Next Article in Journal
Fluoride Consumption and Its Impact on Oral Health
Next Article in Special Issue
Lysyl Oxidase, A Critical Intra- and Extra-Cellular Target in the Lung for Cigarette Smoke Pathogenesis
Previous Article in Journal
Constitutive, but Not Challenge-Induced, Interleukin-10 Production Is Robust in Acute Pre-Pubescent Protein and Energy Deficits: New Support for the Tolerance Hypothesis of Malnutrition-Associated Immune Depression Based on Cytokine Production in vivo
Previous Article in Special Issue
The Impact of Menthol Cigarettes on Smoking Initiation among Non-Smoking Young Females in Japan
Int. J. Environ. Res. Public Health 2011, 8(1), 136-147; doi:10.3390/ijerph8010136
Review

Smoking Related Diseases: The Central Role of Monoamine Oxidase

1,* , 2
,
3
,
4
 and
2
Received: 3 December 2010 / Revised: 24 December 2010 / Accepted: 6 January 2011 / Published: 14 January 2011
(This article belongs to the Special Issue Tobacco Smoking: Public Health, Science and Policy)
View Full-Text   |   Download PDF [606 KB, 19 June 2014; original version 19 June 2014]   |   Browse Figures

Abstract

Smoking is a major risk factor of morbidity and mortality. It is well established that monoamine oxidase (MAO) activity is decreased in smokers. Serotonin (5-HT), a major substrate for MAO that circulates as a reserve pool stored in platelets, is a marker of platelet activation. We recently reported that smoking durably modifies the platelet 5-HT/MAO system by inducing a demethylation of the MAO gene promoter resulting in high MAO protein concentration persisting more than ten years after quitting smoking. The present data enlarges the results to another MAO substrate, norepinephrine (NE), further confirming the central role of MAO in tobacco use-induced diseases. Thus, MAO could be a readily accessible and helpful marker in the risk evaluation of smoking-related diseases, from cardiovascular and pulmonary diseases to depression, anxiety and cancer. The present review implements the new finding of epigenetic regulation of MAO and suggests that smoking-induced MAO demethylation can be considered as a hallmark of smoking-related cancers similarly to other aberrant DNA methylations.
Keywords: smoking; serotonin; norepinephrine; monoamine oxidase; cardiovascular; platelets; epigenetic; cancer; depression smoking; serotonin; norepinephrine; monoamine oxidase; cardiovascular; platelets; epigenetic; cancer; depression
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote
MDPI and ACS Style

Rendu, F.; Peoc’h, K.; Berlin, I.; Thomas, D.; Launay, J.-M. Smoking Related Diseases: The Central Role of Monoamine Oxidase. Int. J. Environ. Res. Public Health 2011, 8, 136-147.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here

Comments

Cited By

[Return to top]
Int. J. Environ. Res. Public Health EISSN 1660-4601 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert