, L.L. Diagnostic X-rays and ultrasound exposure and risk of childhood acute lymphoblastic leukemia by immunophenotype. Cancer Epidemiol. Biomarkers Prev. 2002, 11, 177-185. 62. Parent, M.E.; Siemiatycki, J.; Fritschi, L. Workplace exposures and oesophageal cancer. Occup. Environ. Med. 2000, 57, 325-334. 63. Pesch, B.; Haerting, J.; Ranft, U.; Klimpel, A.; Oelschlagel, B.; Schill, W. Occupational risk factors for urothelial carcinoma: Agent-specific results from a case-control study in Germany. MURC study group. Multicenter urothelial and renal cancer. Int. J. Epidemiol. 2000, 29, 238-247. 64. De Roos, A.J.; Teschke, K.; Savitz, D.A.; Poole, C.; Grufferman, S.; Pollock, B.H.; Olshan, A.F. Parental occupational exposures to electromagnetic fields and radiation and the incidence of neuroblastoma in offspring. Epidemiology 2001, 12, 508-517. 65. Goldberg, M.S.; Parent, M.E.; Siemiatycki, J.; Desy, M.; Nadon, L.; Richardson, L.; Lakhani, R.; Latreille, B.; Valois, M.F. A case-control study of the relationship between the risk of colon cancer in men and exposures to occupational agents. Am. J. Ind. Med. 2001, 39, 531-546. 66. Costas, K.; Knorr, R.S.; Condon, S.K. A case-control study of childhood leukemia in Woburn, Massachusetts: The relationship between leukemia incidence and exposure to public drinking water. Sci. Total Environ. 2002, 300, 23-35. 67. Krishnadasan, A.; Kennedy, N.; Zhao, Y.; Morgenstern, H.; Ritz, B. Nested case-control study of occupational chemical exposures and prostate cancer in aerospace and radiation workers. Am. J. Ind. Med. 2007, 50, 383-390. 68. Ritz, B. Cancer mortality among workers exposed to chemicals during uranium processing. J. Occup. Environ. Med. 1999, 41, 556-566. 69. Henschler, D.; Vamvakas, S.; Lammert, M.; Dekant, W.; Kraus, B.; Thomas, B.; Ulm, K. Increased incidence of renal cell tumors in a cohort of cardboard workers exposed to trichloroethene. Arch. Toxicol. 1995, 69, 291-299. 70. Vamvakas, S.; Bruning, T.; Thomasson, B.; Lammert, M.; Baumuller74 t e f r  @ ҽү}qfq}qfbqbZbq}UNDhF%h)|5CJ hF%h)| hF%5h,=mmH sH h,=mhch,=mnHtHh,=mB*nHphtHhpDh,=mB*nHphtH#hwOBh,=m5B*H*nHphtH hpDh,=m5B*nHphtHh,=m5B*nHphtH(hpDh,=m5B*CJ$aJ$nHphtH"h,=m5B*CJ$aJ$nHphtHh,=m6B*nHphtHh26B*nHphtH r s  & . @ d$Ifgdw$dTxa$gd82V$hdT^h`a$gd,=mgd,=m hdT^hgd,=mhdT^h`gd,=m dTgd,=mdTgd,=m dTgd,=m @ A h i j ..;Ikd$$IfT:4&' t'44 :af4ytwT d$Ifgdwokd$$IfT:4FmP& x t'    44 :af4ytwT@ j u v w QRSTUVWXY̯̿re\eN̯̿hjh)|6CJmHsHhF%h lCJjhF%h lCJU.jhF%hSO<CJUmHnHsHuhF%hSO<CJmHnHsHu(jhF%hSO<CJUmHnHsHuhF%hC|CJmHnHsHuhF%hC|CJmHsH!jhF%h lCJUmHsHhF%h CCJmHsHhF%h)|CJmHsHhF%h)|CJ )./01@AUVWXYZ[ӳzmmYE'j hF%h lCJUmHsH'jhF%h lCJUmHsHhF%hC|CJmHsHhjh)|6CJmHsHhF%h)|CJmHsHhF%h CCJmHsH!jhF%h lCJUmHsHhF%hC|CJmHnHsHuhF%hSO<CJmHnHsHu(jhF%hSO<CJUmHnHsHu.jhF%hSO<CJUmHnHsHuӳzmmYE'jhF%h lCJUmHsH'jhF%h lCJUmHsHhF%hC|CJmHsHhjh)|6CJmHsHhF%h)|CJmHsHhF%h CCJmHsH!jhF%h lCJUmHsHhF%hC|CJmHnHsHuhF%hSO<CJmHnHsHu(jhF%hSO<CJUmHnHsHu.j&hF%hSO<CJUmHnHsHu     ,-ABCӳ{m{`SS?'j)hF%h lCJUmHsHhF%hC|CJmHsHhF%hZVCJmHsHhjh&6CJmHsHhF%h&CJmHsHhF%h)|CJmHsHhF%h CCJmHsH!jhF%h lCJUmHsHhF%hC|CJmHnHsHuhF%hSO<CJmHnHsHu(jhF%hSO<CJUmHnHsHu.j!)hF%hSO<CJUmHnHsHuCDEFGyz{|}~ʵڀsfXNAAhF%hC|CJmHsHhjCJmHsHhjh)|6CJmHsHhF%h)|CJmHsHhF%h&CJmHsHhF%hZVCJmHsH.j@:hF%hSO<CJUmHnHsHuhF%hSO<CJmHnHsHu(jhF%hSO<CJUmHnHsHuhF%hC|CJmHnHsHu!jhF%h lCJUmHsH'j1hF%h lCJUmHsH)ڶyl_Q_lDDhF%hC|CJmHsHhjh)|6CJmHsHhF%h)|CJmHsHhF%hZVCJmHsH.jMhF%hSO<CJUmHnHsHuhF%hSO<CJmHnHsHu(jhF%hSO<CJUmHnHsHuhF%hC|CJmHnHsHu'jDhF%h lCJUmHsH!jhF%h lCJUmHsH'j:hF%h lCJUmHsH)*+,-./cdefghijqvwxyڶyl_Q_lDDhF%hC|CJmHsHhjh)|6CJmHsHhF%h)|CJmHsHhF%hZVCJmHsH.jRahF%hSO<CJUmHnHsHuhF%hSO<CJmHnHsHu(jhF%hSO<CJUmHnHsHuhF%hC|CJmHnHsHu'jWhF%h lCJUmHsH!jhF%h lCJUmHsH'jMhF%h lCJUmHsH     ڶyaTGhF%h)|CJmHsHhF%hZVCJmHsH.j؅hF%hSO<CJUmHnHsHu.jehF%hSO<CJUmHnHsHuhF%hSO<CJmHnHsHu(jhF%hSO<CJUmHnHsHuhF%hC|CJmHnHsHu'jshF%h lCJUmHsH!jhF%h lCJUmHsH'jahF%h lCJUmHsH !"12FGHIJKLƹƹƑƁl\Dl\lƹƹ.jhF%hSO<CJUmHnHsHuhF%hSO<CJmHnHsHu(jhF%hSO<CJUmHnHsHuhF%hC|CJmHnHsHu'jhF%h lCJUmHsH'jKhF%h lCJUmHsHhF%hC|CJmHsH!jhF%h lCJUmHsHhF%hZVCJmHsHhF%h)|CJmHsHhjh)|6CJmHsH $%9ڶyl_Q_lDDhF%hC|CJmHsHhjh)|6CJmHsHhF%h)|CJmHsHhF%hZVCJmHsH.jhF%hSO<CJUmHnHsHuhF%hSO<CJmHnHsHu(jhF%hSO<CJUmHnHsHuhF%hC|CJmHnHsHu'jܡhF%h lCJUmHsH!jhF%h lCJUmHsH'j0hF%h lCJUmHsH9:;<=>?pqrtuvwx####7#ڶyl_Q_lDڶhF%hC|CJmHsHhjh)|6CJmHsHhF%h)|CJmHsHhF%hZVCJmHsH.j!hF%hSO<CJUmHnHsHuhF%hSO<CJmHnHsHu(jhF%hSO<CJUmHnHsHuhF%hC|CJmHnHsHu'jhF%h lCJUmHsH!jhF%h lCJUmHsH'jhF%h lCJUmHsH7#8#9#;#<#=#>#?#H#M#N#O#P#_#`#t#u#v#w#x#y#z##ӳzmmYE'jhF%h lCJUmHsH'j hF%h lCJUmHsHhF%hC|CJmHsHhjh)|6CJmHsHhF%h)|CJmHsHhF%hZVCJmHsH!jhF%h lCJUmHsHhF%hC|CJmHnHsHuhF%hSO<CJmHnHsHu(jhF%hSO<CJUmHnHsHu.jhF%hSO<CJUmHnHsHu######################ӳzm``L8'jhF%h lCJUmHsH'jhF%h lCJUmHsHhF%hC|CJmHsHhF%h}CJmHsHhjh>"6CJmHsHhF%h>"CJmHsHhF%hZVCJmHsH!jhF%h lCJUmHsHhF%hC|CJmHnHsHuhF%hSO<CJmHnHsHu(jhF%hSO<CJUmHnHsHu.jhF%hSO<CJUmHnHsHu#5$6$7$9$:$;$<$=$>$?$D$I$J$K$L$[$\$p$q$r$s$t$²}obbN:'j[hF%h lCJUmHsH'j hF%h lCJUmHsHhF%hC|CJmHsHhjh)|6CJmHsHhjCJmHsHhF%h)|CJmHsHhF%hZVCJmHsH!jhF%h lCJUmHsHhF%hC|CJmHnHsHu(jhF%hSO<CJUmHnHsHu.jhF%hSO<CJUmHnHsHuhF%hSO<CJmHnHsHut$u$v$$$$$$$$$$$$$$$$$$$$ʲyl__K7'j hF%h lCJUmHsH'jhF%h lCJUmHsHhF%hC|CJmHsHhF%h}$CJmHsHhjh)|6CJmHsHhF%h)|CJmHsHhF%hZVCJmHsH!jhF%h lCJUmHsH.jhF%hSO<CJUmHnHsHuhF%hSO<CJmHnHsHu(jhF%hSO<CJUmHnHsHuhF%hC|CJmHnHsHu$$$$%%%%% %!%"%-%2%3%4%5%D%E%Y%Z%[%ɹɹyl__K'jhF%h lCJUmHsHhF%hC|CJmHsHhF%h}$CJmHsHhjh)|6CJmHsHhF%h)|CJmHsHhF%hZVCJmHsH.jFhF%hSO<CJUmHnHsHuhF%hSO<CJmHnHsHu(jhF%hSO<CJUmHnHsHuhF%hC|CJmHnHsHu!jhF%h lCJUmHsH[%\%]%^%_%%%%%%%%%%%%%%%%%%ʵڀsi[sNAAhF%hC|CJmHsHhF%h!NCJmHsHhjh)|6CJmHsHhjCJmHsHhF%h)|CJmHsHhF%hZVCJmHsH.j+,hF%hSO<CJUmHnHsHuhF%hSO<CJmHnHsHu(jhF%hSO<CJUmHnHsHuhF%hC|CJmHnHsHu!jhF%h lCJUmHsH'j"hF%h lCJUmHsH%%%%%%% & & &&&&&&&&& &!&"&ڶyl_lQD7hF%h!NCJmHsHhF%h|tDCJmHsHhjhaD6CJmHsHhF%h,CJmHsHhF%haDCJmHsH.j>hF%hSO<CJUmHnHsHuhF%hSO<CJmHnHsHu(jhF%hSO<CJUmHnHsHuhF%hC|CJmHnHsHu'j5hF%h lCJUmHsH!jhF%h lCJUmHsH'j,hF%h lCJUmHsH"&1&2&F&G&H&I&J&K&L&}&~&&&&&&&&&&&&⪕m`SF`9`hF%hZVCJmHsHhF%h!NCJmHsHhF%h,CJmHsHhF%h)|CJmHsH.j}QhF%hSO<CJUmHnHsHuhF%hSO<CJmHnHsHu(jhF%hSO<CJUmHnHsHuhF%hC|CJmHnHsHu'jQHhF%h lCJUmHsH'j%?hF%h lCJUmHsH!jhF%h lCJUmHsHhF%hC|CJmHsH&&&&&&&&&&&&&&&&&&&&&'ƹƹƑƁl\Dl\l7hF%h!NCJmHsH.j ghF%hSO<CJUmHnHsHuhF%hSO<CJmHnHsHu(jhF%hSO<CJUmHnHsHuhF%hC|CJmHnHsHu'j~\hF%h lCJUmHsH'jQhF%h lCJUmHsHhF%hC|CJmHsH!jhF%h lCJUmHsHhF%hZVCJmHsHhF%h)|CJmHsHhjh)|6CJmHsH'' ' '''''3'4'5'6'7'8'9'j'k'l'n'o'p'q'ǺǺǒǂm]Em]m.jG{hF%hSO<CJUmHnHsHuhF%hSO<CJmHnHsHu(jhF%hSO<CJUmHnHsHuhF%hC|CJmHnHsHu'jcqhF%h lCJUmHsH'jghF%h lCJUmHsHhF%hC|CJmHsH!jhF%h lCJUmHsHhF%hZVCJmHsHhjhu 16CJmHsHhF%hu 1CJmHsHq'r'y'~'''''''''''''''''''˺u`P8`P`u.j`hF%hSO<CJUmHnHsHuhF%hSO<CJmHnHsHu(jhF%hSO<CJUmHnHsHuhF%hC|CJmHnHsHu'jhF%h lCJUmHsH'j{hF%h lCJUmHsHhF%hC|CJmHsH!jhF%h lCJUmHsHhF%hZVCJmHsHhjhu 16CJmHsHhF%hu 1CJmHsHhF%h!NCJmHsH''''''''m.n.o.p.........////?0Թw_wRICICI hCJhF%h)|CJhF%h)|CJmHsH.jՏhF%hSO<CJUmHnHsHuhF%hSO<CJmHnHsHu(jhF%hSO<CJUmHnHsHuhF%hC|CJmHnHsHuhF%hC|CJmHsHhF%hZVCJmHsHhjhA6CJmHsHhF%hACJmHsHhF%h!NCJmHsH!jhF%h lCJUmHsH./ 0000001wkkk d$Ifgd8E $dTxa$gdwokdJ$$IfT:4FmP& x t'    44 :af4ytwT d$Ifgdw?0@0U0[00000001D1E1p4q4r4s4444444444;;;;(<)<*<,<-<.</<6<}g*jyhF%hwCJUmHnHu*jhF%hwCJUmHnHu$jhF%hwCJUmHnHuhF%hwCJmHnHujhF%hwCJUhF%hwCJhF%hw5CJhwhw6hwhw5hwhF%hCJhF%h)|CJ h]CJ%11<1=1>1A:B;Ikd$$IfT:4&' t'44 :af4yt8ET d$Ifgd8Eokd$$IfT:4FmP& x t'    44 :af4yt8ET6<;<=<><AAAAAAAAAAAAA=BFBKBMBNBHHHHIѾѨѾ쑃rrbMb(jhF%hwCJUmHnHsHuhF%hwCJmHnHsHu!jhF%hwCJUmHsHh0lhw6CJmHsHhF%hwCJmHsHh2hw6CJ*jhF%hwCJUmHnHu$jhF%hwCJUmHnHuhF%hwCJmHnHujhF%hwCJUhF%hwCJh 0hw6CJ:B;B=Bg d$Ifgd8Eokdc$$IfT:4FmP& x t'    44 :af4yt8ETIII I I I IIIIIII.I/ICIDIEIFIGIHIII|I}I~IIIIIIòxdLò.jإhF%hwCJUmHnHsHu'j"hF%hwCJUmHsH'jlhF%hwCJUmHsHh82V6CJmHsHh0lhw6CJmHsHhF%hwCJmHsH!jhF%hwCJUmHsHhF%hwCJmHnHsHu(jhF%hwCJUmHnHsHu.jhF%hwCJUmHnHsHuIIOOOOHOIOJOLOMONOOO[O`ObOcOrOsOOOOOOOOOOOOOOOOѼѤѼnѼVѼ.jhF%hwCJUmHnHsHu'j8hF%hwCJUmHsH'j¦hF%hwCJUmHsHh0lhw6CJmHsH.jMhF%hwCJUmHnHsHu(jhF%hwCJUmHnHsHuhF%hwCJmHnHsHuhF%hwCJmHsH!jhF%hwCJUmHsH!OOOOOO7V8V9V:VmVnVoVqVrVsVtV|VVVVVVVVVVVVVVȸwcȸ'j$hF%hwCJUmHsH'jhF%hwCJUmHsH.j#hF%hwCJUmHnHsHu(jhF%hwCJUmHnHsHuhF%hwCJmHnHsHu!jhF%hwCJUmHsHhF%hwCJmHsHh82V6CJmHsHh0lhw6CJmHsHVVVVVVVVVVVY]Z][]\]]]]]]]]]]bbbbbbbbbbc0còòg.jhF%hwCJUmHnHsHu.j%hF%hwCJUmHnHsHuh0lhw6CJmHsHhF%hwCJmHsH!jhF%hwCJUmHsHhF%hwCJmHnHsHu(jhF%hwCJUmHnHsHu.jhF%hwCJUmHnHsHu#0c1c2c4c5c6c7c@cAc,j-j.j/jajbjcjejfjgjhjqjvjxjyjYqZq[q\qqqqqqqqqqqqyyòÍògò.jhF%hwCJUmHnHsHuh0lhw6CJmHsH.jhF%hwCJUmHnHsHuhF%hwCJmHsH!jhF%hwCJUmHsHhF%hwCJmHnHsHu(jhF%hwCJUmHnHsHu.jhF%hwCJUmHnHsHu(yyyyyyyyyyyyyyyyzzzzzzz=z>z?zAzBzCzDzYzZz}~ﱤnVﱤ.jhF%hwCJUmHnHsHu'jhF%hwCJUmHsH'jhF%hwCJUmHsHh0lhw6CJmHsHhF%hwCJmHsH!jhF%hwCJUmHsH.jnhF%hwCJUmHnHsHu(jhF%hwCJUmHnHsHuhF%hwCJmHnHsHu!~āƁǁZ[\]ﱤ~ﱤt\.jhF%hwCJUmHnHsHuh82VCJmHsH.jhF%hwCJUmHnHsHuh0lhw6CJmHsHhF%hwCJmHsH!jhF%hwCJUmHsH.jhF%hwCJUmHnHsHu(jhF%hwCJUmHnHsHuhF%hwCJmHnHsHu$ʐː̐͐ΐϐА9:;=>?@HMOPʽʽʽʇoWʽ.jlhF%hwCJUmHnHsHu.jhF%hwCJUmHnHsHu'j3hF%hwCJUmHsH'johF%hwCJUmHsHh0lhw6CJmHsHhF%hwCJmHsH!jhF%hwCJUmHsHhF%hwCJmHnHsHu(jhF%hwCJUmHnHsHu"P_`tuvwxyzLMNO⪕}⪕e.jRhF%hwCJUmHnHsHu.jhF%hwCJUmHnHsHu(jhF%hwCJUmHnHsHuhF%hwCJmHnHsHu'j_hF%hwCJUmHsH'jhF%hwCJUmHsH!jhF%hwCJUmHsHhF%hwCJmHsHƙ˙͙Ιݙޙ()*,-./_òoW.j8<hF%hwCJUmHnHsHu'j*hF%hwCJUmHsH'j<hF%hwCJUmHsHh0lhw6CJmHsHhF%hwCJmHsH!jhF%hwCJUmHsHhF%hwCJmHnHsHu(jhF%hwCJUmHnHsHu.jhF%hwCJUmHnHsHu_`acdefg áġšǡȡɡòsseRehF%hwCJUmHnHuhMhw6CJ*j+>hF%hwCJUmHnHu$jhF%hwCJUmHnHuhF%hwCJmHnHuh0lhw6CJ h0lCJhF%hwCJjhF%hwCJU*  !#%&bcdeABCDxɿߢɿߌɆ h<CJ*j?hF%hwCJUmHnHu*j?hF%hwCJUmHnHu h82V6CJhMhw6CJhF%hwCJjhF%hwCJUhF%hwCJmHnHu$jhF%hwCJUmHnHu-xyz|}~FɼɌɼ|ljJhF%hwCJUj^AhF%hwCJU*j@hF%hwCJUmHnHu h82V6CJhMhw6CJhF%hwCJjhF%hwCJUhF%hwCJmHnHu$jhF%hwCJUmHnHu*jt@hF%hwCJUmHnHu%FGHJKLMOPTY[\klɼmW*jxhF%hwCJUmHnHu*j;xhF%hwCJUmHnHujqfhF%hwCJUjThF%hwCJUhMhw6CJ h82VCJhF%hwCJjhF%hwCJUhF%hwCJmHnHu$jhF%hwCJUmHnHu*j2ThF%hwCJUmHnHu"+,-/012<ACDѾѨѾѾrѾѾ*jΊhF%hwCJUmHnHuj4hF%hwCJUjyhF%hwCJU*j%yhF%hwCJUmHnHu$jhF%hwCJUmHnHuhF%hwCJmHnHuhMhw6CJhF%hwCJjhF%hwCJU,$)+,;<PQRSTUV񻲨񻲨rjhF%hwCJUj-hF%hwCJU*jhF%hwCJUmHnHuhMhw6CJhF%hwCJjhF%hwCJU$jhF%hwCJUmHnHu*jChF%hwCJUmHnHuhF%hwCJmHnHu$ noɼmɼ*jrhF%hwCJUmHnHujhF%hwCJUjhF%hwCJUhMhw6CJ hMCJhF%hwCJjhF%hwCJUhF%hwCJmHnHu$jhF%hwCJUmHnHu*jEhF%hwCJUmHnHu#ghiW d$Ifgd8Eokd$$IfT:4FmP& x t'    44 :af4yt8ETJKLNOPQ. / 0 ɼɍɼwɼsl h)|h)|hw*jhF%hwCJUmHnHu*jhF%hwCJUmHnHuhMhw6CJ h<CJhF%hwCJjhF%hwCJUhF%hwCJmHnHu$jhF%hwCJUmHnHu*j{hF%hwCJUmHnHu)R d$Ifgd8Eokd$$IfT:4FmP& x t'    44 :af4yt8ET-  d$Ifgd8Eokd$$IfT:4FmP& x t'    44 :af4ytrE<T- . / 0          |pppppppp d$Ifgdo $dTxa$gdF%gd)|okd$$IfT:4FmP& x t'    44 :af4ytrE<T 0 F       P Q o p       J K U V              h j r t ~   ƼƼƼƼƼƼƼyohoh )CJ\h$hG6CJ\hohGCJ\ h]CJ\hohmCJH*\ h82VCJ\hohm6CJ\ h<CJ\hohmCJ\hohmCJhoh65CJ\hohm5CJ\hmhm5\hF%h)|\ hF%5\)     2&&& d$Ifgdokd$$IfTs4ִp B6$3'-8FL t    44 saytoT      o  d$Ifgdoo p q r x 4((( d$Ifgdokd$$IfTsִp B6$3'-8FL t    44 saytoTx }      d$Ifgdo     4((( d$Ifgdokd$$IfTsִp B6$3'-8FL t    44 saytoT       d$Ifgdo     4((( d$Ifgdokd$$IfTsִp B6$3'-8FL t    44 saytoT     U  d$IfgdoU V c e l 4((( d$Ifgdokd$$IfTsִp B6$3'-8FL t    44 saytoTl q v {     d$Ifgdo     4((( d$Ifgdokd$$IfTsִp B6$3'-8FL t    44 saytoT       d$Ifgdo     4((( d$Ifgdokd$$IfTsִp B6$3'-8FL t    44 saytoT    & L  d$Ifgdo d$Ifgd]           8 : < @ B D F H L N     񳟏xnd[dQEQh$hG6CJ\hohGCJ\hohmCJhohmCJ\hohCJ\-jIhohSO<CJU\mHnHuhohSO<CJ\mHnHu'jhohSO<CJU\mHnHuhohC|CJ\mHnHu"jhoh lCJU\"jhoh lCJU\hohC|CJ\jhoh lCJU\L N P V d 4((( d$Ifgdokd$$IfTsִp B6$3'-8FL t    44 saytoTd n x    d$Ifgdo     789:;<=>JKPU樔mcYRYFh$hG6CJ\ h82VCJ\hohmCJ\hoh~tCJ\-jhohSO<CJU\mHnHuhohSO<CJ\mHnHu'jhohSO<CJU\mHnHuhohC|CJ\mHnHu"j4hoh lCJU\"jhoh lCJU\hohC|CJ\jhoh lCJU\hoh )CJ\UVWXgh|}~  ܮܞzczYOFOhohmCJhohmCJ\hohCJ\-jhohSO<CJU\mHnHuhohSO<CJ\mHnHu'jhohSO<CJU\mHnHuhohC|CJ\mHnHu"johoh lCJU\"j!hoh lCJU\hohC|CJ\jhoh lCJU\hoh )CJ\hohGCJ\4((( d$Ifgdokd2$$IfTsִp B6$3'-8FL t    44 saytoT d$Ifgdo [\]^y`yQG=4=hohmCJhohmCJ\hohCJ\jhoh lCJU\1j.hohSO<CJU\mHnHsHu"hohSO<CJ\mHnHsHu+jhohSO<CJU\mHnHsHu"hohC|CJ\mHnHsHuhohC|CJ\mHsH$jhoh lCJU\mHsHhoh )CJ\mHsHhohGCJ\mHsHh$hG6CJ\mHsH4((( d$Ifgdokd$$IfTsִp B6$3'-8FL t    44 saytoTB d$Ifgdo,-./012BC{ƴТВ~nW~n~MDMhohmCJhohmCJ\-j hohSO<CJU\mHnHuhohSO<CJ\mHnHu'jhohSO<CJU\mHnHuhohC|CJ\mHnHu"j+hoh lCJU\"jhoh lCJU\hohC|CJ\jhoh lCJU\hoh )CJ\h$h~t6CJ\hoh~tCJ\BCDGN4((( d$Ifgdokd,$$IfTsִp B6$3'-8FL t    44 saytoTNSX]f d$Ifgdo{|̾̾̒̀jX?jXj1j0"hohSO<CJU\mHnHsHu"hohSO<CJ\mHnHsHu+jhohSO<CJU\mHnHsHu"hohC|CJ\mHnHsHu*jhoh lCJU\mHsH*j(hoh lCJU\mHsHhohC|CJ\mHsH$jhoh lCJU\mHsHhoh )CJ\h$hXX6CJ\hohXXCJ\>?DEFGVWklmnopqʾʴ}gU?+jhohSO<CJU\mHnHsHu"hohC|CJ\mHnHsHu*j%-hoh lCJU\mHsH*j#hoh lCJU\mHsHhohC|CJ\mHsH$jhoh lCJU\mHsHhoh )CJ\h$hRD6CJ\hohRDCJ\hohmCJhohmCJ\hoh|tDCJ\jhoh lCJU\ 4((( d$Ifgdokd"$$IfTsִp B6$3'-8FL t    44 sayt7wT ) d$Ifgdoq56fkտ}yrh^RI?3h$h6CJ\hhCJ\hoh7wCJhoh7w5CJ\hmh7w5\h7wh7w6\ h7w5\h7whohmCJhohmCJ\ h]CJ\ h<CJ\jhoh lCJU\"hohC|CJ\mHnHsHu+jhohSO<CJU\mHnHsHu1j6hohSO<CJU\mHnHsHu"hohSO<CJ\mHnHsHu4' $dTxa$gd7wkd7$$IfTsִp B6$3'-8FL t    44 sayt7wT ,5 d$Ifgd8E567:A2&&& d$Ifgd8Ekd(8$$IfTs4ִp B6$3'-8FL t    44 saytTAFKPY d$Ifgd8Ekmn}~#$%&'+,WXp"j_hhCJU\"jUhhCJU\"j^LhhCJU\h$h6CJ\ h<CJ\hohCJ"jCBhhCJU\"j;9hhCJU\jhhCJU\hhCJ\&2&&& d$Ifgd8EkdKK$$IfTs4ִp B6$3'-8FL t    44 saytTW d$Ifgd8EWXY\c2&&& d$Ifgd8Ekd^$$IfTs4ִp B6$3'-8FL t    44 saytTchmr{ d$Ifgd8E#$%&'+,23noծߜՊxnh82VhCJ\"j$hhCJU\"jΏhhCJU\"j2hhCJU\"jthhCJU\h$h6CJ\hohCJhhCJ\jhhCJU\"jihhCJU\'2&&& d$Ifgd8Ekds$$IfTs4ִp B6$3'-8FL t    44 saytT2 d$Ifgd8E23KNU2&&& d$Ifgd8Ekdč$$IfTs4ִp B6$3'-8FL t    44 saytTUZ_dmn d$Ifgd8Enopsz2&&& d$Ifgd8EkdɎ$$IfTs4ִp B6$3'-8FL t    44 saytTz* d$Ifgd8E7#8#9#:#;#<#I#N#P#Q#****************/+4+6+7+F+G+[+\+]+^+_+`+a+b+c+m+r+t+u+22222222ې"jթhhCJU\"jhhCJU\ heCJ\hhh(ACJ\hohCJh82VhCJ\jhhCJU\hhCJ\hZoh6CJ\8*****2&&& d$Ifgd8Ekdz$$IfTs4ִp B6$3'-8FL t    44 saytT****+: d$Ifgd8E d$Ifgde222O:P:Q:S:T:U::::::::::;!;#;@;[;d;;;;;;;xng`XNhQ%hQ%5\hmh)|\ hm5\ hm5\hhFCJ\hh +CJ\hh6CJ\hh CCJ\hhO3wCJ\hhGCJ\hhmCJ\hhCJH*\hhmCJH*\hohCJ h<CJ\h82VhCJ\jhhCJU\hhCJ\:::2$27d]2^7a$gdkd+$$IfTs4ִp B6$3'-8FL t    44 saytT:;;;< <<<(<1< d$Ifgd7 $dTxa$gdm$77d]7^7a$gd ;1<2<<<<<<<<<<= = = = = ==@=A=B=C=D=E=F=P=˼~jZCjZj~-jhcThSO<CJU\mHnHuhcThSO<CJ\mHnHu'jhcThSO<CJU\mHnHuhcThC|CJ\mHnHu"jUhcTh lCJU\"jhcTh lCJU\hcThC|CJ\jhcTh lCJU\hcTh&CJ\hZohW6CJ\hcThWCJ\hcThWCJhcThW5CJ\1<2<U<\<a<f<k<C77777 d$Ifgd7kd>$$IfTs4֞ qf!2 83 t44 s4:ayt7Tk<t<<<<<<9kd#$$IfTs֞ qf!2 83 t44 s4:ayt7T d$Ifgd7<<<<<<LL d$Ifgd7P=U=V=W=X=DDDDDDDDDDDDDDDDhLiLjLkLLLLLLLLLLLѷ|ѷe\hcThWCJ-jhcThSO<CJU\mHnHu-jhcThSO<CJU\mHnHuhcThSO<CJ\mHnHu'jhcThSO<CJU\mHnHuhcThC|CJ\mHnHuhcThC|CJ\jhcTh lCJU\hcTh&CJ\hcThWCJ\hZohW6CJ\"LLLMM MME99999 d$Ifgd7kd$$IfTs֞ qf!2 83 t44 s4:ayt7TLLL#M(M)M*M+M:M;MOMPMQMRMSMTMUMMMMMMMMM̽k[Dk[k-j,hcThSO<CJU\mHnHuhcThSO<CJ\mHnHu'jhcThSO<CJU\mHnHuhcThC|CJ\mHnHu"jhcTh lCJU\"jhcTh lCJU\hcThC|CJ\jhcTh lCJU\hcTh&CJ\hZohW6CJ\hcThWCJ\hcThWCJH*\ hlCJ\MM)N*N+N2N7N7kd&$$IfTs4֞ qf!2` 83 t44 s4:ayt7T d$Ifgd7MMMMMMMMMMMMMMMNNNNNNN)N*NVN[N\N]NɿɿɛɋwgPwgwGhcThWCJ-jhcThSO<CJU\mHnHuhcThSO<CJ\mHnHu'jhcThSO<CJU\mHnHuhcThC|CJ\mHnHu"jhcTh lCJU\"jhcTh lCJU\hcThC|CJ\jhcTh lCJU\hcTh&CJ\hcThWCJ\hZohW6CJ\ h<CJ\7N*CJ\hcThWCJ\jhcTh lCJU\1jhcThSO<CJU\mHnHsHu"hcThSO<CJ\mHnHsHu+jhcThSO<CJU\mHnHsHu"hcThC|CJ\mHnHsHu*j hcTh lCJU\mHsH*j}hcTh lCJU\mHsHhcThC|CJ\mHsH$jhcTh lCJU\mHsHOOOOP(PR?RoRpRqRrRsRtRuRvRRRRRRRRRR樔mf\U\I\hZohW6CJ\ hlCJ\hcThWCJ\ h<CJ\-j?hcThSO<CJU\mHnHuhcThSO<CJ\mHnHu'jhcThSO<CJU\mHnHuhcThC|CJ\mHnHu"jM6hcTh lCJU\"j,hcTh lCJU\hcThC|CJ\jhcTh lCJU\hcTh&CJ\RRRRRRRRRRRRRRRRRR!S&S'S(S)S8S9SMSԲwmcZcNcmhZohW6CJ\hcThWCJhcThWCJ\hcTh&CJ\-jThcThSO<CJU\mHnHuhcThSO<CJ\mHnHu'jhcThSO<CJU\mHnHuhcThC|CJ\mHnHu"jJhcTh lCJU\jhcTh lCJU\"j:@hcTh lCJU\hcThC|CJ\RRSS SSS d$Ifgd7MSNSOSPSQSRSSSSSSSSSSSSlTvTxTzT|TTTT߽xoxcxYOOhcThC|CJ\hcTh&CJ\hP:hW6CJ\hcThWCJhcThWCJ\-jihcThSO<CJU\mHnHuhcThSO<CJ\mHnHu'jhcThSO<CJU\mHnHuhcThC|CJ\mHnHu"j`hcTh lCJU\jhcTh lCJU\"j/VhcTh lCJU\SSSST(TUBUDUFUHUJUVVVVVVVVV߽{qhq\qPqFhcTh&CJ\hP:hW6CJ\hcThW6CJ\hcThWCJhcThWCJ\ h<CJ\-j}hcThSO<CJU\mHnHuhcThSO<CJ\mHnHu'jhcThSO<CJU\mHnHuhcThC|CJ\mHnHu"jthcTh lCJU\jhcTh lCJU\"jPkhcTh lCJU\VVVVHWIW7kd$$IfTs4֞ qf!2  83 t44 s4:ayt7T d$Ifgd7VVVWWWWWW W:W;WW?W@WAWBWHWIWJWKWW沞wpf]QE;hcThQ%CJ\hcThcTCJH*\hcThQ%CJH*\hcThWCJhcThWCJ\ h<CJ\-j=hcThSO<CJU\mHnHuhcThSO<CJ\mHnHu'jhcThSO<CJU\mHnHuhcThC|CJ\mHnHu"jhcTh lCJU\"jhcTh lCJU\jhcTh lCJU\hcThC|CJ\IWWcXXXXXXXXXY d$IfgdJ $dTxa$gdA;$77d]7^7a$gd": WWWWXcXdXzXXXXXYYYYYYYYYYYYY|p|fWMWMhA;hC|CJ\jhA;h lCJU\hA;h&CJ\hP:hk6CJ\hA;hkCJ\ hfX7CJ\hA;hxcCJ\hA;hxcCJhA;h5CJ\hA;hxc5CJ\hA;hxc\hA;h)|\ hA;5\hQ%hQ%\hcTh +CJ\hcTh CCJ\hcThCJ\hcTh~wCJ\YYY#Y%Y5))) d$IfgdJkd$$IfTs4ִ I$2 88 t    44 saytJT%Y,Y1Y6Y;YDYUYWZ d$IfgdJYYYYYYYZZZZZZZ/Z0Z8Z9ZWZXZqZrZb[c[z[{[|[[߽xlxex\x\x\xUIxhA;hxcCJH*\ h3{CJ\hA;hxcCJ h<CJ\hA;hxc6CJ\hA;hxcCJ\-jhA;hSO<CJU\mHnHuhA;hSO<CJ\mHnHu'jhA;hSO<CJU\mHnHuhA;hC|CJ\mHnHu"jhA;h lCJU\jhA;h lCJU\"jzhA;h lCJU\WZXZYZZZ`Z6*** d$IfgdJkd$$IfTsִ I$2 88 t    44 saytJT`ZeZjZoZpZqZ d$IfgdJqZrZZZZ6*** d$IfgdJkdҮ$$IfTsִ I$2 88 t    44 saytJTZZZZZb[ d$IfgdJb[c[}[[[6*** d$IfgdJkd$$IfTsִ I$2 88 t    44 saytJT[[[[[\ d$IfgdJ[[[[[[[[[[[[[[[[[\\ \"\#\$\%\6\7\<\ǽǽǙljueNueuDhA;hxcCJ\-jhA;hSO<CJU\mHnHuhA;hSO<CJ\mHnHu'jhA;hSO<CJU\mHnHuhA;hC|CJ\mHnHu"jhA;h lCJU\"jlhA;h lCJU\hA;hC|CJ\jhA;h lCJU\hA;h&CJ\h3{6CJ\hP:hu6CJ\hA;huCJ\<\=\>\?\N\O\c\d\e\f\g\h\i\\\\\\\\\\\\ܮܞzczYOFOhA;hxcCJhA;hxcCJ\hA;hCJ\-jqhA;hSO<CJU\mHnHuhA;hSO<CJ\mHnHu'jhA;hSO<CJU\mHnHuhA;hC|CJ\mHnHu"jhA;h lCJU\"j}hA;h lCJU\hA;hC|CJ\jhA;h lCJU\hA;h&CJ\hA;huCJ\\\\\\6*** d$IfgdJkd$$IfTsִ I$2 88 t    44 saytJT\\\\\x] d$IfgdJ\\\\\\\\\\\\]]1]2]3]4]5]6]7]8]c]d]x]ǵѣѓoXoNGN h3{CJ\hA;hxcCJ\-jEhA;hSO<CJU\mHnHuhA;hSO<CJ\mHnHu'jhA;hSO<CJU\mHnHuhA;hC|CJ\mHnHu"j{hA;h lCJU\"jhA;h lCJU\hA;hC|CJ\jhA;h lCJU\hA;h&CJ\hA;huCJ\hP:hu6CJ\x]y]z]|]]6*** d$IfgdJkd$$IfTsִ I$2 88 t    44 saytJTx]y]]]]]]]eeeeLeMeNeOePeQeReSeTeUeeeeeeeeee;i_;M"jhA;h lCJU\hA;hCJ\-jhA;hSO<CJU\mHnHuhA;hSO<CJ\mHnHu'jhA;hSO<CJU\mHnHuhA;hC|CJ\mHnHuhA;hC|CJ\jhA;h lCJU\hA;h&CJ\hP:hu6CJ\hA;huCJ\hA;hxcCJ\hA;hxcCJ]]]]]Te d$IfgdJTeUeVeXe_e6*** d$IfgdJkd$$IfTsִ I$2 88 t    44 saytJT_edeienewee d$IfgdJeeeeeeeeeeeeeeee8f9flfmffffffnnnϻwwpdZPFhA;hC|CJ\hA;h&CJ\hA;hkCJ\hP:hk6CJ\ h<CJ\hA;hxcCJhA;hxcCJ\hA;huCJ\-jhA;hSO<CJU\mHnHuhA;hSO<CJ\mHnHu'jhA;hSO<CJU\mHnHuhA;hC|CJ\mHnHu"j-hA;h lCJU\jhA;h lCJU\eefff6*** d$IfgdJkd$$IfTsִ I$2 88 t    44 saytJTff$f)f.f7f8f d$IfgdJ8f9f:f{C{S{^{g{i{{ d,$IfgdB{{{{{2&&& d,$IfgdBkdHD$$IfTs4ִ n8#3X8s0` t_4    44 saytBT{{{{{| d,$IfgdB||||%|2&&& d,$IfgdBkdLE$$IfTs4ִ n8#3X8s0  t_4    44 saytBT%|*|/|4|D|O|Y|[| d,$IfgdB[|\|^|`|f|2&&& d,$IfgdBkdPF$$IfTs4ִ n8#3X8s0` t_4    44 saytBTf|k|p|u|v|x| d,$IfgdBx|y||||2&&& d,$IfgdBkdTG$$IfTs4ִ n8#3X8s0  t_4    44 sayt2T|||||||||||} d,$IfgdB ||||||||}}}}}}}}}N}O}P}R}S}T}U}}˼~jZCjZj~-j\h`hSO<CJU\mHnHuh`hSO<CJ\mHnHu'jh`hSO<CJU\mHnHuh`hC|CJ\mHnHu"jRh`h lCJU\"jXHh`h lCJU\h`hC|CJ\jh`h lCJU\h`h&CJ\hP:hk6CJ\h`hkCJ\h`hToCJ\h`hCJ\}}}}}2&&& d,$IfgdBkdi]$$IfTs4ִ n8#3`X8s0 t_4    44 sayt2T}}}}}}}}}}}}}}}}}}}}}}~~saQh`hC|CJ\mHnHu"jgh`h lCJU\"j{^h`h lCJU\h`hC|CJ\jh`h lCJU\h`h&CJ\h`hCJ\hP:h6CJ\h`hTo5CJ\h`hCJ\h`hTo6CJH*\h`hTo6CJ\h`hToCJ\h`hToCJ}}}}}}}~ d,$IfgdB~~2~3~4~5~6~7~8~D~E~I~J~O~P~Q~R~a~b~v~w~x~y~z~{~|~~봥~tjjXF"j0|h`h lCJU\"jqh`h lCJU\h`hC|CJ\h`h&CJ\hP:hk6CJ\h`hkCJ\ h|CJ\h`hToCJ\jh`h lCJU\h`hC|CJ\mHnHu-joqh`hSO<CJU\mHnHuh`hSO<CJ\mHnHu'jh`hSO<CJU\mHnHu~~~~~~~~~~~~~~~~~~~!"'(Դ||oeYOCOhP:h6CJ\h`hCJ\h`hTo5CJ\h`hCJ\h`hTo6CJH*\h`hTo6CJ\h`hToCJh`hToCJ\h`hCJ\jh`h lCJU\h`hC|CJ\mHnHuh`hSO<CJ\mHnHu'jh`hSO<CJU\mHnHu-j~h`hSO<CJU\mHnHu~~~~~2&&& d,$IfgdBkd$$IfTs4ִ n8#3 X8s0 t_4    44 sayt2T~~~~~~~ d,$IfgdB()*pqrsنچ̸}t}h}^}hQ}^}h`hTo6CJH*\h`hCJ\h`hTo6CJ\h`hToCJh`hToCJ\h`hCJ\-jh`hSO<CJU\mHnHuh`hSO<CJ\mHnHu'jh`hSO<CJU\mHnHuh`hC|CJ\mHnHuh`hC|CJ\jh`h lCJU\h`h&CJ\2&&& d,$IfgdBkdx$$IfTs4ִ n8#3 X8s0 t_4    44 sayt2TÆȆ؆ d,$IfgdB#$%&'()YZ[\]^_ǵѣѓoXoNEAhBh`hToCJh`hToCJ\-jh`hSO<CJU\mHnHuh`hSO<CJ\mHnHu'jh`hSO<CJU\mHnHuh`hC|CJ\mHnHu"jTh`h lCJU\"jh`h lCJU\h`hC|CJ\jh`h lCJU\h`h&CJ\h`hVCJ\hP:hV6CJ\ه2% $dTxa$gdBkd$$IfTs4ִ n8#3 X8s0 t_4    44 sayt2Tه!"lqst otvwҍӍY^`apqȼȭȭȣȭȗȭȭȅsȣȭȗȭȭ"jhBhBCJU\"j/hBhBCJU\h"hB6CJ\h|hBCJ\jhBhBCJU\h|hB6CJ\hBhBCJ\hBhBCJhBhB5CJ\h`hB\ hB5\h)|hB5\)ه ! d,$Ifgd8E!" kd$$IfTs4ִ n8#3X8s0 t0_4    44 saytBT"#&-27<LW` d,$Ifgd8E  kd$$IfTs4ִ n8#3X8s0 t0_4    44 saytBT&+05EPYҍ d,$Ifgd8E ҍӍ kd7$$IfTs4ִ n8#3X8s0 t0_4    44 saytBTӍ  #3@I d,$Ifgd8E ǎȎɎʎˎ͎̎ΎώùòæÔ߂ùp^ù"jhBhBCJU\"jhBhBCJU\"jEhBhBCJU\"jhBhBCJU\h"hB6CJ\ h|CJ\h|hBCJ\hBhBCJ\"jhBhBCJU\jhBhBCJU\"johBhBCJU\$',./>?STUVWXYZ[qvxy͏Ώv"jhBhBCJU\"jM hBhBCJU\"jhBhBCJU\h|hBCJ\"jhBhBCJU\"jKhBhBCJU\h"hB6CJ\jhBhBCJU\hBhBCJ\)46HP  wĒߒջմխ•ukaWMah(*hjCJ\h(*hFmCJ\h(*h\`CJ\h(*h[CJ\h(*hCJ\h(*hToCJ\h(*h(*CJH*\h(*hToCJH*\h h CJH*\ h CJ\ h<CJ\ hfX7CJ\hBhBCJh|hBCJ\hBhBCJ\jhBhBCJU\"j!hBhBCJU\ kdc+$$IfTs4ִ n8#3X8s0 t0_4    44 saytBT  *4>^t d,$Ifgd8E  kd,$$IfTs4ִ n8#3X8s0 t0_4    44 saytBT",04 d,$Ifgd8E46 kd-$$IfTs4ִ n8#3X8s0 t0_4    44 saytBT68:H\p d,$Ifgd8E kd /$$IfTs4ִ n8#3X8s0 t0_4    44 saytBTߒ)+,JKa CDMNO/0͕֕̕וؕ34=>?\abcͻxoh;h!$KCJh"hXy6CJh;hXyCJH* hE:lCJh;hXy6CJH*h;hXy6CJh;hXyCJh;hXy5CJh;hL)5\h;h[x\h;h)|\ h;5\hTohTo\ h2CJ\h(*hFmCJ\h(*h[CJ\'JKɓϓ  d$Ifgd; $dTxa$gd;gdTo$27d]2^7a$gdjo  #2&&& d$Ifgd;kdC0$$IfTs4ִ |-"49 8sy t4    44 saytOGCT#(-2BMV d$Ifgd;2&&& d$Ifgd;kd\1$$IfTs4ִ |-"4`9 8s`y t4    44 saytOGCT d$Ifgd;Ŕ2&&& d$Ifgd;kds2$$IfTs4ִ |-"4 9 8s y t4    44 saytOGCTŔʔϔԔ: d$Ifgd;:;<>D2&&& d$Ifgd;kd|3$$IfTs4ִ |-"4`9 8s`y t4    44 saytOGCTDINST d$Ifgd;2&&& d$Ifgd;kd4$$IfTs4ִ |-"4 9 8s y t4    44 saytOGCTÕȕ֕ߕ d$Ifgd;2&&& d$Ifgd;kd5$$IfTs4ִ |-"4`9 8s`y t4    44 saytOGCT d$Ifgd; 2&&& d$Ifgd;kd6$$IfTs4ִ |-"4 9 8s y t4    44 saytT %*/=FR d$Ifgd;cdstʖ˖̖ΖϖЖҖ  ?@qrl_V_MGM=h;hXy6CJ hE:lCJh;hXyCJh;h lCJjh;h lCJU.j\h;hSO<CJUmHnHsHuh;hSO<CJmHnHsHu(jh;hSO<CJUmHnHsHuh;hC|CJmHnHsHu'j0Jh;h lCJUmHsH'j7h;h lCJUmHsHh;hC|CJmHsH!jh;h lCJUmHsHRSTW^2&&& d$Ifgd;kd5]$$IfTs4ִ |-"4`9 8sy t4    44 saytT^chm{ d$Ifgd;r{|} !"12FwiSwiw*jph;hSO<CJUmHnHuh;hSO<CJmHnHu$jh;hSO<CJUmHnHuh;hC|CJmHnHujsgh;h lCJUjG^h;h lCJUh;hC|CJjh;h lCJUh;h!$KCJh"hXy6CJh;hXy6CJH*h;hXy6CJh;hXyCJ FGHIJKLј֘טؘ٘ızznbXN?jh;h lCJU\h;h!$KCJ\h;hXyCJ\h"hXy6CJ\h;hXy6CJH*h;hXy6CJh;hXyCJ*j$h;hSO<CJUmHnHuh;hSO<CJmHnHu$jh;hSO<CJUmHnHuh;hC|CJmHnHujzh;h lCJUjh;h lCJUjqh;h lCJU2&&& d$Ifgd;kd$$IfTs4ִ |-"4 9 8sy t4    44 saytTǘv d$Ifgd;٘345789;hjϙ沞wjajXNXNBXh;hXy6CJH*h;hXy6CJh;hXyCJh;h lCJjh;h lCJU-jh;hSO<CJU\mHnHuh;hSO<CJ\mHnHu'jh;hSO<CJU\mHnHuh;hC|CJ\mHnHu"jјh;h lCJU\"jh;h lCJU\jh;h lCJU\h;hC|CJ\vwx{2&&& d$Ifgd;kdl$$IfTs4ִ |-"4 9 8sy t4    44 saytTc d$Ifgd;ϙЙؙݙޙߙ&'()[\]^_`ab!"#$VѺzppdѺh;hXy6CJH*h;hXy6CJh;hCJ*j~h;hSO<CJUmHnHuh;hSO<CJmHnHu$jh;hSO<CJUmHnHuh;hC|CJmHnHuh;hC|CJjh;h lCJUh;h!$KCJh"hXy6CJh;hXyCJ hE:lCJ!cdeho2&&& d$Ifgd;kd$$IfTs4ִ |-"4 9 8sy t4    44 saytToty~ d$Ifgd;VWXZ[\]ƨǨȨɨب٨%׻|sscSjh;h lCJUjh;h lCJUh;hC|CJh;h!$KCJh"hXy6CJh;hXy6CJH*h;hXy6CJh;hXyCJjh;h lCJUh;hC|CJmHnHuh;hSO<CJmHnHu$jh;hSO<CJUmHnHu*jh;hSO<CJUmHnHu2&&& d$Ifgd;kdx$$IfTs4ִ |-"4 9 8sy t4    44 saytT> d$Ifgd;%&')*+,?@V>CEFUVjkl׻~ulblUlUlEUjRhKhKCJUjhKhKCJUh"hK6CJhKhKCJh;hKCJh;hK5CJh;hK5\h;hK\ hK5\hKh;hXyCJjh;h lCJUh;hC|CJmHnHuh;hSO<CJmHnHu$jh;hSO<CJUmHnHu*jh;hSO<CJUmHnHu>?2% $dTxa$gdKkd'$$IfTs4ִ |-"4 9 8sy t4    44 saytTĩ٩ d$Ifgd8E  2&&& d$Ifgd8Ekd9$$IfTs4ִ |-"49 8sy t4    44 saytKT )2y d$Ifgd8Elmnopqryz9:;=>?OP !"#knz|ɺٽٽdz{t h2CJ\hThjCJhThDCJ\hThk 8CJhThDCJhThL)CJhThTCJH*hThL)CJH*h"hK6CJh;hKCJhE:lhKCJhKhKCJjhKhKCJUjhKhKCJU-yz{~2&&& d$Ifgd8Ekd"$$IfTs4ִ |-"49 8sy t4    44 saytKTO d$Ifgd8EOPQT[2&&& d$Ifgd8Ekd;$$IfTs4ִ |-"49 8sy t4    44 saytKT[`ejx  d$Ifgd8E !i2$27d]2^7a$gdKkdF$$IfTs4ִ |-"49 8sy t4    44 saytKTNOPgûĻʻ˻?@BCDEWZ[\]^uz{}~õ{miaYh(h45h(h(5hDjh~+UmHnHuh:h:h:6\ h:5\h: j_hAh~+UmHnHuh'h4ehh4jh:UmHnHuhr\ h<\h9h:5\h:h:\ h:5\ h)|hL)hThL)CJhThDCJ\ iOP@DEFGHIJKLMNOPQRSTUVW[$77dT]7^7a$gd:gd)|$77d]7^7a$gdT[]{_@}tX>A$3dT^`3a$gd( dTgd(gd)| $dTa$gd:Ѽټڼ79NOVDdjkw,0167=޹ްřřŋނ~sŋhhh(6mHnHuh_:6mHnHuh*-hmHnHuhSO<hSO<5mHnHuht6mHnHuhSO<hF~ mHnHuhF~ mHnHuhSO<h?smHnHuhSO<hSO<6mHnHuh (K6mHnHuhSO<hSO<mHnHuh (KmHnHuh&jh lU(=>FGNRTV 0Odey|}Eekmntu}~ͰͰ͜hvU6mHnHuhvUmHnHuhpQ6mHnHuhpQmHnHuh4-6mHnHuhSO<mHnHuhSO<hSO<mHnHuhSO<hSO<5mHnHuhSO<hSO<6mHnHuh(6mHnHu5'(-135:@AMQRTU[\`aijquwy=>GJEFrt͹͵͡͡͡h|=16mHnHuhSO<mHnHuh{t6mHnHuh*-h.mHnHuhc6mHnHuhSO<hSO<mHnHuhSO<hSO<5mHnHuhSO<hSO<6mHnHuh#6mHnHu8tu{|`awx=>Dwz{}~Y\]_`dejnprͻͻͧhmo6mHnHuhxJ6mHnHuhSO<hF~ mHnHuhF~ mHnHuh|6mHnHuhSO<mHnHuh|mHnHuhSO<hSO<mHnHuhSO<hSO<5mHnHuhSO<hSO<6mHnHuh. 6mHnHu2Taegi489?@EIKM#$)-/1 ().246 !"-136ܤܛܛh{6mHnHuh.mHnHuh{mHnHuhX6mHnHuh 6mHnHuhsb6mHnHuhSO<hSO<5mHnHuhSO<hSO<mHnHuhSO<hSO<6mHnHuhsbmHnHu7AA|3sV$anh"p$3dT^`3a$gd([efgkmo| @`|/07d꺶ܙܙܙ܅܅hhv6mHnHuhhvmHnHuh?l6mHnHuhzmHnHuh?lmHnHuh]h]mHnHuhSO<hSO<5mHnHuh&B6mHnHuhSO<hSO<6mHnHuhSO<hSO<mHnHuh&BmHnHu0"Wrst{#%&*012ʼʼէvh\՞hMhMmHnHuhMhSO<5mHnHuhMhbc6mHnHuhMhSO<6mHnHuhMhbcmHnHuhBmHnHuhMhSO<mHnHuh<mHnHuh(hSO<6mHnHuh(6mHnHuhSO<hSO<mHnHuhF~ mHnHuhSO<h(mHnHuh(mHnHu"wyz~  LNOQR\]^bdgijhd*6mHnHuhS2mHnHuhS26mHnHuhSO<hbM_mHnHuhbM_mHnHuhc6mHnHuhSO<hSO<5mHnHuhbc6mHnHuhSO<hSO<6mHnHuhSO<hSO<mHnHuh*-6Ss~24578<=ABCGIK Qqh'6mHnHuh<@?mHnHuh>mHnHuh>6mHnHuh/umHnHuhFj6mHnHuhSO<hSO<5mHnHuh{,6mHnHuh{,mHnHuhSO<hSO<mHnHuhSO<hSO<6mHnHu5'0678=ABCIOPRTY[eúñ~pbغغVh~hb4mHnHuhb4hb46mHnHuhb4h<6mHnHuhb4hn6mHnHuhb4hSO<6mHnHuhb46mHnHuhSO<h%=mHnHuh%=mHnHuh~mHnHuhSO<hb4mHnHuhb4mHnHuhSO<hSO<mHnHuhSO<hSO<5mHnHuhSO<hSO<6mHnHu=>EGIJLMWXYǹǹҔދvj\Q\Q\Q\h+16mHnHuhSO<hSO<6mHnHuhSO<h?smHnHuh?smHnHuhSO<h~mHnHuh~mHnHuhY~mHnHuhY~h<6mHnHuhY~hn6mHnHuhY~hSO<6mHnHuhY~6mHnHuhSO<hSO<mHnHuh%=mHnHuhSO<hb4mHnHuh~h~mHnHuY]_bhiBEFHISTUY[]滲اااا؜؜؜ؑh! 6mHnHuhP_6mHnHuh6mHnHuh5RmHnHuh~\mHnHuh+16mHnHuh+1mHnHuhSO<hSO<6mHnHuhSO<hSO<mHnHuhSO<hSO<5mHnHu94TZklrstxz|Ͱ͜znhSO<hn+mHnHuh?shn+mHnHuh&6mHnHuhn+6mHnHuhn+mHnHuhw6mHnHuh3mHnHuh36mHnHuh_YmHnHuhSO<hSO<mHnHuhSO<hSO<5mHnHuhSO<hSO<6mHnHuh! 6mHnHu+#)*128EGOPQXcijtǹǹҢҙ҄xlxlahw56mHnHuhG/hG/mHnHuhSO<hw5mHnHuhG/hw5mHnHuh<mHnHuh mHnHuhn+mHnHuhgh]w;6mHnHuhghSO<6mHnHuhg6mHnHuhSO<hSO<mHnHuh?smHnHuhSO<hn+mHnHuh?sh?smHnHu  '016;>CERT\]^ervw);?ABDGNOPEĻĤĤĊ~rĤggĤh{Y6mHnHuh]h]mHnHuh]hNmHnHuh]hSO<mHnHuhSO<hSO<5mHnHuhSO<hSO<6mHnHuh<mHnHuhG/mHnHuhSO<hSO<mHnHuhw5mHnHuhw56mHnHuhw5h]w;6mHnHuhw5hSO<6mHnHu(p}Qj&%B*K [<02$3dT^`3a$gd-$3dT^`3a$gd(EFrsNUY[]   ؿؿ궪궪궪ؿ؟؟؟؟ؿꖊhSO<hi]5mHnHuhi]5mHnHuhP6mHnHuhSO<hgEmHnHuhgEmHnHuhSO<hSO<5mHnHuh{Y6mHnHuhSO<hSO<6mHnHuh*-hSO<hSO<mHnHuh{YmHnHu6}~ ()-./357зޮޥޥޥЎЎЎзޅЎЎЎзhTmHnHuhT6mHnHuhSO<hG/mHnHuhG/mHnHuh mHnHuhSO<hSO<5mHnHuh 6mHnHuhSO<hSO<6mHnHuhSO<hSO<mHnHuhSO<hi]5mHnHuhi]5mHnHu4%&67ĸͤ̓xxh,D6mHnHuh,DmHnHuhWq6mHnHuh]h]mHnHuh `{mHnHuhXt6mHnHuhSO<hc1mHnHuhc1mHnHuhSO<hSO<mHnHuhSO<hSO<5mHnHuhv-:6mHnHuhSO<hSO<6mHnHu/78<>@dejlĸظĸؙhSO<h9mHnHuh9mHnHuh! 6mHnHuhan6mHnHuhSO<hc1mHnHuhc1mHnHuhJHr6mHnHuhSO<hSO<mHnHuhSO<hSO<5mHnHuhSO<hSO<6mHnHu7lmy01289ABFGHLNP'()-/100000000000ззЬЬЬЬзССзޟДДДДh}z6mHnHuUh6H6mHnHuh> 6mHnHuhSO<hSO<5mHnHuh'6mHnHuhSO<hSO<6mHnHuhSO<hSO<mHnHuhSO<h9mHnHuh9mHnHu:, A.; Bolt, H.M.; Dekant, W.; Birner, G.; Henschler, D.; Ulm, K. Renal cell cancer correlated with occupational exposure to trichloroethene. J. Cancer Res. Clin. Oncol. 1998, 124, 374-382. 71. Morgan, R.W.; Kelsh, M.A.; Zhao, K.; Heringer, S. Final Report Cohort Mortality Study of Aerospace Workers with Exposure to Trichloroethylene., Letter from Paul A. Cammer, Ph.D., Trichloroethylene Issues Group, to Cheryl Siegel Scott, US EPA, ID 645806; US EPA, Health and Environmental Reserach Online (HERO): Durham, NC, USA, 1997. Available online: http://hero.epa.gov/index.cfm?heroid=645806&action=search.do&submit=Search&portal=true&sort=year&all=&exact=&any=&author=&journal=&singleyear=&startyear=&endyear= (accessed on 30 August 2011).  2011 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).     PAGE 17 Int. J. Environ. Res. Public Health 2011, 8 -2.0 -1.5 -1.0 -0.5 0.0 0.5 1.0 1.5 2.0 0.0 0.2 0.4 0.6 0.8 Standard Error Log risk ratio Funnel Plot of Standard Error by Log risk ratio 0000000111?1P1Q1R1S1q1r111111#222222333333̙̐̐uqieaYUYUhn rjhn rUh&h=jh lUhSO<h(\hEh mHnHuh hEmHnHuhEmHnHuhIhE6mHnHuhEh(\hE6h(\hE6mHnHuhE6mHnHuh(\hEmHnHuhSO<hSO<6mHnHuhSO<hSO<mHnHuhSO<hSO<5mHnHu!233333333334444444 4%4&4+4,4gdpYgd> gdb'dTgdrE< hdT]hgdrE<$&`#$a$gdrE< $dTa$gd=33333333333 4 4444444444 4$4%4&4*4+4,4041424647484;4<4=4@4A4B4E4F4G4J4K4L4O4P4Q4T4U4󏆂h lh:hpYCJ/h:hpY5B*CJ OJQJ\^JaJphhw?@hpYh8Ehw hrE<6hrE< hrE<5hhrE<6hE0J5mHnHuhKhrE<0J5jhKhrE<0J5Uhn rjhn rU3,414247484<4=4A4B4F4G4K4L4P4Q4U4V4Z4[4_4`4d4e4i4j4y4z444gdpYU4V4Y4Z4[4^4_4`4c4d4e4h4i4j4x4y4z4444444444h&hw?@h,=m+h:hpY5B*CJOJQJ\^Jphh:hpYCJ/h:hpY5B*CJ OJQJ\^JaJphh l444444 $dTa$gd=gdpY< 0 0&P 1h:pZ}0. A!"#$%R2 &P +p,p-p.p1h00/R 4567:pZ}0A .!"#$%R2 51h0:pZ}0= /!"#$% 5 01h:p/ =!"#$% @=vy d^e+8..|hi^~DxZpw%\O$0CREL$": L:#&VjZb43IV*TfZ  c}{R v~KD:A\|>27MFF02NH pw^9f)LUTS1n5V(ZPu\QϽJ݊(DҨG|ḧfˠC#QcI7D'ymQv1[W/]1_ȵþ] b7CQ]Ɍl G;a8D ]m|/,[џ$3&Õ)񹣍kʡ"5rGFF,P5 ,94P.Ks檘\tƢ8lcto\ۉp({U\޵p޿ޖ() XzI7B}VSHݜȢ9Ff7.{$qs! ̰dH>_H#F<2ۚ1isv4%`98?q$9n'ojMo0f*:"?h%ྯXKe\}Յ9WRUeU\U\3*NsŹsz=V<9WRM"ιf0W`|/OU\G]gpuk%OU}꜈qBWeAiFx=-[e>M9m ܾ)stŭ/Jלmɺ. g]Nu(ҺN9r5ڢd]Jcκp55+M? 3'UEu[s^i:stWVs*7Mzt=\bO"mE+BE*YtYD y˽-|/L-,o, bCg*/M}"X>oe"£v9VfwdwY=*Qѩe5ީ t޷q?]37I}BZ;B~땉++7/Pѩ.*Hke5'k^Yv&NYevftg9{dH =k7wtwwuGa~u3JE\(e]ƮfR70uy~[Vp kx@j}re [O}C{1j9clՐiGeœR9y)4z|+ſ%1{GPڊhˮyO-ܽ(\  URv{rrmV q)1>uzًJu{7xG ăZC*y閍p߽=|/+r]f {Xgeo E:{qާ1ɱ2K}UE`Zd?Pt6婊rc{Ğ',s4%⛍bb0D7Eˆ߷]+Td1g ȝrƭϴ }X:@YH}B7q,S7 UNHDAR^ǵ`d{ko65e/dMo}^T5%={ַ>ނq} ݞ#\+~>l )vkNQۺ?][rw<[Y 9RQVG3}jMQgn,Xl݈auq~znKm8AbI)1zTnE ?{~ZdѿMBÜg|u@,3t}'ݜg|]J~*}kf?5uJDqž4uJDq{$f?3qJDqs>y=cԹDZ*Zko}`gZ|-Ozb}sюc_FpLǾǎ_ឧih}鬏[Ak@^DNц/ 'Lr>hKc? })q\ ;e͒&Xb`ve~y:G6;> /|B7ފ~|K/c_`oXAy;\ }fع{Lľ Нv!+MξN\fعkX?_Gٱσt7A^Xg}ie|0?BSW<vuJ^ ڲcm V.P׸ 㧰OmE䘶I|M+ D})ec8⾻T(3SʔE 1֒/ d8yc wo,.,>.!Cٟ2^+SaY0m^J}+dV nse0plB.}/Yf5Ƽ\ /vu23)16~)Vc ?]d5YE"9Oys7h|=uRo XZ}̢uťt.˗^Liヨ[29(S(R>\9P="K5u4a(ޚAWξc6Gլ)w;|&dU> w˫7_גdDNvBVAP-^C@8;D)0v= K n=AQo wxlyU~1H 4?1]2dȮn[l^Z켥yBIJϩ]k̟Iv(g'1Oϩ}o|j0w'zܧHS<icS%(@3ΨnYԭ3A Q< b fF'ּ]ȣ0>oX,Yn؞<Xu6.=1>eks >P}&71P|}Itۋ G& x:+>g3:Gرrc'zL|pLtU qmG:VKnN5S6x~qziԥ۴Q1|z.oʘu;2~ң׿/1d0ԬeX#`B&#DifԱĵs@\M]&TSm=X}Wa?Q]uAlڟ$$If!vh55 5x#v#v #vx:V :4 t'55 5x/ 44 :f4ytwTt$$If!vh5'#v':V :4 t'5'/ 44 :f4ytwTsDyK  _ENREF_1sDyK  _ENREF_2 DHardell1994144[3]14414417Hardell, L.Eriksson, M.Degerman, A.Department of Oncology, Orebro Medical Center, SwedenExposure to phenoxyacetic acids, chlorophenols, or organic solvents in relation to histopathology, stage, and anatomical localization of non-Hodgkin's lymphomaCancer ResearchCancer Research2386-2389549NOT IN FILE2,4,5-Trichlorophenoxyacetic Acid2,4-Dichlorophenoxyacetic AcidAAcetic AcidAcetic AcidsAcidsAdultadverse effectsAgedAged,80 and overanalysisarticleAsbestosCase-Control Studieschemically inducedChlorophenolsControlDiseaseexposureHuman-KWHumansLymphomaLymphoma,Non-HodgkinMaleMiddle AgedMultivariate AnalysisNeoplasm StagingobtainedOdds RatioOrdered 6-28-06organic solventORGANIC SOLVENTSORISEpathologyPDFPrognosisRiskrisk factorSelectedSmokingsolventSolventsstudySurvivalSwedenU.S.EPA,TCE Issue Papers,20051994PM:8162585file://L:\Lab\NCEA\TCE Documents\TCE PDFs4\ Hardell 1994.pdf DHardell1994144[3]14414417Hardell, L.Eriksson, M.Degerman, A.Department of Oncology, Orebro Medical Center, SwedenExposure to phenoxyacetic acids, chlorophenols, or organic solvents in relation to histopathology, stage, and anatomical localization of non-Hodgkin's lymphomaCancer ResearchCancer Research2386-2389549NOT IN FILE2,4,5-Trichlorophenoxyacetic Acid2,4-Dichlorophenoxyacetic AcidAAcetic AcidAcetic AcidsAcidsAdultadverse effectsAgedAged,80 and overanalysisarticleAsbestosCase-Control Studieschemically inducedChlorophenolsControlDiseaseexposureHuman-KWHumansLymphomaLymphoma,Non-HodgkinMaleMiddle AgedMultivariate AnalysisNeoplasm StagingobtainedOdds RatioOrdered 6-28-06organic solventORGANIC SOLVENTSORISEpathologyPDFPrognosisRiskrisk factorSelectedSmokingsolventSolventsstudySurvivalSwedenU.S.EPA,TCE Issue Papers,20051994PM:8162585file://L:\Lab\NCEA\TCE Documents\TCE PDFs4\ Hardell 1994.pdfsDyK  _ENREF_3D DGreenland1994141[4]14114117Greenland, S.Salvan, A.Wegman, D. H.Hallock, M. F.Smith, T. J.Department of Epidemiology, UCLA School of Public Health 90024-1772A case-control study of cancer mortality at a transformer-assembly facilityInt.Arch.Occup.Environ.HealthInt.Arch.Occup.Environ.Health49-54661NOT IN FILEAAdultadverse effectsageAgedAged,80 and overAir Pollutants,OccupationalanalysisarticleAsbestosAssociationBenzenecancerCarcinogensCase-Control StudiesCause of Deathchemically inducedControldeathElectric Power SuppliesEmploymentepidemiologyexposureHealthHumansIndustrial OilsLunglung cancerMaleMiddle AgedmortalityNeoplasmsOccupational DiseasesOdds RatioResearchResearch SupportResins,PlantSelectedsolventSolventsstudyTrichloroethylene1994PM:7927843D DGreenland1994141[4]14114117Greenland, S.Salvan, A.Wegman, D. H.Hallock, M. F.Smith, T. J.Department of Epidemiology, UCLA School of Public Health 90024-1772A case-control study of cancer mortality at a transformer-assembly facilityInt.Arch.Occup.Environ.HealthInt.Arch.Occup.Environ.Health49-54661NOT IN FILEAAdultadverse effectsageAgedAged,80 and overAir Pollutants,OccupationalanalysisarticleAsbestosAssociationBenzenecancerCarcinogensCase-Control StudiesCause of Deathchemically inducedControldeathElectric Power SuppliesEmploymentepidemiologyexposureHealthHumansIndustrial OilsLunglung cancerMaleMiddle AgedmortalityNeoplasmsOccupational DiseasesOdds RatioResearchResearch SupportResins,PlantSelectedsolventSolventsstudyTrichloroethylene1994PM:7927843sDyK  _ENREF_4VDAnttila1995119[5]11911917Anttila, A.Pukkala, E.Sallmen, M.Hernberg, S.Hemminki, K.Finnish Institute of Occupational Health, HelsinkiCancer incidence among Finnish workers exposed to halogenated hydrocarbonsJ.Occup.Environ.Med.J.Occup.Environ.Med.797-806377NOT IN FILEAAdultadverse effectsarticlecancerchemically inducedCohort StudiesEpidemiologic StudiesepidemiologyexposureFemaleFinlandHealthHumansHydrocarbons,HalogenatedIncidenceLiverLymphomaMaleMiddle AgedmortalityMultiple MyelomaNeoplasmsnonhodgkin lymphomaOccupational DiseasesOccupational ExposurePopulationResearchResearch SupportRisksolventSolventsstudyTrichloroethyleneworker1995PM:7552463VDAnttila1995119[5]11911917Anttila, A.Pukkala, E.Sallmen, M.Hernberg, S.Hemminki, K.Finnish Institute of Occupational Health, HelsinkiCancer incidence among Finnish workers exposed to halogenated hydrocarbonsJ.Occup.Environ.Med.J.Occup.Environ.Med.797-806377NOT IN FILEAAdultadverse effectsarticlecancerchemically inducedCohort StudiesEpidemiologic StudiesepidemiologyexposureFemaleFinlandHealthHumansHydrocarbons,HalogenatedIncidenceLiverLymphomaMaleMiddle AgedmortalityMultiple MyelomaNeoplasmsnonhodgkin lymphomaOccupational DiseasesOccupational ExposurePopulationResearchResearch SupportRisksolventSolventsstudyTrichloroethyleneworker1995PM:7552463sDyK  _ENREF_5h DMorgan1998157[6]15715717Morgan, R. W.Kelsh, M. A.Zhao, K.Heringer, S.Exponent Health Group, Menlo Park, CA, USAMortality of aerospace workers exposed to trichloroethyleneEpidemiologyEpidemiology424-43194NOT IN FILEAAdultadverse effectsAgedAircraftArizonaarticleAssociationAviationcancerCarcinogensCause of Deathchemically inducedclassificationCohort Studiesconfidence intervalConfidence IntervalsDiseaseepidemiologyexposureFemaleHealthHumansIndustryKidneyLeukemiaLiverliver cancerLymphomaMaleMiddle AgedmortalityNeoplasmsOccupational DiseasesOccupational ExposureProportional Hazards ModelsRATEResearchResearch SupportRespiratory Tract DiseasesRisksolventSolventsstatistics & numerical dataTrichloroethyleneworker1998PM:9647907h DMorgan1998157[6]15715717Morgan, R. W.Kelsh, M. A.Zhao, K.Heringer, S.Exponent Health Group, Menlo Park, CA, USAMortality of aerospace workers exposed to trichloroethyleneEpidemiologyEpidemiology424-43194NOT IN FILEAAdultadverse effectsAgedAircraftArizonaarticleAssociationAviationcancerCarcinogensCause of Deathchemically inducedclassificationCohort Studiesconfidence intervalConfidence IntervalsDiseaseepidemiologyexposureFemaleHealthHumansIndustryKidneyLeukemiaLiverliver cancerLymphomaMaleMiddle AgedmortalityNeoplasmsOccupational DiseasesOccupational ExposureProportional Hazards ModelsRATEResearchResearch SupportRespiratory Tract DiseasesRisksolventSolventsstatistics & numerical dataTrichloroethyleneworker1998PM:9647907sDyK  _ENREF_6 DNordstrom1998160[7]16016017Nordstrom, M.Hardell, L.Magnuson, A.Hagberg, H.Rask-Andersen, A.Department of Oncology, Orebro Medical CentreOccupational exposures, animal exposure and smoking as risk factors for hairy cell leukaemia evaluated in a case-control studyBr.J.CancerBr.J.Cancer2048-20527711NOT IN FILEAAdultadverse effectsageAgedAged,80 and overAnimalAnimalsarticleCase-Control StudiesCattleconfidence intervalControletiologyexposureherbicideHerbicidesHorsesHumansinsecticideInsecticidesLeukemia,Hairy CellMaleMiddle AgedmodelMultivariate AnalysisOccupational ExposureOdds Ratioorganic solventORGANIC SOLVENTSpatientPatientsPoultryrecallResearchResearch SupportRiskrisk factorRisk FactorsSexSheepSmokingsolventSolventsstudySwineUltraviolet Rays1998PM:9667691 DNordstrom1998160[7]16016017Nordstrom, M.Hardell, L.Magnuson, A.Hagberg, H.Rask-Andersen, A.Department of Oncology, Orebro Medical CentreOccupational exposures, animal exposure and smoking as risk factors for hairy cell leukaemia evaluated in a case-control studyBr.J.CancerBr.J.Cancer2048-20527711NOT IN FILEAAdultadverse effectsageAgedAged,80 and overAnimalAnimalsarticleCase-Control StudiesCattleconfidence intervalControletiologyexposureherbicideHerbicidesHorsesHumansinsecticideInsecticidesLeukemia,Hairy CellMaleMiddle AgedmodelMultivariate AnalysisOccupational ExposureOdds Ratioorganic solventORGANIC SOLVENTSpatientPatientsPoultryrecallResearchResearch SupportRiskrisk factorRisk FactorsSexSheepSmokingsolventSolventsstudySwineUltraviolet Rays1998PM:9667691sDyK  _ENREF_7DBoice2006128[8,9]12812817Boice, J. D., Jr.Marano, D. E.Cohen, S. S.Mumma, M. T.Blot, W. J.Brill, A. B.Fryzek, J. P.Henderson, B. E.McLaughlin, J. K.International Epidemiology Institute, Rockville, Maryland 20850, USA. john.boice@vanderbilt.eduMortality among Rocketdyne workers who tested rocket engines, 1948-1999J.Occup.Environ.Med.J.Occup.Environ.Med.1070-10924810NOT IN FILEAAdultadverse effectsarticleAssociationAviationCaliforniacancerchemically inducedCohort StudiesConfidence IntervalsEngineeringepidemiologyexposureFemaleHealthHumansHydrazinesIndustryLungMalemethodsMiddle AgedmortalityNeoplasmsOccupational DiseasesOccupational ExposurePopulationResearchResearch SupportRetrospective StudiesRisksolventSolventsstatistics & numerical datastudytrendsTrichloroethyleneworker2006PM:17033507Boice199912612612617Boice, J. D., Jr.Marano, D. E.Fryzek, J. P.Sadler, C. J.McLaughlin, J. K.International Epidemiology Institute, Rockville, MD 20850-3127, USAMortality among aircraft manufacturing workersOccup.Environ.Med.Occup.Environ.Med.581-597569NOT IN FILEAadverse effectsageAircraftarticleCaliforniacancerCause of Deathchemically inducedChromatesCohort StudiesdeathDiseaseepidemiologyexposureFemaleHumansLungLymphomaMalemethodsmortalityNationalNeoplasmsobtainedOccupational DiseasesOccupational ExposurePopulationRATEResearchResearch SupportRisksolventSolventsstatistics & numerical datastudyTetrachloroethylenetrendsTrichloroethyleneworker1999PM:10615290DBoice2006128[8,9]12812817Boice, J. D., Jr.Marano, D. E.Cohen, S. S.Mumma, M. T.Blot, W. J.Brill, A. B.Fryzek, J. P.Henderson, B. E.McLaughlin, J. K.International Epidemiology Institute, Rockville, Maryland 20850, USA. john.boice@vanderbilt.eduMortality among Rocketdyne workers who tested rocket engines, 1948-1999J.Occup.Environ.Med.J.Occup.Environ.Med.1070-10924810NOT IN FILEAAdultadverse effectsarticleAssociationAviationCaliforniacancerchemically inducedCohort StudiesConfidence IntervalsEngineeringepidemiologyexposureFemaleHealthHumansHydrazinesIndustryLungMalemethodsMiddle AgedmortalityNeoplasmsOccupational DiseasesOccupational ExposurePopulationResearchResearch SupportRetrospective StudiesRisksolventSolventsstatistics & numerical datastudytrendsTrichloroethyleneworker2006PM:17033507Boice199912612612617Boice, J. D., Jr.Marano, D. E.Fryzek, J. P.Sadler, C. J.McLaughlin, J. K.International Epidemiology Institute, Rockville, MD 20850-3127, USAMortality among aircraft manufacturing workersOccup.Environ.Med.Occup.Environ.Med.581-597569NOT IN FILEAadverse effectsageAircraftarticleCaliforniacancerCause of Deathchemically inducedChromatesCohort StudiesdeathDiseaseepidemiologyexposureFemaleHumansLungLymphomaMalemethodsmortalityNationalNeoplasmsobtainedOccupational DiseasesOccupational ExposurePopulationRATEResearchResearch SupportRisksolventSolventsstatistics & numerical datastudyTetrachloroethylenetrendsTrichloroethyleneworker1999PM:10615290sDyK  _ENREF_8sDyK  _ENREF_98 DDosemeci1999324[10]32432417Dosemeci, M.Cocco, P.Chow, W. H.Occupational Epidemiology Branch, National Cancer Institute, Bethesda, Maryland, USA. dosemecm@epndce.nci.nih.govGender differences in risk of renal cell carcinoma and occupational exposures to chlorinated aliphatic hydrocarbonsAm J Ind MedAm J Ind Med54-93611999/06/11AdultAgedAged, 80 and overCarcinoma, Renal Cell/*chemically induced/epidemiologyCase-Control StudiesConfidence IntervalsDisease Susceptibility/epidemiologyFemaleHumansHydrocarbons, Chlorinated/*adverse effectsKidney Neoplasms/*chemically induced/epidemiologyLogistic ModelsMaleMiddle AgedMinnesota/epidemiologyOccupational Diseases/*chemically induced/epidemiologyOccupational Exposure/*adverse effects/statistics & numerical dataOccupations/classification/statistics & numerical dataOdds RatioSex FactorsSolvents/*adverse effects1999Jul0271-3586 (Print) 0271-3586 (Linking)10361587http://www.ncbi.nlm.nih.gov/pubmed/1036158710.1002/(SICI)1097-0274(199907)36:1<54::AID-AJIM8>3.0.CO;2-0 [pii]eng8 DDosemeci1999324[10]32432417Dosemeci, M.Cocco, P.Chow, W. H.Occupational Epidemiology Branch, National Cancer Institute, Bethesda, Maryland, USA. dosemecm@epndce.nci.nih.govGender differences in risk of renal cell carcinoma and occupational exposures to chlorinated aliphatic hydrocarbonsAm J Ind MedAm J Ind Med54-93611999/06/11AdultAgedAged, 80 and overCarcinoma, Renal Cell/*chemically induced/epidemiologyCase-Control StudiesConfidence IntervalsDisease Susceptibility/epidemiologyFemaleHumansHydrocarbons, Chlorinated/*adverse effectsKidney Neoplasms/*chemically induced/epidemiologyLogistic ModelsMaleMiddle AgedMinnesota/epidemiologyOccupational Diseases/*chemically induced/epidemiologyOccupational Exposure/*adverse effects/statistics & numerical dataOccupations/classification/statistics & numerical dataOdds RatioSex FactorsSolvents/*adverse effects1999Jul0271-3586 (Print) 0271-3586 (Linking)10361587http://www.ncbi.nlm.nih.gov/pubmed/1036158710.1002/(SICI)1097-0274(199907)36:1<54::AID-AJIM8>3.0.CO;2-0 [pii]enguDyK  _ENREF_10DPersson1999166[11]16616617Persson, B.Fredrikson, M.Department of Occupational and Environmental Medicine, Centre for Public Health Sciences, Linkoping, SwedenSome risk factors for non-Hodgkin's lymphomaInt.J.Occup.Med.Environ.HealthInt.J.Occup.Med.Environ.Health135-142122NOT IN FILEAanalysisarticleAviationBenzeneCONTAMINATIONEmploymentepidemiologyetiologyexposureGasolineHealthherbicideHerbicidesHumansinformationLymphomaLymphoma,Non-HodgkinNON-HODGKIN'S LYMPHOMAobtainedOccupational DiseasesOccupational ExposureOdds RatiopainterplasticPopulationPublic HealthquestionnaireQuestionnairesRiskrisk factorRisk FactorsRubberSciencesolventSolventsstudySwedenthinnerWood1999PM:10465904DPersson1999166[11]16616617Persson, B.Fredrikson, M.Department of Occupational and Environmental Medicine, Centre for Public Health Sciences, Linkoping, SwedenSome risk factors for non-Hodgkin's lymphomaInt.J.Occup.Med.Environ.HealthInt.J.Occup.Med.Environ.Health135-142122NOT IN FILEAanalysisarticleAviationBenzeneCONTAMINATIONEmploymentepidemiologyetiologyexposureGasolineHealthherbicideHerbicidesHumansinformationLymphomaLymphoma,Non-HodgkinNON-HODGKIN'S LYMPHOMAobtainedOccupational DiseasesOccupational ExposureOdds RatiopainterplasticPopulationPublic HealthquestionnaireQuestionnairesRiskrisk factorRisk FactorsRubberSciencesolventSolventsstudySwedenthinnerWood1999PM:10465904uDyK  _ENREF_11 DPesch2000167[12]16716717Pesch, B.Haerting, J.Ranft, U.Klimpel, A.Oelschlagel, B.Schill, W.Medical Institute for Environmental Hygiene at the Heinrich Heine University of Dusseldorf, GermanyOccupational risk factors for renal cell carcinoma: agent-specific results from a case-control study in Germany. MURC Study Group. Multicenter urothelial and renal cancer studyInt.J Epidemiol.Int.J Epidemiol.1014-1024296NOT IN FILEAagearomatic hydrocarbonAROMATIC HYDROCARBONSarticleAsbestosAssociationBenzeneCadmiumcancerCarcinomaCarcinoma,Renal CellCase-Control StudiesControlDevelopmentepidemiologyexposureFemaleGermanyHabitshistoryHuman-KWHumanshydrocarbonHydrocarbonshygieneIndustryKidneyKidney NeoplasmsLeadlifestyleLogistic ModelsMalemetalMetalsmethodsMineral OilNRC 2006 documentobtainedOccupational DiseasesOccupational ExposureOdds RatiooilOilsOrdered 6-28-06organic solventORGANIC SOLVENTSORISEPaintPDFPrintingResearch Support,Non-U.S.Gov'tRiskrisk factorRisk FactorsRubberSelectedSexSmokingsolventSolventsstudyU.S.EPA,TCE Issue Papers,2005universityWelding2000PM:11101542file://L:\Lab\NCEA\TCE Documents\TCE PDFs4\ Pesch 2000.pdf DPesch2000167[12]16716717Pesch, B.Haerting, J.Ranft, U.Klimpel, A.Oelschlagel, B.Schill, W.Medical Institute for Environmental Hygiene at the Heinrich Heine University of Dusseldorf, GermanyOccupational risk factors for renal cell carcinoma: agent-specific results from a case-control study in Germany. MURC Study Group. Multicenter urothelial and renal cancer studyInt.J Epidemiol.Int.J Epidemiol.1014-1024296NOT IN FILEAagearomatic hydrocarbonAROMATIC HYDROCARBONSarticleAsbestosAssociationBenzeneCadmiumcancerCarcinomaCarcinoma,Renal CellCase-Control StudiesControlDevelopmentepidemiologyexposureFemaleGermanyHabitshistoryHuman-KWHumanshydrocarbonHydrocarbonshygieneIndustryKidneyKidney NeoplasmsLeadlifestyleLogistic ModelsMalemetalMetalsmethodsMineral OilNRC 2006 documentobtainedOccupational DiseasesOccupational ExposureOdds RatiooilOilsOrdered 6-28-06organic solventORGANIC SOLVENTSORISEPaintPDFPrintingResearch Support,Non-U.S.Gov'tRiskrisk factorRisk FactorsRubberSelectedSexSmokingsolventSolventsstudyU.S.EPA,TCE Issue Papers,2005universityWelding2000PM:11101542file://L:\Lab\NCEA\TCE Documents\TCE PDFs4\ Pesch 2000.pdfuDyK  _ENREF_12uDyK  _ENREF_13 DBruning2003131[14]13113117Bruning, T.Pesch, B.Wiesenhutter, B.Rabstein, S.Lammert, M.Baumuller, A.Bolt, H. M.Institut fur Arbeitsphysiologie an der Universitat Dortmund (IfADo), Dortmund, GermanyRenal cell cancer risk and occupational exposure to trichloroethylene: results of a consecutive case-control study in Arnsberg, GermanyAm.J.Ind.Med.Am.J.Ind.Med.274-285433NOT IN FILEAadverse effectsageAgedarticlecancerCarcinoma,Renal CellCase-Control Studieschemically inducedepidemiologyexposureFemaleGermanyhistoryhumanHumansIndustryinformationInterviews as TopicKidney NeoplasmsLogistic ModelsMaleMetallurgymethodsOccupational ExposureOccupationsResearchResearch SupportRiskRisk FactorsSmokingsolventSolventsstatistics & numerical datastudyTrichloroethylene2003PM:12594774 DBruning2003131[14]13113117Bruning, T.Pesch, B.Wiesenhutter, B.Rabstein, S.Lammert, M.Baumuller, A.Bolt, H. M.Institut fur Arbeitsphysiologie an der Universitat Dortmund (IfADo), Dortmund, GermanyRenal cell cancer risk and occupational exposure to trichloroethylene: results of a consecutive case-control study in Arnsberg, GermanyAm.J.Ind.Med.Am.J.Ind.Med.274-285433NOT IN FILEAadverse effectsageAgedarticlecancerCarcinoma,Renal CellCase-Control Studieschemically inducedepidemiologyexposureFemaleGermanyhistoryhumanHumansIndustryinformationInterviews as TopicKidney NeoplasmsLogistic ModelsMaleMetallurgymethodsOccupational ExposureOccupationsResearchResearch SupportRiskRisk FactorsSmokingsolventSolventsstatistics & numerical datastudyTrichloroethylene2003PM:12594774uDyK  _ENREF_14 DRaaschou-Nielsen2003168[15]16816817Raaschou-Nielsen, O.Hansen, J.McLaughlin, J. K.Kolstad, H.Christensen, J. M.Tarone, R. E.Olsen, J. H.Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark. ole@cancer.dkCancer risk among workers at Danish companies using trichloroethylene: a cohort studyAm.J.Epidemiol.Am.J.Epidemiol.1182-119215812NOT IN FILEAAdenocarcinomaAdultadverse effectsAgedAnimalarticleAssociationcancercancer riskCarcinomachemically inducedCohort Studiesconfidence intervalDenmarkEmploymentepidemiologyexposureFemalehumanHumansIncidenceLymphomaMaleMiddle AgedNeoplasmsNON-HODGKIN'S LYMPHOMAOccupational DiseasesOccupational ExposureProbabilityResearchResearch SupportRiskRisk AssessmentsolventSolventsstudyTime FactorstoxicityTrichloroethyleneworker2003PM:14652303 DRaaschou-Nielsen2003168[15]16816817Raaschou-Nielsen, O.Hansen, J.McLaughlin, J. K.Kolstad, H.Christensen, J. M.Tarone, R. E.Olsen, J. H.Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark. ole@cancer.dkCancer risk among workers at Danish companies using trichloroethylene: a cohort studyAm.J.Epidemiol.Am.J.Epidemiol.1182-119215812NOT IN FILEAAdenocarcinomaAdultadverse effectsAgedAnimalarticleAssociationcancercancer riskCarcinomachemically inducedCohort Studiesconfidence intervalDenmarkEmploymentepidemiologyexposureFemalehumanHumansIncidenceLymphomaMaleMiddle AgedNeoplasmsNON-HODGKIN'S LYMPHOMAOccupational DiseasesOccupational ExposureProbabilityResearchResearch SupportRiskRisk AssessmentsolventSolventsstudyTime FactorstoxicityTrichloroethyleneworker2003PM:14652303uDyK  _ENREF_15N DZhao2005184[16]18418417Zhao, Y.Krishnadasan, A.Kennedy, N.Morgenstern, H.Ritz, B.Department of Epidemiology, School of Public Health, UCLA, Los Angeles, California, USAEstimated effects of solvents and mineral oils on cancer incidence and mortality in a cohort of aerospace workersAm.J.Ind.Med.Am.J.Ind.Med.249-258484NOT IN FILEAAdultAgedaromatic hydrocarbonAROMATIC HYDROCARBONSarticleAssociationAviationBenzeneCaliforniacancerchemically inducedCohort Studiesconfidence intervalepidemiologyexposureHealthHumanshydrocarbonHydrocarbonsIncidenceKidneykidney cancerLeukemiaLunglung cancerLymphomaMaleMelanomamethodsMineral OilmodelmortalityNeoplasmsNON-HODGKIN'S LYMPHOMAOccupational DiseasesOccupational HealthoilOilsPublic HealthRATERetrospective StudiesRiskRisk AssessmentsolventSolventsStomachstudytoxicityTrichloroethyleneworker2005PM:16167347N DZhao2005184[16]18418417Zhao, Y.Krishnadasan, A.Kennedy, N.Morgenstern, H.Ritz, B.Department of Epidemiology, School of Public Health, UCLA, Los Angeles, California, USAEstimated effects of solvents and mineral oils on cancer incidence and mortality in a cohort of aerospace workersAm.J.Ind.Med.Am.J.Ind.Med.249-258484NOT IN FILEAAdultAgedaromatic hydrocarbonAROMATIC HYDROCARBONSarticleAssociationAviationBenzeneCaliforniacancerchemically inducedCohort Studiesconfidence intervalepidemiologyexposureHealthHumanshydrocarbonHydrocarbonsIncidenceKidneykidney cancerLeukemiaLunglung cancerLymphomaMaleMelanomamethodsMineral OilmodelmortalityNeoplasmsNON-HODGKIN'S LYMPHOMAOccupational DiseasesOccupational HealthoilOilsPublic HealthRATERetrospective StudiesRiskRisk AssessmentsolventSolventsStomachstudytoxicityTrichloroethyleneworker2005PM:16167347uDyK  _ENREF_16 DMiligi2006155[17]15515517Miligi, L.Costantini, A. S.Benvenuti, A.Kriebel, D.Bolejack, V.Tumino, R.Ramazzotti, V.Rodella, S.Stagnaro, E.Crosignani, P.Amadori, D.Mirabelli, D.Sommani, L.Belletti, I.Troschel, L.Romeo, L.Miceli, G.Tozzi, G. A.Mendico, I.Vineis, P.Istituto Toscano Tumori, Unit of Environmental and Occupational Epidemiology, Centre for Study and Prevention of Cancer, Via di S. Salvi 12, 50135 Florence, ItalyOccupational exposure to solvents and the risk of lymphomasEpidemiologyEpidemiology552-561175NOT IN FILEAAdultadverse effectsageAgedanalysisaromatic hydrocarbonAROMATIC HYDROCARBONSarticleAssociationBenzenecancerCase-Control Studieschlorinated hydrocarbonconfidence intervalControlDeveloped CountriesDiseaseepidemiologyetiologyexposureFemaleHodgkin DiseaseHumanshydrocarbonHydrocarbonsHydrocarbons,AromaticHydrocarbons,ChlorinatedItalyLeukemia,Lymphocytic,Chronic,B-CellLymphomaLymphoma,Non-HodgkinMalemethodsMiddle Agednonhodgkin lymphomaOccupational ExposureOdds RatioPopulationpreventionProbabilityquestionnaireResearchResearch SupportRiskrisk factorRisk FactorsSexsolventSolventsstudyTolueneXYLENE2006PM:16878041 DMiligi2006155[17]15515517Miligi, L.Costantini, A. S.Benvenuti, A.Kriebel, D.Bolejack, V.Tumino, R.Ramazzotti, V.Rodella, S.Stagnaro, E.Crosignani, P.Amadori, D.Mirabelli, D.Sommani, L.Belletti, I.Troschel, L.Romeo, L.Miceli, G.Tozzi, G. A.Mendico, I.Vineis, P.Istituto Toscano Tumori, Unit of Environmental and Occupational Epidemiology, Centre for Study and Prevention of Cancer, Via di S. Salvi 12, 50135 Florence, ItalyOccupational exposure to solvents and the risk of lymphomasEpidemiologyEpidemiology552-561175NOT IN FILEAAdultadverse effectsageAgedanalysisaromatic hydrocarbonAROMATIC HYDROCARBONSarticleAssociationBenzenecancerCase-Control Studieschlorinated hydrocarbonconfidence intervalControlDeveloped CountriesDiseaseepidemiologyetiologyexposureFemaleHodgkin DiseaseHumanshydrocarbonHydrocarbonsHydrocarbons,AromaticHydrocarbons,ChlorinatedItalyLeukemia,Lymphocytic,Chronic,B-CellLymphomaLymphoma,Non-HodgkinMalemethodsMiddle Agednonhodgkin lymphomaOccupational ExposureOdds RatioPopulationpreventionProbabilityquestionnaireResearchResearch SupportRiskrisk factorRisk FactorsSexsolventSolventsstudyTolueneXYLENE2006PM:16878041uDyK  _ENREF_178 DCharbotel2006132[18]13213217Charbotel, B.Fevotte, J.Hours, M.Martin, J. L.Bergeret, A.Epidemiological Research and Surveillance Unit in Transport, Occupation and Environment, Universite Claude Bernard Lyon 1, F-69373 Lyon, France. barbara.charbotel@rockefeller.univ-lyon1.frCase-control study on renal cell cancer and occupational exposure to trichloroethylene. Part II: Epidemiological aspectsAnn.Occup.Hyg.Ann.Occup.Hyg.777-787508NOT IN FILEAadverse effectsageAgedAged,80 and overanalysisarticleAssociationcancerCarcinogensCarcinoma,Renal CellCase-Control Studieschemically inducedEnvironmentepidemiologyexposureFemaleFranceHumansIndustryKidney NeoplasmsMalemethodsMiddle AgedOccupational ExposureResearchResearch SupportRetrospective StudiesRiskRisk AssessmentSelectedSmokingsolventSolventsstudytoxicityTrichloroethylene2006PM:168404358 DCharbotel2006132[18]13213217Charbotel, B.Fevotte, J.Hours, M.Martin, J. L.Bergeret, A.Epidemiological Research and Surveillance Unit in Transport, Occupation and Environment, Universite Claude Bernard Lyon 1, F-69373 Lyon, France. barbara.charbotel@rockefeller.univ-lyon1.frCase-control study on renal cell cancer and occupational exposure to trichloroethylene. Part II: Epidemiological aspectsAnn.Occup.Hyg.Ann.Occup.Hyg.777-787508NOT IN FILEAadverse effectsageAgedAged,80 and overanalysisarticleAssociationcancerCarcinogensCarcinoma,Renal CellCase-Control Studieschemically inducedEnvironmentepidemiologyexposureFemaleFranceHumansIndustryKidney NeoplasmsMalemethodsMiddle AgedOccupational ExposureResearchResearch SupportRetrospective StudiesRiskRisk AssessmentSelectedSmokingsolventSolventsstudytoxicityTrichloroethylene2006PM:16840435uDyK  _ENREF_18 DRadican2008169[19]16916917Radican, L.Blair, A.Stewart, P.Wartenberg, D.Global Outcomes Research Department, Merck and Co, Inc, NJ 08889, USA. larry_radican@merck.comMortality of aircraft maintenance workers exposed to trichloroethylene and other hydrocarbons and chemicals: extended follow-upJ.Occup.Environ.Med.J.Occup.Environ.Med.1306-13195011NOT IN FILEadverse effectsAgedAged,80 and overAircraftarticleAssociationcancerCause of Deathchemically induceddeathepidemiologyexposureFemalefollow upFollow-Up StudiesHumanshydrocarbonHydrocarbonsliteratureMaintenanceMalemethodsMiddle AgedmodelmortalityOccupational DiseasesOccupational ExposurePrivate SectorProportional Hazards ModelsResearchResearch SupportRiskRisk AssessmenttrendsTrichloroethyleneUtahVital Statisticsworker2008PM:19001957 DRadican2008169[19]16916917Radican, L.Blair, A.Stewart, P.Wartenberg, D.Global Outcomes Research Department, Merck and Co, Inc, NJ 08889, USA. larry_radican@merck.comMortality of aircraft maintenance workers exposed to trichloroethylene and other hydrocarbons and chemicals: extended follow-upJ.Occup.Environ.Med.J.Occup.Environ.Med.1306-13195011NOT IN FILEadverse effectsAgedAged,80 and overAircraftarticleAssociationcancerCause of Deathchemically induceddeathepidemiologyexposureFemalefollow upFollow-Up StudiesHumanshydrocarbonHydrocarbonsliteratureMaintenanceMalemethodsMiddle AgedmodelmortalityOccupational DiseasesOccupational ExposurePrivate SectorProportional Hazards ModelsResearchResearch SupportRiskRisk AssessmenttrendsTrichloroethyleneUtahVital Statisticsworker2008PM:19001957uDyK  _ENREF_19, DBlair1998125[20]12512517Blair, A.Hartge, P.Stewart, P. A.McAdams, M.Lubin, J.Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892-7364, USAMortality and cancer incidence of aircraft maintenance workers exposed to trichloroethylene and other organic solvents and chemicals: extended follow upOccup.Environ.Med.Occup.Environ.Med.161-171553NOT IN FILEAAccidentsadverse effectsageAircraftarticleAssociationAsthmaAviationcancerCohort StudiesDiseaseepidemiologyexposureFemalegeneticsHumansIncidenceLiverLymphomaMalemethodsmortalityMultiple MyelomaMyocardial IschemiaNationalNeoplasmsOccupational ExposurePopulationResearchResearch SupportRetrospective StudiesRisksolventSolventsstudyTime FactorsTrichloroethyleneUtahworker1998PM:9624267, DBlair1998125[20]12512517Blair, A.Hartge, P.Stewart, P. A.McAdams, M.Lubin, J.Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892-7364, USAMortality and cancer incidence of aircraft maintenance workers exposed to trichloroethylene and other organic solvents and chemicals: extended follow upOccup.Environ.Med.Occup.Environ.Med.161-171553NOT IN FILEAAccidentsadverse effectsageAircraftarticleAssociationAsthmaAviationcancerCohort StudiesDiseaseepidemiologyexposureFemalegeneticsHumansIncidenceLiverLymphomaMalemethodsmortalityMultiple MyelomaMyocardial IschemiaNationalNeoplasmsOccupational ExposurePopulationResearchResearch SupportRetrospective StudiesRisksolventSolventsstudyTime FactorsTrichloroethyleneUtahworker1998PM:9624267uDyK  _ENREF_20 DWang2009179[21]17917917Wang, R.Zhang, Y.Lan, Q.Holford, T. R.Leaderer, B.Zahm, S. H.Boyle, P.Dosemeci, M.Rothman, N.Zhu, Y.Qin, Q.Zheng, T.Division of Environmental Health Sciences, Yale University School of Public Health, New Haven, Connecticut 06520-8034, USAOccupational exposure to solvents and risk of non-Hodgkin lymphoma in Connecticut womenAm.J.Epidemiol.Am.J.Epidemiol.176-1851692NOT IN FILEAAdultadverse effectsAgedAged,80 and overarticleAssociationBenzeneCarbonCarbon TetrachlorideCase-Control Studieschemically inducedconfidence intervalConfidence IntervalsConnecticutControlEnvironmental HealthepidemiologyexposureFemaleFormaldehydeHealthHumansLymphomaLymphoma,Non-HodgkinMiddle Agednonhodgkin lymphomaOccupational DiseasesOccupational ExposureOdds Ratioorganic solventORGANIC SOLVENTSProbabilityPublic HealthResearchResearch SupportRiskRisk AssessmentSciencesolventSolventsstudytoxicityuniversity2009PM:19056833 DWang2009179[21]17917917Wang, R.Zhang, Y.Lan, Q.Holford, T. R.Leaderer, B.Zahm, S. H.Boyle, P.Dosemeci, M.Rothman, N.Zhu, Y.Qin, Q.Zheng, T.Division of Environmental Health Sciences, Yale University School of Public Health, New Haven, Connecticut 06520-8034, USAOccupational exposure to solvents and risk of non-Hodgkin lymphoma in Connecticut womenAm.J.Epidemiol.Am.J.Epidemiol.176-1851692NOT IN FILEAAdultadverse effectsAgedAged,80 and overarticleAssociationBenzeneCarbonCarbon TetrachlorideCase-Control Studieschemically inducedconfidence intervalConfidence IntervalsConnecticutControlEnvironmental HealthepidemiologyexposureFemaleFormaldehydeHealthHumansLymphomaLymphoma,Non-HodgkinMiddle Agednonhodgkin lymphomaOccupational DiseasesOccupational ExposureOdds Ratioorganic solventORGANIC SOLVENTSProbabilityPublic HealthResearchResearch SupportRiskRisk AssessmentSciencesolventSolventsstudytoxicityuniversity2009PM:19056833uDyK  _ENREF_21 DMoore2010236[22]23623617Moore, L. E.Boffetta, P.Karami, S.Brennan, P.Stewart, P. S.Hung, R.Zaridze, D.Matveev, V.Janout, V.Kollarova, H.Bencko, V.Navratilova, M.Szeszenia-Dabrowska, N.Mates, D.Gromiec, J.Holcatova, I.Merino, M.Chanock, S.Chow, W. H.Rothman, N.Division of Cancer Epidemiology and Genetics, NIH, National Cancer Institute, NIH, Bethesda, Maryland 20852, USA. moorele@mail.nih.govOccupational trichloroethylene exposure and renal carcinoma risk: evidence of genetic susceptibility by reductive metabolism gene variantsCancer ResCancer Res6527-3670162010/07/29Carbon-Sulfur Lyases/genetics/metabolismCase-Control Studies*CocarcinogenesisFemaleGenetic Predisposition to DiseaseGlutathione Transferase/genetics/metabolismHumansKidney Neoplasms/*chemically induced/enzymology/*geneticsMaleOccupational Exposure/*adverse effectsPolymorphism, Single NucleotideTrichloroethylene/*poisoning2010Aug 151538-7445 (Electronic) 0008-5472 (Linking)20663906http://www.ncbi.nlm.nih.gov/pubmed/2066390629224180008-5472.CAN-09-4167 [pii] 10.1158/0008-5472.CAN-09-4167eng DMoore2010236[22]23623617Moore, L. E.Boffetta, P.Karami, S.Brennan, P.Stewart, P. S.Hung, R.Zaridze, D.Matveev, V.Janout, V.Kollarova, H.Bencko, V.Navratilova, M.Szeszenia-Dabrowska, N.Mates, D.Gromiec, J.Holcatova, I.Merino, M.Chanock, S.Chow, W. H.Rothman, N.Division of Cancer Epidemiology and Genetics, NIH, National Cancer Institute, NIH, Bethesda, Maryland 20852, USA. moorele@mail.nih.govOccupational trichloroethylene exposure and renal carcinoma risk: evidence of genetic susceptibility by reductive metabolism gene variantsCancer ResCancer Res6527-3670162010/07/29Carbon-Sulfur Lyases/genetics/metabolismCase-Control Studies*CocarcinogenesisFemaleGenetic Predisposition to DiseaseGlutathione Transferase/genetics/metabolismHumansKidney Neoplasms/*chemically induced/enzymology/*geneticsMaleOccupational Exposure/*adverse effectsPolymorphism, Single NucleotideTrichloroethylene/*poisoning2010Aug 151538-7445 (Electronic) 0008-5472 (Linking)20663906http://www.ncbi.nlm.nih.gov/pubmed/2066390629224180008-5472.CAN-09-4167 [pii] 10.1158/0008-5472.CAN-09-4167enguDyK  _ENREF_22 DCocco2010232[23]23223217Cocco, P.t'Mannetje, A.Fadda, D.Melis, M.Becker, N.de Sanjose, S.Foretova, L.Mareckova, J.Staines, A.Kleefeld, S.Maynadie, M.Nieters, A.Brennan, P.Boffetta, P.Department of Public Health, Occupational Health Section, University of Cagliari, Asse Didattico - Policlinico Universitario, SS 554, km 4,500, 09042 Monserrato (Cagliari), Italy. coccop@medicina.unica.itOccupational exposure to solvents and risk of lymphoma subtypes: results from the Epilymph case-control studyOccup Environ MedOccup Environ Med341-76752010/05/08AdultAgedAged, 80 and overBenzene/*toxicityCase-Control StudiesEurope/epidemiologyFemaleHodgkin Disease/chemically induced/*epidemiologyHumansLymphoma, Non-Hodgkin/chemically induced/*epidemiologyLymphoma, T-Cell/chemically induced/epidemiologyMaleMiddle AgedOccupational Diseases/chemically induced/*epidemiologyOccupational Exposure/*adverse effectsRisk FactorsSolvents/*toxicity2010May1470-7926 (Electronic) 1351-0711 (Linking)20447988http://www.ncbi.nlm.nih.gov/pubmed/2044798867/5/341 [pii] 10.1136/oem.2009.046839eng DCocco2010232[23]23223217Cocco, P.t'Mannetje, A.Fadda, D.Melis, M.Becker, N.de Sanjose, S.Foretova, L.Mareckova, J.Staines, A.Kleefeld, S.Maynadie, M.Nieters, A.Brennan, P.Boffetta, P.Department of Public Health, Occupational Health Section, University of Cagliari, Asse Didattico - Policlinico Universitario, SS 554, km 4,500, 09042 Monserrato (Cagliari), Italy. coccop@medicina.unica.itOccupational exposure to solvents and risk of lymphoma subtypes: results from the Epilymph case-control studyOccup Environ MedOccup Environ Med341-76752010/05/08AdultAgedAged, 80 and overBenzene/*toxicityCase-Control StudiesEurope/epidemiologyFemaleHodgkin Disease/chemically induced/*epidemiologyHumansLymphoma, Non-Hodgkin/chemically induced/*epidemiologyLymphoma, T-Cell/chemically induced/epidemiologyMaleMiddle AgedOccupational Diseases/chemically induced/*epidemiologyOccupational Exposure/*adverse effectsRisk FactorsSolvents/*toxicity2010May1470-7926 (Electronic) 1351-0711 (Linking)20447988http://www.ncbi.nlm.nih.gov/pubmed/2044798867/5/341 [pii] 10.1136/oem.2009.046839enguDyK  _ENREF_23uDyK  _ENREF_24$$If!vh55 5x#v#v #vx:V :4 t'55 5x/ 44 :f4ytwT$$If!vh55 5x#v#v #vx:V :4 t'55 5x/ 44 :f4yt8ETt$$If!vh5'#v':V :4 t'5'/ 44 :f4yt8ETuDyK  _ENREF_25uDyK  _ENREF_26uDyK  _ENREF_27$$If!vh55 5x#v#v #vx:V :4 t'55 5x44 :f4yt8ETuDyK  _ENREF_28DIsacson1985519[29]51951917Isacson, P.Bean, J. A.Splinter, R.Olson, D. B.Kohler, J.Drinking water and cancer incidence in Iowa. III. Association of cancer with indices of contaminationAm J EpidemiolAm J Epidemiol856-6912161985/06/01AdolescentAdultAgedCarcinogens, Environmental/*analysisChildChild, PreschoolChlorineColonic Neoplasms/epidemiologyEthylene Dichlorides/analysisFemaleHumansInfantIowaLung Neoplasms/epidemiologyMaleMiddle AgedNeoplasms/chemically induced/*epidemiologyNickel/analysisRectal Neoplasms/epidemiologyRiskSocioeconomic FactorsTetrachloroethylene/analysisTrichloroethanes/analysisTrichloroethylene/analysisUrinary Bladder Neoplasms/epidemiologyWater Pollutants/*adverse effectsWater Pollutants, Chemical/*adverse effects1985Jun0002-9262 (Print) 0002-9262 (Linking)4014178http://www.ncbi.nlm.nih.gov/pubmed/4014178engDIsacson1985519[29]51951917Isacson, P.Bean, J. A.Splinter, R.Olson, D. B.Kohler, J.Drinking water and cancer incidence in Iowa. III. Association of cancer with indices of contaminationAm J EpidemiolAm J Epidemiol856-6912161985/06/01AdolescentAdultAgedCarcinogens, Environmental/*analysisChildChild, PreschoolChlorineColonic Neoplasms/epidemiologyEthylene Dichlorides/analysisFemaleHumansInfantIowaLung Neoplasms/epidemiologyMaleMiddle AgedNeoplasms/chemically induced/*epidemiologyNickel/analysisRectal Neoplasms/epidemiologyRiskSocioeconomic FactorsTetrachloroethylene/analysisTrichloroethanes/analysisTrichloroethylene/analysisUrinary Bladder Neoplasms/epidemiologyWater Pollutants/*adverse effectsWater Pollutants, Chemical/*adverse effects1985Jun0002-9262 (Print) 0002-9262 (Linking)4014178http://www.ncbi.nlm.nih.gov/pubmed/4014178enguDyK  _ENREF_29uDyK  _ENREF_30v DGarabrant1988139[31]13913917Garabrant, D. H.Held, J.Langholz, B.Bernstein, L.Mortality of aircraft manufacturing workers in Southern CaliforniaAm J Ind MedAm J Ind Med683-694136NOT IN FILE11/06/2007AAircraftBiochemistryBowler-Neurotox-Nov.2007BrainCaliforniacancerCarcinogensCopy Citation Back to TCE dbdeathDiseaseEcologyEmploymentEnvironmental Pollutantsexposurefollow upGenitaliaHominidaehumanHuman-KWMelanomaMorbiditymortalityNationalNecrosisNeoplasmsNervous SystemNervous System DiseasesNRC 2006 documentobtainedOccupational DiseasesOccupational Health ServicesOct.2007 Neurotox TaskOrdered 6-28-06ORISEpathologyPDFphysiopathologypoisoningPublic Health AdministrationRATEReproductionRiskSelectedSkin DiseasesSocial BehaviorStatisticsstudyToxicologyTOXLINE no TCE in titleU.S.EPA,TCE Issue Papers,2005worker1988PM:3389363file://L:\Lab\NCEA\TCE Documents\TCE PDFs4\ Garabrant 1988.pdfv DGarabrant1988139[31]13913917Garabrant, D. H.Held, J.Langholz, B.Bernstein, L.Mortality of aircraft manufacturing workers in Southern CaliforniaAm J Ind MedAm J Ind Med683-694136NOT IN FILE11/06/2007AAircraftBiochemistryBowler-Neurotox-Nov.2007BrainCaliforniacancerCarcinogensCopy Citation Back to TCE dbdeathDiseaseEcologyEmploymentEnvironmental Pollutantsexposurefollow upGenitaliaHominidaehumanHuman-KWMelanomaMorbiditymortalityNationalNecrosisNeoplasmsNervous SystemNervous System DiseasesNRC 2006 documentobtainedOccupational DiseasesOccupational Health ServicesOct.2007 Neurotox TaskOrdered 6-28-06ORISEpathologyPDFphysiopathologypoisoningPublic Health AdministrationRATEReproductionRiskSelectedSkin DiseasesSocial BehaviorStatisticsstudyToxicologyTOXLINE no TCE in titleU.S.EPA,TCE Issue Papers,2005worker1988PM:3389363file://L:\Lab\NCEA\TCE Documents\TCE PDFs4\ Garabrant 1988.pdfuDyK  _ENREF_31uDyK  _ENREF_32DBlair1989123[33]12312317Blair, A.Haas, T.Prosser, R.Morrissette, M.Blackman, K.Grauman, D.van, Dusen P.Moran, F.Epidemiology and Biostatistics Program, National Cancer Institute, Bethesda, MarylandMortality among United States Coast Guard marine inspectorsArch.Environ.HealthArch.Environ.Health150-156443NOT IN FILEAAccidentsAccidents,TrafficAdultageAge DistributionarticlecancerCause of DeathdeathDevelopmentDiseaseEnvironmental ExposureepidemiologyexposureHematopoietic SystemhistoryHumansLeukemiaLiverliver cancerLiver CirrhosisLiver NeoplasmsMaleMiddle AgedmortalityMyeloproliferative DisordersNationalobtainedPopulationProbabilityRATEShipsUnited States1989PM:2751350DBlair1989123[33]12312317Blair, A.Haas, T.Prosser, R.Morrissette, M.Blackman, K.Grauman, D.van, Dusen P.Moran, F.Epidemiology and Biostatistics Program, National Cancer Institute, Bethesda, MarylandMortality among United States Coast Guard marine inspectorsArch.Environ.HealthArch.Environ.Health150-156443NOT IN FILEAAccidentsAccidents,TrafficAdultageAge DistributionarticlecancerCause of DeathdeathDevelopmentDiseaseEnvironmental ExposureepidemiologyexposureHematopoietic SystemhistoryHumansLeukemiaLiverliver cancerLiver CirrhosisLiver NeoplasmsMaleMiddle AgedmortalityMyeloproliferative DisordersNationalobtainedPopulationProbabilityRATEShipsUnited States1989PM:2751350uDyK  _ENREF_33uDyK  _ENREF_34uDyK  _ENREF_35uDyK  _ENREF_36uDyK  _ENREF_37uDyK  _ENREF_38uDyK  _ENREF_39DVartiainen1993560[40]56056017Vartiainen, T.Pukkala, E.Rienoja, T.Strandman, T.Kaksonen, K.Vartiainen, T Natl Publ Hlth Inst,Div Environm Hlth,Pob 95,Sf-70701 Kuopio,Finland Natl Publ Hlth Inst,Div Environm Hlth,Pob 95,Sf-70701 Kuopio,Finland Finnish Canc Registry,Sf-00170 Helsinki,Finland Hlth Ctr Riihimaki Dist,Sf-11101 Riihimaki,Finland Hlth Ctr Hameenlinna Dist,Sf-13111 Hameenlinna,FinlandPopulation Exposure to Trichloroethene and Tetrachloroethene and Cancer Risk - 2 Cases of Drinking-Water PollutionChemosphereChemosphereChemosphereChemosphereChemosphereChemosphere1171-1181277trichloroethenetetrachloroethenedichloroacetic acidtrichloroacetic aciddrinking waterenvironmental exposureliver cancernon-hodgkins lymphomashodgkins diseasemultiple myelomaleukemiaoccupational exposuremetabolismpharmacokineticscarcinogenicitycontaminationrats1993Sep0045-6535ISI:A1993LY92100005<Go to ISI>://A1993LY92100005EnglishDVartiainen1993560[40]56056017Vartiainen, T.Pukkala, E.Rienoja, T.Strandman, T.Kaksonen, K.Vartiainen, T Natl Publ Hlth Inst,Div Environm Hlth,Pob 95,Sf-70701 Kuopio,Finland Natl Publ Hlth Inst,Div Environm Hlth,Pob 95,Sf-70701 Kuopio,Finland Finnish Canc Registry,Sf-00170 Helsinki,Finland Hlth Ctr Riihimaki Dist,Sf-11101 Riihimaki,Finland Hlth Ctr Hameenlinna Dist,Sf-13111 Hameenlinna,FinlandPopulation Exposure to Trichloroethene and Tetrachloroethene and Cancer Risk - 2 Cases of Drinking-Water PollutionChemosphereChemosphereChemosphereChemosphereChemosphereChemosphere1171-1181277trichloroethenetetrachloroethenedichloroacetic acidtrichloroacetic aciddrinking waterenvironmental exposureliver cancernon-hodgkins lymphomashodgkins diseasemultiple myelomaleukemiaoccupational exposuremetabolismpharmacokineticscarcinogenicitycontaminationrats1993Sep0045-6535ISI:A1993LY92100005<Go to ISI>://A1993LY92100005EnglishuDyK  _ENREF_40uDyK  _ENREF_41uDyK  _ENREF_42uDyK  _ENREF_43DChang2003576[44,45]57657617Chang, Y. M.Tai, C. F.Yang, S. C.Chen, C. J.Shih, T. S.Lin, R. S.Liou, S. H.Graduate Institute of Life Sciences, National Defense Medical Center, Institute of Occupational Safety and Health, Council of Labor Affairs, Executive Yuan, Taipei, Taiwan, Republic of China.A cohort mortality study of workers exposed to chlorinated organic solvents in TaiwanAnn EpidemiolAnn Epidemiol652-601392004/01/21AdultCohort StudiesFemaleHumansMaleMiddle AgedNeoplasms/*chemically induced/mortality*Occupational ExposureRetrospective StudiesSolvents/toxicityTaiwan/epidemiologyTetrachloroethylene/*toxicityTime FactorsTrichloroethylene/*toxicity2003Oct1047-2797 (Print) 1047-2797 (Linking)14732305http://www.ncbi.nlm.nih.gov/pubmed/1473230510.1016/S1047-2797(03)00038-3 S1047279703000383 [pii]engChang200557557557517Chang, Y. M.Tai, C. F.Yang, S. C.Lin, R. S.Sung, F. C.Shih, T. S.Liou, S. H.Graduate Institute of Life Sciences, National Defense Medical Center, National Defense University, Taiwan, Republic of China.Cancer incidence among workers potentially exposed to chlorinated solvents in an electronics factoryJ Occup HealthJ Occup Health171-804722005/04/13AdultAged*ElectronicsFemaleHumansHydrocarbons, Chlorinated/*adverse effectsIncidenceMaleMiddle AgedNeoplasms/*chemically induced/epidemiology*Occupational Exposure*Occupational HealthRegistriesRetrospective StudiesSolvents/*adverse effectsTaiwan/epidemiologyTime Factors2005Mar1341-9145 (Print) 1341-9145 (Linking)15824483http://www.ncbi.nlm.nih.gov/pubmed/15824483JST.JSTAGE/joh/47.171 [pii]engDChang2003576[44,45]57657617Chang, Y. M.Tai, C. F.Yang, S. C.Chen, C. J.Shih, T. S.Lin, R. S.Liou, S. H.Graduate Institute of Life Sciences, National Defense Medical Center, Institute of Occupational Safety and Health, Council of Labor Affairs, Executive Yuan, Taipei, Taiwan, Republic of China.A cohort mortality study of workers exposed to chlorinated organic solvents in TaiwanAnn EpidemiolAnn Epidemiol652-601392004/01/21AdultCohort StudiesFemaleHumansMaleMiddle AgedNeoplasms/*chemically induced/mortality*Occupational ExposureRetrospective StudiesSolvents/toxicityTaiwan/epidemiologyTetrachloroethylene/*toxicityTime FactorsTrichloroethylene/*toxicity2003Oct1047-2797 (Print) 1047-2797 (Linking)14732305http://www.ncbi.nlm.nih.gov/pubmed/1473230510.1016/S1047-2797(03)00038-3 S1047279703000383 [pii]engChang200557557557517Chang, Y. M.Tai, C. F.Yang, S. C.Lin, R. S.Sung, F. C.Shih, T. S.Liou, S. H.Graduate Institute of Life Sciences, National Defense Medical Center, National Defense University, Taiwan, Republic of China.Cancer incidence among workers potentially exposed to chlorinated solvents in an electronics factoryJ Occup HealthJ Occup Health171-804722005/04/13AdultAged*ElectronicsFemaleHumansHydrocarbons, Chlorinated/*adverse effectsIncidenceMaleMiddle AgedNeoplasms/*chemically induced/epidemiology*Occupational Exposure*Occupational HealthRegistriesRetrospective StudiesSolvents/*adverse effectsTaiwan/epidemiologyTime Factors2005Mar1341-9145 (Print) 1341-9145 (Linking)15824483http://www.ncbi.nlm.nih.gov/pubmed/15824483JST.JSTAGE/joh/47.171 [pii]enguDyK  _ENREF_44uDyK  _ENREF_45~ DCoyle2005584[46]58458417Coyle, Y. M.Hynan, L. S.Euhus, D. M.Minhajuddin, A. T.Department of Internal Medicine, Hamon Center for Therapeutic Oncology Research, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390-9103, USA. yvonne.coyle@utsouthwestern.eduAn ecological study of the association of environmental chemicals on breast cancer incidence in TexasBreast Cancer Res TreatBreast Cancer Res Treat107-149222005/06/30AdolescentAdultAge DistributionAgedAged, 80 and overBreast Neoplasms/epidemiology/*etiologyBreast Neoplasms, Male/epidemiology/etiologyChildChild, PreschoolEnvironmental Exposure/*adverse effectsEthnic Groups/statistics & numerical dataFemaleHazardous Substances/*adverse effectsHumansInfantInfant, NewbornLinear ModelsMaleMetals/*adverse effectsMiddle AgedMultivariate AnalysisRiskSex DistributionStyrene/adverse effectsTexas/epidemiology2005Jul0167-6806 (Print) 0167-6806 (Linking)15986119http://www.ncbi.nlm.nih.gov/pubmed/1598611910.1007/s10549-004-8268-zeng~ DCoyle2005584[46]58458417Coyle, Y. M.Hynan, L. S.Euhus, D. M.Minhajuddin, A. T.Department of Internal Medicine, Hamon Center for Therapeutic Oncology Research, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390-9103, USA. yvonne.coyle@utsouthwestern.eduAn ecological study of the association of environmental chemicals on breast cancer incidence in TexasBreast Cancer Res TreatBreast Cancer Res Treat107-149222005/06/30AdolescentAdultAge DistributionAgedAged, 80 and overBreast Neoplasms/epidemiology/*etiologyBreast Neoplasms, Male/epidemiology/etiologyChildChild, PreschoolEnvironmental Exposure/*adverse effectsEthnic Groups/statistics & numerical dataFemaleHazardous Substances/*adverse effectsHumansInfantInfant, NewbornLinear ModelsMaleMetals/*adverse effectsMiddle AgedMultivariate AnalysisRiskSex DistributionStyrene/adverse effectsTexas/epidemiology2005Jul0167-6806 (Print) 0167-6806 (Linking)15986119http://www.ncbi.nlm.nih.gov/pubmed/1598611910.1007/s10549-004-8268-zenguDyK  _ENREF_46uDyK  _ENREF_47uDyK  _ENREF_48~DSung2007582[49,50]58258217Sung, T. I.Chen, P. C.Jyuhn-Hsiarn Lee, L.Lin, Y. P.Hsieh, G. Y.Wang, J. D.Institute of Occupational Medicine and Industrial Hygiene, National Taiwan University College of Public Health, Taipei, Taiwan. d91841001@ntu.edu.tw <d91841001@ntu.edu.tw>Increased standardized incidence ratio of breast cancer in female electronics workersBMC Public HealthBMC Public Health10272007/06/15AdultAge FactorsBreast Neoplasms/chemically induced/*epidemiologyElectronicsFemaleFollow-Up StudiesHazardous WasteHumansHydrocarbons, Chlorinated/*toxicityIncidenceMedical Record LinkageMiddle AgedNeoplasms/epidemiologyOccupational Diseases/chemically induced/*epidemiologyOccupational Exposure/*adverse effects/statistics & numerical dataRetrospective StudiesSolvents/*toxicityTaiwan/epidemiologyTime FactorsTrichloroethylene/toxicity20071471-2458 (Electronic) 1471-2458 (Linking)17559641http://www.ncbi.nlm.nih.gov/pubmed/1755964119067571471-2458-7-102 [pii] 10.1186/1471-2458-7-102engSung200858158158117Sung, T. I.Wang, J. D.Chen, P. C.Institute of Occupational Medicine and Industrial Hygiene, National Taiwan University College of Public Health, Taipei, Taiwan.Increased risk of cancer in the offspring of female electronics workersReprod ToxicolReprod Toxicol115-92512007/10/10AdolescentChildChild, Preschool*Electronics/statistics & numerical dataFemaleHumansIncidenceInfantLeukemia/chemically induced/epidemiology/*etiologyMale*Maternal ExposureNeoplasms/chemically induced/epidemiology/*etiologyOccupational Diseases/chemically induced/epidemiology/*etiology*Occupational ExposurePoisson DistributionPregnancy*Prenatal Exposure Delayed EffectsRetrospective StudiesRisk AssessmentRisk FactorsSolvents/*adverse effectsTaiwan/epidemiology2008Jan0890-6238 (Print) 0890-6238 (Linking)17923386http://www.ncbi.nlm.nih.gov/pubmed/17923386S0890-6238(07)00277-8 [pii] 10.1016/j.reprotox.2007.08.004eng~DSung2007582[49,50]58258217Sung, T. I.Chen, P. C.Jyuhn-Hsiarn Lee, L.Lin, Y. P.Hsieh, G. Y.Wang, J. D.Institute of Occupational Medicine and Industrial Hygiene, National Taiwan University College of Public Health, Taipei, Taiwan. d91841001@ntu.edu.tw <d91841001@ntu.edu.tw>Increased standardized incidence ratio of breast cancer in female electronics workersBMC Public HealthBMC Public Health10272007/06/15AdultAge FactorsBreast Neoplasms/chemically induced/*epidemiologyElectronicsFemaleFollow-Up StudiesHazardous WasteHumansHydrocarbons, Chlorinated/*toxicityIncidenceMedical Record LinkageMiddle AgedNeoplasms/epidemiologyOccupational Diseases/chemically induced/*epidemiologyOccupational Exposure/*adverse effects/statistics & numerical dataRetrospective StudiesSolvents/*toxicityTaiwan/epidemiologyTime FactorsTrichloroethylene/toxicity20071471-2458 (Electronic) 1471-2458 (Linking)17559641http://www.ncbi.nlm.nih.gov/pubmed/1755964119067571471-2458-7-102 [pii] 10.1186/1471-2458-7-102engSung200858158158117Sung, T. I.Wang, J. D.Chen, P. C.Institute of Occupational Medicine and Industrial Hygiene, National Taiwan University College of Public Health, Taipei, Taiwan.Increased risk of cancer in the offspring of female electronics workersReprod ToxicolReprod Toxicol115-92512007/10/10AdolescentChildChild, Preschool*Electronics/statistics & numerical dataFemaleHumansIncidenceInfantLeukemia/chemically induced/epidemiology/*etiologyMale*Maternal ExposureNeoplasms/chemically induced/epidemiology/*etiologyOccupational Diseases/chemically induced/epidemiology/*etiology*Occupational ExposurePoisson DistributionPregnancy*Prenatal Exposure Delayed EffectsRetrospective StudiesRisk AssessmentRisk FactorsSolvents/*adverse effectsTaiwan/epidemiology2008Jan0890-6238 (Print) 0890-6238 (Linking)17923386http://www.ncbi.nlm.nih.gov/pubmed/17923386S0890-6238(07)00277-8 [pii] 10.1016/j.reprotox.2007.08.004enguDyK  _ENREF_49uDyK  _ENREF_50$$If!vh55 5x#v#v #vx:V :4 t'55 5x44 :f4yt8ETuDyK  _ENREF_51uDyK  _ENREF_52uDyK  _ENREF_53uDyK  _ENREF_54uDyK  _ENREF_55uDyK  _ENREF_56uDyK  _ENREF_57uDyK  _ENREF_58j DKernan1999636[59]63663617Kernan, G. J.Ji, B. T.Dosemeci, M.Silverman, D. T.Balbus, J.Zahm, S. H.WS Atkins-Polska Ltd., Warsaw, Poland.Occupational risk factors for pancreatic cancer: a case-control study based on death certificates from 24 U.S. statesAm J Ind MedAm J Ind Med260-703621999/07/10African Continental Ancestry GroupCase-Control StudiesChemical IndustryCommunicationConfidence IntervalsDeath CertificatesDisinfectants/adverse effectsEuropean Continental Ancestry GroupFemaleFormaldehyde/adverse effectsHealth OccupationsHumansMaleOccupational Diseases/*mortalityOccupational ExposureOdds RatioPancreatic Neoplasms/*mortalityPaperPetroleumPopulation SurveillancePrintingRisk FactorsSex FactorsSolvents/adverse effectsTransportationUnited States/epidemiology1999Aug0271-3586 (Print) 0271-3586 (Linking)10398934http://www.ncbi.nlm.nih.gov/pubmed/1039893410.1002/(SICI)1097-0274(199908)36:2<260::AID-AJIM5>3.0.CO;2-P [pii]engj DKernan1999636[59]63663617Kernan, G. J.Ji, B. T.Dosemeci, M.Silverman, D. T.Balbus, J.Zahm, S. H.WS Atkins-Polska Ltd., Warsaw, Poland.Occupational risk factors for pancreatic cancer: a case-control study based on death certificates from 24 U.S. statesAm J Ind MedAm J Ind Med260-703621999/07/10African Continental Ancestry GroupCase-Control StudiesChemical IndustryCommunicationConfidence IntervalsDeath CertificatesDisinfectants/adverse effectsEuropean Continental Ancestry GroupFemaleFormaldehyde/adverse effectsHealth OccupationsHumansMaleOccupational Diseases/*mortalityOccupational ExposureOdds RatioPancreatic Neoplasms/*mortalityPaperPetroleumPopulation SurveillancePrintingRisk FactorsSex FactorsSolvents/adverse effectsTransportationUnited States/epidemiology1999Aug0271-3586 (Print) 0271-3586 (Linking)10398934http://www.ncbi.nlm.nih.gov/pubmed/1039893410.1002/(SICI)1097-0274(199908)36:2<260::AID-AJIM5>3.0.CO;2-P [pii]enguDyK  _ENREF_59DShu2004641[60,61]64164117Shu, X. O.Perentesis, J. P.Wen, W.Buckley, J. D.Boyle, E.Ross, J. A.Robison, L. L.Vanderbilt-Ingram Cancer Center and Vanderbilt Center for Health Services Research, Vanderbilt University, Nashville, Tennessee, USA. Xiao-Ou.Shu@vanderbilt.eduParental exposure to medications and hydrocarbons and ras mutations in children with acute lymphoblastic leukemia: a report from the Children's Oncology GroupCancer Epidemiol Biomarkers PrevCancer Epidemiol Biomarkers Prev1230-51372004/07/13AdolescentAllelesAmphetamines/*toxicityBone Marrow ExaminationCase-Control StudiesChildChild, PreschoolCocaine/toxicityFemaleGenes, ras/*drug effects/geneticsHumansHydrocarbons/*toxicityInfantInterviews as TopicLogistic ModelsMaleMaternal Exposure/*adverse effectsMutationPaternal Exposure/*adverse effectsPolymerase Chain ReactionPrecursor Cell Lymphoblastic Leukemia-Lymphoma/*chemicallyinduced/*geneticsPregnancyRisk Factors2004Jul1055-9965 (Print) 1055-9965 (Linking)15247135http://www.ncbi.nlm.nih.gov/pubmed/1524713513/7/1230 [pii]engShu200264464464417Shu, X. O.Potter, J. D.Linet, M. S.Severson, R. K.Han, D.Kersey, J. H.Neglia, J. P.Trigg, M. E.Robison, L. L.University of Minnesota, Minneapolis, Minnesota, USA. xiao.ou.shu@vanderbilt.eduDiagnostic X-rays and ultrasound exposure and risk of childhood acute lymphoblastic leukemia by immunophenotypeCancer Epidemiol Biomarkers PrevCancer Epidemiol Biomarkers Prev177-851122002/02/28AdolescentCase-Control StudiesChildChild, PreschoolFemaleHumansImmunophenotypingInfantInfant, NewbornLogistic ModelsMalePelvimetryPrecursor Cell LymphoblasticLeukemia-Lymphoma/epidemiology/*etiology/immunologyPregnancy*Prenatal Exposure Delayed EffectsRisk FactorsUltrasonography, Prenatal/*adverse effectsX-Rays/*adverse effects2002Feb1055-9965 (Print) 1055-9965 (Linking)11867505http://www.ncbi.nlm.nih.gov/pubmed/11867505engDShu2004641[60,61]64164117Shu, X. O.Perentesis, J. P.Wen, W.Buckley, J. D.Boyle, E.Ross, J. A.Robison, L. L.Vanderbilt-Ingram Cancer Center and Vanderbilt Center for Health Services Research, Vanderbilt University, Nashville, Tennessee, USA. Xiao-Ou.Shu@vanderbilt.eduParental exposure to medications and hydrocarbons and ras mutations in children with acute lymphoblastic leukemia: a report from the Children's Oncology GroupCancer Epidemiol Biomarkers PrevCancer Epidemiol Biomarkers Prev1230-51372004/07/13AdolescentAllelesAmphetamines/*toxicityBone Marrow ExaminationCase-Control StudiesChildChild, PreschoolCocaine/toxicityFemaleGenes, ras/*drug effects/geneticsHumansHydrocarbons/*toxicityInfantInterviews as TopicLogistic ModelsMaleMaternal Exposure/*adverse effectsMutationPaternal Exposure/*adverse effectsPolymerase Chain ReactionPrecursor Cell Lymphoblastic Leukemia-Lymphoma/*chemicallyinduced/*geneticsPregnancyRisk Factors2004Jul1055-9965 (Print) 1055-9965 (Linking)15247135http://www.ncbi.nlm.nih.gov/pubmed/1524713513/7/1230 [pii]engShu200264464464417Shu, X. O.Potter, J. D.Linet, M. S.Severson, R. K.Han, D.Kersey, J. H.Neglia, J. P.Trigg, M. E.Robison, L. L.University of Minnesota, Minneapolis, Minnesota, USA. xiao.ou.shu@vanderbilt.eduDiagnostic X-rays and ultrasound exposure and risk of childhood acute lymphoblastic leukemia by immunophenotypeCancer Epidemiol Biomarkers PrevCancer Epidemiol Biomarkers Prev177-851122002/02/28AdolescentCase-Control StudiesChildChild, PreschoolFemaleHumansImmunophenotypingInfantInfant, NewbornLogistic ModelsMalePelvimetryPrecursor Cell LymphoblasticLeukemia-Lymphoma/epidemiology/*etiology/immunologyPregnancy*Prenatal Exposure Delayed EffectsRisk FactorsUltrasonography, Prenatal/*adverse effectsX-Rays/*adverse effects2002Feb1055-9965 (Print) 1055-9965 (Linking)11867505http://www.ncbi.nlm.nih.gov/pubmed/11867505enguDyK  _ENREF_60uDyK  _ENREF_61uDyK  _ENREF_62DPesch2000631[63]63163117Pesch, B.Haerting, J.Ranft, U.Klimpel, A.Oelschlagel, B.Schill, W.Unit of Environmental Epidemiology, Medical Institute for Environmental Hygiene at the Heinrich Heine University of Dusseldorf, Germany.Occupational risk factors for urothelial carcinoma: agent-specific results from a case-control study in Germany. MURC Study Group. Multicenter Urothelial and Renal CancerInt J EpidemiolInt J Epidemiol238-472922000/05/19AgedAmines/*adverse effectsFemaleGermany/epidemiologyHumansHydrocarbons, Chlorinated/*adverse effectsIncidenceMaleMiddle AgedOccupational Diseases/*chemically induced/epidemiologyOccupational Exposure/*adverse effectsOdds RatioPolycyclic Hydrocarbons, Aromatic/*adverse effectsQuestionnairesRetrospective StudiesRisk FactorsSex DistributionUrologic Neoplasms/*chemically induced/epidemiology2000Apr0300-5771 (Print) 0300-5771 (Linking)10817119http://www.ncbi.nlm.nih.gov/pubmed/10817119engDPesch2000631[63]63163117Pesch, B.Haerting, J.Ranft, U.Klimpel, A.Oelschlagel, B.Schill, W.Unit of Environmental Epidemiology, Medical Institute for Environmental Hygiene at the Heinrich Heine University of Dusseldorf, Germany.Occupational risk factors for urothelial carcinoma: agent-specific results from a case-control study in Germany. MURC Study Group. Multicenter Urothelial and Renal CancerInt J EpidemiolInt J Epidemiol238-472922000/05/19AgedAmines/*adverse effectsFemaleGermany/epidemiologyHumansHydrocarbons, Chlorinated/*adverse effectsIncidenceMaleMiddle AgedOccupational Diseases/*chemically induced/epidemiologyOccupational Exposure/*adverse effectsOdds RatioPolycyclic Hydrocarbons, Aromatic/*adverse effectsQuestionnairesRetrospective StudiesRisk FactorsSex DistributionUrologic Neoplasms/*chemically induced/epidemiology2000Apr0300-5771 (Print) 0300-5771 (Linking)10817119http://www.ncbi.nlm.nih.gov/pubmed/10817119enguDyK  _ENREF_63uDyK  _ENREF_64uDyK  _ENREF_65DCostas2002655[66]65565517Costas, K.Knorr, R. S.Condon, S. K.Bureau of Environmental Health Assessment, 250 Washington Street, Boston, MA 02108-4619, USA. kevin.costas@state.ma.usA case-control study of childhood leukemia in Woburn, Massachusetts: the relationship between leukemia incidence and exposure to public drinking waterSci Total EnvironSci Total Environ23-353001-32003/04/11AdolescentAdultCase-Control StudiesChemical IndustryChildChild WelfareChild, PreschoolFemaleHumansIncidenceIndustrial WasteInfantInfant, NewbornLeukemia/*epidemiology/*etiologyMaleMassachusetts/epidemiologyPregnancy*Prenatal Exposure Delayed EffectsRisk AssessmentSolvents/adverse effectsTrichloroethylene/adverse effects*Water Supply2002Dec 20048-9697 (Print) 0048-9697 (Linking)12685468http://www.ncbi.nlm.nih.gov/pubmed/12685468S0048-9697(02)00169-9 [pii]engDCostas2002655[66]65565517Costas, K.Knorr, R. S.Condon, S. K.Bureau of Environmental Health Assessment, 250 Washington Street, Boston, MA 02108-4619, USA. kevin.costas@state.ma.usA case-control study of childhood leukemia in Woburn, Massachusetts: the relationship between leukemia incidence and exposure to public drinking waterSci Total EnvironSci Total Environ23-353001-32003/04/11AdolescentAdultCase-Control StudiesChemical IndustryChildChild WelfareChild, PreschoolFemaleHumansIncidenceIndustrial WasteInfantInfant, NewbornLeukemia/*epidemiology/*etiologyMaleMassachusetts/epidemiologyPregnancy*Prenatal Exposure Delayed EffectsRisk AssessmentSolvents/adverse effectsTrichloroethylene/adverse effects*Water Supply2002Dec 20048-9697 (Print) 0048-9697 (Linking)12685468http://www.ncbi.nlm.nih.gov/pubmed/12685468S0048-9697(02)00169-9 [pii]enguDyK  _ENREF_66\DKrishnadasan2007657[67]65765717Krishnadasan, A.Kennedy, N.Zhao, Y.Morgenstern, H.Ritz, B.Department of Epidemiology, School of Public Health, University of California, Los Angeles, CA, USA. akrishna@ucla.eduNested case-control study of occupational chemical exposures and prostate cancer in aerospace and radiation workersAm J Ind MedAm J Ind Med383-905052007/04/05AdultAged*AviationCalifornia/epidemiologyCase-Control StudiesHumansHydrazines/*toxicityMaleMiddle AgedMotor ActivityOccupational Exposure/*adverse effectsPolycyclic Hydrocarbons, Aromatic/*toxicityProstatic Neoplasms/*epidemiology/etiology*RadiationRegistriesRisk AssessmentRisk FactorsTrichloroethylene/*toxicityUnited States/epidemiology2007May0271-3586 (Print) 0271-3586 (Linking)17407146http://www.ncbi.nlm.nih.gov/pubmed/1740714610.1002/ajim.20458eng\DKrishnadasan2007657[67]65765717Krishnadasan, A.Kennedy, N.Zhao, Y.Morgenstern, H.Ritz, B.Department of Epidemiology, School of Public Health, University of California, Los Angeles, CA, USA. akrishna@ucla.eduNested case-control study of occupational chemical exposures and prostate cancer in aerospace and radiation workersAm J Ind MedAm J Ind Med383-905052007/04/05AdultAged*AviationCalifornia/epidemiologyCase-Control StudiesHumansHydrazines/*toxicityMaleMiddle AgedMotor ActivityOccupational Exposure/*adverse effectsPolycyclic Hydrocarbons, Aromatic/*toxicityProstatic Neoplasms/*epidemiology/etiology*RadiationRegistriesRisk AssessmentRisk FactorsTrichloroethylene/*toxicityUnited States/epidemiology2007May0271-3586 (Print) 0271-3586 (Linking)17407146http://www.ncbi.nlm.nih.gov/pubmed/1740714610.1002/ajim.20458enguDyK  _ENREF_67$$If!vh55 5x#v#v #vx:V :4 t'55 5x44 :f4yt8ETuDyK  _ENREF_68$$If!vh55 5x#v#v #vx:V :4 t'55 5x44 :f4yt8ETuDyK  _ENREF_69$$If!vh55 5x#v#v #vx:V :4 t'55 5x44 :f4ytrE<TuDyK  _ENREF_70$$If!vh55 5x#v#v #vx:V :4 t'55 5x/ 44 :f4ytrE<T$$If!vh55'5-585F5L55#v#v'#v-#v8#vF#vL#v#v:V s4 t,55'5-585F5L55/ 44 sytoT$$If!vh55'5-585F5L55#v#v'#v-#v8#vF#vL#v#v:V s t55'5-585F5L55/ 44 sytoT$$If!vh55'5-585F5L55#v#v'#v-#v8#vF#vL#v#v:V s t55'5-585F5L5544 sytoT$$If!vh55'5-585F5L55#v#v'#v-#v8#vF#vL#v#v:V s t55'5-585F5L5544 sytoT$$If!vh55'5-585F5L55#v#v'#v-#v8#vF#vL#v#v:V s t55'5-585F5L5544 sytoT$$If!vh55'5-585F5L55#v#v'#v-#v8#vF#vL#v#v:V s t55'5-585F5L5544 sytoT$$If!vh55'5-585F5L55#v#v'#v-#v8#vF#vL#v#v:V s t55'5-585F5L5544 sytoTN DZhao2005184[16]18418417Zhao, Y.Krishnadasan, A.Kennedy, N.Morgenstern, H.Ritz, B.Department of Epidemiology, School of Public Health, UCLA, Los Angeles, California, USAEstimated effects of solvents and mineral oils on cancer incidence and mortality in a cohort of aerospace workersAm.J.Ind.Med.Am.J.Ind.Med.249-258484NOT IN FILEAAdultAgedaromatic hydrocarbonAROMATIC HYDROCARBONSarticleAssociationAviationBenzeneCaliforniacancerchemically inducedCohort Studiesconfidence intervalepidemiologyexposureHealthHumanshydrocarbonHydrocarbonsIncidenceKidneykidney cancerLeukemiaLunglung cancerLymphomaMaleMelanomamethodsMineral OilmodelmortalityNeoplasmsNON-HODGKIN'S LYMPHOMAOccupational DiseasesOccupational HealthoilOilsPublic HealthRATERetrospective StudiesRiskRisk AssessmentsolventSolventsStomachstudytoxicityTrichloroethyleneworker2005PM:16167347N DZhao2005184[16]18418417Zhao, Y.Krishnadasan, A.Kennedy, N.Morgenstern, H.Ritz, B.Department of Epidemiology, School of Public Health, UCLA, Los Angeles, California, USAEstimated effects of solvents and mineral oils on cancer incidence and mortality in a cohort of aerospace workersAm.J.Ind.Med.Am.J.Ind.Med.249-258484NOT IN FILEAAdultAgedaromatic hydrocarbonAROMATIC HYDROCARBONSarticleAssociationAviationBenzeneCaliforniacancerchemically inducedCohort Studiesconfidence intervalepidemiologyexposureHealthHumanshydrocarbonHydrocarbonsIncidenceKidneykidney cancerLeukemiaLunglung cancerLymphomaMaleMelanomamethodsMineral OilmodelmortalityNeoplasmsNON-HODGKIN'S LYMPHOMAOccupational DiseasesOccupational HealthoilOilsPublic HealthRATERetrospective StudiesRiskRisk AssessmentsolventSolventsStomachstudytoxicityTrichloroethyleneworker2005PM:16167347uDyK  _ENREF_16$$If!vh55'5-585F5L55#v#v'#v-#v8#vF#vL#v#v:V s t55'5-585F5L5544 sytoTz DBoice2006128[8]12812817Boice, J. D., Jr.Marano, D. E.Cohen, S. S.Mumma, M. T.Blot, W. J.Brill, A. B.Fryzek, J. P.Henderson, B. E.McLaughlin, J. K.International Epidemiology Institute, Rockville, Maryland 20850, USA. john.boice@vanderbilt.eduMortality among Rocketdyne workers who tested rocket engines, 1948-1999J.Occup.Environ.Med.J.Occup.Environ.Med.1070-10924810NOT IN FILEAAdultadverse effectsarticleAssociationAviationCaliforniacancerchemically inducedCohort StudiesConfidence IntervalsEngineeringepidemiologyexposureFemaleHealthHumansHydrazinesIndustryLungMalemethodsMiddle AgedmortalityNeoplasmsOccupational DiseasesOccupational ExposurePopulationResearchResearch SupportRetrospective StudiesRisksolventSolventsstatistics & numerical datastudytrendsTrichloroethyleneworker2006PM:17033507z DBoice2006128[8]12812817Boice, J. D., Jr.Marano, D. E.Cohen, S. S.Mumma, M. T.Blot, W. J.Brill, A. B.Fryzek, J. P.Henderson, B. E.McLaughlin, J. K.International Epidemiology Institute, Rockville, Maryland 20850, USA. john.boice@vanderbilt.eduMortality among Rocketdyne workers who tested rocket engines, 1948-1999J.Occup.Environ.Med.J.Occup.Environ.Med.1070-10924810NOT IN FILEAAdultadverse effectsarticleAssociationAviationCaliforniacancerchemically inducedCohort StudiesConfidence IntervalsEngineeringepidemiologyexposureFemaleHealthHumansHydrazinesIndustryLungMalemethodsMiddle AgedmortalityNeoplasmsOccupational DiseasesOccupational ExposurePopulationResearchResearch SupportRetrospective StudiesRisksolventSolventsstatistics & numerical datastudytrendsTrichloroethyleneworker2006PM:17033507sDyK  _ENREF_8N DZhao2005184[16]18418417Zhao, Y.Krishnadasan, A.Kennedy, N.Morgenstern, H.Ritz, B.Department of Epidemiology, School of Public Health, UCLA, Los Angeles, California, USAEstimated effects of solvents and mineral oils on cancer incidence and mortality in a cohort of aerospace workersAm.J.Ind.Med.Am.J.Ind.Med.249-258484NOT IN FILEAAdultAgedaromatic hydrocarbonAROMATIC HYDROCARBONSarticleAssociationAviationBenzeneCaliforniacancerchemically inducedCohort Studiesconfidence intervalepidemiologyexposureHealthHumanshydrocarbonHydrocarbonsIncidenceKidneykidney cancerLeukemiaLunglung cancerLymphomaMaleMelanomamethodsMineral OilmodelmortalityNeoplasmsNON-HODGKIN'S LYMPHOMAOccupational DiseasesOccupational HealthoilOilsPublic HealthRATERetrospective StudiesRiskRisk AssessmentsolventSolventsStomachstudytoxicityTrichloroethyleneworker2005PM:16167347N DZhao2005184[16]18418417Zhao, Y.Krishnadasan, A.Kennedy, N.Morgenstern, H.Ritz, B.Department of Epidemiology, School of Public Health, UCLA, Los Angeles, California, USAEstimated effects of solvents and mineral oils on cancer incidence and mortality in a cohort of aerospace workersAm.J.Ind.Med.Am.J.Ind.Med.249-258484NOT IN FILEAAdultAgedaromatic hydrocarbonAROMATIC HYDROCARBONSarticleAssociationAviationBenzeneCaliforniacancerchemically inducedCohort Studiesconfidence intervalepidemiologyexposureHealthHumanshydrocarbonHydrocarbonsIncidenceKidneykidney cancerLeukemiaLunglung cancerLymphomaMaleMelanomamethodsMineral OilmodelmortalityNeoplasmsNON-HODGKIN'S LYMPHOMAOccupational DiseasesOccupational HealthoilOilsPublic HealthRATERetrospective StudiesRiskRisk AssessmentsolventSolventsStomachstudytoxicityTrichloroethyleneworker2005PM:16167347uDyK  _ENREF_16$$If!vh55'5-585F5L55#v#v'#v-#v8#vF#vL#v#v:V s t55'5-585F5L5544 sytoTsDyK  _ENREF_2$$If!vh55'5-585F5L55#v#v'#v-#v8#vF#vL#v#v:V s t55'5-585F5L5544 sytoT DMorgan1998157646937[6]15715717Morgan, R. W.Kelsh, M. A.Zhao, K.Heringer, S.Exponent Health Group, Menlo Park, CA, USAMortality of aerospace workers exposed to trichloroethyleneEpidemiologyEpidemiology424-43194NOT IN FILEAAdultadverse effectsAgedAircraftArizonaarticleAssociationAviationcancerCarcinogensCause of Deathchemically inducedclassificationCohort Studiesconfidence intervalConfidence IntervalsDiseaseepidemiologyexposureFemaleHealthHumansIndustryKidneyLeukemiaLiverliver cancerLymphomaMaleMiddle AgedmortalityNeoplasmsOccupational DiseasesOccupational ExposureProportional Hazards ModelsRATEResearchResearch SupportRespiratory Tract DiseasesRisksolventSolventsstatistics & numerical dataTrichloroethyleneworker1998PM:9647907 DMorgan1998157646937[6]15715717Morgan, R. W.Kelsh, M. A.Zhao, K.Heringer, S.Exponent Health Group, Menlo Park, CA, USAMortality of aerospace workers exposed to trichloroethyleneEpidemiologyEpidemiology424-43194NOT IN FILEAAdultadverse effectsAgedAircraftArizonaarticleAssociationAviationcancerCarcinogensCause of Deathchemically inducedclassificationCohort Studiesconfidence intervalConfidence IntervalsDiseaseepidemiologyexposureFemaleHealthHumansIndustryKidneyLeukemiaLiverliver cancerLymphomaMaleMiddle AgedmortalityNeoplasmsOccupational DiseasesOccupational ExposureProportional Hazards ModelsRATEResearchResearch SupportRespiratory Tract DiseasesRisksolventSolventsstatistics & numerical dataTrichloroethyleneworker1998PM:9647907sDyK  _ENREF_6$$If!vh55'5-585F5L55#v#v'#v-#v8#vF#vL#v#v:V s t55'5-585F5L5544 sytoT DRaaschou-Nielsen2003168[15]16816817Raaschou-Nielsen, O.Hansen, J.McLaughlin, J. K.Kolstad, H.Christensen, J. M.Tarone, R. E.Olsen, J. H.Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark. ole@cancer.dkCancer risk among workers at Danish companies using trichloroethylene: a cohort studyAm.J.Epidemiol.Am.J.Epidemiol.1182-119215812NOT IN FILEAAdenocarcinomaAdultadverse effectsAgedAnimalarticleAssociationcancercancer riskCarcinomachemically inducedCohort Studiesconfidence intervalDenmarkEmploymentepidemiologyexposureFemalehumanHumansIncidenceLymphomaMaleMiddle AgedNeoplasmsNON-HODGKIN'S LYMPHOMAOccupational DiseasesOccupational ExposureProbabilityResearchResearch SupportRiskRisk AssessmentsolventSolventsstudyTime FactorstoxicityTrichloroethyleneworker2003PM:14652303 DRaaschou-Nielsen2003168[15]16816817Raaschou-Nielsen, O.Hansen, J.McLaughlin, J. K.Kolstad, H.Christensen, J. M.Tarone, R. E.Olsen, J. H.Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark. ole@cancer.dkCancer risk among workers at Danish companies using trichloroethylene: a cohort studyAm.J.Epidemiol.Am.J.Epidemiol.1182-119215812NOT IN FILEAAdenocarcinomaAdultadverse effectsAgedAnimalarticleAssociationcancercancer riskCarcinomachemically inducedCohort Studiesconfidence intervalDenmarkEmploymentepidemiologyexposureFemalehumanHumansIncidenceLymphomaMaleMiddle AgedNeoplasmsNON-HODGKIN'S LYMPHOMAOccupational DiseasesOccupational ExposureProbabilityResearchResearch SupportRiskRisk AssessmentsolventSolventsstudyTime FactorstoxicityTrichloroethyleneworker2003PM:14652303uDyK  _ENREF_15$$If!vh55'5-585F5L55#v#v'#v-#v8#vF#vL#v#v:V s t55'5-585F5L5544 syt7wT DRaaschou-Nielsen2003168[15]16816817Raaschou-Nielsen, O.Hansen, J.McLaughlin, J. K.Kolstad, H.Christensen, J. M.Tarone, R. E.Olsen, J. H.Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark. ole@cancer.dkCancer risk among workers at Danish companies using trichloroethylene: a cohort studyAm.J.Epidemiol.Am.J.Epidemiol.1182-119215812NOT IN FILEAAdenocarcinomaAdultadverse effectsAgedAnimalarticleAssociationcancercancer riskCarcinomachemically inducedCohort Studiesconfidence intervalDenmarkEmploymentepidemiologyexposureFemalehumanHumansIncidenceLymphomaMaleMiddle AgedNeoplasmsNON-HODGKIN'S LYMPHOMAOccupational DiseasesOccupational ExposureProbabilityResearchResearch SupportRiskRisk AssessmentsolventSolventsstudyTime FactorstoxicityTrichloroethyleneworker2003PM:14652303 DRaaschou-Nielsen2003168[15]16816817Raaschou-Nielsen, O.Hansen, J.McLaughlin, J. K.Kolstad, H.Christensen, J. M.Tarone, R. E.Olsen, J. H.Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark. ole@cancer.dkCancer risk among workers at Danish companies using trichloroethylene: a cohort studyAm.J.Epidemiol.Am.J.Epidemiol.1182-119215812NOT IN FILEAAdenocarcinomaAdultadverse effectsAgedAnimalarticleAssociationcancercancer riskCarcinomachemically inducedCohort Studiesconfidence intervalDenmarkEmploymentepidemiologyexposureFemalehumanHumansIncidenceLymphomaMaleMiddle AgedNeoplasmsNON-HODGKIN'S LYMPHOMAOccupational DiseasesOccupational ExposureProbabilityResearchResearch SupportRiskRisk AssessmentsolventSolventsstudyTime FactorstoxicityTrichloroethyleneworker2003PM:14652303uDyK  _ENREF_15$$If!vh55'5-585F5L55#v#v'#v-#v8#vF#vL#v#v:V s t55'5-585F5L55/ 44 syt7wT$$If!vh55'5-585F5L55#v#v'#v-#v8#vF#vL#v#v:V s4 t,55'5-585F5L55/ 44 sytT DBruning2003131[14]13113117Bruning, T.Pesch, B.Wiesenhutter, B.Rabstein, S.Lammert, M.Baumuller, A.Bolt, H. M.Institut fur Arbeitsphysiologie an der Universitat Dortmund (IfADo), Dortmund, GermanyRenal cell cancer risk and occupational exposure to trichloroethylene: results of a consecutive case-control study in Arnsberg, GermanyAm.J.Ind.Med.Am.J.Ind.Med.274-285433NOT IN FILEAadverse effectsageAgedarticlecancerCarcinoma,Renal CellCase-Control Studieschemically inducedepidemiologyexposureFemaleGermanyhistoryhumanHumansIndustryinformationInterviews as TopicKidney NeoplasmsLogistic ModelsMaleMetallurgymethodsOccupational ExposureOccupationsResearchResearch SupportRiskRisk FactorsSmokingsolventSolventsstatistics & numerical datastudyTrichloroethylene2003PM:12594774 DBruning2003131[14]13113117Bruning, T.Pesch, B.Wiesenhutter, B.Rabstein, S.Lammert, M.Baumuller, A.Bolt, H. M.Institut fur Arbeitsphysiologie an der Universitat Dortmund (IfADo), Dortmund, GermanyRenal cell cancer risk and occupational exposure to trichloroethylene: results of a consecutive case-control study in Arnsberg, GermanyAm.J.Ind.Med.Am.J.Ind.Med.274-285433NOT IN FILEAadverse effectsageAgedarticlecancerCarcinoma,Renal CellCase-Control Studieschemically inducedepidemiologyexposureFemaleGermanyhistoryhumanHumansIndustryinformationInterviews as TopicKidney NeoplasmsLogistic ModelsMaleMetallurgymethodsOccupational ExposureOccupationsResearchResearch SupportRiskRisk FactorsSmokingsolventSolventsstatistics & numerical datastudyTrichloroethylene2003PM:12594774$$If!vh55'5-585F5L55#v#v'#v-#v8#vF#vL#v#v:V s4 t,55'5-585F5L55/ 44 sytT8 DCharbotel2006132[18]13213217Charbotel, B.Fevotte, J.Hours, M.Martin, J. L.Bergeret, A.Epidemiological Research and Surveillance Unit in Transport, Occupation and Environment, Universite Claude Bernard Lyon 1, F-69373 Lyon, France. barbara.charbotel@rockefeller.univ-lyon1.frCase-control study on renal cell cancer and occupational exposure to trichloroethylene. Part II: Epidemiological aspectsAnn.Occup.Hyg.Ann.Occup.Hyg.777-787508NOT IN FILEAadverse effectsageAgedAged,80 and overanalysisarticleAssociationcancerCarcinogensCarcinoma,Renal CellCase-Control Studieschemically inducedEnvironmentepidemiologyexposureFemaleFranceHumansIndustryKidney NeoplasmsMalemethodsMiddle AgedOccupational ExposureResearchResearch SupportRetrospective StudiesRiskRisk AssessmentSelectedSmokingsolventSolventsstudytoxicityTrichloroethylene2006PM:168404358 DCharbotel2006132[18]13213217Charbotel, B.Fevotte, J.Hours, M.Martin, J. L.Bergeret, A.Epidemiological Research and Surveillance Unit in Transport, Occupation and Environment, Universite Claude Bernard Lyon 1, F-69373 Lyon, France. barbara.charbotel@rockefeller.univ-lyon1.frCase-control study on renal cell cancer and occupational exposure to trichloroethylene. Part II: Epidemiological aspectsAnn.Occup.Hyg.Ann.Occup.Hyg.777-787508NOT IN FILEAadverse effectsageAgedAged,80 and overanalysisarticleAssociationcancerCarcinogensCarcinoma,Renal CellCase-Control Studieschemically inducedEnvironmentepidemiologyexposureFemaleFranceHumansIndustryKidney NeoplasmsMalemethodsMiddle AgedOccupational ExposureResearchResearch SupportRetrospective StudiesRiskRisk AssessmentSelectedSmokingsolventSolventsstudytoxicityTrichloroethylene2006PM:16840435$$If!vh55'5-585F5L55#v#v'#v-#v8#vF#vL#v#v:V s4 t,55'5-585F5L5544 sytT DMoore2010236[22]23623617Moore, L. E.Boffetta, P.Karami, S.Brennan, P.Stewart, P. S.Hung, R.Zaridze, D.Matveev, V.Janout, V.Kollarova, H.Bencko, V.Navratilova, M.Szeszenia-Dabrowska, N.Mates, D.Gromiec, J.Holcatova, I.Merino, M.Chanock, S.Chow, W. H.Rothman, N.Division of Cancer Epidemiology and Genetics, NIH, National Cancer Institute, NIH, Bethesda, Maryland 20852, USA. moorele@mail.nih.govOccupational trichloroethylene exposure and renal carcinoma risk: evidence of genetic susceptibility by reductive metabolism gene variantsCancer ResCancer Res6527-3670162010/07/29Carbon-Sulfur Lyases/genetics/metabolismCase-Control Studies*CocarcinogenesisFemaleGenetic Predisposition to DiseaseGlutathione Transferase/genetics/metabolismHumansKidney Neoplasms/*chemically induced/enzymology/*geneticsMaleOccupational Exposure/*adverse effectsPolymorphism, Single NucleotideTrichloroethylene/*poisoning2010Aug 151538-7445 (Electronic) 0008-5472 (Linking)20663906http://www.ncbi.nlm.nih.gov/pubmed/2066390629224180008-5472.CAN-09-4167 [pii] 10.1158/0008-5472.CAN-09-4167eng DMoore2010236[22]23623617Moore, L. E.Boffetta, P.Karami, S.Brennan, P.Stewart, P. S.Hung, R.Zaridze, D.Matveev, V.Janout, V.Kollarova, H.Bencko, V.Navratilova, M.Szeszenia-Dabrowska, N.Mates, D.Gromiec, J.Holcatova, I.Merino, M.Chanock, S.Chow, W. H.Rothman, N.Division of Cancer Epidemiology and Genetics, NIH, National Cancer Institute, NIH, Bethesda, Maryland 20852, USA. moorele@mail.nih.govOccupational trichloroethylene exposure and renal carcinoma risk: evidence of genetic susceptibility by reductive metabolism gene variantsCancer ResCancer Res6527-3670162010/07/29Carbon-Sulfur Lyases/genetics/metabolismCase-Control Studies*CocarcinogenesisFemaleGenetic Predisposition to DiseaseGlutathione Transferase/genetics/metabolismHumansKidney Neoplasms/*chemically induced/enzymology/*geneticsMaleOccupational Exposure/*adverse effectsPolymorphism, Single NucleotideTrichloroethylene/*poisoning2010Aug 151538-7445 (Electronic) 0008-5472 (Linking)20663906http://www.ncbi.nlm.nih.gov/pubmed/2066390629224180008-5472.CAN-09-4167 [pii] 10.1158/0008-5472.CAN-09-4167eng$$If!vh55'5-585F5L55#v#v'#v-#v8#vF#vL#v#v:V s4 t,55'5-585F5L5544 sytT DPesch2000167[12]16716717Pesch, B.Haerting, J.Ranft, U.Klimpel, A.Oelschlagel, B.Schill, W.Medical Institute for Environmental Hygiene at the Heinrich Heine University of Dusseldorf, GermanyOccupational risk factors for renal cell carcinoma: agent-specific results from a case-control study in Germany. MURC Study Group. Multicenter urothelial and renal cancer studyInt.J Epidemiol.Int.J Epidemiol.1014-1024296NOT IN FILEAagearomatic hydrocarbonAROMATIC HYDROCARBONSarticleAsbestosAssociationBenzeneCadmiumcancerCarcinomaCarcinoma,Renal CellCase-Control StudiesControlDevelopmentepidemiologyexposureFemaleGermanyHabitshistoryHuman-KWHumanshydrocarbonHydrocarbonshygieneIndustryKidneyKidney NeoplasmsLeadlifestyleLogistic ModelsMalemetalMetalsmethodsMineral OilNRC 2006 documentobtainedOccupational DiseasesOccupational ExposureOdds RatiooilOilsOrdered 6-28-06organic solventORGANIC SOLVENTSORISEPaintPDFPrintingResearch Support,Non-U.S.Gov'tRiskrisk factorRisk FactorsRubberSelectedSexSmokingsolventSolventsstudyU.S.EPA,TCE Issue Papers,2005universityWelding2000PM:11101542file://L:\Lab\NCEA\TCE Documents\TCE PDFs4\ Pesch 2000.pdf DPesch2000167[12]16716717Pesch, B.Haerting, J.Ranft, U.Klimpel, A.Oelschlagel, B.Schill, W.Medical Institute for Environmental Hygiene at the Heinrich Heine University of Dusseldorf, GermanyOccupational risk factors for renal cell carcinoma: agent-specific results from a case-control study in Germany. MURC Study Group. Multicenter urothelial and renal cancer studyInt.J Epidemiol.Int.J Epidemiol.1014-1024296NOT IN FILEAagearomatic hydrocarbonAROMATIC HYDROCARBONSarticleAsbestosAssociationBenzeneCadmiumcancerCarcinomaCarcinoma,Renal CellCase-Control StudiesControlDevelopmentepidemiologyexposureFemaleGermanyHabitshistoryHuman-KWHumanshydrocarbonHydrocarbonshygieneIndustryKidneyKidney NeoplasmsLeadlifestyleLogistic ModelsMalemetalMetalsmethodsMineral OilNRC 2006 documentobtainedOccupational DiseasesOccupational ExposureOdds RatiooilOilsOrdered 6-28-06organic solventORGANIC SOLVENTSORISEPaintPDFPrintingResearch Support,Non-U.S.Gov'tRiskrisk factorRisk FactorsRubberSelectedSexSmokingsolventSolventsstudyU.S.EPA,TCE Issue Papers,2005universityWelding2000PM:11101542file://L:\Lab\NCEA\TCE Documents\TCE PDFs4\ Pesch 2000.pdf$$If!vh55'5-585F5L55#v#v'#v-#v8#vF#vL#v#v:V s4 t,55'5-585F5L5544 sytT$$If!vh55'5-585F5L55#v#v'#v-#v8#vF#vL#v#v:V s4 t,55'5-585F5L5544 sytTVDAnttila1995119[5]11911917Anttila, A.Pukkala, E.Sallmen, M.Hernberg, S.Hemminki, K.Finnish Institute of Occupational Health, HelsinkiCancer incidence among Finnish workers exposed to halogenated hydrocarbonsJ.Occup.Environ.Med.J.Occup.Environ.Med.797-806377NOT IN FILEAAdultadverse effectsarticlecancerchemically inducedCohort StudiesEpidemiologic StudiesepidemiologyexposureFemaleFinlandHealthHumansHydrocarbons,HalogenatedIncidenceLiverLymphomaMaleMiddle AgedmortalityMultiple MyelomaNeoplasmsnonhodgkin lymphomaOccupational DiseasesOccupational ExposurePopulationResearchResearch SupportRisksolventSolventsstudyTrichloroethyleneworker1995PM:7552463VDAnttila1995119[5]11911917Anttila, A.Pukkala, E.Sallmen, M.Hernberg, S.Hemminki, K.Finnish Institute of Occupational Health, HelsinkiCancer incidence among Finnish workers exposed to halogenated hydrocarbonsJ.Occup.Environ.Med.J.Occup.Environ.Med.797-806377NOT IN FILEAAdultadverse effectsarticlecancerchemically inducedCohort StudiesEpidemiologic StudiesepidemiologyexposureFemaleFinlandHealthHumansHydrocarbons,HalogenatedIncidenceLiverLymphomaMaleMiddle AgedmortalityMultiple MyelomaNeoplasmsnonhodgkin lymphomaOccupational DiseasesOccupational ExposurePopulationResearchResearch SupportRisksolventSolventsstudyTrichloroethyleneworker1995PM:7552463$$If!vh55'5-585F5L55#v#v'#v-#v8#vF#vL#v#v:V s4 t,55'5-585F5L5544 sytTVDAnttila1995119[5]11911917Anttila, A.Pukkala, E.Sallmen, M.Hernberg, S.Hemminki, K.Finnish Institute of Occupational Health, HelsinkiCancer incidence among Finnish workers exposed to halogenated hydrocarbonsJ.Occup.Environ.Med.J.Occup.Environ.Med.797-806377NOT IN FILEAAdultadverse effectsarticlecancerchemically inducedCohort StudiesEpidemiologic StudiesepidemiologyexposureFemaleFinlandHealthHumansHydrocarbons,HalogenatedIncidenceLiverLymphomaMaleMiddle AgedmortalityMultiple MyelomaNeoplasmsnonhodgkin lymphomaOccupational DiseasesOccupational ExposurePopulationResearchResearch SupportRisksolventSolventsstudyTrichloroethyleneworker1995PM:7552463VDAnttila1995119[5]11911917Anttila, A.Pukkala, E.Sallmen, M.Hernberg, S.Hemminki, K.Finnish Institute of Occupational Health, HelsinkiCancer incidence among Finnish workers exposed to halogenated hydrocarbonsJ.Occup.Environ.Med.J.Occup.Environ.Med.797-806377NOT IN FILEAAdultadverse effectsarticlecancerchemically inducedCohort StudiesEpidemiologic StudiesepidemiologyexposureFemaleFinlandHealthHumansHydrocarbons,HalogenatedIncidenceLiverLymphomaMaleMiddle AgedmortalityMultiple MyelomaNeoplasmsnonhodgkin lymphomaOccupational DiseasesOccupational ExposurePopulationResearchResearch SupportRisksolventSolventsstudyTrichloroethyleneworker1995PM:7552463$$If!vh55'5-585F5L55#v#v'#v-#v8#vF#vL#v#v:V s4 t,55'5-585F5L55/ 44 sytT$$If!vh5 58555553#v #v8#v#v#v3:V s4 t,5 585553/ 44 s4:yt7T$$If!vh5 58555553#v #v8#v#v#v3:V s t5 585553/ 44 s4:yt7TVDAnttila1995119[5]11911917Anttila, A.Pukkala, E.Sallmen, M.Hernberg, S.Hemminki, K.Finnish Institute of Occupational Health, HelsinkiCancer incidence among Finnish workers exposed to halogenated hydrocarbonsJ.Occup.Environ.Med.J.Occup.Environ.Med.797-806377NOT IN FILEAAdultadverse effectsarticlecancerchemically inducedCohort StudiesEpidemiologic StudiesepidemiologyexposureFemaleFinlandHealthHumansHydrocarbons,HalogenatedIncidenceLiverLymphomaMaleMiddle AgedmortalityMultiple MyelomaNeoplasmsnonhodgkin lymphomaOccupational DiseasesOccupational ExposurePopulationResearchResearch SupportRisksolventSolventsstudyTrichloroethyleneworker1995PM:7552463VDAnttila1995119[5]11911917Anttila, A.Pukkala, E.Sallmen, M.Hernberg, S.Hemminki, K.Finnish Institute of Occupational Health, HelsinkiCancer incidence among Finnish workers exposed to halogenated hydrocarbonsJ.Occup.Environ.Med.J.Occup.Environ.Med.797-806377NOT IN FILEAAdultadverse effectsarticlecancerchemically inducedCohort StudiesEpidemiologic StudiesepidemiologyexposureFemaleFinlandHealthHumansHydrocarbons,HalogenatedIncidenceLiverLymphomaMaleMiddle AgedmortalityMultiple MyelomaNeoplasmsnonhodgkin lymphomaOccupational DiseasesOccupational ExposurePopulationResearchResearch SupportRisksolventSolventsstudyTrichloroethyleneworker1995PM:7552463sDyK  _ENREF_5sDyK  _ENREF_2uDyK  _ENREF_13$$If!vh5 58555553#v #v8#v#v#v3:V s t5 58555344 s4:yt7T, DBlair1998125[20]12512517Blair, A.Hartge, P.Stewart, P. A.McAdams, M.Lubin, J.Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892-7364, USAMortality and cancer incidence of aircraft maintenance workers exposed to trichloroethylene and other organic solvents and chemicals: extended follow upOccup.Environ.Med.Occup.Environ.Med.161-171553NOT IN FILEAAccidentsadverse effectsageAircraftarticleAssociationAsthmaAviationcancerCohort StudiesDiseaseepidemiologyexposureFemalegeneticsHumansIncidenceLiverLymphomaMalemethodsmortalityMultiple MyelomaMyocardial IschemiaNationalNeoplasmsOccupational ExposurePopulationResearchResearch SupportRetrospective StudiesRisksolventSolventsstudyTime FactorsTrichloroethyleneUtahworker1998PM:9624267, DBlair1998125[20]12512517Blair, A.Hartge, P.Stewart, P. A.McAdams, M.Lubin, J.Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892-7364, USAMortality and cancer incidence of aircraft maintenance workers exposed to trichloroethylene and other organic solvents and chemicals: extended follow upOccup.Environ.Med.Occup.Environ.Med.161-171553NOT IN FILEAAccidentsadverse effectsageAircraftarticleAssociationAsthmaAviationcancerCohort StudiesDiseaseepidemiologyexposureFemalegeneticsHumansIncidenceLiverLymphomaMalemethodsmortalityMultiple MyelomaMyocardial IschemiaNationalNeoplasmsOccupational ExposurePopulationResearchResearch SupportRetrospective StudiesRisksolventSolventsstudyTime FactorsTrichloroethyleneUtahworker1998PM:9624267uDyK  _ENREF_20 DRadican2008169[19]16916917Radican, L.Blair, A.Stewart, P.Wartenberg, D.Global Outcomes Research Department, Merck and Co, Inc, NJ 08889, USA. larry_radican@merck.comMortality of aircraft maintenance workers exposed to trichloroethylene and other hydrocarbons and chemicals: extended follow-upJ.Occup.Environ.Med.J.Occup.Environ.Med.1306-13195011NOT IN FILEadverse effectsAgedAged,80 and overAircraftarticleAssociationcancerCause of Deathchemically induceddeathepidemiologyexposureFemalefollow upFollow-Up StudiesHumanshydrocarbonHydrocarbonsliteratureMaintenanceMalemethodsMiddle AgedmodelmortalityOccupational DiseasesOccupational ExposurePrivate SectorProportional Hazards ModelsResearchResearch SupportRiskRisk AssessmenttrendsTrichloroethyleneUtahVital Statisticsworker2008PM:19001957 DRadican2008169[19]16916917Radican, L.Blair, A.Stewart, P.Wartenberg, D.Global Outcomes Research Department, Merck and Co, Inc, NJ 08889, USA. larry_radican@merck.comMortality of aircraft maintenance workers exposed to trichloroethylene and other hydrocarbons and chemicals: extended follow-upJ.Occup.Environ.Med.J.Occup.Environ.Med.1306-13195011NOT IN FILEadverse effectsAgedAged,80 and overAircraftarticleAssociationcancerCause of Deathchemically induceddeathepidemiologyexposureFemalefollow upFollow-Up StudiesHumanshydrocarbonHydrocarbonsliteratureMaintenanceMalemethodsMiddle AgedmodelmortalityOccupational DiseasesOccupational ExposurePrivate SectorProportional Hazards ModelsResearchResearch SupportRiskRisk AssessmenttrendsTrichloroethyleneUtahVital Statisticsworker2008PM:19001957uDyK  _ENREF_19$$If!vh5 58555553#v #v8#v#v#v3:V s4 t+5 585553/ 44 s4:yt7T DMorgan1998157646937[6]15715717Morgan, R. W.Kelsh, M. A.Zhao, K.Heringer, S.Exponent Health Group, Menlo Park, CA, USAMortality of aerospace workers exposed to trichloroethyleneEpidemiologyEpidemiology424-43194NOT IN FILEAAdultadverse effectsAgedAircraftArizonaarticleAssociationAviationcancerCarcinogensCause of Deathchemically inducedclassificationCohort Studiesconfidence intervalConfidence IntervalsDiseaseepidemiologyexposureFemaleHealthHumansIndustryKidneyLeukemiaLiverliver cancerLymphomaMaleMiddle AgedmortalityNeoplasmsOccupational DiseasesOccupational ExposureProportional Hazards ModelsRATEResearchResearch SupportRespiratory Tract DiseasesRisksolventSolventsstatistics & numerical dataTrichloroethyleneworker1998PM:9647907 DMorgan1998157646937[6]15715717Morgan, R. W.Kelsh, M. A.Zhao, K.Heringer, S.Exponent Health Group, Menlo Park, CA, USAMortality of aerospace workers exposed to trichloroethyleneEpidemiologyEpidemiology424-43194NOT IN FILEAAdultadverse effectsAgedAircraftArizonaarticleAssociationAviationcancerCarcinogensCause of Deathchemically inducedclassificationCohort Studiesconfidence intervalConfidence IntervalsDiseaseepidemiologyexposureFemaleHealthHumansIndustryKidneyLeukemiaLiverliver cancerLymphomaMaleMiddle AgedmortalityNeoplasmsOccupational DiseasesOccupational ExposureProportional Hazards ModelsRATEResearchResearch SupportRespiratory Tract DiseasesRisksolventSolventsstatistics & numerical dataTrichloroethyleneworker1998PM:9647907sDyK  _ENREF_6$$If!vh5 58555553#v #v8#v#v#v3:V s4 t+5 585553/ 44 s4:yt7T DRaaschou-Nielsen2003168[15]16816817Raaschou-Nielsen, O.Hansen, J.McLaughlin, J. K.Kolstad, H.Christensen, J. M.Tarone, R. E.Olsen, J. H.Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark. ole@cancer.dkCancer risk among workers at Danish companies using trichloroethylene: a cohort studyAm.J.Epidemiol.Am.J.Epidemiol.1182-119215812NOT IN FILEAAdenocarcinomaAdultadverse effectsAgedAnimalarticleAssociationcancercancer riskCarcinomachemically inducedCohort Studiesconfidence intervalDenmarkEmploymentepidemiologyexposureFemalehumanHumansIncidenceLymphomaMaleMiddle AgedNeoplasmsNON-HODGKIN'S LYMPHOMAOccupational DiseasesOccupational ExposureProbabilityResearchResearch SupportRiskRisk AssessmentsolventSolventsstudyTime FactorstoxicityTrichloroethyleneworker2003PM:14652303 DRaaschou-Nielsen2003168[15]16816817Raaschou-Nielsen, O.Hansen, J.McLaughlin, J. K.Kolstad, H.Christensen, J. M.Tarone, R. E.Olsen, J. H.Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark. ole@cancer.dkCancer risk among workers at Danish companies using trichloroethylene: a cohort studyAm.J.Epidemiol.Am.J.Epidemiol.1182-119215812NOT IN FILEAAdenocarcinomaAdultadverse effectsAgedAnimalarticleAssociationcancercancer riskCarcinomachemically inducedCohort Studiesconfidence intervalDenmarkEmploymentepidemiologyexposureFemalehumanHumansIncidenceLymphomaMaleMiddle AgedNeoplasmsNON-HODGKIN'S LYMPHOMAOccupational DiseasesOccupational ExposureProbabilityResearchResearch SupportRiskRisk AssessmentsolventSolventsstudyTime FactorstoxicityTrichloroethyleneworker2003PM:14652303uDyK  _ENREF_15$$If!vh5 58555553#v #v8#v#v#v3:V s4 t+5 585553/ 44 s4:yt7TN DZhao2005184[16]18418417Zhao, Y.Krishnadasan, A.Kennedy, N.Morgenstern, H.Ritz, B.Department of Epidemiology, School of Public Health, UCLA, Los Angeles, California, USAEstimated effects of solvents and mineral oils on cancer incidence and mortality in a cohort of aerospace workersAm.J.Ind.Med.Am.J.Ind.Med.249-258484NOT IN FILEAAdultAgedaromatic hydrocarbonAROMATIC HYDROCARBONSarticleAssociationAviationBenzeneCaliforniacancerchemically inducedCohort Studiesconfidence intervalepidemiologyexposureHealthHumanshydrocarbonHydrocarbonsIncidenceKidneykidney cancerLeukemiaLunglung cancerLymphomaMaleMelanomamethodsMineral OilmodelmortalityNeoplasmsNON-HODGKIN'S LYMPHOMAOccupational DiseasesOccupational HealthoilOilsPublic HealthRATERetrospective StudiesRiskRisk AssessmentsolventSolventsStomachstudytoxicityTrichloroethyleneworker2005PM:16167347N DZhao2005184[16]18418417Zhao, Y.Krishnadasan, A.Kennedy, N.Morgenstern, H.Ritz, B.Department of Epidemiology, School of Public Health, UCLA, Los Angeles, California, USAEstimated effects of solvents and mineral oils on cancer incidence and mortality in a cohort of aerospace workersAm.J.Ind.Med.Am.J.Ind.Med.249-258484NOT IN FILEAAdultAgedaromatic hydrocarbonAROMATIC HYDROCARBONSarticleAssociationAviationBenzeneCaliforniacancerchemically inducedCohort Studiesconfidence intervalepidemiologyexposureHealthHumanshydrocarbonHydrocarbonsIncidenceKidneykidney cancerLeukemiaLunglung cancerLymphomaMaleMelanomamethodsMineral OilmodelmortalityNeoplasmsNON-HODGKIN'S LYMPHOMAOccupational DiseasesOccupational HealthoilOilsPublic HealthRATERetrospective StudiesRiskRisk AssessmentsolventSolventsStomachstudytoxicityTrichloroethyleneworker2005PM:16167347uDyK  _ENREF_16$$If!vh5 58555553#v #v8#v#v#v3:V s4 t+5 585553/ 44 s4:yt7Tz DBoice2006128[8]12812817Boice, J. D., Jr.Marano, D. E.Cohen, S. S.Mumma, M. T.Blot, W. J.Brill, A. B.Fryzek, J. P.Henderson, B. E.McLaughlin, J. K.International Epidemiology Institute, Rockville, Maryland 20850, USA. john.boice@vanderbilt.eduMortality among Rocketdyne workers who tested rocket engines, 1948-1999J.Occup.Environ.Med.J.Occup.Environ.Med.1070-10924810NOT IN FILEAAdultadverse effectsarticleAssociationAviationCaliforniacancerchemically inducedCohort StudiesConfidence IntervalsEngineeringepidemiologyexposureFemaleHealthHumansHydrazinesIndustryLungMalemethodsMiddle AgedmortalityNeoplasmsOccupational DiseasesOccupational ExposurePopulationResearchResearch SupportRetrospective StudiesRisksolventSolventsstatistics & numerical datastudytrendsTrichloroethyleneworker2006PM:17033507z DBoice2006128[8]12812817Boice, J. D., Jr.Marano, D. E.Cohen, S. S.Mumma, M. T.Blot, W. J.Brill, A. B.Fryzek, J. P.Henderson, B. E.McLaughlin, J. K.International Epidemiology Institute, Rockville, Maryland 20850, USA. john.boice@vanderbilt.eduMortality among Rocketdyne workers who tested rocket engines, 1948-1999J.Occup.Environ.Med.J.Occup.Environ.Med.1070-10924810NOT IN FILEAAdultadverse effectsarticleAssociationAviationCaliforniacancerchemically inducedCohort StudiesConfidence IntervalsEngineeringepidemiologyexposureFemaleHealthHumansHydrazinesIndustryLungMalemethodsMiddle AgedmortalityNeoplasmsOccupational DiseasesOccupational ExposurePopulationResearchResearch SupportRetrospective StudiesRisksolventSolventsstatistics & numerical datastudytrendsTrichloroethyleneworker2006PM:17033507sDyK  _ENREF_8N DZhao2005184[16]18418417Zhao, Y.Krishnadasan, A.Kennedy, N.Morgenstern, H.Ritz, B.Department of Epidemiology, School of Public Health, UCLA, Los Angeles, California, USAEstimated effects of solvents and mineral oils on cancer incidence and mortality in a cohort of aerospace workersAm.J.Ind.Med.Am.J.Ind.Med.249-258484NOT IN FILEAAdultAgedaromatic hydrocarbonAROMATIC HYDROCARBONSarticleAssociationAviationBenzeneCaliforniacancerchemically inducedCohort Studiesconfidence intervalepidemiologyexposureHealthHumanshydrocarbonHydrocarbonsIncidenceKidneykidney cancerLeukemiaLunglung cancerLymphomaMaleMelanomamethodsMineral OilmodelmortalityNeoplasmsNON-HODGKIN'S LYMPHOMAOccupational DiseasesOccupational HealthoilOilsPublic HealthRATERetrospective StudiesRiskRisk AssessmentsolventSolventsStomachstudytoxicityTrichloroethyleneworker2005PM:16167347N DZhao2005184[16]18418417Zhao, Y.Krishnadasan, A.Kennedy, N.Morgenstern, H.Ritz, B.Department of Epidemiology, School of Public Health, UCLA, Los Angeles, California, USAEstimated effects of solvents and mineral oils on cancer incidence and mortality in a cohort of aerospace workersAm.J.Ind.Med.Am.J.Ind.Med.249-258484NOT IN FILEAAdultAgedaromatic hydrocarbonAROMATIC HYDROCARBONSarticleAssociationAviationBenzeneCaliforniacancerchemically inducedCohort Studiesconfidence intervalepidemiologyexposureHealthHumanshydrocarbonHydrocarbonsIncidenceKidneykidney cancerLeukemiaLunglung cancerLymphomaMaleMelanomamethodsMineral OilmodelmortalityNeoplasmsNON-HODGKIN'S LYMPHOMAOccupational DiseasesOccupational HealthoilOilsPublic HealthRATERetrospective StudiesRiskRisk AssessmentsolventSolventsStomachstudytoxicityTrichloroethyleneworker2005PM:16167347uDyK  _ENREF_16$$If!vh5 58555553#v #v8#v#v#v3:V s4 t+5 585553/ 44 s4:yt7T DMoore2010236[22]23623617Moore, L. E.Boffetta, P.Karami, S.Brennan, P.Stewart, P. S.Hung, R.Zaridze, D.Matveev, V.Janout, V.Kollarova, H.Bencko, V.Navratilova, M.Szeszenia-Dabrowska, N.Mates, D.Gromiec, J.Holcatova, I.Merino, M.Chanock, S.Chow, W. H.Rothman, N.Division of Cancer Epidemiology and Genetics, NIH, National Cancer Institute, NIH, Bethesda, Maryland 20852, USA. moorele@mail.nih.govOccupational trichloroethylene exposure and renal carcinoma risk: evidence of genetic susceptibility by reductive metabolism gene variantsCancer ResCancer Res6527-3670162010/07/29Carbon-Sulfur Lyases/genetics/metabolismCase-Control Studies*CocarcinogenesisFemaleGenetic Predisposition to DiseaseGlutathione Transferase/genetics/metabolismHumansKidney Neoplasms/*chemically induced/enzymology/*geneticsMaleOccupational Exposure/*adverse effectsPolymorphism, Single NucleotideTrichloroethylene/*poisoning2010Aug 151538-7445 (Electronic) 0008-5472 (Linking)20663906http://www.ncbi.nlm.nih.gov/pubmed/2066390629224180008-5472.CAN-09-4167 [pii] 10.1158/0008-5472.CAN-09-4167eng DMoore2010236[22]23623617Moore, L. E.Boffetta, P.Karami, S.Brennan, P.Stewart, P. S.Hung, R.Zaridze, D.Matveev, V.Janout, V.Kollarova, H.Bencko, V.Navratilova, M.Szeszenia-Dabrowska, N.Mates, D.Gromiec, J.Holcatova, I.Merino, M.Chanock, S.Chow, W. H.Rothman, N.Division of Cancer Epidemiology and Genetics, NIH, National Cancer Institute, NIH, Bethesda, Maryland 20852, USA. moorele@mail.nih.govOccupational trichloroethylene exposure and renal carcinoma risk: evidence of genetic susceptibility by reductive metabolism gene variantsCancer ResCancer Res6527-3670162010/07/29Carbon-Sulfur Lyases/genetics/metabolismCase-Control Studies*CocarcinogenesisFemaleGenetic Predisposition to DiseaseGlutathione Transferase/genetics/metabolismHumansKidney Neoplasms/*chemically induced/enzymology/*geneticsMaleOccupational Exposure/*adverse effectsPolymorphism, Single NucleotideTrichloroethylene/*poisoning2010Aug 151538-7445 (Electronic) 0008-5472 (Linking)20663906http://www.ncbi.nlm.nih.gov/pubmed/2066390629224180008-5472.CAN-09-4167 [pii] 10.1158/0008-5472.CAN-09-4167enguDyK  _ENREF_22$$If!vh5 58555553#v #v8#v#v#v3:V s4 t+5 585553/ 44 s4:yt7T8 DCharbotel2006132[18]13213217Charbotel, B.Fevotte, J.Hours, M.Martin, J. L.Bergeret, A.Epidemiological Research and Surveillance Unit in Transport, Occupation and Environment, Universite Claude Bernard Lyon 1, F-69373 Lyon, France. barbara.charbotel@rockefeller.univ-lyon1.frCase-control study on renal cell cancer and occupational exposure to trichloroethylene. Part II: Epidemiological aspectsAnn.Occup.Hyg.Ann.Occup.Hyg.777-787508NOT IN FILEAadverse effectsageAgedAged,80 and overanalysisarticleAssociationcancerCarcinogensCarcinoma,Renal CellCase-Control Studieschemically inducedEnvironmentepidemiologyexposureFemaleFranceHumansIndustryKidney NeoplasmsMalemethodsMiddle AgedOccupational ExposureResearchResearch SupportRetrospective StudiesRiskRisk AssessmentSelectedSmokingsolventSolventsstudytoxicityTrichloroethylene2006PM:168404358 DCharbotel2006132[18]13213217Charbotel, B.Fevotte, J.Hours, M.Martin, J. L.Bergeret, A.Epidemiological Research and Surveillance Unit in Transport, Occupation and Environment, Universite Claude Bernard Lyon 1, F-69373 Lyon, France. barbara.charbotel@rockefeller.univ-lyon1.frCase-control study on renal cell cancer and occupational exposure to trichloroethylene. Part II: Epidemiological aspectsAnn.Occup.Hyg.Ann.Occup.Hyg.777-787508NOT IN FILEAadverse effectsageAgedAged,80 and overanalysisarticleAssociationcancerCarcinogensCarcinoma,Renal CellCase-Control Studieschemically inducedEnvironmentepidemiologyexposureFemaleFranceHumansIndustryKidney NeoplasmsMalemethodsMiddle AgedOccupational ExposureResearchResearch SupportRetrospective StudiesRiskRisk AssessmentSelectedSmokingsolventSolventsstudytoxicityTrichloroethylene2006PM:16840435uDyK  _ENREF_18$$If!vh5 58555553#v #v8#v#v#v3:V s4 t+5 585553/ 44 s4:yt7T DPesch2000167[12]16716717Pesch, B.Haerting, J.Ranft, U.Klimpel, A.Oelschlagel, B.Schill, W.Medical Institute for Environmental Hygiene at the Heinrich Heine University of Dusseldorf, GermanyOccupational risk factors for renal cell carcinoma: agent-specific results from a case-control study in Germany. MURC Study Group. Multicenter urothelial and renal cancer studyInt.J Epidemiol.Int.J Epidemiol.1014-1024296NOT IN FILEAagearomatic hydrocarbonAROMATIC HYDROCARBONSarticleAsbestosAssociationBenzeneCadmiumcancerCarcinomaCarcinoma,Renal CellCase-Control StudiesControlDevelopmentepidemiologyexposureFemaleGermanyHabitshistoryHuman-KWHumanshydrocarbonHydrocarbonshygieneIndustryKidneyKidney NeoplasmsLeadlifestyleLogistic ModelsMalemetalMetalsmethodsMineral OilNRC 2006 documentobtainedOccupational DiseasesOccupational ExposureOdds RatiooilOilsOrdered 6-28-06organic solventORGANIC SOLVENTSORISEPaintPDFPrintingResearch Support,Non-U.S.Gov'tRiskrisk factorRisk FactorsRubberSelectedSexSmokingsolventSolventsstudyU.S.EPA,TCE Issue Papers,2005universityWelding2000PM:11101542file://L:\Lab\NCEA\TCE Documents\TCE PDFs4\ Pesch 2000.pdf DPesch2000167[12]16716717Pesch, B.Haerting, J.Ranft, U.Klimpel, A.Oelschlagel, B.Schill, W.Medical Institute for Environmental Hygiene at the Heinrich Heine University of Dusseldorf, GermanyOccupational risk factors for renal cell carcinoma: agent-specific results from a case-control study in Germany. MURC Study Group. Multicenter urothelial and renal cancer studyInt.J Epidemiol.Int.J Epidemiol.1014-1024296NOT IN FILEAagearomatic hydrocarbonAROMATIC HYDROCARBONSarticleAsbestosAssociationBenzeneCadmiumcancerCarcinomaCarcinoma,Renal CellCase-Control StudiesControlDevelopmentepidemiologyexposureFemaleGermanyHabitshistoryHuman-KWHumanshydrocarbonHydrocarbonshygieneIndustryKidneyKidney NeoplasmsLeadlifestyleLogistic ModelsMalemetalMetalsmethodsMineral OilNRC 2006 documentobtainedOccupational DiseasesOccupational ExposureOdds RatiooilOilsOrdered 6-28-06organic solventORGANIC SOLVENTSORISEPaintPDFPrintingResearch Support,Non-U.S.Gov'tRiskrisk factorRisk FactorsRubberSelectedSexSmokingsolventSolventsstudyU.S.EPA,TCE Issue Papers,2005universityWelding2000PM:11101542file://L:\Lab\NCEA\TCE Documents\TCE PDFs4\ Pesch 2000.pdfuDyK  _ENREF_12$$If!vh5 58555553#v #v8#v#v#v3:V s4 t+5 585553/ 44 s4:yt7T$$If!vh5 585855555#v #v8#v#v#v:V s4 t,5 58555/ 44 sytJT DRaaschou-Nielsen2003168[15]16816817Raaschou-Nielsen, O.Hansen, J.McLaughlin, J. K.Kolstad, H.Christensen, J. M.Tarone, R. E.Olsen, J. H.Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark. ole@cancer.dkCancer risk among workers at Danish companies using trichloroethylene: a cohort studyAm.J.Epidemiol.Am.J.Epidemiol.1182-119215812NOT IN FILEAAdenocarcinomaAdultadverse effectsAgedAnimalarticleAssociationcancercancer riskCarcinomachemically inducedCohort Studiesconfidence intervalDenmarkEmploymentepidemiologyexposureFemalehumanHumansIncidenceLymphomaMaleMiddle AgedNeoplasmsNON-HODGKIN'S LYMPHOMAOccupational DiseasesOccupational ExposureProbabilityResearchResearch SupportRiskRisk AssessmentsolventSolventsstudyTime FactorstoxicityTrichloroethyleneworker2003PM:14652303 DRaaschou-Nielsen2003168[15]16816817Raaschou-Nielsen, O.Hansen, J.McLaughlin, J. K.Kolstad, H.Christensen, J. M.Tarone, R. E.Olsen, J. H.Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark. ole@cancer.dkCancer risk among workers at Danish companies using trichloroethylene: a cohort studyAm.J.Epidemiol.Am.J.Epidemiol.1182-119215812NOT IN FILEAAdenocarcinomaAdultadverse effectsAgedAnimalarticleAssociationcancercancer riskCarcinomachemically inducedCohort Studiesconfidence intervalDenmarkEmploymentepidemiologyexposureFemalehumanHumansIncidenceLymphomaMaleMiddle AgedNeoplasmsNON-HODGKIN'S LYMPHOMAOccupational DiseasesOccupational ExposureProbabilityResearchResearch SupportRiskRisk AssessmentsolventSolventsstudyTime FactorstoxicityTrichloroethyleneworker2003PM:14652303uDyK  _ENREF_15$$If!vh5 585855555#v #v8#v#v#v:V s t5 58555/ 44 sytJT$$If!vh5 585855555#v #v8#v#v#v:V s t5 5855544 sytJT$$If!vh5 585855555#v #v8#v#v#v:V s t5 5855544 sytJTN DZhao2005184[16]18418417Zhao, Y.Krishnadasan, A.Kennedy, N.Morgenstern, H.Ritz, B.Department of Epidemiology, School of Public Health, UCLA, Los Angeles, California, USAEstimated effects of solvents and mineral oils on cancer incidence and mortality in a cohort of aerospace workersAm.J.Ind.Med.Am.J.Ind.Med.249-258484NOT IN FILEAAdultAgedaromatic hydrocarbonAROMATIC HYDROCARBONSarticleAssociationAviationBenzeneCaliforniacancerchemically inducedCohort Studiesconfidence intervalepidemiologyexposureHealthHumanshydrocarbonHydrocarbonsIncidenceKidneykidney cancerLeukemiaLunglung cancerLymphomaMaleMelanomamethodsMineral OilmodelmortalityNeoplasmsNON-HODGKIN'S LYMPHOMAOccupational DiseasesOccupational HealthoilOilsPublic HealthRATERetrospective StudiesRiskRisk AssessmentsolventSolventsStomachstudytoxicityTrichloroethyleneworker2005PM:16167347N DZhao2005184[16]18418417Zhao, Y.Krishnadasan, A.Kennedy, N.Morgenstern, H.Ritz, B.Department of Epidemiology, School of Public Health, UCLA, Los Angeles, California, USAEstimated effects of solvents and mineral oils on cancer incidence and mortality in a cohort of aerospace workersAm.J.Ind.Med.Am.J.Ind.Med.249-258484NOT IN FILEAAdultAgedaromatic hydrocarbonAROMATIC HYDROCARBONSarticleAssociationAviationBenzeneCaliforniacancerchemically inducedCohort Studiesconfidence intervalepidemiologyexposureHealthHumanshydrocarbonHydrocarbonsIncidenceKidneykidney cancerLeukemiaLunglung cancerLymphomaMaleMelanomamethodsMineral OilmodelmortalityNeoplasmsNON-HODGKIN'S LYMPHOMAOccupational DiseasesOccupational HealthoilOilsPublic HealthRATERetrospective StudiesRiskRisk AssessmentsolventSolventsStomachstudytoxicityTrichloroethyleneworker2005PM:16167347uDyK  _ENREF_16z DBoice2006128[8]12812817Boice, J. D., Jr.Marano, D. E.Cohen, S. S.Mumma, M. T.Blot, W. J.Brill, A. B.Fryzek, J. P.Henderson, B. E.McLaughlin, J. K.International Epidemiology Institute, Rockville, Maryland 20850, USA. john.boice@vanderbilt.eduMortality among Rocketdyne workers who tested rocket engines, 1948-1999J.Occup.Environ.Med.J.Occup.Environ.Med.1070-10924810NOT IN FILEAAdultadverse effectsarticleAssociationAviationCaliforniacancerchemically inducedCohort StudiesConfidence IntervalsEngineeringepidemiologyexposureFemaleHealthHumansHydrazinesIndustryLungMalemethodsMiddle AgedmortalityNeoplasmsOccupational DiseasesOccupational ExposurePopulationResearchResearch SupportRetrospective StudiesRisksolventSolventsstatistics & numerical datastudytrendsTrichloroethyleneworker2006PM:17033507z DBoice2006128[8]12812817Boice, J. D., Jr.Marano, D. E.Cohen, S. S.Mumma, M. T.Blot, W. J.Brill, A. B.Fryzek, J. P.Henderson, B. E.McLaughlin, J. K.International Epidemiology Institute, Rockville, Maryland 20850, USA. john.boice@vanderbilt.eduMortality among Rocketdyne workers who tested rocket engines, 1948-1999J.Occup.Environ.Med.J.Occup.Environ.Med.1070-10924810NOT IN FILEAAdultadverse effectsarticleAssociationAviationCaliforniacancerchemically inducedCohort StudiesConfidence IntervalsEngineeringepidemiologyexposureFemaleHealthHumansHydrazinesIndustryLungMalemethodsMiddle AgedmortalityNeoplasmsOccupational DiseasesOccupational ExposurePopulationResearchResearch SupportRetrospective StudiesRisksolventSolventsstatistics & numerical datastudytrendsTrichloroethyleneworker2006PM:17033507sDyK  _ENREF_8$$If!vh5 585855555#v #v8#v#v#v:V s t5 5855544 sytJTDBoice1999126[9]12612617Boice, J. D., Jr.Marano, D. E.Fryzek, J. P.Sadler, C. J.McLaughlin, J. K.International Epidemiology Institute, Rockville, MD 20850-3127, USAMortality among aircraft manufacturing workersOccup.Environ.Med.Occup.Environ.Med.581-597569NOT IN FILEAadverse effectsageAircraftarticleCaliforniacancerCause of Deathchemically inducedChromatesCohort StudiesdeathDiseaseepidemiologyexposureFemaleHumansLungLymphomaMalemethodsmortalityNationalNeoplasmsobtainedOccupational DiseasesOccupational ExposurePopulationRATEResearchResearch SupportRisksolventSolventsstatistics & numerical datastudyTetrachloroethylenetrendsTrichloroethyleneworker1999PM:10615290DBoice1999126[9]12612617Boice, J. D., Jr.Marano, D. E.Fryzek, J. P.Sadler, C. J.McLaughlin, J. K.International Epidemiology Institute, Rockville, MD 20850-3127, USAMortality among aircraft manufacturing workersOccup.Environ.Med.Occup.Environ.Med.581-597569NOT IN FILEAadverse effectsageAircraftarticleCaliforniacancerCause of Deathchemically inducedChromatesCohort StudiesdeathDiseaseepidemiologyexposureFemaleHumansLungLymphomaMalemethodsmortalityNationalNeoplasmsobtainedOccupational DiseasesOccupational ExposurePopulationRATEResearchResearch SupportRisksolventSolventsstatistics & numerical datastudyTetrachloroethylenetrendsTrichloroethyleneworker1999PM:10615290sDyK  _ENREF_9$$If!vh5 585855555#v #v8#v#v#v:V s t5 5855544 sytJTsDyK  _ENREF_2$$If!vh5 585855555#v #v8#v#v#v:V s t5 5855544 sytJTh DMorgan1998157[6]15715717Morgan, R. W.Kelsh, M. A.Zhao, K.Heringer, S.Exponent Health Group, Menlo Park, CA, USAMortality of aerospace workers exposed to trichloroethyleneEpidemiologyEpidemiology424-43194NOT IN FILEAAdultadverse effectsAgedAircraftArizonaarticleAssociationAviationcancerCarcinogensCause of Deathchemically inducedclassificationCohort Studiesconfidence intervalConfidence IntervalsDiseaseepidemiologyexposureFemaleHealthHumansIndustryKidneyLeukemiaLiverliver cancerLymphomaMaleMiddle AgedmortalityNeoplasmsOccupational DiseasesOccupational ExposureProportional Hazards ModelsRATEResearchResearch SupportRespiratory Tract DiseasesRisksolventSolventsstatistics & numerical dataTrichloroethyleneworker1998PM:9647907h DMorgan1998157[6]15715717Morgan, R. W.Kelsh, M. A.Zhao, K.Heringer, S.Exponent Health Group, Menlo Park, CA, USAMortality of aerospace workers exposed to trichloroethyleneEpidemiologyEpidemiology424-43194NOT IN FILEAAdultadverse effectsAgedAircraftArizonaarticleAssociationAviationcancerCarcinogensCause of Deathchemically inducedclassificationCohort Studiesconfidence intervalConfidence IntervalsDiseaseepidemiologyexposureFemaleHealthHumansIndustryKidneyLeukemiaLiverliver cancerLymphomaMaleMiddle AgedmortalityNeoplasmsOccupational DiseasesOccupational ExposureProportional Hazards ModelsRATEResearchResearch SupportRespiratory Tract DiseasesRisksolventSolventsstatistics & numerical dataTrichloroethyleneworker1998PM:9647907sDyK  _ENREF_6$$If!vh5 585855555#v #v8#v#v#v:V s t5 5855544 sytJT$$If!vh5 585855555#v #v8#v#v#v:V s4 t+5 5855544 sytJTuDyK  _ENREF_13N DZhao2005184[16]18418417Zhao, Y.Krishnadasan, A.Kennedy, N.Morgenstern, H.Ritz, B.Department of Epidemiology, School of Public Health, UCLA, Los Angeles, California, USAEstimated effects of solvents and mineral oils on cancer incidence and mortality in a cohort of aerospace workersAm.J.Ind.Med.Am.J.Ind.Med.249-258484NOT IN FILEAAdultAgedaromatic hydrocarbonAROMATIC HYDROCARBONSarticleAssociationAviationBenzeneCaliforniacancerchemically inducedCohort Studiesconfidence intervalepidemiologyexposureHealthHumanshydrocarbonHydrocarbonsIncidenceKidneykidney cancerLeukemiaLunglung cancerLymphomaMaleMelanomamethodsMineral OilmodelmortalityNeoplasmsNON-HODGKIN'S LYMPHOMAOccupational DiseasesOccupational HealthoilOilsPublic HealthRATERetrospective StudiesRiskRisk AssessmentsolventSolventsStomachstudytoxicityTrichloroethyleneworker2005PM:16167347N DZhao2005184[16]18418417Zhao, Y.Krishnadasan, A.Kennedy, N.Morgenstern, H.Ritz, B.Department of Epidemiology, School of Public Health, UCLA, Los Angeles, California, USAEstimated effects of solvents and mineral oils on cancer incidence and mortality in a cohort of aerospace workersAm.J.Ind.Med.Am.J.Ind.Med.249-258484NOT IN FILEAAdultAgedaromatic hydrocarbonAROMATIC HYDROCARBONSarticleAssociationAviationBenzeneCaliforniacancerchemically inducedCohort Studiesconfidence intervalepidemiologyexposureHealthHumanshydrocarbonHydrocarbonsIncidenceKidneykidney cancerLeukemiaLunglung cancerLymphomaMaleMelanomamethodsMineral OilmodelmortalityNeoplasmsNON-HODGKIN'S LYMPHOMAOccupational DiseasesOccupational HealthoilOilsPublic HealthRATERetrospective StudiesRiskRisk AssessmentsolventSolventsStomachstudytoxicityTrichloroethyleneworker2005PM:16167347uDyK  _ENREF_16$$If!vh5 585855555#v #v8#v#v#v:V s4 t+5 5855544 sytJTh DMorgan1998157[6]15715717Morgan, R. W.Kelsh, M. A.Zhao, K.Heringer, S.Exponent Health Group, Menlo Park, CA, USAMortality of aerospace workers exposed to trichloroethyleneEpidemiologyEpidemiology424-43194NOT IN FILEAAdultadverse effectsAgedAircraftArizonaarticleAssociationAviationcancerCarcinogensCause of Deathchemically inducedclassificationCohort Studiesconfidence intervalConfidence IntervalsDiseaseepidemiologyexposureFemaleHealthHumansIndustryKidneyLeukemiaLiverliver cancerLymphomaMaleMiddle AgedmortalityNeoplasmsOccupational DiseasesOccupational ExposureProportional Hazards ModelsRATEResearchResearch SupportRespiratory Tract DiseasesRisksolventSolventsstatistics & numerical dataTrichloroethyleneworker1998PM:9647907h DMorgan1998157[6]15715717Morgan, R. W.Kelsh, M. A.Zhao, K.Heringer, S.Exponent Health Group, Menlo Park, CA, USAMortality of aerospace workers exposed to trichloroethyleneEpidemiologyEpidemiology424-43194NOT IN FILEAAdultadverse effectsAgedAircraftArizonaarticleAssociationAviationcancerCarcinogensCause of Deathchemically inducedclassificationCohort Studiesconfidence intervalConfidence IntervalsDiseaseepidemiologyexposureFemaleHealthHumansIndustryKidneyLeukemiaLiverliver cancerLymphomaMaleMiddle AgedmortalityNeoplasmsOccupational DiseasesOccupational ExposureProportional Hazards ModelsRATEResearchResearch SupportRespiratory Tract DiseasesRisksolventSolventsstatistics & numerical dataTrichloroethyleneworker1998PM:9647907sDyK  _ENREF_6 DRaaschou-Nielsen2003168[15]16816817Raaschou-Nielsen, O.Hansen, J.McLaughlin, J. K.Kolstad, H.Christensen, J. M.Tarone, R. E.Olsen, J. H.Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark. ole@cancer.dkCancer risk among workers at Danish companies using trichloroethylene: a cohort studyAm.J.Epidemiol.Am.J.Epidemiol.1182-119215812NOT IN FILEAAdenocarcinomaAdultadverse effectsAgedAnimalarticleAssociationcancercancer riskCarcinomachemically inducedCohort Studiesconfidence intervalDenmarkEmploymentepidemiologyexposureFemalehumanHumansIncidenceLymphomaMaleMiddle AgedNeoplasmsNON-HODGKIN'S LYMPHOMAOccupational DiseasesOccupational ExposureProbabilityResearchResearch SupportRiskRisk AssessmentsolventSolventsstudyTime FactorstoxicityTrichloroethyleneworker2003PM:14652303 DRaaschou-Nielsen2003168[15]16816817Raaschou-Nielsen, O.Hansen, J.McLaughlin, J. K.Kolstad, H.Christensen, J. M.Tarone, R. E.Olsen, J. H.Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark. ole@cancer.dkCancer risk among workers at Danish companies using trichloroethylene: a cohort studyAm.J.Epidemiol.Am.J.Epidemiol.1182-119215812NOT IN FILEAAdenocarcinomaAdultadverse effectsAgedAnimalarticleAssociationcancercancer riskCarcinomachemically inducedCohort Studiesconfidence intervalDenmarkEmploymentepidemiologyexposureFemalehumanHumansIncidenceLymphomaMaleMiddle AgedNeoplasmsNON-HODGKIN'S LYMPHOMAOccupational DiseasesOccupational ExposureProbabilityResearchResearch SupportRiskRisk AssessmentsolventSolventsstudyTime FactorstoxicityTrichloroethyleneworker2003PM:14652303uDyK  _ENREF_15sDyK  _ENREF_2$$If!vh5 585855555#v #v8#v#v#v:V s4/ t+5 58555/ 44 sytJT$$If!vh5X5585s50555#vX#v#v8#vs#v0#v#v#v:V s4 t_4,5X5585s50555/ 44 sytBT$$If!vh5X5585s50555#vX#v#v8#vs#v0#v#v#v:V s4 t_4+5X5585s50555/ 44 sytBT$$If!vh5X5585s50555#vX#v#v8#vs#v0#v#v#v:V s4 t_4+5X5585s5055544 sytBT$$If!vh5X5585s50555#vX#v#v8#vs#v0#v#v#v:V s4 t_4+5X5585s5055544 sytBT$$If!vh5X5585s50555#vX#v#v8#vs#v0#v#v#v:V s4 t_4+5X5585s5055544 sytBT$$If!vh5X5585s50555#vX#v#v8#vs#v0#v#v#v:V s4 t_4+5X5585s5055544 sytBT$$If!vh5X5585s50555#vX#v#v8#vs#v0#v#v#v:V s4 t_4+5X5585s5055544 syt2TN DZhao2005184[16]18418417Zhao, Y.Krishnadasan, A.Kennedy, N.Morgenstern, H.Ritz, B.Department of Epidemiology, School of Public Health, UCLA, Los Angeles, California, USAEstimated effects of solvents and mineral oils on cancer incidence and mortality in a cohort of aerospace workersAm.J.Ind.Med.Am.J.Ind.Med.249-258484NOT IN FILEAAdultAgedaromatic hydrocarbonAROMATIC HYDROCARBONSarticleAssociationAviationBenzeneCaliforniacancerchemically inducedCohort Studiesconfidence intervalepidemiologyexposureHealthHumanshydrocarbonHydrocarbonsIncidenceKidneykidney cancerLeukemiaLunglung cancerLymphomaMaleMelanomamethodsMineral OilmodelmortalityNeoplasmsNON-HODGKIN'S LYMPHOMAOccupational DiseasesOccupational HealthoilOilsPublic HealthRATERetrospective StudiesRiskRisk AssessmentsolventSolventsStomachstudytoxicityTrichloroethyleneworker2005PM:16167347N DZhao2005184[16]18418417Zhao, Y.Krishnadasan, A.Kennedy, N.Morgenstern, H.Ritz, B.Department of Epidemiology, School of Public Health, UCLA, Los Angeles, California, USAEstimated effects of solvents and mineral oils on cancer incidence and mortality in a cohort of aerospace workersAm.J.Ind.Med.Am.J.Ind.Med.249-258484NOT IN FILEAAdultAgedaromatic hydrocarbonAROMATIC HYDROCARBONSarticleAssociationAviationBenzeneCaliforniacancerchemically inducedCohort Studiesconfidence intervalepidemiologyexposureHealthHumanshydrocarbonHydrocarbonsIncidenceKidneykidney cancerLeukemiaLunglung cancerLymphomaMaleMelanomamethodsMineral OilmodelmortalityNeoplasmsNON-HODGKIN'S LYMPHOMAOccupational DiseasesOccupational HealthoilOilsPublic HealthRATERetrospective StudiesRiskRisk AssessmentsolventSolventsStomachstudytoxicityTrichloroethyleneworker2005PM:16167347uDyK  _ENREF_16$$If!vh5X5585s50555#vX#v#v8#vs#v0#v#v#v:V s4 t_4+5X5585s50555/ 44 syt2Tz DBoice2006128[8]12812817Boice, J. D., Jr.Marano, D. E.Cohen, S. S.Mumma, M. T.Blot, W. J.Brill, A. B.Fryzek, J. P.Henderson, B. E.McLaughlin, J. K.International Epidemiology Institute, Rockville, Maryland 20850, USA. john.boice@vanderbilt.eduMortality among Rocketdyne workers who tested rocket engines, 1948-1999J.Occup.Environ.Med.J.Occup.Environ.Med.1070-10924810NOT IN FILEAAdultadverse effectsarticleAssociationAviationCaliforniacancerchemically inducedCohort StudiesConfidence IntervalsEngineeringepidemiologyexposureFemaleHealthHumansHydrazinesIndustryLungMalemethodsMiddle AgedmortalityNeoplasmsOccupational DiseasesOccupational ExposurePopulationResearchResearch SupportRetrospective StudiesRisksolventSolventsstatistics & numerical datastudytrendsTrichloroethyleneworker2006PM:17033507z DBoice2006128[8]12812817Boice, J. D., Jr.Marano, D. E.Cohen, S. S.Mumma, M. T.Blot, W. J.Brill, A. B.Fryzek, J. P.Henderson, B. E.McLaughlin, J. K.International Epidemiology Institute, Rockville, Maryland 20850, USA. john.boice@vanderbilt.eduMortality among Rocketdyne workers who tested rocket engines, 1948-1999J.Occup.Environ.Med.J.Occup.Environ.Med.1070-10924810NOT IN FILEAAdultadverse effectsarticleAssociationAviationCaliforniacancerchemically inducedCohort StudiesConfidence IntervalsEngineeringepidemiologyexposureFemaleHealthHumansHydrazinesIndustryLungMalemethodsMiddle AgedmortalityNeoplasmsOccupational DiseasesOccupational ExposurePopulationResearchResearch SupportRetrospective StudiesRisksolventSolventsstatistics & numerical datastudytrendsTrichloroethyleneworker2006PM:17033507sDyK  _ENREF_8N DZhao2005184[16]18418417Zhao, Y.Krishnadasan, A.Kennedy, N.Morgenstern, H.Ritz, B.Department of Epidemiology, School of Public Health, UCLA, Los Angeles, California, USAEstimated effects of solvents and mineral oils on cancer incidence and mortality in a cohort of aerospace workersAm.J.Ind.Med.Am.J.Ind.Med.249-258484NOT IN FILEAAdultAgedaromatic hydrocarbonAROMATIC HYDROCARBONSarticleAssociationAviationBenzeneCaliforniacancerchemically inducedCohort Studiesconfidence intervalepidemiologyexposureHealthHumanshydrocarbonHydrocarbonsIncidenceKidneykidney cancerLeukemiaLunglung cancerLymphomaMaleMelanomamethodsMineral OilmodelmortalityNeoplasmsNON-HODGKIN'S LYMPHOMAOccupational DiseasesOccupational HealthoilOilsPublic HealthRATERetrospective StudiesRiskRisk AssessmentsolventSolventsStomachstudytoxicityTrichloroethyleneworker2005PM:16167347N DZhao2005184[16]18418417Zhao, Y.Krishnadasan, A.Kennedy, N.Morgenstern, H.Ritz, B.Department of Epidemiology, School of Public Health, UCLA, Los Angeles, California, USAEstimated effects of solvents and mineral oils on cancer incidence and mortality in a cohort of aerospace workersAm.J.Ind.Med.Am.J.Ind.Med.249-258484NOT IN FILEAAdultAgedaromatic hydrocarbonAROMATIC HYDROCARBONSarticleAssociationAviationBenzeneCaliforniacancerchemically inducedCohort Studiesconfidence intervalepidemiologyexposureHealthHumanshydrocarbonHydrocarbonsIncidenceKidneykidney cancerLeukemiaLunglung cancerLymphomaMaleMelanomamethodsMineral OilmodelmortalityNeoplasmsNON-HODGKIN'S LYMPHOMAOccupational DiseasesOccupational HealthoilOilsPublic HealthRATERetrospective StudiesRiskRisk AssessmentsolventSolventsStomachstudytoxicityTrichloroethyleneworker2005PM:16167347uDyK  _ENREF_16$$If!vh5X5585s50555#vX#v#v8#vs#v0#v#v#v:V s4 t_4+5X5585s50555/ 44 syt2TsDyK  _ENREF_2$$If!vh5X5585s50555#vX#v#v8#vs#v0#v#v#v:V s4 t_4+5X5585s50555/ 44 syt2TDBoice1999126[9]12612617Boice, J. D., Jr.Marano, D. E.Fryzek, J. P.Sadler, C. J.McLaughlin, J. K.International Epidemiology Institute, Rockville, MD 20850-3127, USAMortality among aircraft manufacturing workersOccup.Environ.Med.Occup.Environ.Med.581-597569NOT IN FILEAadverse effectsageAircraftarticleCaliforniacancerCause of Deathchemically inducedChromatesCohort StudiesdeathDiseaseepidemiologyexposureFemaleHumansLungLymphomaMalemethodsmortalityNationalNeoplasmsobtainedOccupational DiseasesOccupational ExposurePopulationRATEResearchResearch SupportRisksolventSolventsstatistics & numerical datastudyTetrachloroethylenetrendsTrichloroethyleneworker1999PM:10615290DBoice1999126[9]12612617Boice, J. D., Jr.Marano, D. E.Fryzek, J. P.Sadler, C. J.McLaughlin, J. K.International Epidemiology Institute, Rockville, MD 20850-3127, USAMortality among aircraft manufacturing workersOccup.Environ.Med.Occup.Environ.Med.581-597569NOT IN FILEAadverse effectsageAircraftarticleCaliforniacancerCause of Deathchemically inducedChromatesCohort StudiesdeathDiseaseepidemiologyexposureFemaleHumansLungLymphomaMalemethodsmortalityNationalNeoplasmsobtainedOccupational DiseasesOccupational ExposurePopulationRATEResearchResearch SupportRisksolventSolventsstatistics & numerical datastudyTetrachloroethylenetrendsTrichloroethyleneworker1999PM:10615290sDyK  _ENREF_9$$If!vh5X5585s50555#vX#v#v8#vs#v0#v#v#v:V s4 t_4+5X5585s50555/ 44 syt2TD$$If!vh5X5585s50555#vX#v#v8#vs#v0#v#v#v:V s4 t0_4,5X5585s50555/ 44 sytBTD$$If!vh5X5585s50555#vX#v#v8#vs#v0#v#v#v:V s4 t0_4,5X5585s50555/ 44 sytBT DRaaschou-Nielsen2003168[15]16816817Raaschou-Nielsen, O.Hansen, J.McLaughlin, J. K.Kolstad, H.Christensen, J. M.Tarone, R. E.Olsen, J. H.Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark. ole@cancer.dkCancer risk among workers at Danish companies using trichloroethylene: a cohort studyAm.J.Epidemiol.Am.J.Epidemiol.1182-119215812NOT IN FILEAAdenocarcinomaAdultadverse effectsAgedAnimalarticleAssociationcancercancer riskCarcinomachemically inducedCohort Studiesconfidence intervalDenmarkEmploymentepidemiologyexposureFemalehumanHumansIncidenceLymphomaMaleMiddle AgedNeoplasmsNON-HODGKIN'S LYMPHOMAOccupational DiseasesOccupational ExposureProbabilityResearchResearch SupportRiskRisk AssessmentsolventSolventsstudyTime FactorstoxicityTrichloroethyleneworker2003PM:14652303 DRaaschou-Nielsen2003168[15]16816817Raaschou-Nielsen, O.Hansen, J.McLaughlin, J. K.Kolstad, H.Christensen, J. M.Tarone, R. E.Olsen, J. H.Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark. ole@cancer.dkCancer risk among workers at Danish companies using trichloroethylene: a cohort studyAm.J.Epidemiol.Am.J.Epidemiol.1182-119215812NOT IN FILEAAdenocarcinomaAdultadverse effectsAgedAnimalarticleAssociationcancercancer riskCarcinomachemically inducedCohort Studiesconfidence intervalDenmarkEmploymentepidemiologyexposureFemalehumanHumansIncidenceLymphomaMaleMiddle AgedNeoplasmsNON-HODGKIN'S LYMPHOMAOccupational DiseasesOccupational ExposureProbabilityResearchResearch SupportRiskRisk AssessmentsolventSolventsstudyTime FactorstoxicityTrichloroethyleneworker2003PM:146523036$$If!vh5X5585s50555#vX#v#v8#vs#v0#v#v#v:V s4 t0_4,5X5585s5055544 sytBT DMiligi2006155[17]15515517Miligi, L.Costantini, A. S.Benvenuti, A.Kriebel, D.Bolejack, V.Tumino, R.Ramazzotti, V.Rodella, S.Stagnaro, E.Crosignani, P.Amadori, D.Mirabelli, D.Sommani, L.Belletti, I.Troschel, L.Romeo, L.Miceli, G.Tozzi, G. A.Mendico, I.Vineis, P.Istituto Toscano Tumori, Unit of Environmental and Occupational Epidemiology, Centre for Study and Prevention of Cancer, Via di S. Salvi 12, 50135 Florence, ItalyOccupational exposure to solvents and the risk of lymphomasEpidemiologyEpidemiology552-561175NOT IN FILEAAdultadverse effectsageAgedanalysisaromatic hydrocarbonAROMATIC HYDROCARBONSarticleAssociationBenzenecancerCase-Control Studieschlorinated hydrocarbonconfidence intervalControlDeveloped CountriesDiseaseepidemiologyetiologyexposureFemaleHodgkin DiseaseHumanshydrocarbonHydrocarbonsHydrocarbons,AromaticHydrocarbons,ChlorinatedItalyLeukemia,Lymphocytic,Chronic,B-CellLymphomaLymphoma,Non-HodgkinMalemethodsMiddle Agednonhodgkin lymphomaOccupational ExposureOdds RatioPopulationpreventionProbabilityquestionnaireResearchResearch SupportRiskrisk factorRisk FactorsSexsolventSolventsstudyTolueneXYLENE2006PM:16878041 DMiligi2006155[17]15515517Miligi, L.Costantini, A. S.Benvenuti, A.Kriebel, D.Bolejack, V.Tumino, R.Ramazzotti, V.Rodella, S.Stagnaro, E.Crosignani, P.Amadori, D.Mirabelli, D.Sommani, L.Belletti, I.Troschel, L.Romeo, L.Miceli, G.Tozzi, G. A.Mendico, I.Vineis, P.Istituto Toscano Tumori, Unit of Environmental and Occupational Epidemiology, Centre for Study and Prevention of Cancer, Via di S. Salvi 12, 50135 Florence, ItalyOccupational exposure to solvents and the risk of lymphomasEpidemiologyEpidemiology552-561175NOT IN FILEAAdultadverse effectsageAgedanalysisaromatic hydrocarbonAROMATIC HYDROCARBONSarticleAssociationBenzenecancerCase-Control Studieschlorinated hydrocarbonconfidence intervalControlDeveloped CountriesDiseaseepidemiologyetiologyexposureFemaleHodgkin DiseaseHumanshydrocarbonHydrocarbonsHydrocarbons,AromaticHydrocarbons,ChlorinatedItalyLeukemia,Lymphocytic,Chronic,B-CellLymphomaLymphoma,Non-HodgkinMalemethodsMiddle Agednonhodgkin lymphomaOccupational ExposureOdds RatioPopulationpreventionProbabilityquestionnaireResearchResearch SupportRiskrisk factorRisk FactorsSexsolventSolventsstudyTolueneXYLENE2006PM:16878041 DNordstrom1998160[7]16016017Nordstrom, M.Hardell, L.Magnuson, A.Hagberg, H.Rask-Andersen, A.Department of Oncology, Orebro Medical CentreOccupational exposures, animal exposure and smoking as risk factors for hairy cell leukaemia evaluated in a case-control studyBr.J.CancerBr.J.Cancer2048-20527711NOT IN FILEAAdultadverse effectsageAgedAged,80 and overAnimalAnimalsarticleCase-Control StudiesCattleconfidence intervalControletiologyexposureherbicideHerbicidesHorsesHumansinsecticideInsecticidesLeukemia,Hairy CellMaleMiddle AgedmodelMultivariate AnalysisOccupational ExposureOdds Ratioorganic solventORGANIC SOLVENTSpatientPatientsPoultryrecallResearchResearch SupportRiskrisk factorRisk FactorsSexSheepSmokingsolventSolventsstudySwineUltraviolet Rays1998PM:9667691 DNordstrom1998160[7]16016017Nordstrom, M.Hardell, L.Magnuson, A.Hagberg, H.Rask-Andersen, A.Department of Oncology, Orebro Medical CentreOccupational exposures, animal exposure and smoking as risk factors for hairy cell leukaemia evaluated in a case-control studyBr.J.CancerBr.J.Cancer2048-20527711NOT IN FILEAAdultadverse effectsageAgedAged,80 and overAnimalAnimalsarticleCase-Control StudiesCattleconfidence intervalControletiologyexposureherbicideHerbicidesHorsesHumansinsecticideInsecticidesLeukemia,Hairy CellMaleMiddle AgedmodelMultivariate AnalysisOccupational ExposureOdds Ratioorganic solventORGANIC SOLVENTSpatientPatientsPoultryrecallResearchResearch SupportRiskrisk factorRisk FactorsSexSheepSmokingsolventSolventsstudySwineUltraviolet Rays1998PM:9667691DPersson1999166[11]16616617Persson, B.Fredrikson, M.Department of Occupational and Environmental Medicine, Centre for Public Health Sciences, Linkoping, SwedenSome risk factors for non-Hodgkin's lymphomaInt.J.Occup.Med.Environ.HealthInt.J.Occup.Med.Environ.Health135-142122NOT IN FILEAanalysisarticleAviationBenzeneCONTAMINATIONEmploymentepidemiologyetiologyexposureGasolineHealthherbicideHerbicidesHumansinformationLymphomaLymphoma,Non-HodgkinNON-HODGKIN'S LYMPHOMAobtainedOccupational DiseasesOccupational ExposureOdds RatiopainterplasticPopulationPublic HealthquestionnaireQuestionnairesRiskrisk factorRisk FactorsRubberSciencesolventSolventsstudySwedenthinnerWood1999PM:10465904DPersson1999166[11]16616617Persson, B.Fredrikson, M.Department of Occupational and Environmental Medicine, Centre for Public Health Sciences, Linkoping, SwedenSome risk factors for non-Hodgkin's lymphomaInt.J.Occup.Med.Environ.HealthInt.J.Occup.Med.Environ.Health135-142122NOT IN FILEAanalysisarticleAviationBenzeneCONTAMINATIONEmploymentepidemiologyetiologyexposureGasolineHealthherbicideHerbicidesHumansinformationLymphomaLymphoma,Non-HodgkinNON-HODGKIN'S LYMPHOMAobtainedOccupational DiseasesOccupational ExposureOdds RatiopainterplasticPopulationPublic HealthquestionnaireQuestionnairesRiskrisk factorRisk FactorsRubberSciencesolventSolventsstudySwedenthinnerWood1999PM:10465904D DGreenland1994141[4]14114117Greenland, S.Salvan, A.Wegman, D. H.Hallock, M. F.Smith, T. J.Department of Epidemiology, UCLA School of Public Health 90024-1772A case-control study of cancer mortality at a transformer-assembly facilityInt.Arch.Occup.Environ.HealthInt.Arch.Occup.Environ.Health49-54661NOT IN FILEAAdultadverse effectsageAgedAged,80 and overAir Pollutants,OccupationalanalysisarticleAsbestosAssociationBenzenecancerCarcinogensCase-Control StudiesCause of Deathchemically inducedControldeathElectric Power SuppliesEmploymentepidemiologyexposureHealthHumansIndustrial OilsLunglung cancerMaleMiddle AgedmortalityNeoplasmsOccupational DiseasesOdds RatioResearchResearch SupportResins,PlantSelectedsolventSolventsstudyTrichloroethylene1994PM:7927843D DGreenland1994141[4]14114117Greenland, S.Salvan, A.Wegman, D. H.Hallock, M. F.Smith, T. J.Department of Epidemiology, UCLA School of Public Health 90024-1772A case-control study of cancer mortality at a transformer-assembly facilityInt.Arch.Occup.Environ.HealthInt.Arch.Occup.Environ.Health49-54661NOT IN FILEAAdultadverse effectsageAgedAged,80 and overAir Pollutants,OccupationalanalysisarticleAsbestosAssociationBenzenecancerCarcinogensCase-Control StudiesCause of Deathchemically inducedControldeathElectric Power SuppliesEmploymentepidemiologyexposureHealthHumansIndustrial OilsLunglung cancerMaleMiddle AgedmortalityNeoplasmsOccupational DiseasesOdds RatioResearchResearch SupportResins,PlantSelectedsolventSolventsstudyTrichloroethylene1994PM:7927843z DBoice2006128[8]12812817Boice, J. D., Jr.Marano, D. E.Cohen, S. S.Mumma, M. T.Blot, W. J.Brill, A. B.Fryzek, J. P.Henderson, B. E.McLaughlin, J. K.International Epidemiology Institute, Rockville, Maryland 20850, USA. john.boice@vanderbilt.eduMortality among Rocketdyne workers who tested rocket engines, 1948-1999J.Occup.Environ.Med.J.Occup.Environ.Med.1070-10924810NOT IN FILEAAdultadverse effectsarticleAssociationAviationCaliforniacancerchemically inducedCohort StudiesConfidence IntervalsEngineeringepidemiologyexposureFemaleHealthHumansHydrazinesIndustryLungMalemethodsMiddle AgedmortalityNeoplasmsOccupational DiseasesOccupational ExposurePopulationResearchResearch SupportRetrospective StudiesRisksolventSolventsstatistics & numerical datastudytrendsTrichloroethyleneworker2006PM:17033507z DBoice2006128[8]12812817Boice, J. D., Jr.Marano, D. E.Cohen, S. S.Mumma, M. T.Blot, W. J.Brill, A. B.Fryzek, J. P.Henderson, B. E.McLaughlin, J. K.International Epidemiology Institute, Rockville, Maryland 20850, USA. john.boice@vanderbilt.eduMortality among Rocketdyne workers who tested rocket engines, 1948-1999J.Occup.Environ.Med.J.Occup.Environ.Med.1070-10924810NOT IN FILEAAdultadverse effectsarticleAssociationAviationCaliforniacancerchemically inducedCohort StudiesConfidence IntervalsEngineeringepidemiologyexposureFemaleHealthHumansHydrazinesIndustryLungMalemethodsMiddle AgedmortalityNeoplasmsOccupational DiseasesOccupational ExposurePopulationResearchResearch SupportRetrospective StudiesRisksolventSolventsstatistics & numerical datastudytrendsTrichloroethyleneworker2006PM:17033507N DZhao2005184[16]18418417Zhao, Y.Krishnadasan, A.Kennedy, N.Morgenstern, H.Ritz, B.Department of Epidemiology, School of Public Health, UCLA, Los Angeles, California, USAEstimated effects of solvents and mineral oils on cancer incidence and mortality in a cohort of aerospace workersAm.J.Ind.Med.Am.J.Ind.Med.249-258484NOT IN FILEAAdultAgedaromatic hydrocarbonAROMATIC HYDROCARBONSarticleAssociationAviationBenzeneCaliforniacancerchemically inducedCohort Studiesconfidence intervalepidemiologyexposureHealthHumanshydrocarbonHydrocarbonsIncidenceKidneykidney cancerLeukemiaLunglung cancerLymphomaMaleMelanomamethodsMineral OilmodelmortalityNeoplasmsNON-HODGKIN'S LYMPHOMAOccupational DiseasesOccupational HealthoilOilsPublic HealthRATERetrospective StudiesRiskRisk AssessmentsolventSolventsStomachstudytoxicityTrichloroethyleneworker2005PM:16167347N DZhao2005184[16]18418417Zhao, Y.Krishnadasan, A.Kennedy, N.Morgenstern, H.Ritz, B.Department of Epidemiology, School of Public Health, UCLA, Los Angeles, California, USAEstimated effects of solvents and mineral oils on cancer incidence and mortality in a cohort of aerospace workersAm.J.Ind.Med.Am.J.Ind.Med.249-258484NOT IN FILEAAdultAgedaromatic hydrocarbonAROMATIC HYDROCARBONSarticleAssociationAviationBenzeneCaliforniacancerchemically inducedCohort Studiesconfidence intervalepidemiologyexposureHealthHumanshydrocarbonHydrocarbonsIncidenceKidneykidney cancerLeukemiaLunglung cancerLymphomaMaleMelanomamethodsMineral OilmodelmortalityNeoplasmsNON-HODGKIN'S LYMPHOMAOccupational DiseasesOccupational HealthoilOilsPublic HealthRATERetrospective StudiesRiskRisk AssessmentsolventSolventsStomachstudytoxicityTrichloroethyleneworker2005PM:161673476$$If!vh5X5585s50555#vX#v#v8#vs#v0#v#v#v:V s4 t0_4,5X5585s5055544 sytBT6$$If!vh5X5585s50555#vX#v#v8#vs#v0#v#v#v:V s4 t0_4,5X5585s5055544 sytBT6$$If!vh5X5585s50555#vX#v#v8#vs#v0#v#v#v:V s4 t0_4,5X5585s5055544 sytBT6$$If!vh5X5585s50555#vX#v#v8#vs#v0#v#v#v:V s4 t0_4,5X5585s5055544 sytBT$$If!vh595 585s5555y#v9#v #v8#vs#v#v#v#vy:V s4 t4,,595 585s5555y/ 44 sytOGCT$$If!vh595 585s5555y#v9#v #v8#vs#v#v#v#vy:V s4 t4++595 585s5555y/ 44 sytOGCT$$If!vh595 585s5555y#v9#v #v8#vs#v#v#v#vy:V s4 t4++595 585s5555y44 sytOGCT$$If!vh595 585s5555y#v9#v #v8#vs#v#v#v#vy:V s4 t4++595 585s5555y44 sytOGCT$$If!vh595 585s5555y#v9#v #v8#vs#v#v#v#vy:V s4 t4++595 585s5555y44 sytOGCT$$If!vh595 585s5555y#v9#v #v8#vs#v#v#v#vy:V s4 t4++595 585s5555y44 sytOGCT$$If!vh595 585s5555y#v9#v #v8#vs#v#v#v#vy:V s4 t4++595 585s5555y44 sytTDRaaschou-Nielsen2003168[15]16816817Raaschou-Nielsen, O.Hansen, J.McLaughlin, J. K.Kolstad, H.Christensen, J. M.Tarone, R. E.Olsen, J. H.Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark. ole@cancer.dkCancer risk among workers at Danish companies using trichloroethylene: a cohort studyAm.J.Epidemiol.Am.J.Epidemiol.1182-119215812NOT IN FILEAAdenocarcinomaAdultadverse effectsAgedAnimalarticleAssociationcancercancer riskCarcinomachemically inducedCohort Studiesconfidence intervalDenmarkEmploymentepidemiologyexposureFemalehumanHumansIncidenceLymphomaMaleMiddle AgedNeoplasmsNON-HODGKIN'S LYMPHOMAOccupational DiseasesOccupational ExposureProbabilityResearchResearch SupportRiskRisk AssessmentsolventSolventsstudyTime FactorstoxicityTrichloroethyleneworker2003PM:14652303Raaschou-Nielsen200316816816817Raaschou-Nielsen, O.Hansen, J.McLaughlin, J. K.Kolstad, H.Christensen, J. M.Tarone, R. E.Olsen, J. H.Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark. ole@cancer.dkCancer risk among workers at Danish companies using trichloroethylene: a cohort studyAm.J.Epidemiol.Am.J.Epidemiol.1182-119215812NOT IN FILEAAdenocarcinomaAdultadverse effectsAgedAnimalarticleAssociationcancercancer riskCarcinomachemically inducedCohort Studiesconfidence intervalDenmarkEmploymentepidemiologyexposureFemalehumanHumansIncidenceLymphomaMaleMiddle AgedNeoplasmsNON-HODGKIN'S LYMPHOMAOccupational DiseasesOccupational ExposureProbabilityResearchResearch SupportRiskRisk AssessmentsolventSolventsstudyTime FactorstoxicityTrichloroethyleneworker2003PM:14652303DRaaschou-Nielsen2003168[15]16816817Raaschou-Nielsen, O.Hansen, J.McLaughlin, J. K.Kolstad, H.Christensen, J. M.Tarone, R. E.Olsen, J. H.Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark. ole@cancer.dkCancer risk among workers at Danish companies using trichloroethylene: a cohort studyAm.J.Epidemiol.Am.J.Epidemiol.1182-119215812NOT IN FILEAAdenocarcinomaAdultadverse effectsAgedAnimalarticleAssociationcancercancer riskCarcinomachemically inducedCohort Studiesconfidence intervalDenmarkEmploymentepidemiologyexposureFemalehumanHumansIncidenceLymphomaMaleMiddle AgedNeoplasmsNON-HODGKIN'S LYMPHOMAOccupational DiseasesOccupational ExposureProbabilityResearchResearch SupportRiskRisk AssessmentsolventSolventsstudyTime FactorstoxicityTrichloroethyleneworker2003PM:14652303Raaschou-Nielsen200316816816817Raaschou-Nielsen, O.Hansen, J.McLaughlin, J. K.Kolstad, H.Christensen, J. M.Tarone, R. E.Olsen, J. H.Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark. ole@cancer.dkCancer risk among workers at Danish companies using trichloroethylene: a cohort studyAm.J.Epidemiol.Am.J.Epidemiol.1182-119215812NOT IN FILEAAdenocarcinomaAdultadverse effectsAgedAnimalarticleAssociationcancercancer riskCarcinomachemically inducedCohort Studiesconfidence intervalDenmarkEmploymentepidemiologyexposureFemalehumanHumansIncidenceLymphomaMaleMiddle AgedNeoplasmsNON-HODGKIN'S LYMPHOMAOccupational DiseasesOccupational ExposureProbabilityResearchResearch SupportRiskRisk AssessmentsolventSolventsstudyTime FactorstoxicityTrichloroethyleneworker2003PM:14652303uDyK  _ENREF_15$$If!vh595 585s5555y#v9#v #v8#vs#v#v#v#vy:V s4 t4+595 585s5555y/ 44 sytT, DBlair1998125[20]12512517Blair, A.Hartge, P.Stewart, P. A.McAdams, M.Lubin, J.Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892-7364, USAMortality and cancer incidence of aircraft maintenance workers exposed to trichloroethylene and other organic solvents and chemicals: extended follow upOccup.Environ.Med.Occup.Environ.Med.161-171553NOT IN FILEAAccidentsadverse effectsageAircraftarticleAssociationAsthmaAviationcancerCohort StudiesDiseaseepidemiologyexposureFemalegeneticsHumansIncidenceLiverLymphomaMalemethodsmortalityMultiple MyelomaMyocardial IschemiaNationalNeoplasmsOccupational ExposurePopulationResearchResearch SupportRetrospective StudiesRisksolventSolventsstudyTime FactorsTrichloroethyleneUtahworker1998PM:9624267, DBlair1998125[20]12512517Blair, A.Hartge, P.Stewart, P. A.McAdams, M.Lubin, J.Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892-7364, USAMortality and cancer incidence of aircraft maintenance workers exposed to trichloroethylene and other organic solvents and chemicals: extended follow upOccup.Environ.Med.Occup.Environ.Med.161-171553NOT IN FILEAAccidentsadverse effectsageAircraftarticleAssociationAsthmaAviationcancerCohort StudiesDiseaseepidemiologyexposureFemalegeneticsHumansIncidenceLiverLymphomaMalemethodsmortalityMultiple MyelomaMyocardial IschemiaNationalNeoplasmsOccupational ExposurePopulationResearchResearch SupportRetrospective StudiesRisksolventSolventsstudyTime FactorsTrichloroethyleneUtahworker1998PM:9624267uDyK  _ENREF_20 DRadican2008169[19]16916917Radican, L.Blair, A.Stewart, P.Wartenberg, D.Global Outcomes Research Department, Merck and Co, Inc, NJ 08889, USA. larry_radican@merck.comMortality of aircraft maintenance workers exposed to trichloroethylene and other hydrocarbons and chemicals: extended follow-upJ.Occup.Environ.Med.J.Occup.Environ.Med.1306-13195011NOT IN FILEadverse effectsAgedAged,80 and overAircraftarticleAssociationcancerCause of Deathchemically induceddeathepidemiologyexposureFemalefollow upFollow-Up StudiesHumanshydrocarbonHydrocarbonsliteratureMaintenanceMalemethodsMiddle AgedmodelmortalityOccupational DiseasesOccupational ExposurePrivate SectorProportional Hazards ModelsResearchResearch SupportRiskRisk AssessmenttrendsTrichloroethyleneUtahVital Statisticsworker2008PM:19001957 DRadican2008169[19]16916917Radican, L.Blair, A.Stewart, P.Wartenberg, D.Global Outcomes Research Department, Merck and Co, Inc, NJ 08889, USA. larry_radican@merck.comMortality of aircraft maintenance workers exposed to trichloroethylene and other hydrocarbons and chemicals: extended follow-upJ.Occup.Environ.Med.J.Occup.Environ.Med.1306-13195011NOT IN FILEadverse effectsAgedAged,80 and overAircraftarticleAssociationcancerCause of Deathchemically induceddeathepidemiologyexposureFemalefollow upFollow-Up StudiesHumanshydrocarbonHydrocarbonsliteratureMaintenanceMalemethodsMiddle AgedmodelmortalityOccupational DiseasesOccupational ExposurePrivate SectorProportional Hazards ModelsResearchResearch SupportRiskRisk AssessmenttrendsTrichloroethyleneUtahVital Statisticsworker2008PM:19001957uDyK  _ENREF_19$$If!vh595 585s5555y#v9#v #v8#vs#v#v#v#vy:V s4 t4+595 585s5555y/ 44 sytT&DZhao2005184[16]18418417Zhao, Y.Krishnadasan, A.Kennedy, N.Morgenstern, H.Ritz, B.Department of Epidemiology, School of Public Health, UCLA, Los Angeles, California, USAEstimated effects of solvents and mineral oils on cancer incidence and mortality in a cohort of aerospace workersAm.J.Ind.Med.Am.J.Ind.Med.249-258484NOT IN FILEAAdultAgedaromatic hydrocarbonAROMATIC HYDROCARBONSarticleAssociationAviationBenzeneCaliforniacancerchemically inducedCohort Studiesconfidence intervalepidemiologyexposureHealthHumanshydrocarbonHydrocarbonsIncidenceKidneykidney cancerLeukemiaLunglung cancerLymphomaMaleMelanomamethodsMineral OilmodelmortalityNeoplasmsNON-HODGKIN'S LYMPHOMAOccupational DiseasesOccupational HealthoilOilsPublic HealthRATERetrospective StudiesRiskRisk AssessmentsolventSolventsStomachstudytoxicityTrichloroethyleneworker2005PM:16167347Zhao200518418418417Zhao, Y.Krishnadasan, A.Kennedy, N.Morgenstern, H.Ritz, B.Department of Epidemiology, School of Public Health, UCLA, Los Angeles, California, USAEstimated effects of solvents and mineral oils on cancer incidence and mortality in a cohort of aerospace workersAm.J.Ind.Med.Am.J.Ind.Med.249-258484NOT IN FILEAAdultAgedaromatic hydrocarbonAROMATIC HYDROCARBONSarticleAssociationAviationBenzeneCaliforniacancerchemically inducedCohort Studiesconfidence intervalepidemiologyexposureHealthHumanshydrocarbonHydrocarbonsIncidenceKidneykidney cancerLeukemiaLunglung cancerLymphomaMaleMelanomamethodsMineral OilmodelmortalityNeoplasmsNON-HODGKIN'S LYMPHOMAOccupational DiseasesOccupational HealthoilOilsPublic HealthRATERetrospective StudiesRiskRisk AssessmentsolventSolventsStomachstudytoxicityTrichloroethyleneworker2005PM:16167347&DZhao2005184[16]18418417Zhao, Y.Krishnadasan, A.Kennedy, N.Morgenstern, H.Ritz, B.Department of Epidemiology, School of Public Health, UCLA, Los Angeles, California, USAEstimated effects of solvents and mineral oils on cancer incidence and mortality in a cohort of aerospace workersAm.J.Ind.Med.Am.J.Ind.Med.249-258484NOT IN FILEAAdultAgedaromatic hydrocarbonAROMATIC HYDROCARBONSarticleAssociationAviationBenzeneCaliforniacancerchemically inducedCohort Studiesconfidence intervalepidemiologyexposureHealthHumanshydrocarbonHydrocarbonsIncidenceKidneykidney cancerLeukemiaLunglung cancerLymphomaMaleMelanomamethodsMineral OilmodelmortalityNeoplasmsNON-HODGKIN'S LYMPHOMAOccupational DiseasesOccupational HealthoilOilsPublic HealthRATERetrospective StudiesRiskRisk AssessmentsolventSolventsStomachstudytoxicityTrichloroethyleneworker2005PM:16167347Zhao200518418418417Zhao, Y.Krishnadasan, A.Kennedy, N.Morgenstern, H.Ritz, B.Department of Epidemiology, School of Public Health, UCLA, Los Angeles, California, USAEstimated effects of solvents and mineral oils on cancer incidence and mortality in a cohort of aerospace workersAm.J.Ind.Med.Am.J.Ind.Med.249-258484NOT IN FILEAAdultAgedaromatic hydrocarbonAROMATIC HYDROCARBONSarticleAssociationAviationBenzeneCaliforniacancerchemically inducedCohort Studiesconfidence intervalepidemiologyexposureHealthHumanshydrocarbonHydrocarbonsIncidenceKidneykidney cancerLeukemiaLunglung cancerLymphomaMaleMelanomamethodsMineral OilmodelmortalityNeoplasmsNON-HODGKIN'S LYMPHOMAOccupational DiseasesOccupational HealthoilOilsPublic HealthRATERetrospective StudiesRiskRisk AssessmentsolventSolventsStomachstudytoxicityTrichloroethyleneworker2005PM:16167347uDyK  _ENREF_16$$If!vh595 585s5555y#v9#v #v8#vs#v#v#v#vy:V s4 t4+595 585s5555y/ 44 sytTsDyK  _ENREF_2$$If!vh595 585s5555y#v9#v #v8#vs#v#v#v#vy:V s4 t4+595 585s5555y/ 44 sytTuDyK  _ENREF_24$$If!vh595 585s5555y#v9#v #v8#vs#v#v#v#vy:V s4 t4+595 585s5555y/ 44 sytT DMiligi2006155[17]15515517Miligi, L.Costantini, A. S.Benvenuti, A.Kriebel, D.Bolejack, V.Tumino, R.Ramazzotti, V.Rodella, S.Stagnaro, E.Crosignani, P.Amadori, D.Mirabelli, D.Sommani, L.Belletti, I.Troschel, L.Romeo, L.Miceli, G.Tozzi, G. A.Mendico, I.Vineis, P.Istituto Toscano Tumori, Unit of Environmental and Occupational Epidemiology, Centre for Study and Prevention of Cancer, Via di S. Salvi 12, 50135 Florence, ItalyOccupational exposure to solvents and the risk of lymphomasEpidemiologyEpidemiology552-561175NOT IN FILEAAdultadverse effectsageAgedanalysisaromatic hydrocarbonAROMATIC HYDROCARBONSarticleAssociationBenzenecancerCase-Control Studieschlorinated hydrocarbonconfidence intervalControlDeveloped CountriesDiseaseepidemiologyetiologyexposureFemaleHodgkin DiseaseHumanshydrocarbonHydrocarbonsHydrocarbons,AromaticHydrocarbons,ChlorinatedItalyLeukemia,Lymphocytic,Chronic,B-CellLymphomaLymphoma,Non-HodgkinMalemethodsMiddle Agednonhodgkin lymphomaOccupational ExposureOdds RatioPopulationpreventionProbabilityquestionnaireResearchResearch SupportRiskrisk factorRisk FactorsSexsolventSolventsstudyTolueneXYLENE2006PM:16878041 DMiligi2006155[17]15515517Miligi, L.Costantini, A. S.Benvenuti, A.Kriebel, D.Bolejack, V.Tumino, R.Ramazzotti, V.Rodella, S.Stagnaro, E.Crosignani, P.Amadori, D.Mirabelli, D.Sommani, L.Belletti, I.Troschel, L.Romeo, L.Miceli, G.Tozzi, G. A.Mendico, I.Vineis, P.Istituto Toscano Tumori, Unit of Environmental and Occupational Epidemiology, Centre for Study and Prevention of Cancer, Via di S. Salvi 12, 50135 Florence, ItalyOccupational exposure to solvents and the risk of lymphomasEpidemiologyEpidemiology552-561175NOT IN FILEAAdultadverse effectsageAgedanalysisaromatic hydrocarbonAROMATIC HYDROCARBONSarticleAssociationBenzenecancerCase-Control Studieschlorinated hydrocarbonconfidence intervalControlDeveloped CountriesDiseaseepidemiologyetiologyexposureFemaleHodgkin DiseaseHumanshydrocarbonHydrocarbonsHydrocarbons,AromaticHydrocarbons,ChlorinatedItalyLeukemia,Lymphocytic,Chronic,B-CellLymphomaLymphoma,Non-HodgkinMalemethodsMiddle Agednonhodgkin lymphomaOccupational ExposureOdds RatioPopulationpreventionProbabilityquestionnaireResearchResearch SupportRiskrisk factorRisk FactorsSexsolventSolventsstudyTolueneXYLENE2006PM:16878041uDyK  _ENREF_17$$If!vh595 585s5555y#v9#v #v8#vs#v#v#v#vy:V s4 t4+595 585s5555y/ 44 sytT$$If!vh595 585s5555y#v9#v #v8#vs#v#v#v#vy:V s4 t4,,595 585s5555y/ 44 sytKTh DMorgan1998157[6]15715717Morgan, R. W.Kelsh, M. A.Zhao, K.Heringer, S.Exponent Health Group, Menlo Park, CA, USAMortality of aerospace workers exposed to trichloroethyleneEpidemiologyEpidemiology424-43194NOT IN FILEAAdultadverse effectsAgedAircraftArizonaarticleAssociationAviationcancerCarcinogensCause of Deathchemically inducedclassificationCohort Studiesconfidence intervalConfidence IntervalsDiseaseepidemiologyexposureFemaleHealthHumansIndustryKidneyLeukemiaLiverliver cancerLymphomaMaleMiddle AgedmortalityNeoplasmsOccupational DiseasesOccupational ExposureProportional Hazards ModelsRATEResearchResearch SupportRespiratory Tract DiseasesRisksolventSolventsstatistics & numerical dataTrichloroethyleneworker1998PM:9647907h DMorgan1998157[6]15715717Morgan, R. W.Kelsh, M. A.Zhao, K.Heringer, S.Exponent Health Group, Menlo Park, CA, USAMortality of aerospace workers exposed to trichloroethyleneEpidemiologyEpidemiology424-43194NOT IN FILEAAdultadverse effectsAgedAircraftArizonaarticleAssociationAviationcancerCarcinogensCause of Deathchemically inducedclassificationCohort Studiesconfidence intervalConfidence IntervalsDiseaseepidemiologyexposureFemaleHealthHumansIndustryKidneyLeukemiaLiverliver cancerLymphomaMaleMiddle AgedmortalityNeoplasmsOccupational DiseasesOccupational ExposureProportional Hazards ModelsRATEResearchResearch SupportRespiratory Tract DiseasesRisksolventSolventsstatistics & numerical dataTrichloroethyleneworker1998PM:9647907$$If!vh595 585s5555y#v9#v #v8#vs#v#v#v#vy:V s4 t4,,595 585s5555y/ 44 sytKT $$If!vh595 585s5555y#v9#v #v8#vs#v#v#v#vy:V s4 t4,,595 585s5555y44 sytKT$$If!vh595 585s5555y#v9#v #v8#vs#v#v#v#vy:V s4 t4,,595 585s5555y/ 44 sytKT\Ddt$"Ol  HA?Picture 142.B}]ٻH4x `!p.B}]ٻH4e'kZ MC>x͝ xUՕᥖС@B B0F @" !(q538"Zo Z#Q;V)uΌb09搐p1>k>nޘ9ƴ3W>{hG/Hd3y$}D| +1ɳg 9\͐Q 1mމַy72cI2͕H.]@lx(d cGS޷a4s_jM)}֦#S͟]D;jpw7#ȫ#g7?9\m8:jEr}74♁x@oy I'!o#f]nױ>K(i>6pzGVdO}Rhk} 2\uޝ.#w~tťvj\k(J( Hn]4d;V> ]S׍0F$d 6E#f tnj$bmIp>aL-eO5cOcmȇtTÀ-ѶѬm毞 2N2W2$MS_#;mTc8Z[Ѷ8 ,c<Gҟ UD/ncP WadA_=볖/W>j;v9JOj7E7 /zrCs R쉹F{TSҗ/\%d6b3 m-"׳zl/Aև"W'7m=a3qZOkelS}APzϠM3hsxw=bO6M[OQ'j=TlcVϡDxΫǦ̾秸W9) 'U @g뱽5C>fnDl[\Oco-{{.`S3@Z{]P[c}To?kd9o_$}[Дq}[ ^}[}^RChJQw Tbcyr(btoύb uSb}~&ubomf0 [ .$oR{ɂrhJg.HMݔ;$=O[{}CSb"\ִqøDLf0 9(6)'ta`1^޾T1}oE\[2o/ś}:Qy+m`ry;V63$XEśz.!Ig=/eQyjJ^oǷu{ٵE\mt#i^N"(v;.?&o0'r}F (>`26XD͟gxwֺ .[:a `z廳U=Xe9*w̙^XceKYW!\܅oL5wobpse%- Ԋk;eW\&XvCZ^Ke~/_}ߒq~[iƕ3X1cm+mŵO=|=|kaWaU3J%܇3S_r|&ådM!߁✑973=r]܃Yy=yk@8]7wO6؀VPߣ< n8TɼR |CNiȷ:m| nBW-pW>?FZngq/s#7g>>z|䚬G0k8cЕ~Ky?ӧrN|eNpT>獚I̝q &k82*<2jStߒqsث\cn07?/|K8W[1.ݴ߭n:zo8ƇGɕy~W+w*[g3ƨܿnMPkM^,ܔ^ 3(.<"h;@A6x/Mo59N_#@y \A8>9>q2Uug\*zvB; / q})m4(mٲo!+4BdM%{g3”L;H=vB-~YP{}-z'15C}thM@W`{OcfΘ_{O]rLr~6cVldTQ0+3%x5J5Qnap>S棫fҷ6)%CҐE@ |:V\ĥ`NA`@%~0ƣYԍ?V7~3dR:ŠsG{ߦL]NߜiͿoTSٻOS_A\x ShY҉wss!:`Ol.}dVN 2vf>{K%2Sl)Dמ3r2E_W[O{/ט=cّtQji꓾j $S[WҷwӞD`+Q֢ ضJ P; v&mnGΆz;]̙Љ굿8M]TZ\Q^8P_rw3G7W:ٲ͕Σ.tΞϊ5QNl{wZ?,e4=+޿:^'IܘB$ޘMOWyaTI39=IG*3v)9gq+R>ʭ(ȝoNo^\J5~ 3Kg*^pLa[BmONd$m|6E84v^꜏8;zw2G׸mO7̓e0?܇;!F W.sӇỻc~c~SNȹ1aF_͖d1ou,6|j\~1ϋ_wg5ίo^_;slJ6=7cwю;wOjG~{e~'W,sn5#ݪ+] ӯݣ㵺,umwV; ,uRDsձ nepc[-sCgS$ڪΫܨWb&kp#m4')&+Huqxs vq(ufx}oX뜸Jz퍻fy,^j?z~qy޸ +Y^wt&'#l޸ zq^fxq~^fw^`a<^h{7^NAiNâ^WE.e8yV7S(=Pr\R_8O,E|s;YL%`!(6䷛E2e;eA>/`1(#&f K9D^I%zKѯ`']axםɛ(5r*_.xa'ѣX< 2d#Q'Y6"HF6_8Ol:f /9~f+z;x?vO #';gss{*>U/sڻc.*&i|4s:o1*wcfbV̋(^7m//a{q0[7{vvzǿ?cĦ²HEqNoVs:ZG*Vɻri7x?s+;۹W^ 2co7\n]rվF'c} Sl"E*#e "u=R\h{H{zCL+ F~tdWS.Hc~ϻ2's=6] 﫼=:PUK+AgśQeU? b 666666666vvvvvvvvv66666>66666666666666666666666666666666666666666666666hH6666666666666666666666666666666666666666666666666666666666666666662 0@P`p2( 0@P`p 0@P`p 0@P`p 0@P`p 0@P`p 0@P`p8XV~PJ_HmH nHsH tH@`@ &NormalCJ_HaJmH sH tH DA`D Default Paragraph FontRi@R 0 Table Normal4 l4a (k ( 0No List 4 @4 )|0Footer H$.. )|0 Footer Char6U6 &0 Hyperlink >*B*phB'!B ,+Comment ReferenceCJaJ<2< ,+0 Comment TextCJaJBAB ,+0Comment Text CharCJaJ@j12@ ,+0Comment Subject5\FBaF ,+0Comment Subject Char5\HrH ,+0 Balloon TextCJOJQJ^JaJNN ,+0Balloon Text CharCJOJQJ^JaJ.)@. To Page NumberROR ,=m M_received dT6B*PJaJphtH4@4 wHeader  !:: w0 Header Char CJaJtH PK![Content_Types].xmlj0Eжr(΢Iw},-j4 wP-t#bΙ{UTU^hd}㨫)*1P' ^W0)T9<l#$yi};~@(Hu* Dנz/0ǰ $ X3aZ,D0j~3߶b~i>3\`?/[G\!-Rk.sԻ..a濭?PK!֧6 _rels/.relsj0 }Q%v/C/}(h"O = C?hv=Ʌ%[xp{۵_Pѣ<1H0ORBdJE4b$q_6LR7`0̞O,En7Lib/SeеPK!kytheme/theme/themeManager.xml M @}w7c(EbˮCAǠҟ7՛K Y, e.|,H,lxɴIsQ}#Ր ֵ+!,^$j=GW)E+& 8PK!Ptheme/theme/theme1.xmlYOo6w toc'vuر-MniP@I}úama[إ4:lЯGRX^6؊>$ !)O^rC$y@/yH*񄴽)޵߻UDb`}"qۋJחX^)I`nEp)liV[]1M<OP6r=zgbIguSebORD۫qu gZo~ٺlAplxpT0+[}`jzAV2Fi@qv֬5\|ʜ̭NleXdsjcs7f W+Ն7`g ȘJj|h(KD- dXiJ؇(x$( :;˹! I_TS 1?E??ZBΪmU/?~xY'y5g&΋/ɋ>GMGeD3Vq%'#q$8K)fw9:ĵ x}rxwr:\TZaG*y8IjbRc|XŻǿI u3KGnD1NIBs RuK>V.EL+M2#'fi ~V vl{u8zH *:(W☕ ~JTe\O*tHGHY}KNP*ݾ˦TѼ9/#A7qZ$*c?qUnwN%Oi4 =3ڗP 1Pm \\9Mؓ2aD];Yt\[x]}Wr|]g- eW )6-rCSj id DЇAΜIqbJ#x꺃 6k#ASh&ʌt(Q%p%m&]caSl=X\P1Mh9MVdDAaVB[݈fJíP|8 քAV^f Hn- "d>znNJ ة>b&2vKyϼD:,AGm\nziÙ.uχYC6OMf3or$5NHT[XF64T,ќM0E)`#5XY`פ;%1U٥m;R>QD DcpU'&LE/pm%]8firS4d 7y\`JnίI R3U~7+׸#m qBiDi*L69mY&iHE=(K&N!V.KeLDĕ{D vEꦚdeNƟe(MN9ߜR6&3(a/DUz<{ˊYȳV)9Z[4^n5!J?Q3eBoCM m<.vpIYfZY_p[=al-Y}Nc͙ŋ4vfavl'SA8|*u{-ߟ0%M07%<ҍPK! ѐ'theme/theme/_rels/themeManager.xml.relsM 0wooӺ&݈Э5 6?$Q ,.aic21h:qm@RN;d`o7gK(M&$R(.1r'JЊT8V"AȻHu}|$b{P8g/]QAsم(#L[PK-![Content_Types].xmlPK-!֧6 +_rels/.relsPK-!kytheme/theme/themeManager.xmlPK-!Ptheme/theme/theme1.xmlPK-! ѐ' theme/theme/_rels/themeManager.xml.relsPK]  "',16;@EJZjvwxyz{|}~ "',16;@EJZj 0B>BBB NNNNNNNNPPPPPPRRRRRRRRRU@ C)97###t$$[%%"&&'q''?06<IIOV0cy~P_ɡ xF0   U {qk2;P=LM]NOORRMSTVWY[<\\x]ennAppxy|}~~(ߒcrF٘ϙV%l=tYE7l03U44      !"#$&'()*+,.2ADEHKNORW\cfimoqsuwz{}     @ .1:B g-   o x     U l     L d BN5AWc2Unz**::1<k<<LM7NNO yO[ i[Ap2,444%-/013456789:;<=>?@BCFGIJLMPQSTUVXYZ[]^_`abdeghjklnprtvxy|~ vRTVX0@VXZ ,BDFz|~*,.dfhx  !1GIK$:<>qtv8;=O_uwy69;K[qsu 4DZ\^ !1GIK~468knpm&o&&&&D)p,r,,,,,33)4,4.4=499999M:@@A A AA.ADAFAHA}AAAAGGIGLGNGbGrGGGGGGGG7N9NnNqNsNNNNNNNNNNYU[UUUUUZZZZZ1[4[6[@[,b.bbbebgbxbYi[iiiiiqqqqqqqrrr>rArCrYr}yyyyyyZ\ˈ͈ψ:=?O_uwyLN͑ݑ),.`ceęǙə}Р|~̨Ұ԰ %bd׿ڿܿACy|~GJL[k,/1C+;QSU nKNP+;QSU"$&AQgikE G { }       m}0@VXZWg}w!%:!! "0"F"H"L"^")))91>133333+4-4/4A4;;;;;;RCTCCCCD$D:DDqDtDvDDDDDDDEEGEWEmEoEqEEEEFF-F/F1FoFrFtFGG(G*G,G^GaGcGGGHHH:HH[HkHHHHHHHHIIIIOIRITIIIIII J JJIKYKoKqKsKKKKN,NBNDNFNNNN.P>PTPVPXPPPPPPPPPQQ QAQQQgQiQkQQQQ;RYYYYYYZZZZRZTZVZZrbtbbbbbbbbbcc!cccccccccdd-d/d1dodrdtddkkllllHlIl^pnpppppppBqRqhqjqlqqqqqqqqqrrrryyzzzizyzzzzzzz{ns ˁہ 359Tdz|ł  (8NPUΈވ69;<vw')+^acCSikmӋԋJǓɓ˓šŚǚ3CY[]֜؜ܜ)zQXt̕XQXt̕QQDXt̕QQDXt̕QQDXt̕QQDXt̕QQDXt̕QQDXtXt̕QQDXt̕QQDXt̕QQDXt̕QXt̕QQDXt̕QQDXt̕QQDXt̕QQDXt̕QQDXt̕QQDXt̕QQDXt̕QQDXt̕QQDXt̕QQDXt̕QXt̕QXt̕QXt̕QXt̕QXt̕QQDXt̕QXt̕QQDXt̕QXt̕QQDXt̕QXt̕QXtXt̕QXt̕QXt̕QXt̕QQDXt̕QXt̕QXt̕QXt̕QQDXtXt̕QQDXt̕QXtXt̕QQDXtXt̕QXt̕QXt̕QXt̕QXt̕QXt̕QXt̕QXt̕QXt̕QQDXt̕QQDXtXt̕QXt̕QQDXt̕QXt̕QXt̕QQDXt̕QQDXt̕QXt̕QXt̕QXt̕QQDXt̕QQDXt̕QQDXt̕QXt̕QQDXt̕QQDXt̕QQDXt̕QQDQQDQQDQQDQQDQQQQDQQQQDXt̕QXt̕QXt̕QQDXt̕QQDXt̕QQDXt̕QQDXt̕QQDXt̕QQDXt̕QQDXt̕QQDXt̕QQDXt̕QQDXt̕QQDXt̕QQDXt̕QQDXt̕QQDXt̕QXt̕QQDXt̕QXt̕QQDXt̕QQDXt̕QQDXt̕QXt̕XQQDXt̕QQDXt̕QQDXt̕QXt̕QQDXt̕QQQDQQDQQDQQDQQDQQDQQDQQDXt̕XQQDXt̕QQDXt̕QQDXt̕XQXt̕QXt̕QQDXt̕QQDQQQ U!7,"$y d^e+~2C# AA@6^(    b{{%fA?"Picture 443#" ?xt   t S"?h u S X?"`  v <vZ  w <wZ   x <x1 Z7   y <ydZi  z <zZ  { <{Z  | <|Z  } <}KZ  ~ < ~}ZO  BB   |}BB   BB     BB   BB   GHBB   z{BB   BB   BB   BB   BB   |  < :  BB   c|  < -  BB   c |   <  s   BB   cV|W  <    BB   |  <Q BB   kBB    H2  # H2  # 2 f H2  # f _ H2  # m_H2  #  \H2  # / K H2  #   cf H2  # %Q ~ H2  # @ H2  # vXH2  # fH2  # ;H2  #  } y H2  #  / H2  #  80   b@AB|CbEF1b|1@`/  < i    <'^    <Pv B S  ?tYtg(8"44Q _Toc242603514 _Toc242505426 _Toc242505428 _Toc242505430 _Toc242505421 _Toc242505423 _Toc242505437_ENREF_1_ENREF_2_ENREF_3_ENREF_4_ENREF_5_ENREF_6_ENREF_7_ENREF_8_ENREF_9 _ENREF_10 _ENREF_11 _ENREF_12 _ENREF_13 _ENREF_14 _ENREF_15 _ENREF_16 _ENREF_17 _ENREF_18 _ENREF_19 _ENREF_20 _ENREF_21 _ENREF_22 _ENREF_23 _ENREF_24 _ENREF_25 _ENREF_26 _ENREF_27 _ENREF_28 _ENREF_29 _ENREF_30 _ENREF_31 _ENREF_32 _ENREF_33 _ENREF_34 _ENREF_35 _ENREF_36 _ENREF_37 _ENREF_38 _ENREF_39 _ENREF_40 _ENREF_41 _ENREF_42 _ENREF_43 _ENREF_44 _ENREF_45 _ENREF_46 _ENREF_47 _ENREF_48 _ENREF_49 _ENREF_50 _ENREF_51 _ENREF_52 _ENREF_53 _ENREF_54 _ENREF_55 _ENREF_56 _ENREF_57 _ENREF_58 _ENREF_59 _ENREF_60 _ENREF_61 _ENREF_62 _ENREF_63 _ENREF_64 _ENREF_65 _ENREF_66 _ENREF_67 _ENREF_68 _ENREF_69 _ENREF_70 _ENREF_71 OLE_LINK1 OLE_LINK2 OLE_LINK302Am lʱj ߼ý.b j _l-'pA!P'[)r_:][w_?  !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKLMNOP2#Mmkɱi ޼½-a i ^k,&o@ O&Z(q^9\Zv^>ju!/ kw y@N<=?DGI#3 s=:L:AAAAAAAA[GaGGGGG|NNNN9[?[qbvbiiqqMrXryyHN̙̑יĨ߿PS7;U] ?BHOadSVx{""O"V"c1l1*2-222332494DDEEoGwGGGIIu(QH%'2lM~ \lmٜ{ƮʱǶ÷ }ý  -'-A 'lD[)":Sw?  !#&(+-0257:<?ADFIKNPSUces^m 0Ew)AuWt$/?l- ZnG/> ! > F~ qG1(7M}"B6qFF%DpYW&BP:jDm< "}$E^$Vj$Q%Y'(:(L) )d* +,+n+~+M-b-Z}0u 11+1|=1c1S233b4y44K5!M5i]5<76fX7k 88X9v-:A;S;]w;<rE<SO<i<<@?w?@ COGC,DRD|tD}DE8EgE'GxJ!$K (K4LM!N7%O5Ri>RvRTFTcTvU82VZVbWeNXXX|X_YdYlY{YzZOd\r\]:.^bM_P_\`sbbc::cxgc8fHg`i.k llE:l,=mFmQm &nanoZojo8qn rJHrstsLtXt{t/uvu7wO3wxwMyXy `{)|%j}Y~)k[x&u_cyv(*] g":,VNYTb'c4-To:O3TMmmhv[ jmo~t! 24JeX6xcWaD:Xg0lpQS_:7Jj?sj&;9J}>,k6HT&49~LQ~\F~5\]1&x. Fqt x{&KxbWq8' ;~w323{5`~4_|>{,B4eAF@qS(c}z>":%4$(ezw5~PMVdB*-Pb.[<tC|'67[EN.InstantFormat EN.Layout  EN.Librariesw<ENInstantFormat><Enabled>0</Enabled><ScanUnformatted>1</ScanUnformatted><ScanChanges>1</ScanChanges></ENInstantFormat><ENLayout><Style>MDPI Copy</Style><LeftDelim>{</LeftDelim><RightDelim>}</RightDelim><FontName>Times New Roman</FontName><FontSize>12</FontSize><ReflistTitle></ReflistTitle><StartingRefnum>1</StartingRefnum><FirstLineIndent>0</FirstLineIndent><HangingIndent>720</HangingIndent><LineSpacing>0</LineSpacing><SpaceAfter>0</SpaceAfter><HyperlinksEnabled>1</HyperlinksEnabled><HyperlinksVisible>0</HyperlinksVisible></ENLayout><Libraries><item db-id="0aftzztxwzptt3e2eznvf50o0de9xvevzrtt">TCE_MetaAnalysis_MS_Refs Copy<record-ids><item>119</item><item>120</item><item>123</item><item>125</item><item>126</item><item>128</item><item>131</item><item>132</item><item>139</item><item>141</item><item>142</item><item>144</item><item>155</item><item>157</item><item>160</item><item>166</item><item>167</item><item>168</item><item>169</item><item>174</item><item>179</item><item>184</item><item>208</item><item>232</item><item>236</item><item>324</item><item>337</item><item>342</item><item>499</item><item>502</item><item>508</item><item>513</item><item>519</item><item>524</item><item>532</item><item>534</item><item>538</item><item>539</item><item>560</item><item>564</item><item>565</item><item>573</item><item>575</item><item>576</item><item>581</item><item>582</item><item>584</item><item>585</item><item>586</item><item>587</item><item>588</item><item>589</item><item>591</item><item>593</item><item>599</item><item>610</item><item>614</item><item>615</item><item>622</item><item>623</item><item>626</item><item>629</item><item>631</item><item>636</item><item>641</item><item>644</item><item>653</item><item>655</item><item>657</item><item>660</item><item>679</item></record-ids></item></Libraries>@FGkIkJkbkckk@ @P@T@n@$@`@UnknownG* Times New Roman5Symbol3. * Arial7.{ @Calibri5. *aTahomaA BCambria Math"qh0fmBFUFydIT|{I٢}x20Y 3qHX  $P)|2!xx Cheryl Scott Chelly ChengOh+'0  < H T `lt|Cheryl ScottNormalChelly Cheng147Microsoft Office Word@L@f83w@G@dIT՜.+,D՜.+,0 hp  US-EPA|  Title4! 8@ _PID_HLINKSA  @n  _ENREF_17 Cf  _ENREF_24 C`  _ENREF_2 @[  _ENREF_15 @W  _ENREF_16 @O  _ENREF_19 CG  _ENREF_20 @@  _ENREF_14 @<  _ENREF_15 H  _ENREF_9 C  _ENREF_2 @  _ENREF_16 I  _ENREF_8 @  _ENREF_16 F  _ENREF_70 C  _ENREF_2 @  _ENREF_15 G  _ENREF_6 @  _ENREF_16 @  _ENREF_13 G  _ENREF_6 C  _ENREF_2 H  _ENREF_9 I  _ENREF_8 @  _ENREF_16 @  _ENREF_15 @  _ENREF_12 @  _ENREF_18 C  _ENREF_22 @{  _ENREF_16 Is  _ENREF_8 @k  _ENREF_16 @c  _ENREF_15 G[  _ENREF_6 @S  _ENREF_19 CK  _ENREF_20 @C  _ENREF_13 C=  _ENREF_2 D7  _ENREF_5 @  _ENREF_15 @  _ENREF_15 G  _ENREF_6 C  _ENREF_2 @  _ENREF_16 I  _ENREF_8 @  _ENREF_16 F  _ENREF_70 G  _ENREF_69 G  _ENREF_68 G  _ENREF_67 G  _ENREF_66 G  _ENREF_65 G  _ENREF_64 G  _ENREF_63 G  _ENREF_62 G  _ENREF_61 G  _ENREF_60 D  _ENREF_59 D  _ENREF_58 Dz  _ENREF_57 Dt  _ENREF_56 Dn  _ENREF_55 Dh  _ENREF_54 Db  _ENREF_53 D\  _ENREF_52 DV  _ENREF_51 DP  _ENREF_50 EM  _ENREF_49 EE  _ENREF_48 EB  _ENREF_47 E<  _ENREF_46 E4  _ENREF_45 E1  _ENREF_44 E)  _ENREF_43 E#  _ENREF_42 E  _ENREF_41 E  _ENREF_40 B  _ENREF_39 B   _ENREF_38 B  _ENREF_37 B  _ENREF_36 B  _ENREF_35 B  _ENREF_34 B  _ENREF_33 B  _ENREF_32 B  _ENREF_31 B  _ENREF_30 C  _ENREF_29 C  _ENREF_28 C  _ENREF_27 C  _ENREF_26 C  _ENREF_25 C  _ENREF_24 C  _ENREF_23 C  _ENREF_22 C  _ENREF_21 C  _ENREF_20 @  _ENREF_19 @  _ENREF_18 @|  _ENREF_17 @t  _ENREF_16 @l  _ENREF_15 @d  _ENREF_14 @\  _ENREF_13 @V  _ENREF_12 @N  _ENREF_11 @F  _ENREF_10 H>  _ENREF_9 I;  _ENREF_8 F3  _ENREF_7 G+  _ENREF_6 D#  _ENREF_5 E  _ENREF_4 B  _ENREF_3 C   _ENREF_2 @  _ENREF_1 @  _ENREF_1  !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]^_`abcdefghijklmnopqrstuvwxyz{|}~      !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]^_`abcdefghijklmnopqrstuvwxyz{|}~      !"#$%&'(*+,-./0123456789:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]^_`abcdefghijklmnopqrstuvwxyz{|}~      !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]^_`abcdefghijklmnopqrstuvwxyz{|}~      !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]^_`abcdefghijklmnopqrstuvwxyz{|}~      !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]^_`abcdefghijklmnopqrstuvwxyz{|}~Root Entry FD`)Data )1TableWordDocument QSummaryInformation(DocumentSummaryInformation8d"MsoDataStoreO)])0AWAI3Q==2O)])Item  PropertiesUCompObj y   F'Microsoft Office Word 97-2003 Document MSWordDocWord.Document.89q