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Int. J. Environ. Res. Public Health 2011, 8(1), 136-147; doi:10.3390/ijerph8010136
Review

Smoking Related Diseases: The Central Role of Monoamine Oxidase

1,* , 2
, 3
, 4
 and 2
Received: 3 December 2010; in revised form: 24 December 2010 / Accepted: 6 January 2011 / Published: 14 January 2011
(This article belongs to the Special Issue Tobacco Smoking: Public Health, Science and Policy)
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Abstract: Smoking is a major risk factor of morbidity and mortality. It is well established that monoamine oxidase (MAO) activity is decreased in smokers. Serotonin (5-HT), a major substrate for MAO that circulates as a reserve pool stored in platelets, is a marker of platelet activation. We recently reported that smoking durably modifies the platelet 5-HT/MAO system by inducing a demethylation of the MAO gene promoter resulting in high MAO protein concentration persisting more than ten years after quitting smoking. The present data enlarges the results to another MAO substrate, norepinephrine (NE), further confirming the central role of MAO in tobacco use-induced diseases. Thus, MAO could be a readily accessible and helpful marker in the risk evaluation of smoking-related diseases, from cardiovascular and pulmonary diseases to depression, anxiety and cancer. The present review implements the new finding of epigenetic regulation of MAO and suggests that smoking-induced MAO demethylation can be considered as a hallmark of smoking-related cancers similarly to other aberrant DNA methylations.
Keywords: smoking; serotonin; norepinephrine; monoamine oxidase; cardiovascular; platelets; epigenetic; cancer; depression smoking; serotonin; norepinephrine; monoamine oxidase; cardiovascular; platelets; epigenetic; cancer; depression
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Rendu, F.; Peoc’h, K.; Berlin, I.; Thomas, D.; Launay, J.-M. Smoking Related Diseases: The Central Role of Monoamine Oxidase. Int. J. Environ. Res. Public Health 2011, 8, 136-147.

AMA Style

Rendu F, Peoc’h K, Berlin I, Thomas D, Launay J-M. Smoking Related Diseases: The Central Role of Monoamine Oxidase. International Journal of Environmental Research and Public Health. 2011; 8(1):136-147.

Chicago/Turabian Style

Rendu, Francine; Peoc’h, Katell; Berlin, Ivan; Thomas, Daniel; Launay, Jean-Marie. 2011. "Smoking Related Diseases: The Central Role of Monoamine Oxidase." Int. J. Environ. Res. Public Health 8, no. 1: 136-147.



Int. J. Environ. Res. Public Health EISSN 1660-4601 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert