Perinatal Bisphenol A Exposure in C57B6/129svj Male Mice: Potential Altered Cytokine/Chemokine Production in Adulthood

doi:10.3390/ijerph7072845

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Int. J. Environ. Res. Public Health 2010, 7(7), 2845-2852; doi:10.3390/ijerph7072845

Article

Perinatal Bisphenol A Exposure in C57B6/129svj Male Mice: Potential Altered Cytokine/Chemokine Production in Adulthood

Steven D. Holladay^1,* , Shuo Xiao^2,3, Honglu Diao^2,3, Jamie Barber⁴, Tomas Nagy⁵, Xiaoqin Ye^2,3 and Robert M. Gogal Jr.¹

¹ Department of Anatomy and Radiology, College of Veterinary Medicine, University of Georgia, Athens, Georgia, GA 30602, USA ² Physiology and Pharmacology, College of Veterinary Medicine, University of Georgia, Athens, Georgia, GA 30602, USA ³ Interdisciplinary Toxicology Program, University of Georgia, Athens, GA 30602, USA ⁴ Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, Georgia, GA 30602, USA ⁵ Pathology, College of Veterinary Medicine, University of Georgia, Athens, Georgia, GA 30602, USA

* Author to whom correspondence should be addressed.

Received: 29 June 2010 / Accepted: 9 July 2010 / Published: 12 July 2010

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Abstract: Pregnant mice (n = 3) were exposed to BPA by intraperitoneal injection, from gestation day 9.5 until end of lactation. Male offspring were evaluated for cytokine production at 20 wk-of-age. One pregnant control mouse produced no males, precluding statistical analysis. However, recurring shifts in cytokines were suggested in the adult BPA offspring. Serum showed a numeric increase in 16 of 21 basal cytokine levels. ConA-stimulated splenocytes showed a numeric increase in 17 of 21 cytokines, and LPS-stimulated splenocytes an increase in 18 of 21 cytokines. The cytokine profile was one of T_H1 up-regulation more than T_H2, and with skewing toward T_H17 responses.

Keywords: bisphenol; developmental; cytokines; immune

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MDPI and ACS Style

Holladay, S.D.; Xiao, S.; Diao, H.; Barber, J.; Nagy, T.; Ye, X.; Gogal, R.M., Jr. Perinatal Bisphenol A Exposure in C57B6/129svj Male Mice: Potential Altered Cytokine/Chemokine Production in Adulthood. Int. J. Environ. Res. Public Health 2010, 7, 2845-2852.

AMA Style

Holladay S.D., Xiao S., Diao H., Barber J., Nagy T., Ye X., Gogal R.M., Jr. Perinatal Bisphenol A Exposure in C57B6/129svj Male Mice: Potential Altered Cytokine/Chemokine Production in Adulthood. International Journal of Environmental Research and Public Health. 2010; 7(7):2845-2852.

Chicago/Turabian Style

Holladay, Steven D.; Xiao, Shuo; Diao, Honglu; Barber, Jamie; Nagy, Tomas; Ye, Xiaoqin; Gogal, Robert M., Jr. 2010. "Perinatal Bisphenol A Exposure in C57B6/129svj Male Mice: Potential Altered Cytokine/Chemokine Production in Adulthood." Int. J. Environ. Res. Public Health 7, no. 7: 2845-2852.

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