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Int. J. Environ. Res. Public Health 2010, 7(7), 2845-2852; doi:10.3390/ijerph7072845
Article

Perinatal Bisphenol A Exposure in C57B6/129svj Male Mice: Potential Altered Cytokine/Chemokine Production in Adulthood

1,* , 2,3, 2,3, 4, 5, 2,3 and Jr. 1
Received: 29 June 2010; Accepted: 9 July 2010 / Published: 12 July 2010
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Abstract: Pregnant mice (n = 3) were exposed to BPA by intraperitoneal injection, from gestation day 9.5 until end of lactation. Male offspring were evaluated for cytokine production at 20 wk-of-age. One pregnant control mouse produced no males, precluding statistical analysis. However, recurring shifts in cytokines were suggested in the adult BPA offspring. Serum showed a numeric increase in 16 of 21 basal cytokine levels. ConA-stimulated splenocytes showed a numeric increase in 17 of 21 cytokines, and LPS-stimulated splenocytes an increase in 18 of 21 cytokines. The cytokine profile was one of TH1 up-regulation more than TH2, and with skewing toward TH17 responses.
Keywords: bisphenol; developmental; cytokines; immune bisphenol; developmental; cytokines; immune
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Holladay, S.D.; Xiao, S.; Diao, H.; Barber, J.; Nagy, T.; Ye, X.; Gogal, R.M., Jr. Perinatal Bisphenol A Exposure in C57B6/129svj Male Mice: Potential Altered Cytokine/Chemokine Production in Adulthood. Int. J. Environ. Res. Public Health 2010, 7, 2845-2852.

AMA Style

Holladay SD, Xiao S, Diao H, Barber J, Nagy T, Ye X, Gogal RM, Jr. Perinatal Bisphenol A Exposure in C57B6/129svj Male Mice: Potential Altered Cytokine/Chemokine Production in Adulthood. International Journal of Environmental Research and Public Health. 2010; 7(7):2845-2852.

Chicago/Turabian Style

Holladay, Steven D.; Xiao, Shuo; Diao, Honglu; Barber, Jamie; Nagy, Tomas; Ye, Xiaoqin; Gogal, Robert M., Jr. 2010. "Perinatal Bisphenol A Exposure in C57B6/129svj Male Mice: Potential Altered Cytokine/Chemokine Production in Adulthood." Int. J. Environ. Res. Public Health 7, no. 7: 2845-2852.


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