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Int. J. Environ. Res. Public Health 2010, 7(7), 2845-2852; doi:10.3390/ijerph7072845
Article

Perinatal Bisphenol A Exposure in C57B6/129svj Male Mice: Potential Altered Cytokine/Chemokine Production in Adulthood

1,* , 2,3, 2,3, 4, 5, 2,3 and Jr. 1
1 Department of Anatomy and Radiology, College of Veterinary Medicine, University of Georgia, Athens, Georgia, GA 30602, USA 2 Physiology and Pharmacology, College of Veterinary Medicine, University of Georgia, Athens, Georgia, GA 30602, USA 3 Interdisciplinary Toxicology Program, University of Georgia, Athens, GA 30602, USA 4 Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, Georgia, GA 30602, USA 5 Pathology, College of Veterinary Medicine, University of Georgia, Athens, Georgia, GA 30602, USA
* Author to whom correspondence should be addressed.
Received: 29 June 2010 / Accepted: 9 July 2010 / Published: 12 July 2010
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Abstract

Pregnant mice (n = 3) were exposed to BPA by intraperitoneal injection, from gestation day 9.5 until end of lactation. Male offspring were evaluated for cytokine production at 20 wk-of-age. One pregnant control mouse produced no males, precluding statistical analysis. However, recurring shifts in cytokines were suggested in the adult BPA offspring. Serum showed a numeric increase in 16 of 21 basal cytokine levels. ConA-stimulated splenocytes showed a numeric increase in 17 of 21 cytokines, and LPS-stimulated splenocytes an increase in 18 of 21 cytokines. The cytokine profile was one of TH1 up-regulation more than TH2, and with skewing toward TH17 responses.
Keywords: bisphenol; developmental; cytokines; immune bisphenol; developmental; cytokines; immune
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Holladay, S.D.; Xiao, S.; Diao, H.; Barber, J.; Nagy, T.; Ye, X.; Gogal, R.M., Jr. Perinatal Bisphenol A Exposure in C57B6/129svj Male Mice: Potential Altered Cytokine/Chemokine Production in Adulthood. Int. J. Environ. Res. Public Health 2010, 7, 2845-2852.

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