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Int. J. Environ. Res. Public Health 2010, 7(5), 2395-2406; doi:10.3390/ijerph7052395
1. Issue Identification
2. Hazard Identification
2.1. Dioxin Toxicity
2.2. Physio-Chemical Properties
2.3. Environmental Fate
2.4. Absorption, Distribution and Excretion
2.5. Human Health Impacts
3. Dose-Response Assessment
4. Exposure Assessment
5. Risk Characterization
6. Stakeholder Engagement, Risk Communication & Community Consultation
7. Risk Management
- Nguyen, TNH; Dong Nai Association of Victims of Agent Orange/Dioxin. Population and size of Trung Dung and Tan Phong wards and Total number of AO victims at Dong Nai Province being identified in 3 surveys. Pers Comm.
- IARC. Monographs on the Evaluation of Carcinogenic Risks to Humans. Polychlorinated Dibenzo-para-Dioxins and Polychlorinated Dibenzofurans; International Agency for Research on Cancer (IARC): Lyon, France, February 1997; Volume 69.
- The American People’s Dioxin Report—Technical Support Document, Center for Health, Environment and Justice, Falls Church, VA, USA, 1999; 11–19.
- Institute of Medicine, Committee to Review the Health Effects in Vietnam Veterans of Exposure to Herbicides. Veterans and Agent Orange: Update 2006; National Academy Press: Washington, DC, USA, 2006; p. 11. [Google Scholar]
- Schecter, A; Dai, LC; Päpke, O; Prange, M; Constable, JD; Matsuda, M; Vu, DT; Piskac, AL. Recent dioxin contamination from Agent Orange in residents of a southern Vietnam city. J. Occup. Environ. Med 2001, 43, 435–443. [Google Scholar]
- Minh, NH; Son, LK; Nguyen, PH. Dioxin contamination in Bien Hoa Airbase and its vicinities: environmental levels and implication of sources. Organohalogen Compound 2008, 70, 000543–000546. [Google Scholar]
- Schecter, A; Pavuk, M; Constable, JD; Dai, LC; Päpke, O. A follow-up: high level of dioxin contamination in Vietnamese from Agent Orange, three decades after the end of spraying. J. Occup. Environ. Med 2002, 44, 218–220. [Google Scholar]
- Schecter, A; Quynh, HT; Pavuk, M; Päpke, O; Malisch, R; Constable, JD. Food as a source of dioxin exposure in the residents of Bien Hoa City, Vietnam. J. Occup. Environ. Med 2003, 45, 781–788. [Google Scholar]
- Le, KS; Former director of Office of The National Steering Committee on overcoming of toxic chemicals used by US during the war in Vietnam-Office 33. Overcoming consequences of toxic chemicals/dioxin. Pers Comm.
- Dwernychuk, LW; Hung, TM; Boivin, TC; Bruce, GS; Dung, PT; Son, LK; Hatfield, CT; Dung, NT; Allan, JA; Nhu, DD; Thuc, PV; Moats, DJ; Borton, L. The agent orange dioxin issue in Vietnam: A manageable problem. Presented at the Oslo Conference, Hatfield, UK, 2006.
- Palmer, MG. The legacy of agent orange: empirical evidence from central Vietnam. Soc. Sci. Med 2005, 60, 1061–1070. [Google Scholar]
- Stellman, JM; Stellman, SD; Christian, R; Weber, T; Tomasallo, C. The extend and patterns of usage of agent orange and other herbicides in Vietnam. Nature 2003, 422, 681–687. [Google Scholar]
- Hatfield Consultants and 10–80 Committee. Preliminary Assessment of Environmental Impacts Related to Spraying of Agent Orange Herbicide During the Viet Nam; War, West Vancouver; Hatfield Consultants Ltd: Hatfield, UK, 2000. [Google Scholar]
- Agency for Toxic Substances and Disease Registry (ATSDR). Toxicity Profile for Chlorinated Dibenzo-p-Dioxins; (update); US Department of Health and Humans Services, Public Health Service: Atlanta, GA, USA, December 1998. [Google Scholar]
- Paustenbach, DL; Wenning, RJ; Lau, V; Harrington, NW; Rennix, DK; Parsons, AH. Recent developments on the hazards posed by 2,3,7,8-tetrachlorodibenzo-p-dioxin in soil: implications for setting risk-based cleanup levels at residential and industrial sites. J. Toxicol. Environ. Health 1992, 36, 103–149. [Google Scholar]
- Hulster, A; Muller, JF; Marschner, H. Soil plant transfer of polychlorinated dibenzo-p-dioxin and dibenzofurans to vegetables of the cucumber family (Cucurbitaceae). Environ. Sci. Technol 1994, 28, 1110–1115. [Google Scholar]
- Muller, JF; Hulster, AA; Papke, OC; Ball, MC; Marschner, H. Transfer of PCDD/PCDF from contaminated soils into carrots, lettuce and peas. Chemosphere 1994, 29, 2175–2181. [Google Scholar]
- Olson, JR. Pharmacokinetics of Dioxins and Related Compounds. In Dioxins and Health; Schecter, A, Ed.; Plenum Press: New York, NY, USA, 1994; pp. 163–197. [Google Scholar]
- Nessel, CS; Amoruso, MA; Umbreit, TH; Meeker, RJ; Gallo, MA. Pulmonary bioavailability and fine particle enrichment of 2,3,7,8-TCDD in respirable soil particles. Fundam. Appl. Toxicol 1992, 19, 279–285. [Google Scholar]
- Diliberto, JJ; Jackson, JA; Birnbaum, LS. Comparison of 2,3,7,8-tetrachloro-dibenzo-p-dioxin (TCDD) disposition following pulmonary, oral, dermal, and parenteral exposures to rats. Toxicol. Appl. Pharmacol 1996, 138, 158–168. [Google Scholar]
- Schlatter, C. Data on kinetics of PCDDs and PCDFs as a prerequisite for human risk assessment. In Biological Basis for Risk Assessment of Dioxins and Related Compounds; Gallo, MA, Scheuplein, RJ, van der Heijnen, KA, Eds.; Cold Spring Harbor Laboratory Press: Cold Spring Harbor, NY, USA, 1991; pp. 215–226. [Google Scholar]
- Van den Berg, M; De Jongh, J; Poiger, H; Olson, JM. The toxicokinetics and metabolism of polychlorinated dibenzo-p-dioxins (PCDDs) and dibenzofurans (PCDFs) and their relevance for toxicity. Crit. Rev. Toxicol 1994, 24, 1–74. [Google Scholar]
- Birnbaum, LS. Distribution and excretion of 2,3,7,8-tetrachlorodibenzo-p-dioxin in congenic mice strains of mice which differ at the Ah locus. Drug Metab. Dispos 1986, 14, 34–40. [Google Scholar]
- Bowman, RE; Schantz, SL; Weerasinghe, NCA; Gross, ML; Barsotti, DA. Chronic dietary intake of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) at 5 or 25 parts per trillion in the monkey: TCDD kinetics and dose-effect estimate of reproductive toxicity. Chemosphere 1989, 18, 243–252. [Google Scholar]
- Michalek, JE; Pirkle, JL; Caudill, SP; Tripathi, RC; Patterson, DG; Needham, LL. Pharmacokinetics of TCDD in veterans of Operation Ranch Hand: 10-year follow-up. J. Toxicol. Environ. Health 1996, 47, 209–220. [Google Scholar]
- Birnbaum, LS. Risk Characterization of Dioxins. Presentation at USEPA National Health and Environmental Effects Laboratory, Research Triangle Park, NC, USA, 17 February 1999.
- Health Assessment Documents for 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) and Related Compounds; Volume I, II, and III, , External Review Draft; EPA/600/BP-92/001a, EPA/600/BP-92/001b, and EPA/600/BP-92/001, Office of Research and Development, U.S. Environmental Protection Agency (USEPA): Washington, DC, USA, June 1994.
- Schecter, A; Papke, O; Lis, A; Ball, M; Ryan, JJ; Olson, JR; Li, L; Kesslerm, H. Decrease in milk and blood dioxin levels over two years in a mother nursing twins: Estimates of decreased maternal and increased infant dioxin body burden from nursing. Chemosphere 1996, 32, 543–549. [Google Scholar]
- Assessment of the Health Risks of Dioxins: Re-evaluation of the Tolerable Daily Intake (TDI), , Executive Summary, Final Draft; World Health Organization (WHO) Consultation of May 25–29, 1998, Geneva; European Centre for Environment and Health, International Programme on Chemical Safety, 1998.
- Le, VA; Nguyen, NB; Nguyen, DM; Nguyen, TH; Do, MS; Tran, TTH. Knowledge, attitude and practice of local residents at Bien Hoa City -Vietnam on preventing dioxin exposure through foods. Organohalogen Compound 2008, 70, 000535–000538. [Google Scholar]
|Species||Effect||Dose||Incremental Body Burden (ng/kg)|
|Rhesus||Object learning||∼160 pg/kg/d||42*|
|Rat||Genital malformation||200 ng/kg #||73*|
|Rat||Immune suppression||100 ng/kg #||50*|
|Rat||Decreased sperm count||64 ng/kg #||28*|
|Mouse||Immune suppression (viral susceptibility)||10 ng/kg #||10|
|Current Average Body Burden Levels in Humans (“Background”)||∼10|
|Types of foods in Bien Hoa||Levels of TCDD contamination (ppt or pg/g)*||Approximate daily food intake (g) that is tolerable for person weighing 50 kg**|
|Duck/wild goose||276–331||0.15–0.6 g|
|Duck/wild goose fat||536–550||0.09–0.36 g|
|Snakehead fish||66||0.76–3.0 g|
|Snakehead fish fat||15,349||0.003–0.013 g|
|Toad fat||11,765||0.004–0.017 g|
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